This package provides a Shiny Web Application to predict and visualize concentrations of pharmaceuticals in the aqueous environment. Jagadeesan K., Barden R. and Kasprzyk-Hordern B. (2022) <https://www.ssrn.com/abstract=4306129>.

Structured fusion Lasso penalized estimation of multi-state models with the penalty applied to absolute effects and absolute effect differences (i.e., effects on transition-type specific hazard rates).

This package provides functionality for Bayesian analysis of replication studies using power prior approaches (Pawel et al., 2023) <doi:10.1007/s11749-023-00888-5>.

Data for the extraterrestrial solar spectral irradiance and ground level solar spectral irradiance and irradiance. In addition data for shade light under vegetation and irradiance time series from different broadband sensors. Part of the r4photobiology suite, Aphalo P. J. (2015) <doi:10.19232/uv4pb.2015.1.14>.

Data analysis based on panel partially-observed Markov process (PanelPOMP) models. To implement such models, simulate them and fit them to panel data, panelPomp extends some of the facilities provided for time series data by the pomp package. Implemented methods include filtering (panel particle filtering) and maximum likelihood estimation (Panel Iterated Filtering) as proposed in Breto, Ionides and King (2020) "Panel Data Analysis via Mechanistic Models" <doi:10.1080/01621459.2019.1604367>.

Estimate complex Structural Equation Models (SEMs) by fitting Partial Least Squares Structural Equation Modeling (PLS-SEM) and Partial Least Squares consistent Structural Equation Modeling (PLSc-SEM) specifications that handle categorical data, non-linear relations, and multilevel structures. The implementation follows Lohmöller (1989) for the classic PLS-SEM algorithm, Dijkstra and Henseler (2015) for consistent PLSc-SEM, Dijkstra et al., (2014) for nonlinear PLSc-SEM, and Schuberth, Henseler, Dijkstra (2018) for ordinal PLS-SEM and PLSc-SEM. Additional extensions are under development. The MC-OrdPLSc algorithm, used to handle ordinal interaction models is detailed in Slupphaug et al., (2026). References: Lohmöller, J.-B. (1989, ISBN:9783790803002). "Latent Variable Path Modeling with Partial Least Squares." Dijkstra, T. K., & Henseler, J. (2015). <doi:10.1016/j.jmva.2015.06.002>. "Consistent partial least squares path modeling." Dijkstra, T. K., & Schermelleh-Engel, K. (2014). <doi:10.1016/j.csda.2014.07.008>. "Consistent partial least squares for nonlinear structural equation models." Schuberth, F., Henseler, J., & Dijkstra, T. K. (2018). <doi:10.1007/s11135-018-0767-9>. "Partial least squares path modeling using ordinal categorical indicators." Slupphaug, K. Mehmetoglu, M. & Mittner, M. (2026). <doi:10.31234/osf.io/fwzj6_v1>. "Consistent Estimates from Biased Estimators: Monte-Carlo Consistent Partial Least Squares for Latent Interaction Models with Ordinal Indicators.".

This package performs partial verification bias (PVB) correction for binary diagnostic tests, where PVB arises from selective patient verification in diagnostic accuracy studies. Supports correction of important accuracy measures -- sensitivity, specificity, positive predictive values and negative predictive value -- under missing-at-random and missing-not-at-random missing data mechanisms. Available methods and references are "Begg and Greenes methods" in Alonzo & Pepe (2005) <doi:10.1111/j.1467-9876.2005.00477.x> and deGroot et al. (2011) <doi:10.1016/j.annepidem.2010.10.004>; "Multiple imputation" in Harel & Zhou (2006) <doi:10.1002/sim.2494>, "EM-based logistic regression" in Kosinski & Barnhart (2003) <doi:10.1111/1541-0420.00019>; "Inverse probability weighting" in Alonzo & Pepe (2005) <doi:10.1111/j.1467-9876.2005.00477.x>; "Inverse probability bootstrap sampling" in Nahorniak et al. (2015) <doi:10.1371/journal.pone.0131765> and Arifin & Yusof (2022) <doi:10.3390/diagnostics12112839>; "Scaled inverse probability resampling methods" in Arifin & Yusof (2025) <doi:10.1371/journal.pone.0321440>.

Computes the minimum sample size required for the external validation of an existing multivariable prediction model using the criteria proposed by Archer (2020) <doi:10.1002/sim.8766> and Riley (2021) <doi:10.1002/sim.9025>.

