Interactive labelling of scatter plots, volcano plots and Manhattan plots using a shiny and plotly interface. Users can hover over points to see where specific points are located and click points on/off to easily label them. Labels can be dragged around the plot to place them optimally. Plots can be exported directly to PDF for publication. For plots with large numbers of points, points can optionally be rasterized as a bitmap, while all other elements (axes, text, labels & lines) are preserved as vector objects. This can dramatically reduce file size for plots with millions of points such as Manhattan plots, and is ideal for publication.

An eikosogram (ancient Greek for probability picture) divides the unit square into rectangular regions whose areas, sides, and widths represent various probabilities associated with the values of one or more categorical variates. Rectangle areas are joint probabilities, widths are always marginal (though possibly joint margins, i.e. marginal joint distributions of two or more variates), and heights of rectangles are always conditional probabilities. Eikosograms embed the rules of probability and are useful for introducing elementary probability theory, including axioms, marginal, conditional, and joint probabilities, and their relationships (including Bayes theorem as a completely trivial consequence). They provide advantages over Venn diagrams for this purpose, particularly in distinguishing probabilistic independence, mutually exclusive events, coincident events, and associations. They also are useful for identifying and understanding conditional independence structure. Eikosograms can be thought of as mosaic plots when only two categorical variates are involved; the layout is quite different when there are more than two variates. Only one categorical variate, designated the "response", presents on the vertical axis and all others, designated the "conditioning" variates, appear on the horizontal. In this way, conditional probability appears only as height and marginal probabilities as widths. The eikosogram is ideal for response models (e.g. logistic models) but equally useful when no variate is distinguished as the response. In such cases, each variate can appear in turn as the response, which is handy for assessing conditional independence in discrete graphical models (i.e. "Bayesian networks" or "BayesNets"). The eikosogram and its value over Venn diagrams in teaching probability is described in W.H. Cherry and R.W. Oldford (2003) <https://math.uwaterloo.ca/~rwoldfor/papers/eikosograms/paper.pdf>, its value in exploring conditional independence structure and relation to graphical and log-linear models is described in R.W. Oldford (2003) <https://math.uwaterloo.ca/~rwoldfor/papers/eikosograms/independence/paper.pdf>, and a number of problems, puzzles, and paradoxes that are easily explained with eikosograms are given in R.W. Oldford (2003) <https://math.uwaterloo.ca/~rwoldfor/papers/eikosograms/examples/paper.pdf>.

Estimate ecosystem metabolism in a Bayesian framework for individual water quality monitoring stations with continuous dissolved oxygen time series. A mass balance equation is used that provides estimates of parameters for gross primary production, respiration, and gas exchange. Methods adapted from Grace et al. (2015) <doi:10.1002/lom3.10011> and Wanninkhof (2014) <doi:10.4319/lom.2014.12.351>. Details in Beck et al. (2024) <doi:10.1002/lom3.10620>.

This package produces tables for descriptive epidemiological analysis. These tables include attack rates, case fatality ratios, and mortality rates (with appropriate confidence intervals), with additional functionality to calculate Mantel-Haenszel odds, risk, and incidence rate ratios. The methods implemented follow standard epidemiological approaches described in Rothman et al. (2008, ISBN:978-0-19-513554-2). This package is part of the R4EPIs project <https://R4EPI.github.io/sitrep/>.

DNA methylation is essential for human, and environment can change the DNA methylation and affect body status. Epigenome-Wide Mediation Analysis Study (EMAS) can find potential mediator CpG sites between exposure (x) and outcome (y) in epigenome-wide. For more information on the methods we used, please see the following references: Tingley, D. (2014) <doi:10.18637/jss.v059.i05>, Turner, S. D. (2018) <doi:10.21105/joss.00731>, Rosseel, D. (2012) <doi:10.18637/jss.v048.i02>.

Use SQLite3 as a database system via a complete SQL free R interface, treating the data as if it was a single spreadsheet.

This comprehensive toolkit for Distributed Elliptical model is designated as "ELIC" (The LIC for Distributed Elliptical Model Analysis) analysis. It is predicated on the assumption that the error term adheres to a Elliptical distribution. The philosophy of the package is described in Guo G. (2020) <doi:10.1080/02664763.2022.2053949>.

Fast implementations of functional enrichment analysis methods using C++ via Rcpp'. Currently provides Over-Representation Analysis (ORA) and Gene Set Enrichment Analysis (GSEA). The multilevel GSEA algorithm is derived from the fgsea package. Methods are described in Subramanian et al. (2005) <doi:10.1073/pnas.0506580102> and Korotkevich et al. (2021) <doi:10.1101/060012>.

This package provides a methodology simple and trustworthy for the analysis of extreme values and multiple threshold tests for a generalized Pareto distribution, together with an automatic threshold selection algorithm. See del Castillo, J, Daoudi, J and Lockhart, R (2014) <doi:10.1111/sjos.12037>.

Efficiently impute large scale matrix with missing values via its unbiased low-rank matrix approximation. Our main approach is Hard-Impute algorithm proposed in <https://www.jmlr.org/papers/v11/mazumder10a.html>, which achieves highly computational advantage by truncated singular-value decomposition.

Open source data allows for reproducible research and helps advance our knowledge. The purpose of this package is to collate open source ophthalmic data sets curated for direct use. This is real life data of people with intravitreal injections with anti-vascular endothelial growth factor (anti-VEGF), due to age-related macular degeneration or diabetic macular edema. Associated publications of the data sets: Fu et al. (2020) <doi:10.1001/jamaophthalmol.2020.5044>, Moraes et al (2020) <doi:10.1016/j.ophtha.2020.09.025>, Fasler et al. (2019) <doi:10.1136/bmjopen-2018-027441>, Arpa et al. (2020) <doi:10.1136/bjophthalmol-2020-317161>, Kern et al. 2020, <doi:10.1038/s41433-020-1048-0>.

