Implementation of the Monothetic Clustering algorithm (Chavent, 1998 <doi:10.1016/S0167-8655(98)00087-7>) on continuous data sets. A lot of extensions are included in the package, including applying Monothetic clustering on data sets with circular variables, visualizations with the results, and permutation and cross-validation based tests to support the decision on the number of clusters.

Multi-Dimensional Analysis (MDA) is an adaptation of factor analysis developed by Douglas Biber (1992) <doi:10.1007/BF00136979>. Its most common use is to describe language as it varies by genre, register, and use. This package contains functions for carrying out the calculations needed to describe and plot MDA results: dimension scores, dimension means, and factor loadings.

This package provides a graphical user interface to apply an advanced method optimization algorithm to various sampling and analysis instruments. This includes generating experimental designs, uploading and viewing data, and performing various analyses to determine the optimal method. Details of the techniques used in this package are published in Gamble, Granger, & Mannion (2024) <doi:10.1021/acs.analchem.3c05763>.

The Prize-Collecting Steiner Tree problem asks to find a subgraph connecting a given set of vertices with the most expensive nodes and least expensive edges. Since it is proven to be NP-hard, exact and efficient algorithm does not exist. This package provides convenient functionality for obtaining an approximate solution to this problem using loopy belief propagation algorithm.

Matches cases to controls based on genotype principal components (PC). In order to produce better results, matches are based on the weighted distance of PCs where the weights are equal to the % variance explained by that PC. A weighted Mahalanobis distance metric (Kidd et al. (1987) <DOI:10.1016/0031-3203(87)90066-5>) is used to determine matches.

Personalize drug regimens using individual pharmacokinetic (PK) and pharmacokinetic-pharmacodynamic (PK-PD) profiles. By combining therapeutic drug monitoring (TDM) data with a population model, posologyr offers accurate posterior estimates and helps compute optimal individualized dosing regimens. The empirical Bayes estimates are computed following the method described by Kang et al. (2012) <doi:10.4196/kjpp.2012.16.2.97>.

Modifies the distance matrix obtained from data with batch effects, so as to improve the performance of sample pattern detection, such as clustering, dimension reduction, and construction of networks between subjects. The method has been published in Bioinformatics (Fei et al, 2018, <doi:10.1093/bioinformatics/bty117>). Also available on GitHub <https://github.com/tengfei-emory/QuantNorm>.

This package implements Bayesian inference in accelerated failure time (AFT) models for right-censored survival times assuming a log-logistic distribution. Details of the variational Bayes algorithms, with and without shared frailty, are described in Xian et al. (2024) <doi:10.1007/s11222-023-10365-6> and Xian et al. (2024) <doi:10.48550/arXiv.2408.00177>, respectively.

This package provides indices and tools for directed acyclic graphs (DAGs), particularly DAG representations of intermittent streams. A detailed introduction to the package can be found in the publication: "Non-perennial stream networks as directed acyclic graphs: The R-package streamDAG" (Aho et al., 2023) <doi:10.1016/j.envsoft.2023.105775>, and in the introductory package vignette.

An interface to access data from Substack publications via API. Users can fetch the latest, top, search for specific posts, or retrieve a single post by its slug. This functionality is useful for developers and researchers looking to analyze Substack content or integrate it into their applications. For more information, visit the API documentation at <https://substackapi.dev/introduction>.

Estimation of mean squared prediction error of a small area predictor is provided. In particular, the recent method of Simple, Unified, Monte-Carlo Assisted approach for the mean squared prediction error estimation of small area predictor is provided. We also provide other existing methods of mean squared prediction error estimation such as jackknife method for the mixed logistic model.

This package provides functions for estimating times of common ancestry and molecular clock rates of evolution using a variety of evolutionary models, parametric and nonparametric bootstrap confidence intervals, methods for detecting outlier lineages, root-to-tip regression, and a statistical test for selecting molecular clock models. For more details see Volz and Frost (2017) <doi:10.1093/ve/vex025>.