This package implements statistical methods for estimating disease penetrance in family-based studies. Penetrance refers to the probability of disease§ manifestation in individuals carrying specific genetic variants. The package provides tools for age-specific penetrance estimation, handling missing data, and accounting for ascertainment bias in family studies. Cite as: Kubista, N., Braun, D. & Parmigiani, G. (2024) <doi:10.48550/arXiv.2411.18816>.

Comprehensive toolkit for generating various numerical features of protein sequences described in Xiao et al. (2015) <DOI:10.1093/bioinformatics/btv042>. For full functionality, the software ncbi-blast+ is needed, see <https://blast.ncbi.nlm.nih.gov/doc/blast-help/downloadblastdata.html> for more information.

An interactive document for preprocessing the dataset using rmarkdown and shiny packages. Runtime examples are provided in the package function as well as at <https://analyticmodels.shinyapps.io/PREPShiny/>.

The Poverty Probability Index (PPI) is a poverty measurement tool for organizations and businesses with a mission to serve the poor. The PPI is statistically-sound, yet simple to use: the answers to 10 questions about a household's characteristics and asset ownership are scored to compute the likelihood that the household is living below the poverty line - or above by only a narrow margin. This package contains country-specific lookup data tables used as reference to determine the poverty likelihood of a household based on their score from the country-specific PPI questionnaire. These lookup tables have been extracted from documentation of the PPI found at <https://www.povertyindex.org> and managed by Innovations for Poverty Action <https://poverty-action.org/>.

Perform a differential analysis at pathway level based on metabolite quantifications and information on pathway metabolite composition. The method, described in Guilmineau et al (2025) <doi:10.1186/s12859-025-06118-z> is based on a Principal Component Analysis step and on a linear mixed model. Automatic query of metabolic pathways is also implemented.

This toolkit is designed for manipulation and analysis of peptides. It provides functionalities to assist researchers in peptide engineering and proteomics. Users can manipulate peptides by adding amino acids at every position, count occurrences of each amino acid at each position, and transform amino acid counts based on probabilities. The package offers functionalities to select the best versus the worst peptides and analyze these peptides, which includes counting specific residues, reducing peptide sequences, extracting features through One Hot Encoding (OHE), and utilizing Quantitative Structure-Activity Relationship (QSAR) properties (based in the package Peptides by Osorio et al. (2015) <doi:10.32614/RJ-2015-001>). This package is intended for both researchers and bioinformatics enthusiasts working on peptide-based projects, especially for their use with machine learning.

High Dynamic Range (HDR) images support a large range in luminosity between the lightest and darkest regions of an image. To capture this range, data in HDR images is often stored as floating point numbers and in formats that capture more data and channels than standard image types. This package supports reading and writing two types of HDR images; PFM (Portable Float Map) and OpenEXR images. HDR images can be converted to lower dynamic ranges (for viewing) using tone-mapping. A number of tone-mapping algorithms are included which are based on Reinhard (2002) "Photographic tone reproduction for digital images" <doi:10.1145/566654.566575>.

It is often useful when developing an R package to track the relationship between functions in order to appropriately test and track changes. This package generates a graph of the relationship between all R functions in a package. It can also be used on any directory containing .R files which can be very useful for shiny apps or other non-package workflows.

