This package provides a systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.

Specify, solve, and estimate dynamic stochastic general equilibrium (DSGE) models by maximum likelihood and Bayesian methods. Supports both linear models via an equation-based formula interface and nonlinear models via string-based equations with first-order perturbation (linearization around deterministic steady state). Solution uses the method of undetermined coefficients (Klein, 2000 <doi:10.1016/S0165-1889(99)00045-7>). Likelihood evaluated via the Kalman filter. Bayesian estimation uses adaptive Random-Walk Metropolis-Hastings with prior specification. Additional tools include Kalman smoothing, historical shock decomposition, local identification diagnostics, parameter sensitivity analysis, second-order perturbation, occasionally binding constraints, impulse-response functions, forecasting, and robust standard errors.

Bayesian networks with continuous and/or discrete variables can be learned and compared from data. The method is described in Boettcher and Dethlefsen (2003), <doi:10.18637/jss.v008.i20>.

This package provides functionality to infer trajectories from single-cell data, represent them into a common format, and adapt them. Other biological information can also be added, such as cellular grouping, RNA velocity and annotation. Saelens et al. (2019) <doi:10.1038/s41587-019-0071-9>.

Validates data frames against a defined schema. Produces a report of the checks performed and any issues found, with index and entry value where appropriate. Backend checks are performed using pointblank Richard Iannone et al (2025) <doi:10.32614/CRAN.package.pointblank>.

When visualising changes between two values over time, a strict linear interpolation can look jarring and unnatural. By applying a non-linear easing to the transition, the motion between values can appear smoother and more natural. This package includes functions for applying such non-linear easings to colors and numeric values, and is useful where smooth animated movement and transitions are desired.

This package provides functionality for users who are learning R or the techniques of data analysis. Written as a collection of wrapper functions, the DTwrapper package facilitates many core operations of data processing. This is achieved with relatively few requirements about the order of the processing steps or knowledge of specialized syntax. DTwrappers creates coding results along with translations to data.table's code. This enables users to benefit from the speed and efficiency of data.table's calculations. Furthermore, the package also provides the translated code for educational purposes so that users can review working examples of coding syntax and calculations.

Identification of causal effects from arbitrary observational and experimental probability distributions via do-calculus and standard probability manipulations using a search-based algorithm by Tikka, Hyttinen and Karvanen (2021) <doi:10.18637/jss.v099.i05>. Allows for the presence of mechanisms related to selection bias (Bareinboim and Tian, 2015) <doi:10.1609/aaai.v29i1.9679>, transportability (Bareinboim and Pearl, 2014) <http://ftp.cs.ucla.edu/pub/stat_ser/r443.pdf>, missing data (Mohan, Pearl, and Tian, 2013) <http://ftp.cs.ucla.edu/pub/stat_ser/r410.pdf>) and arbitrary combinations of these. Also supports identification in the presence of context-specific independence (CSI) relations through labeled directed acyclic graphs (LDAG). For details on CSIs see (Corander et al., 2019) <doi:10.1016/j.apal.2019.04.004>.

An implementation of distributional random forests as introduced in Cevid & Michel & Naf & Meinshausen & Buhlmann (2022) <doi:10.48550/arXiv.2005.14458>.

Discovers small binary-classification biomarker panels from count or expression matrices while prioritizing detectability, expression stability, and univariate discrimination. Candidate filtering and panel selection can be repeated inside nested cross-validation to reduce information leakage. The package provides shared resampling splits, exhaustive small-panel search, logistic model fitting with an automatic ridge fallback for unstable separation-prone fits, out-of-fold evaluation, selection-frequency summaries, and optional DESeq2 differential-expression support. The nested model-selection workflow follows Varma and Simon (2006) <doi:10.1186/1471-2105-7-91>, and the optional differential-expression analysis uses Love, Huber, and Anders (2014) <doi:10.1186/s13059-014-0550-8>.

The Data Driven I-V Feature Extraction is used to extract Current-Voltage (I-V) features from I-V curves. I-V curves indicate the relationship between current and voltage for a solar cell or Photovoltaic (PV) modules. The I-V features such as maximum power point (Pmp), shunt resistance (Rsh), series resistance (Rs),short circuit current (Isc), open circuit voltage (Voc), fill factor (FF), current at maximum power (Imp) and voltage at maximum power(Vmp) contain important information of the performance for PV modules. The traditional method uses the single diode model to model I-V curves and extract I-V features. This package does not use the diode model, but uses data-driven a method which select different linear parts of the I-V curves to extract I-V features. This method also uses a sampling method to calculate uncertainties when extracting I-V features. Also, because of the partially shaded array, "steps" occurs in I-V curves. The "Segmented Regression" method is used to identify steps in I-V curves. This material is based upon work supported by the U.S. Department of Energyâ s Office of Energy Efficiency and Renewable Energy (EERE) under Solar Energy Technologies Office (SETO) Agreement Number DE-EE0007140. Further information can be found in the following paper. [1] Ma, X. et al, 2019. <doi:10.1109/JPHOTOV.2019.2928477>.

