This package provides a ggplot2 extension for visualising uncertainty with the goal of signal suppression. Usually, uncertainty visualisation focuses on expressing uncertainty as a distribution or probability, whereas ggdibbler differentiates itself by viewing an uncertainty visualisation as an adjustment to an existing graphic that incorporates the inherent uncertainty in the estimates. You provide the code for an existing plot, but replace any of the variables with a vector of distributions, and it will convert the visualisation into it's signal suppression counterpart.

This package performs meaningful subgrouping in a meta-analysis. This is a two-step process; first, use the iterative grouping functions (e.g., mgbin(), mgcont() ) to partition studies into statistically homogeneous clusters based on their effect size data. Second, use the meaning() function to analyze these new subgroups and understand their composition based on study-level characteristics (e.g., country, setting). This approach helps to uncover hidden structures in meta-analytic data and provide a deeper interpretation of heterogeneity.

Solver for linear, quadratic, and rational programs with linear, quadratic, and rational constraints. A unified interface to different R packages is provided. Optimization problems are transformed into equivalent formulations and solved by the respective package. For example, quadratic programming problems with linear, quadratic and rational constraints can be solved by augmented Lagrangian minimization using package alabama', or by sequential quadratic programming using solver slsqp'. Alternatively, they can be reformulated as optimization problems with second order cone constraints and solved with package cccp'.

This package provides a high-level plotting system, compatible with `ggplot2` objects, maps from `sf`, `terra`, `raster`, `sp`. It is built primarily on the grid package. The objective of the package is to provide a plotting system that is built for speed and modularity. This is useful for quick visualizations when testing code and for plotting multiple figures to the same device from independent sources that may be independent of one another (i.e., different function or modules the create the visualizations).

G-computation for a set of time-fixed exposures with quantile-based basis functions, possibly under linearity and homogeneity assumptions. Effect measure modification in this method is a way to assess how the effect of the mixture varies by a binary, categorical or continuous variable. Reference: Alexander P. Keil, Jessie P. Buckley, Katie M. OBrien, Kelly K. Ferguson, Shanshan Zhao, and Alexandra J. White (2019) A quantile-based g-computation approach to addressing the effects of exposure mixtures; <doi:10.1289/EHP5838>.

This package provides a pipeline that can process single or multiple Single Cell RNAseq samples primarily specializes in Clustering and Dimensionality Reduction. Meanwhile we use common cell type marker genes for T cells, B cells, Myeloid cells, Epithelial cells, and stromal cells (Fiboblast, Endothelial cells, Pericyte, Smooth muscle cells) to visualize the Seurat clusters, to facilitate labeling them by biological names. Once users named each cluster, they can evaluate the quality of them again and find the de novo marker genes also.

Identifies a bicluster, a submatrix of the data such that the features and observations within the submatrix differ from those not contained in submatrix, using a two-step method. In the first step, observations in the bicluster are identified to maximize the sum of weighted between cluster feature differences. The method is described in Helgeson et al. (2020) <doi:10.1111/biom.13136>. SCBiclust can be used to identify biclusters which differ based on feature means, feature variances, or more general differences.

Estimates the parameter of small area in binary data without auxiliary variable using Empirical Bayes technique, mainly from Rao and Molina (2015,ISBN:9781118735787) with book entitled "Small Area Estimation Second Edition". This package provides another option of direct estimation using weight. This package also features alpha and beta parameter estimation on calculating process of small area. Those methods are Newton-Raphson and Moment which based on Wilcox (1979) <doi:10.1177/001316447903900302> and Kleinman (1973) <doi:10.1080/01621459.1973.10481332>.

Aggregates large single-cell data into metacell dataset by merging together gene expression of very similar cells. SuperCell uses velocyto.R <doi:10.1038/s41586-018-0414-6> <https://github.com/velocyto-team/velocyto.R> for RNA velocity and WeightedCluster <doi:10.12682/lives.2296-1658.2013.24> <https://mephisto.unige.ch/weightedcluster/> for weighted clustering on metacells. We also recommend installing scater Bioconductor package <doi:10.18129/B9.bioc.scater> <https://bioconductor.org/packages/release/bioc/html/scater.html>.

This package implements parametric and non-parametric mediation analysis. This package performs the methods and suggestions in Imai, Keele and Yamamoto (2010) <DOI:10.1214/10-STS321>, Imai, Keele and Tingley (2010) <DOI:10.1037/a0020761>, Imai, Tingley and Yamamoto (2013) <DOI:10.1111/j.1467-985X.2012.01032.x>, Imai and Yamamoto (2013) <DOI:10.1093/pan/mps040> and Yamamoto (2013). In addition to the estimation of causal mediation effects, the software also allows researchers to conduct sensitivity analysis for certain parametric models.

