This package provides computational methods for detecting adverse high-order drug interactions from individual case safety reports using statistical techniques, allowing the exploration of higher-order interactions among drug cocktails.

End-member modelling analysis of grain-size data is an approach to unmix a data set's underlying distributions and their contribution to the data set. EMMAgeo provides deterministic and robust protocols for that purpose.

Augments the eiCompare package's Racially Polarized Voting (RPV) functionality to streamline analyses and visualizations used to support voting rights and redistricting litigation. The package implements methods described in Barreto, M., Collingwood, L., Garcia-Rios, S., & Oskooii, K. A. (2022). "Estimating Candidate Support in Voting Rights Act Cases: Comparing Iterative EI and EI-RÃ C Methods" <doi:10.1177/0049124119852394>.

This package provides a methodology simple and trustworthy for the analysis of extreme values and multiple threshold tests for a generalized Pareto distribution, together with an automatic threshold selection algorithm. See del Castillo, J, Daoudi, J and Lockhart, R (2014) <doi:10.1111/sjos.12037>.

Bindings to edlib, a lightweight performant C/C++ library for exact pairwise sequence alignment using edit distance (Levenshtein distance). The algorithm computes the optimal alignment path, but also can be used to find only the start and/or end of the alignment path for convenience. Edlib was designed to be ultrafast and require little memory, with the capability to handle very large sequences. Three alignment methods are supported: global (Needleman-Wunsch), infix (Hybrid Wunsch), and prefix (Semi-Hybrid Wunsch). The original C/C++ library is described in "Edlib: a C/C++ library for fast, exact sequence alignment using edit distance", M. Å oÅ¡iÄ , M. Å ikiÄ , <doi:10.1093/bioinformatics/btw753>.

Endpoint selection and sample size reassessment for multiple binary endpoints based on blinded and/or unblinded data. Trial design that allows an adaptive modification of the primary endpoint based on blinded information obtained at an interim analysis. The decision rule chooses the endpoint with the lower estimated required sample size. Additionally, the sample size is reassessed using the estimated event probabilities and correlation between endpoints. The implemented design is proposed in Bofill Roig, M., Gómez Melis, G., Posch, M., and Koenig, F. (2022). <doi:10.48550/arXiv.2206.09639>.

This package contains the example EEG data used in the package eegkit. Also contains code for easily creating larger EEG datasets from the EEG Database on the UCI Machine Learning Repository.

This package provides a tool to run Monte Carlo simulation of catastrophe model event loss tables, using a Poisson frequency and Beta severity distribution.

This package provides functions for evaluating and visualizing ecological assessment procedures for surface waters containing physical, chemical and biological assessments in the form of value functions.

Constructs a shiny app function with interactive displays for summary and analysis of variance regression tables, and parallel coordinate plots of data and residuals.

This package provides a comprehensive toolkit for discovering differential and difference equations from empirical time series data using symbolic regression. The package implements a complete workflow from data preprocessing (including Total Variation Regularized differentiation for noisy economic data), visual exploration of dynamical structure, and symbolic equation discovery via genetic algorithms. It leverages a high-performance Julia backend ('SymbolicRegression.jl') to provide industrial-grade robustness, physics-informed constraints, and rigorous out-of-sample validation. Designed for economists, physicists, and researchers studying dynamical systems from observational data.

This package provides a collection of small functions useful for epidemics analysis and infectious disease modelling. This includes computation of basic reproduction numbers from growth rates, generation of hashed labels to anonymize data, and fitting discretized Gamma distributions.

This package provides function to transform latex math expressions into format HTML or Office Open XML Math'. The XML result can then be included in HTML', Microsoft Word documents or Microsoft PowerPoint presentations by using a Markdown document or the R package officer'.

This is a package for exact Confidence Intervals for the difference between two independent or dependent proportions.

Estimation of fully and partially observed Exponential-Family Random Network Models (ERNM). Exponential-family Random Graph Models (ERGM) and Gibbs Fields are special cases of ERNMs and can also be estimated with the package. Please cite Fellows and Handcock (2012), "Exponential-family Random Network Models" available at <doi:10.48550/arXiv.1208.0121>.

This package provides classes and methods for implementing aquatic ecosystem models, for running these models, and for visualizing their results.

This package provides a tool which allows users to create and evaluate ensembles of species distribution model (SDM) predictions. Functionality is offered through R functions or a GUI (R Shiny app). This tool can assist users in identifying spatial uncertainties and making informed conservation and management decisions. The package is further described in Woodman et al (2019) <doi:10.1111/2041-210X.13283>.

Dissimilarity-based analysis functions including ordination and Mantel test functions, intended for use with spatial and community ecological data. The original package description is in Goslee and Urban (2007) <doi:10.18637/jss.v022.i07>, with further statistical detail in Goslee (2010) <doi:10.1007/s11258-009-9641-0>.

Simulate ecological niche models using Mahalanobis distance, transform distances to suitability with 1 - empirical cumulative distribution function and 1 - chi-squared, and generate comparison figures.

This package provides functions to prepare and analyse eye tracking data of reading exercises. The functions allow some basic data preparations and code fixations as first and second pass. First passes can be further devided into forward and reading. The package further allows for aggregating fixation times per AOI or per AOI and per type of pass (first forward, first rereading, second). These methods are based on Hyönä, Lorch, and Rinck (2003) <doi:10.1016/B978-044451020-4/50018-9> and Hyönä, and Lorch (2004) <doi:10.1016/j.learninstruc.2004.01.001>. It is also possible to convert between metric length and visual degrees.

Implementation of uniformly most powerful invariant equivalence tests for one- and two-sample problems (paired and unpaired) as described in Wellek (2010, ISBN:978-1-4398-0818-4). Also one-sided alternatives (non-inferiority and non-superiority tests) are supported. Basically a variant of a t-test with (relaxed) null and alternative hypotheses exchanged.

Fast implementations of functional enrichment analysis methods using C++ via Rcpp'. Currently provides Over-Representation Analysis (ORA) and Gene Set Enrichment Analysis (GSEA). The multilevel GSEA algorithm is derived from the fgsea package. Methods are described in Subramanian et al. (2005) <doi:10.1073/pnas.0506580102> and Korotkevich et al. (2021) <doi:10.1101/060012>.

This package provides tools for training and practicing epidemiologists including methods for two-way and multi-way contingency tables.

Fits a state-space mass-balance model for marine ecosystems, which implements dynamics derived from Ecopath with Ecosim ('EwE') <https://ecopath.org/> while fitting to time-series of fishery catch, biomass indices, age-composition samples, and weight-at-age data. Ecostate fits biological parameters (e.g., equilibrium mass) and measurement parameters (e.g., catchability coefficients) jointly with residual variation in process errors, and can include Bayesian priors for parameters.