Crop production systems are increasingly challenged by climate variability, resource limitations, and bioticâ abiotic stresses. In this context, stress tolerance indices and physiological trait estimators are essential tools to identify stable and superior genotypes, quantify yield stability under stress versus non-stress conditions, and understand plant adaptive responses. The PhysioIndexR package provides a unified framework to compute commonly used stress indices, physiological traits, and derived metrics that are critical in crop improvement, crop physiology, and other agricultural sciences. The package includes functions to calculate classical stress tolerance indices (See Lamba et al., 2023; <doi:10.1038/s41598-023-37634-8>) such as Tolerance (TOL), Stress Tolerance Index (STI), Stress Susceptibility Percentage Index (SSPI), Yield Index (YI), Yield Stability Index (YSI), Relative Stress Index (RSI), Mean Productivity (MP), Geometric Mean Productivity (GMP), Harmonic Mean (HM), Mean Relative Performance (MRP), and Percent Yield Reduction (PYR), along with a convenience wrapper all_indices() that returns all indices simultaneously. The function mfvst_from_indices() integrates these indices into a composite stress score using direction-aware membership values (0â 1 scaling) and also averaging, facilitating genotype ranking and selection (See Vinu et al., 2025; <doi:10.1007/s12355-025-01595-1>). The package also implements two novel composite functions: WMFVST(), which computes the Weighted Mean Membership Function Value for Stress Tolerance, and WASI(), which computes the Weighted Average Stress Index, both derived from membership function values (MFV) and raw stress index values, respectively. Beyond stress indices, the package provides functions for key physiological traits relevant to sugarcane and other crops: bmap() computes biomass accumulation and partitioning between leaf, cane/shoot, and root fractions. chl() estimates total chlorophyll content from Soil-Plant Analysis Development (SPAD) and Chlorophyll Content Index (CCI) values using validated quadratic models particularly for sugarcane (See Krishnapriya et al., 2020; <doi:10.37580/JSR.2019.2.9.150-163>). ctd() calculates canopy temperature depression (CTD) from ambient and canopy temperatures, an important indicator of transpiration efficiency. growth() computes key growth analysis parameters, including Leaf Area Index (LAI), Net Assimilation Rate (NAR), and Crop Growth Rate (CGR) across crop growth stages (See Watson, 1958; <doi:10.1093/oxfordjournals.aob.a083596>). ranking() provides flexible ranking utilities for genotype performance with multiple tie-handling and NA-placement options. Through these tools, the package enables researchers to: (i) quantify crop responses to stress environments, (ii) partition physiological components of yield, (iii) integrate multiple indices into composite metrics for genotype evaluation, and (iv) facilitate informed decision making in breeding pipelines, and plant physiology experiments. By combining physiology-based traits with quantitative stress indices, PhysioIndexR supports comprehensive crop evaluation and helps researchers identify multi-stress-resilient superior genotypes, thereby contributing to genetic improvement and ensuring sustainable production of food, fuel, and fibre in the era of limited resources and climate change.

This package provides a collection of functions to process digital images, depict greenness index trajectories and extract relevant phenological stages.

This package provides a profile boosting framework for feature selection in parametric models. It offers a unified interface pboost() and several wrapped models, including linear model, generalized linear models, quantile regression, Cox proportional hazards model, beta regression. An S3 interface EBIC() is provided as the stopping rule for the profile boosting by default.

This package provides general linear model facilities (single y-variable, multiple x-variables with arbitrary mixture of continuous and categorical and arbitrary interactions) for cross-species data. The method is, however, based on the nowadays rather uncommon situation in which uncertainty about a phylogeny is well represented by adopting a single polytomous tree. The theory is in A. Grafen (1989, Proc. R. Soc. B 326, 119-157) and aims to cope with both recognised phylogeny (closely related species tend to be similar) and unrecognised phylogeny (a polytomy usually indicates ignorance about the true sequence of binary splits).

Implementation of the Partitioned Local Depth (PaLD) approach which provides a measure of local depth and the cohesion of a point to another which (together with a universal threshold for distinguishing strong and weak ties) may be used to reveal local and global structure in data, based on methods described in Berenhaut, Moore, and Melvin (2022) <doi:10.1073/pnas.2003634119>. No extraneous inputs, distributional assumptions, iterative procedures nor optimization criteria are employed. This package includes functions for computing local depths and cohesion as well as flexible functions for plotting community networks and displays of cohesion against distance.

Shrinkage estimator for polygenic risk prediction (PRS) models based on summary statistics of genome-wide association (GWA) studies. Based upon the methods and original PANPRS package as found in: Chen, Chatterjee, Landi, and Shi (2020) <doi:10.1080/01621459.2020.1764849>.

Run simulations to assess the impact of various designs features and the underlying biological behaviour on the outcome of a Patient Derived Xenograft (PDX) population study. This project can either be deployed to a server as a shiny app or installed locally as a package and run the app using the command populationPDXdesignApp()'.

It offers a wide variety of techniques, such as graphics, recoding, or regression models, for a comprehensive analysis of patient-reported outcomes (PRO). Especially novel is the broad range of regression models based on the beta-binomial distribution useful for analyzing binomial data with over-dispersion in cross-sectional, longitudinal, or multidimensional response studies (see Najera-Zuloaga J., Lee D.-J. and Arostegui I. (2019) <doi:10.1002/bimj.201700251>).