Produce maximum likelihood estimates of common accuracy statistics for multiple measurement methods when a gold standard is not available. An R implementation of the expectation maximization algorithms described in Zhou et al. (2011) <doi:10.1002/9780470906514> with additional functions for creating simulated data and visualizing results. Supports binary, ordinal, and continuous measurement methods.

This package provides functions for the simulation and the nonparametric estimation of elliptical distributions, meta-elliptical copulas and trans-elliptical distributions, following the article Derumigny and Fermanian (2022) <doi:10.1016/j.jmva.2022.104962>.

This package provides a consistent set of functions for enriching and analyzing sovereign-level economic data. Economists, data scientists, and financial professionals can use the package to add standardized identifiers, demographic and macroeconomic indicators, and derived metrics such as gross domestic product per capita or government expenditure shares.

This package provides a simple approach to using a probit or logit analysis to calculate lethal concentration (LC) or time (LT) and the appropriate fiducial confidence limits desired for selected LC or LT for ecotoxicology studies (Finney 1971; Wheeler et al. 2006; Robertson et al. 2007). The simplicity of ecotox comes from the syntax it implies within its functions which are similar to functions like glm() and lm(). In addition to the simplicity of the syntax, a comprehensive data frame is produced which gives the user a predicted LC or LT value for the desired level and a suite of important parameters such as fiducial confidence limits and slope. Finney, D.J. (1971, ISBN: 052108041X); Wheeler, M.W., Park, R.M., and Bailer, A.J. (2006) <doi:10.1897/05-320R.1>; Robertson, J.L., Savin, N.E., Russell, R.M., and Preisler, H.K. (2007, ISBN: 0849323312).

Two methods for performing equivalence test for the means of two (test and reference) normal distributions are implemented. The null hypothesis of the equivalence test is that the absolute difference between the two means are greater than or equal to the equivalence margin and the alternative is that the absolute difference is less than the margin. Given that the margin is often difficult to obtain a priori, it is assumed to be a constant multiple of the standard deviation of the reference distribution. The first method assumes a fixed margin which is a constant multiple of the estimated standard deviation of the reference data and whose variability is ignored. The second method takes into account the margin variability. In addition, some tools to summarize and illustrate the data and test results are included to facilitate the evaluation of the data and interpretation of the results.

The EvoPER, Evolutionary Parameter Estimation for Individual-based Models is an extensible package providing optimization driven parameter estimation methods using metaheuristics and evolutionary computation techniques (Particle Swarm Optimization, Simulated Annealing, Ant Colony Optimization for continuous domains, Tabu Search, Evolutionary Strategies, ...) which could be more efficient and require, in some cases, fewer model evaluations than alternatives relying on experimental design. Currently there are built in support for models developed with Repast Simphony Agent-Based framework (<https://repast.github.io/>) and with NetLogo (<https://www.netlogo.org/>) which are the most used frameworks for Agent-based modeling.

Extract features from tabular data in a declarative fashion, with a focus on processing medical records. Features are specified as JSON and are independently processed before being joined. Input data can be provided as CSV files or as data frames. This setup ensures that data is transformed in a modular and reproducible manner, and allows the same pipeline to be easily applied to new data.

It contains functions for dose calculation for different routes, fitting data to probability distributions, random number generation (Monte Carlo simulation) and calculation of systemic and carcinogenic risks. For more information see the publication: Barrio-Parra et al. (2019) "Human-health probabilistic risk assessment: the role of exposure factors in an urban garden scenario" <doi:10.1016/j.landurbplan.2019.02.005>.

This package contains a collection of examples of evidence factors in observational studies from the book Replication and Evidence Factors in Observational Studies by Paul R. Rosenbaum (2021) <doi:10.1201/9781003039648>.

The cointegration based support vector regression model enables researchers to use data obtained from the cointegrating vector as input in the support vector regression model.

Enables users to incorporate expert opinion with parametric survival analysis using a Bayesian or frequentist approach. Expert Opinion can be provided on the survival probabilities at certain time-point(s) or for the difference in mean survival between two treatment arms. Please reference it's use as Cooney, P., White, A. (2023) <doi:10.1177/0272989X221150212>.

Estimates coefficients of extended LASSO penalized linear regression and generalized linear models. Currently lasso and elastic net penalized linear regression and generalized linear models are considered. This package currently utilizes an accurate approximation of L1 penalty and then a modified Jacobi algorithm to estimate the coefficients. There is provision for plotting of the solutions and predictions of coefficients at given values of lambda. This package also contains functions for cross validation to select a suitable lambda value given the data. Also provides a function for estimation in fused lasso penalized linear regression. For more details, see Mandal, B. N.(2014). Computational methods for L1 penalized GLM model fitting, unpublished report submitted to Macquarie University, NSW, Australia.

Software of esDesign is developed to implement the adaptive enrichment designs with sample size re-estimation presented in Lin et al. (2021) <doi: 10.1016/j.cct.2020.106216>. In details, three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR), AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package also contains several widely used adaptive designs, such as the Marker Sequential Test (MaST) design proposed Freidlin et al. (2014) <doi:10.1177/1740774513503739>, the adaptive enrichment designs without early stopping (AED or ES), the sample size re-estimation procedure (SSR) based on the conditional power proposed by Proschan and Hunsberger (1995), and some useful functions. In details, we can calculate the futility and/or efficacy stopping boundaries, the sample size required, calibrate the value of the threshold of the difference between subgroup-specific test statistics, conduct the simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.