Interactive R tutorials and datasets for the textbook Field (2026), "Discovering Statistics Using R and RStudio", <https://www.discovr.rocks/>. Interactive tutorials cover general workflow in R and RStudio', summarizing data, visualizing data, fitting models and bias, correlation, the general linear model (GLM), moderation, mediation, missing values, comparing means using the GLM (analysis of variance), comparing adjusted means (analysis of covariance), factorial designs, multilevel models, repeated measures designs, growth models, exploratory factor analysis (EFA), loglinear analysis, and logistic regression. There are no functions, only datasets and interactive tutorials.

This package provides a tool to sample data with the desired properties.Samples can be drawn by purposive sampling with determining distributional conditions, such as deviation from normality (skewness and kurtosis), and sample size in quantitative research studies. For purposive sampling, a researcher has something in mind and participants that fit the purpose of the study are included (Etikan,Musa, & Alkassim, 2015) <doi:10.11648/j.ajtas.20160501.11>.Purposive sampling can be useful for answering many research questions (Klar & Leeper, 2019) <doi:10.1002/9781119083771.ch21>.

Given count data from two conditions, it determines which transcripts are differentially expressed across the two conditions using Bayesian inference of the parameters of a bottom-up model for PCR amplification. This model is developed in Ndifon Wilfred, Hilah Gal, Eric Shifrut, Rina Aharoni, Nissan Yissachar, Nir Waysbort, Shlomit Reich Zeliger, Ruth Arnon, and Nir Friedman (2012), <http://www.pnas.org/content/109/39/15865.full>, and results in a distribution for the counts that is a superposition of the binomial and negative binomial distribution.

This package provides methods for analyzing population dynamics and movement tracks simulated using the DEPONS model <https://www.depons.eu> (v.3.0), for manipulating input raster files, shipping routes and for analyzing sound propagated from ships.

Easy visualization for datasets with more than two categorical variables and additional continuous variables. The package is particularly useful for exploring complex categorical data in the context of pathway analysis across multiple conditions. This package is now in maintenance-only mode and kept for legacy compatibility; for new projects and active development, please use the successor package ggdiceplot (see <https://github.com/maflot/ggdiceplot> and <https://dice-and-domino-plot.readthedocs.io/en/latest/>).

This package implements the locally efficient doubly robust difference-in-differences (DiD) estimators for the average treatment effect proposed by Sant'Anna and Zhao (2020) <doi:10.1016/j.jeconom.2020.06.003>. The estimator combines inverse probability weighting and outcome regression estimators (also implemented in the package) to form estimators with more attractive statistical properties. Two different estimation methods can be used to estimate the nuisance functions.

This package provides a modern R binding for DataTables V2 with modular extension loading, Bootstrap 5 styling, Shiny integration (proxy, events, inline inputs), server-side processing helpers, and standalone (non-Shiny) support. Configure DataTables options directly via R lists, a 1:1 mapping to the JavaScript API.

Fits the hierarchical summary receiver operating characteristic (HSROC) model of Rutter and Gatsonis (2001) <doi:10.1002/sim.942>, the bivariate binomial-normal model of Reitsma et al. (2005) <doi:10.1016/j.jclinepi.2005.02.022>, the threshold-based bivariate time-to-event model of Hoyer et al. (2018) <doi:10.1002/jrsm.1273>, and the latent class extensions of Liu et al. (2015) <doi:10.1111/biom.12264> for diagnostic studies with an imperfect reference standard. Provides subgroup analyses, HSROC meta-regression, likelihood-ratio tests, summary ROC plots, and coupled forest plots.

This package provides a collection of tools that support data diagnosis, exploration, and transformation. Data diagnostics provides information and visualization of missing values, outliers, and unique and negative values to help you understand the distribution and quality of your data. Data exploration provides information and visualization of the descriptive statistics of univariate variables, normality tests and outliers, correlation of two variables, and the relationship between the target variable and predictor. Data transformation supports binning for categorizing continuous variables, imputes missing values and outliers, and resolves skewness. And it creates automated reports that support these three tasks.

This package provides a drop-in replacement for dplyr', powered by DuckDB for performance. Offers convenient utilities for working with in-memory and larger-than-memory data while retaining full dplyr compatibility.

This package provides a software package for using DEXi models. DEXi models are hierarchical qualitative multi-criteria decision models developed according to the method DEX (Decision EXpert, <https://dex.ijs.si/documentation/DEX_Method/DEX_Method.html>), using the program DEXi (<https://kt.ijs.si/MarkoBohanec/dexi.html>) or DEXiWin (<https://dex.ijs.si/dexisuite/dexiwin.html>). A typical workflow with DEXiR consists of: (1) reading a .dxi file, previously made using the DEXi software (function read_dexi()), (2) making a data frame containing input values of one or more decision alternatives, (3) evaluating those alternatives (function evaluate()), (4) analyzing alternatives (selective_explanation(), plus_minus(), compare_alternatives()), (5) drawing charts. DEXiR is restricted to using models produced externally by the DEXi software and does not provide functionality for creating and/or editing DEXi models directly in R'.

This package provides a simple approach to measure political sophistication based on open-ended survey responses. Discursive sophistication captures the complexity of individual attitude expression by quantifying its relative size, range, and constraint. For more information on the measurement approach see: Kraft, Patrick W. 2023. "Women Also Know Stuff: Challenging the Gender Gap in Political Sophistication." American Political Science Review (forthcoming).

This package provides functions for estimating parameters and hyperparameters of the linearized hyperbolic model, and testing equality of hyperparameters.