This package performs multi-omic differential network analysis by revealing differential interactions between molecular entities (genes, proteins, transcription factors, or other biomolecules) across the omic datasets provided. For each omic dataset, a differential network is constructed where links represent statistically significant differential interactions between entities. These networks are then integrated into a comprehensive visualization using distinct colors to distinguish interactions from different omic layers. This unified display allows interactive exploration of cross-omic patterns, such as differential interactions present at both transcript and protein levels. For each link, users can access differential statistical significance metrics (p values or adjusted p values, calculated via robust or traditional linear regression with interaction term) and differential regression plots. The methods implemented in this package are described in Sciacca et al. (2023) <doi:10.1093/bioinformatics/btad192>.

Implementations of MOSUM-based statistical procedures and algorithms for detecting multiple changes in the mean. This comprises the MOSUM procedure for estimating multiple mean changes from Eichinger and Kirch (2018) <doi:10.3150/16-BEJ887> and the multiscale algorithmic extension from Cho and Kirch (2022) <doi:10.1007/s10463-021-00811-5>, as well as the bootstrap procedure for generating confidence intervals about the locations of change points as proposed in Cho and Kirch (2022) <doi:10.1016/j.csda.2022.107552>. See also Meier, Kirch and Cho (2021) <doi:10.18637/jss.v097.i08> which accompanies the R package.

This package provides a comprehensive collection of linkage methods for agglomerative hierarchical clustering on a matrix of proximity data (distances or similarities), returning a multifurcated dendrogram or multidendrogram. Multidendrograms can group more than two clusters when ties in proximity data occur, and therefore they do not depend on the order of the input data. Descriptive measures to analyze the resulting dendrogram are additionally provided. <doi:10.18637/jss.v114.i02>.

The Cauchy distribution is a special case of the t distribution when the degrees of freedom are equal to 1. The functions are related to the multivariate Cauchy distribution and include simulation, computation of the density, maximum likelihood estimation, contour plot of the bivariate Cauchy distribution, and discriminant analysis. References include: Nadarajah S. and Kotz S. (2008). "Estimation methods for the multivariate t distribution". Acta Applicandae Mathematicae, 102(1): 99--118. <doi:10.1007/s10440-008-9212-8>, and Kanti V. Mardia, John T. Kent and John M. Bibby (1979). "Multivariate analysis", ISBN:978-0124712522. Academic Press, London.

Multi-core replication function to make it easier to do fast Monte Carlo simulation. Based on the mcreplicate() function from the rethinking package. The rethinking package requires installing rstan', which is onerous to install, while also not adding capabilities to this function.

Helper functions that interface with the system utilities to learn about the local build environment. Lets you explore make rules to test the local configuration, or query pkg-config to find compiler flags and libs needed for building packages with external dependencies. Also contains tools to analyze which libraries that a installed R package linked to by inspecting output from ldd in combination with information from your distribution package manager, e.g. rpm or dpkg'.

Simulating data and fitting multi-species N-mixture models using nimble'. Includes features for handling zero-inflation and temporal correlation, Bayesian inference, model diagnostics, parameter estimation, and predictive checks. Designed for ecological studies with zero-altered or time-series data. Mimnagh, N., Parnell, A., Prado, E., & Moral, R. A. (2022) <doi:10.1007/s10651-022-00542-7>. Royle, J. A. (2004) <doi:10.1111/j.0006-341X.2004.00142.x>.

This package provides a complete toolkit to process the Munich ChronoType Questionnaire (MCTQ) for its three versions (standard, micro, and shift). MCTQ is a quantitative and validated tool to assess chronotypes using peoples sleep behavior, originally presented by Till Roenneberg, Anna Wirz-Justice, and Martha Merrow (2003, <doi:10.1177/0748730402239679>).

Transfer learning, as a prevailing technique in computer sciences, aims to improve the performance of a target model by leveraging auxiliary information from heterogeneous source data. We provide novel tools for multi-source transfer learning under statistical models based on model averaging strategies, including linear regression models, partially linear models. Unlike existing transfer learning approaches, this method integrates the auxiliary information through data-driven weight assignments to avoid negative transfer. This is the first package for transfer learning based on the optimal model averaging frameworks, providing efficient implementations for practitioners in multi-source data modeling. The details are described in Hu and Zhang (2023) <https://jmlr.org/papers/v24/23-0030.html>.

Reads, plots, and manipulates large taxonomic data sets, like those generated from modern high-throughput sequencing, such as metabarcoding (i.e. amplification metagenomics, 16S metagenomics, etc). It provides a tree-based visualization called "heat trees" used to depict statistics for every taxon in a taxonomy using color and size. It also provides various functions to do common tasks in microbiome bioinformatics on data in the taxmap format defined by the taxa package. The metacoder package is described in the publication by Foster et al. (2017) <doi:10.1371/journal.pcbi.1005404>.

