Parameters of a user-specified probability distribution are modelled by a multi-layer perceptron artificial neural network. This framework can be used to implement probabilistic nonlinear models including mixture density networks, heteroscedastic regression models, zero-inflated models, etc. following Cannon (2012) <doi:10.1016/j.cageo.2011.08.023>.

Automatically builds 12 classification models from data. The package also returns 25 plots, 5 tables and a summary report.

DNA copy number data evaluation using both their initial form (copy number as a noisy function of genomic position) and their approximation by a piecewise-constant function (segmentation), for the purpose of identifying genomic regions where the copy number differs from the norm.

Compare color palettes with simulations of color vision deficiencies - deuteranopia, protanopia, and tritanopia. It includes calculation of distances between colors, and creating summaries of differences between a color palette and simulations of color vision deficiencies. This work was inspired by the blog post at <https://www.datawrapper.de/blog/colorblind-check>.

Implementation of the CNAIM standard in R. Contains a series of algorithms which determine the probability of failure, consequences of failure and monetary risk associated with electricity distribution companies assets such as transformers and cables. Results are visualized in an easy-to-understand risk matrix.

Computes p-value according to the CRT using the HierNet test statistic. For more details, see Ham, Imai, Janson (2022) "Using Machine Learning to Test Causal Hypotheses in Conjoint Analysis" <arXiv:2201.08343>.

This package provides color palettes based on crayon colors since the early 1900s. Colors are based on various crayon colors, sets, and promotional palettes, most of which can be found at <https://en.wikipedia.org/wiki/List_of_Crayola_crayon_colors>. All palettes are discrete palettes and are not necessarily color-blind friendly. Provides scales for ggplot2 for discrete coloring.

Designs guide sequences for CRISPR/Cas9 genome editing and provides information on sequence features pertinent to guide efficiency. Sequence features include annotated off-target predictions in a user-selected genome and a predicted efficiency score based on the model described in Doench et al. (2016) <doi:10.1038/nbt.3437>. Users are able to import additional genomes and genome annotation files to use when searching and annotating off-target hits. All guide sequences and off-target data can be generated through the R console with sgRNA_Design() or through crispRdesignR's user interface with crispRdesignRUI(). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and the associated protein Cas9 refer to a technique used in genome editing.

Generate balance tables and plots for covariates of groups preprocessed through matching, weighting or subclassification, for example, using propensity scores. Includes integration with MatchIt', WeightIt', MatchThem', twang', Matching', optmatch', CBPS', ebal', cem', sbw', and designmatch for assessing balance on the output of their preprocessing functions. Users can also specify data for balance assessment not generated through the above packages. Also included are methods for assessing balance in clustered or multiply imputed data sets or data sets with multi-category, continuous, or longitudinal treatments.

Immune related gene sets provided along with the cinaR package.

Puzzle game that can be played in the R console. Help the alien to find the ship.

It uses the first-order sensitivity index to measure whether the weights assigned by the creator of the composite indicator match the actual importance of the variables. Moreover, the variance inflation factor is used to reduce the set of correlated variables. In the case of a discrepancy between the importance and the assigned weight, the script determines weights that allow adjustment of the weights to the intended impact of variables. If the optimised weights are unable to reflect the desired importance, the highly correlated variables are reduced, taking into account variance inflation factor. The final outcome of the script is the calculated value of the composite indicator based on optimal weights and a reduced set of variables, and the linear ordering of the analysed objects.

This package provides a framework that facilitates spatio-temporal analysis of climate dynamics through exploring and measuring different dimensions of climate change in space and time.

Chemical analysis of proteins based on their amino acid compositions. Amino acid compositions can be read from FASTA files and used to calculate chemical metrics including carbon oxidation state and stoichiometric hydration state, as described in Dick et al. (2020) <doi:10.5194/bg-17-6145-2020>. Other properties that can be calculated include protein length, grand average of hydropathy (GRAVY), isoelectric point (pI), molecular weight (MW), standard molal volume (V0), and metabolic costs (Akashi and Gojobori, 2002 <doi:10.1073/pnas.062526999>; Wagner, 2005 <doi:10.1093/molbev/msi126>; Zhang et al., 2018 <doi:10.1038/s41467-018-06461-1>). A database of amino acid compositions of human proteins derived from UniProt is provided.