Data structures and methods to work with web tracking data. The functions cover data preprocessing steps, enriching web tracking data with external information and methods for the analysis of digital behavior as used in several academic papers (e.g., Clemm von Hohenberg et al., 2023 <doi:10.17605/OSF.IO/M3U9P>; Stier et al., 2022 <doi:10.1017/S0003055421001222>).

This package provides functionalities to translate gene or protein identifiers between state-of-art biological databases: CARD (<https://card.mcmaster.ca/>), NCBI Protein, Nucleotide and Gene (<https://www.ncbi.nlm.nih.gov/>), UniProt (<https://www.uniprot.org/>) and KEGG (<https://www.kegg.jp>). Also offers complementary functionality like NCBI identical proteins or UniProt similar genes clusters retrieval.

This package contains the experimental data and a complete executable transcript (vignette) of the analysis of the HCT116 genetic interaction matrix presented in the paper "Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping" by C. Laufer, B. Fischer, M. Billmann, W. Huber, M. Boutros; Nature Methods (2013) 10:427-31. doi: 10.1038/nmeth.2436.

This package provides functions for annotation-agnostic differential expression analysis of RNA-seq data. Two implementations of the DER Finder approach are included in this package:

1. single base-level F-statistics and

2. DER identification at the expressed regions-level.

The DER Finder approach can also be used to identify differentially bounded ChIP-seq peaks.

This package provides .C64(), an enhanced version of .C() and .Fortran() from the R foreign function interface. .C64() supports long vectors, arguments of type 64-bit integer, and provides a mechanism to avoid unnecessary copies of read-only and write-only arguments. This makes it a convenient and fast interface to C/C++ and Fortran code.

git-repo provides Git extensions for interacting conveniently with AGit-Flow or Gerrit servers. It makes it possible to create, update or fetch PR, and more. It is based on the repo tool that was developed for the Gerrit project, but also supports AGit-Flow and lifts the requirement to use a manifest file.

The goal of NicheNet is to study intercellular communication from a computational perspective. NicheNet uses human or mouse gene expression data of interacting cells as input and combines this with a prior model that integrates existing knowledge on ligand-to-target signaling paths. This allows to predict ligand-receptor interactions that might drive gene expression changes in cells of interest.

Obtain overlapping clustering models for object-by-variable data matrices using the Additive Profile Clustering (ADPROCLUS) method. Also contains the low dimensional ADPROCLUS method for simultaneous dimension reduction and overlapping clustering. For reference see Depril, Van Mechelen, Mirkin (2008) <doi:10.1016/j.csda.2008.04.014> and Depril, Van Mechelen, Wilderjans (2012) <doi:10.1007/s00357-012-9112-5>.

Transform newswire and earnings call transcripts as PDF obtained from Nexis Uni to R data frames. Various newswires and FairDisclosure earnings call formats are supported. Further, users can apply several pre-defined dictionaries on the data based on Graffin et al. (2016)<doi:10.5465/amj.2013.0288> and Gamache et al. (2015)<doi:10.5465/amj.2013.0377>.

This extension of the pattern-oriented modeling framework of the poems package provides a collection of modules and functions customized for modeling disease transmission on a population scale in a spatiotemporally explicit manner. This includes seasonal time steps, dispersal functions that track disease state of dispersers, results objects that store disease states, and a population simulator that includes disease dynamics.

Long non-coding RNAs identification and analysis. Default models are trained with human, mouse and wheat datasets by employing SVM. Features are based on intrinsic composition of sequence, EIIP value (electron-ion interaction pseudopotential), and secondary structure. This package can also extract other classic features and build new classifiers. Reference: Han S., et al. (2019) <doi:10.1093/bib/bby065>.

Stand-alone HTTP capable R-package repository, that fully supports R's install.packages() and available.packages(). It also contains API endpoints for end-users to add/update packages. This package can supplement miniCRAN', which has functions for maintaining a local (partial) copy of CRAN'. Current version is bare-minimum without any access-control or much security.