This package provides a Seurat'-compatible toolkit for marker gene identification, expression summarization, and visualization of annotated single-cell transcriptomic data. CellWindX identifies top cell-type-enriched markers, calculates marker expression percentages and average expression values across cell groups, and generates publication-oriented dimensional reduction plots, marker heatmaps, and gene-level radar plots. The package includes built-in aesthetic palettes and supports both exploratory analysis and downstream figure preparation for single-cell atlas studies. The workflow is designed to complement single-cell analysis frameworks such as Seurat described by Satija et al. (2015) <doi:10.1038/nbt.3192> and Hao et al. (2021) <doi:10.1016/j.cell.2021.04.048>, as well as heatmap visualization methods implemented in ComplexHeatmap described by Gu et al. (2016) <doi:10.1093/bioinformatics/btw313>.

The beta-binomial test is used for significance analysis of independent samples by Pham et al. (2010) <doi:10.1093/bioinformatics/btp677>. The inverted beta-binomial test is used for paired sample testing, e.g. pre-treatment and post-treatment data, by Pham and Jimenez (2012) <doi:10.1093/bioinformatics/bts394>.

Loads and displays images, selectively masks specified background colors, bins pixels by color using either data-dependent or automatically generated color bins, quantitatively measures color similarity among images using one of several distance metrics for comparing pixel color clusters, and clusters images by object color similarity. Uses CIELAB, RGB, or HSV color spaces. Originally written for use with organism coloration (reef fish color diversity, butterfly mimicry, etc), but easily applicable for any image set.

This package provides utilities for scientific computation and visualisation, with an emphasis on applications in physics and astrophysics. Functionality includes random sampling from spherical and custom distributions, information and entropy analysis, Fourier transforms, two-point correlation estimation, binning and gridding of point sets, two-dimensional interpolation, Monte Carlo integration, vector operations, coordinate transformations, physical constants, and cosmological conversions. Graphics tools support the creation and export of publication-quality plots, animations, colour scales, map projections, and bitmap images. Several of these tools were used by Obreschkow et al. (2020) <doi:10.1093/mnras/staa445>.

This model fitting tool incorporates cyclic coordinate descent and majorization-minimization approaches to fit a variety of regression models found in large-scale observational healthcare data. Implementations focus on computational optimization and fine-scale parallelization to yield efficient inference in massive datasets. Please see: Suchard, Simpson, Zorych, Ryan and Madigan (2013) <doi:10.1145/2414416.2414791>.

Create correlation heatmaps from a numeric matrix. Ensembl Gene ID row names can be converted to Gene Symbols using, e.g., BioMart. Optionally, data can be clustered and filtered by correlation, tree cutting and/or number of missing values. Genes of interest can be highlighted in the plot and correlation significance be indicated by asterisks encoding corresponding P-Values. Plot dimensions and label measures are adjusted automatically by default. The plot features rely on the heatmap.n2() function in the heatmapFlex package.

This package implements Cragg-Donald (1993) <doi:10.1017/S0266466600007519> and Stock and Yogo (2005) <doi:10.1017/CBO9780511614491.006> tests for weak instruments in R.

This package provides a fast, flexible and transparent framework to estimate context-specific word and short document embeddings using the a la carte embeddings approach developed by Khodak et al. (2018) <doi:10.48550/arXiv.1805.05388> and evaluate hypotheses about covariate effects on embeddings using the regression framework developed by Rodriguez et al. (2021)<doi:10.1017/S0003055422001228>. New version of the package applies a new estimator to measure the distance between word embeddings as described in Green et al. (2025) <doi:10.1017/pan.2024.22>.

Classifies the type of cancer using routinely collected data commonly found in cancer registries from pathology reports. The package implements the International Classification of Diseases for Oncology, 3rd Edition site (topography), histology (morphology), and behaviour codes of neoplasms to classify cancer type <https://www.who.int/standards/classifications/other-classifications/international-classification-of-diseases-for-oncology>. Classification in children utilize the International Classification of Childhood Cancer by Steliarova-Foucher et al. (2005) <doi:10.1002/cncr.20910>. Adolescent and young adult cancer classification is based on Barr et al. (2020) <doi:10.1002/cncr.33041>.