This package contains functions to estimate a smoothed and a non-smoothed (empirical) time-dependent receiver operating characteristic curve and the corresponding area under the receiver operating characteristic curve and the optimal cutoff point for the right and interval censored survival data. See Beyene and El Ghouch (2020)<doi:10.1002/sim.8671> and Beyene and El Ghouch (2022) <doi:10.1002/bimj.202000382>.

Calculates confidence intervals after variable selection using repeated data splits. The package offers methods to address the challenges of post-selection inference, ensuring more accurate confidence intervals in models involving variable selection. The two main functions are lmps', which records the different models selected across multiple data splits as well as the corresponding coefficient estimates, and cips', which takes the lmps object as input to select variables and perform inferences using two types of voting.

Develop Nonlinear Mixed Effects (NLME) models for pharmacometrics using a shiny interface. The Pharmacometric Modeling Language (PML) code updates in real time given changes to user inputs. Models can be executed using the Certara.RsNLME package. Additional support to generate the underlying Certara.RsNLME code to recreate the corresponding model in R is provided in the user interface.

Estimates the Concordance Correlation Coefficient to assess agreement. The scenarios considered are non-repeated measures, non-longitudinal repeated measures (replicates) and longitudinal repeated measures. It also includes the estimation of the one-way intraclass correlation coefficient also known as reliability index. The estimation approaches implemented are variance components and U-statistics approaches. Description of methods can be found in Fleiss (1986) <doi:10.1002/9781118032923> and Carrasco et al. (2013) <doi:10.1016/j.cmpb.2012.09.002>.

Estimates nonlinear causal dose-response functions for continuous treatments using spline-based methods under standard causal assumptions (unconfoundedness / ignorability). Implements three identification strategies: Inverse Probability Weighting (IPW) via the generalised propensity score (GPS), G-computation (outcome regression), and a doubly-robust combination. Natural cubic splines and B-splines are supported for both the exposure-response curve f(T) and the propensity nuisance model. Pointwise confidence bands are obtained via the sandwich estimator or nonparametric bootstrap. Also provides fragility diagnostics including pointwise curvature-based fragility, uncertainty-normalised fragility, and regional integration over user-defined treatment intervals. Builds on the framework of Hirano and Imbens (2004) <doi:10.1111/j.1468-0262.2004.00481.x> for continuous treatments and extends it to fully nonparametric spline estimation.

This package implements the chain binomial model for analysis of infectious disease data. Contains functions for calculating probabilities of the final size of infectious disease outbreaks using the method from D. Ludwig (1975) <doi:10.1016/0025-5564(75)90119-4> and for outbreaks that are not concluded, from Lindstrøm et al. (2024) <doi:10.48550/arXiv.2403.03948>. The package also contains methods for estimation and regression analysis of secondary attack rates.

Calculate the confidence interval and p value for change in C-statistic. The adjusted C-statistic is calculated by using formula as "Somers Dxy rank correlation"/2+0.5. The confidence interval was calculated by using the bootstrap method. The p value was calculated by using the Z testing method. Please refer to the article of Peter Ganz et al. (2016) <doi:10.1001/jama.2016.5951>.

This package implements a kernel-based association test for copy number variation (CNV) aggregate analysis in a certain genomic region (e.g., gene set, chromosome, or genome) that is robust to the within-locus and across-locus etiological heterogeneity, and bypass the need to define a "locus" unit for CNVs. Brucker, A., et al. (2020) <doi:10.1101/666875>.

Bayesian and ML Emax model fitting, graphics and simulation for clinical dose response. The summary data from the dose response meta-analyses in Thomas, Sweeney, and Somayaji (2014) <doi:10.1080/19466315.2014.924876> and Thomas and Roy (2016) <doi:10.1080/19466315.2016.1256229> Wu, Banerjee, Jin, Menon, Martin, and Heatherington(2017) <doi:10.1177/0962280216684528> are included in the package. The prior distributions for the Bayesian analyses default to the posterior predictive distributions derived from these references.

This package provides methods for interpreting CoDa (Compositional Data) regression models along the lines of "Pairwise share ratio interpretations of compositional regression models" (Dargel and Thomas-Agnan 2024) <doi:10.1016/j.csda.2024.107945>. The new methods include variation scenarios, elasticities, elasticity differences and share ratio elasticities. These tools are independent of log-ratio transformations and allow an interpretation in the original space of shares. CoDaImpact is designed to be used with the compositions package and its ecosystem.