Computes robust and bias-corrected sandwich variance estimators for multi-state Cox models with clustered time-to-event data. The methodology extends the marginal Cox model bias-correction framework of Wang et al. (2023) <doi:10.1002/bimj.202200113> to the multi-state setting.

Generate the optimal maximin distance, minimax distance (only for low dimensions), and maximum projection designs within the class of Latin hypercube designs efficiently for computer experiments. Generate Pareto front optimal designs for each two of the three criteria and all the three criteria within the class of Latin hypercube designs efficiently. Provide criterion computing functions. References of this package can be found in Morris, M. D. and Mitchell, T. J. (1995) <doi:10.1016/0378-3758(94)00035-T>, Lu Lu and Christine M. Anderson-CookTimothy J. Robinson (2011) <doi:10.1198/Tech.2011.10087>, Joseph, V. R., Gul, E., and Ba, S. (2015) <doi:10.1093/biomet/asv002>.

Implementation of the mid-n algorithms presented in Wellek S (2015) <DOI:10.1111/stan.12063> Statistica Neerlandica 69, 358-373 for exact sample size calculation for superiority trials with binary outcome.

Implementing various things including functions for LaTeX tables, the Kalman filter, QQ-plots with simulation-based confidence intervals, linear regression diagnostics, web scraping, development tools, relative risk and odds rati, GARCH(1,1) Forecasting.

High-throughput, flexible and reproducible extraction of data from figures in primary research papers. metaDigitise() can extract data and / or automatically calculate summary statistics for users from box plots, bar plots (e.g., mean and errors), scatter plots and histograms.

Fast moment-based hierarchical model fitting. Implements methods from the papers "Fast Moment-Based Estimation for Hierarchical Models," by Perry (2017) and "Fitting a Deeply Nested Hierarchical Model to a Large Book Review Dataset Using a Moment-Based Estimator," by Zhang, Schmaus, and Perry (2018).

Computes dielectric response and optical cross-sections of metallic nanoparticles using Drude dielectric model and Rayleigh approximation.

The ultimate goal is to support 2-2-1, 2-1-1, and 1-1-1 models for multilevel mediation, the option of a moderating variable for either the a, b, or both paths, and covariates. Currently the 1-1-1 model is supported and several options of random effects; the initial code for bootstrapping was evaluated in simulations by Falk, Vogel, Hammami, and MioÄ eviÄ (2024) <doi:10.3758/s13428-023-02079-4>. Support for Bayesian estimation using brms comprises ongoing work. Currently only continuous mediators and outcomes are supported. Factors for any predictors must be numerically represented.

This package provides tools for creating agents with persistent state using R6 classes <https://cran.r-project.org/package=R6> and the ellmer package <https://cran.r-project.org/package=ellmer>. Tracks prompts, messages, and agent metadata for reproducible, multi-turn large language model sessions.

This package provides a collection of functions to connect to a Moodle database, cache relevant tables locally and generate learning analytics. Moodle is an open source Learning Management System (LMS) developed by MoodleHQ. For more information about Moodle, visit <https://moodle.org>.

Statistical Analyses and Pooling after Multiple Imputation. A large variety of repeated statistical analysis can be performed and finally pooled. Statistical analysis that are available are, among others, Levene's test, Odds and Risk Ratios, One sample proportions, difference between proportions and linear and logistic regression models. Functions can also be used in combination with the Pipe operator. More and more statistical analyses and pooling functions will be added over time. Heymans (2007) <doi:10.1186/1471-2288-7-33>. Eekhout (2017) <doi:10.1186/s12874-017-0404-7>. Wiel (2009) <doi:10.1093/biostatistics/kxp011>. Marshall (2009) <doi:10.1186/1471-2288-9-57>. Sidi (2021) <doi:10.1080/00031305.2021.1898468>. Lott (2018) <doi:10.1080/00031305.2018.1473796>. Grund (2021) <doi:10.31234/osf.io/d459g>.

For the purposes of teaching, it is often desirable to show examples of working with messy data and how to clean it. This R package creates messy data from clean, tidy data frames so that students have a clean example to work towards.

Perform multi-trait rare-variant association tests using the summary statistics and adjust for possible sample overlap. Package is based on "Multi-Trait Analysis of Rare-Variant Association Summary Statistics using MTAR" by Luo, L., Shen, J., Zhang, H., Chhibber, A. Mehrotra, D.V., Tang, Z., 2019 (submitted).

Application of a test to rule out that trends detected in hydrological time series are explained exclusively by the randomness of the climate. Based on: Ricchetti, (2018) <https://repositorio.uchile.cl/handle/2250/168487>.