Calculates centrality indices additional to the igraph package centrality functions.

Climate stability measures are not formalized in the literature and tools for generating stability metrics from existing data are nascent. This package provides tools for calculating climate stability from raster data encapsulating climate change as a series of time slices. The methods follow Owens and Guralnick <doi:10.17161/bi.v14i0.9786> Biodiversity Informatics.

Variance estimation on indicators of income concentration and poverty using complex sample survey designs. Wrapper around the survey package.

This package provides simple functions to convert between color names and hexadecimal color codes using an extensive database of over 32,000 colors. Includes all 657 R built-in colors plus the comprehensive color-names database. The package supports bidirectional conversion with backward compatibility, prioritizing R colors when available.

This package implements the semiparametric efficient estimators of continuous-time causal models for time-varying treatments and confounders in the presence of dependent censoring (including structural failure time model and Cox proportional hazards marginal structural model). S. Yang, K. Pieper, and F. Cools (2019) <doi:10.1111/biom.12845>.

This package provides functions to perform statistical inference of data organized in contingency tables. This package is a companion to the "Statistical Analysis of Contingency Tables" book by Fagerland et al. <ISBN 9781466588172>.

This package implements the high-dimensional changepoint detection method GeomCP and the related mappings used for changepoint detection. These methods view the changepoint problem from a geometrical viewpoint and aim to extract relevant geometrical features in order to detect changepoints. The geomcp() function should be your first point of call. References: Grundy et al. (2020) <doi:10.1007/s11222-020-09940-y>.

The goal of cvsem is to provide functions that allow for comparing Structural Equation Models (SEM) using cross-validation. Users can specify multiple SEMs using lavaan syntax. cvsem computes the Kullback Leibler (KL) Divergence between 1) the model implied covariance matrix estimated from the training data and 2) the sample covariance matrix estimated from the test data described in Cudeck, Robert & Browne (1983) <doi:10.18637/jss.v048.i02>. The KL Divergence is computed for each of the specified SEMs allowing for the models to be compared based on their prediction errors.

Directory reads and summaries are provided for one or more of the subdirectories of the <https://cran.r-project.org/incoming/> directory, and a compact summary object is returned. The package name is a contraption of CRAN Incoming Watcher'.

This package contains the probability density function, cumulative distribution function, quantile function, and random number generator for composite and discrete composite distributions with Pareto tails. The detailed description of the methods and the applications of the methods can be found in Bowen Liu, Malwane M.A. Ananda (2023) <arXiv:2309.16443>.

Integrative context-dependent clustering for heterogeneous biomedical datasets. Identifies local clustering structures in related datasets, and a global clusters that exist across the datasets.

Estimation and statistical process control are performed under copula-based time-series models. Available are statistical methods in Long and Emura (2014 JCSA), Emura et al. (2017 Commun Stat-Simul) <DOI:10.1080/03610918.2015.1073303>, Huang and Emura (2021 Commun Stat-Simul) <DOI:10.1080/03610918.2019.1602647>, Lin et al. (2021 Comm Stat-Simul) <DOI:10.1080/03610918.2019.1652318>, Sun et al. (2020 JSS Series in Statistics)<DOI:10.1007/978-981-15-4998-4>, and Huang and Emura (2021, in revision).

Use three methods to estimate parameters from a mediation analysis with a binary misclassified mediator. These methods correct for the problem of "label switching" using Youden's J criteria. A detailed description of the analysis methods is available in Webb and Wells (2024), "Effect estimation in the presence of a misclassified binary mediator" <doi:10.48550/arXiv.2407.06970>.

Compute the certainty equivalents and premium risks as tools for risk-efficiency analysis. For more technical information, please refer to: Hardaker, Richardson, Lien, & Schumann (2004) <doi:10.1111/j.1467-8489.2004.00239.x>, and Richardson, & Outlaw (2008) <doi:10.2495/RISK080231>.

Calculate some statistics aiming to help analyzing the clustering tendency of given data. In the first version, Hopkins statistic is implemented. See Hopkins and Skellam (1954) <doi:10.1093/oxfordjournals.aob.a083391>.