This package provides a URL-safe base64 encoder and decoder. In contrast to RFC3548, the 62nd character (+) is replaced with -, the 63rd character (/) is replaced with _. Furthermore, the encoder does not fill the string with trailing =. The resulting encoded strings comply to the regular expression pattern [A-Za-z0-9_-] and thus are safe to use in URLs or for file names. The package also comes with a simple base32 encoder/decoder suited for case insensitive file systems.

To facilitate and streamline phosphoproteomics data analysis, we developed SmartPhos, an R package for the pre-processing, quality control, and exploratory analysis of phosphoproteomics data generated by MaxQuant and Spectronaut. The package can be used either through the R command line or through an interactive ShinyApp called SmartPhos Explorer. The package contains methods such as normalization and normalization correction, transformation, imputation, batch effect correction, PCA, heatmap, differential expression, time-series clustering, gene set enrichment analysis, and kinase activity inference.

An implementation of sensitivity and robustness methods in Bayesian networks in R. It includes methods to perform parameter variations via a variety of co-variation schemes, to compute sensitivity functions and to quantify the dissimilarity of two Bayesian networks via distances and divergences. It further includes diagnostic methods to assess the goodness of fit of a Bayesian networks to data, including global, node and parent-child monitors. Reference: M. Leonelli, R. Ramanathan, R.L. Wilkerson (2022) <doi:10.1016/j.knosys.2023.110882>.

This package provides tools for Delphi's COVIDcast Epidata API: data access, maps and time series plotting, and basic signal processing. The API includes a collection of numerous indicators relevant to the COVID-19 pandemic in the United States, including official reports, de-identified aggregated medical claims data, large-scale surveys of symptoms and public behavior, and mobility data, typically updated daily and at the county level. All data sources are documented at <https://cmu-delphi.github.io/delphi-epidata/api/covidcast.html>.

This package provides methods for powering cluster-randomized trials with two continuous co-primary outcomes using five key design techniques. Includes functions for calculating required sample size and statistical power. For more details on methodology, see Owen et al. (2025) <doi:10.1002/sim.70015>, Yang et al. (2022) <doi:10.1111/biom.13692>, Pocock et al. (1987) <doi:10.2307/2531989>, Vickerstaff et al. (2019) <doi:10.1186/s12874-019-0754-4>, and Li et al. (2020) <doi:10.1111/biom.13212>.

This package implements methods for calculating disproportionate impact: the percentage point gap, proportionality index, and the 80% index. California Community Colleges Chancellor's Office (2017). Percentage Point Gap Method. <https://www.cccco.edu/-/media/CCCCO-Website/About-Us/Divisions/Digital-Innovation-and-Infrastructure/Research/Files/PercentagePointGapMethod2017.ashx>. California Community Colleges Chancellor's Office (2014). Guidelines for Measuring Disproportionate Impact in Equity Plans. <https://www.cccco.edu/-/media/CCCCO-Website/Files/DII/guidelines-for-measuring-disproportionate-impact-in-equity-plans-tfa-ada.pdf>.

Extends the ergm.multi packages from the Statnet suite to fit (temporal) exponential-family random graph models for signed networks. The framework models positive and negative ties as interdependent, which allows estimation and testing of structural balance theory. The package also includes options for descriptive summaries, visualization, and simulation of signed networks. See Krivitsky, Koehly, and Marcum (2020) <doi:10.1007/s11336-020-09720-7> and Fritz, C., Mehrl, M., Thurner, P. W., & Kauermann, G. (2025) <doi:10.1017/pan.2024.21>.

Analysis and visualization of plant disease progress curve data. Functions for fitting two-parameter population dynamics models (exponential, monomolecular, logistic and Gompertz) to proportion data for single or multiple epidemics using either linear or no-linear regression. Statistical and visual outputs are provided to aid in model selection. Synthetic curves can be simulated for any of the models given the parameters. See Laurence V. Madden, Gareth Hughes, and Frank van den Bosch (2007) <doi:10.1094/9780890545058> for further information on the methods.

Comparisons of floating point numbers are problematic due to errors associated with the binary representation of decimal numbers. Despite being aware of these problems, people still use numerical methods that fail to account for these and other rounding errors (this pitfall is the first to be highlighted in Circle 1 of Burns (2012) The R Inferno <https://www.burns-stat.com/pages/Tutor/R_inferno.pdf>). This package provides new relational operators useful for performing floating point number comparisons with a set tolerance.

This package provides classes and functions to calculate various distance measures and routes in heterogeneous geographic spaces represented as grids. The package implements measures to model dispersal histories first presented by van Etten and Hijmans (2010) <doi:10.1371/journal.pone.0012060>. Least-cost distances as well as more complex distances based on (constrained) random walks can be calculated. The distances implemented in the package are used in geographical genetics, accessibility indicators, and may also have applications in other fields of geospatial analysis.

In order to improve performance for HTTP API clients, httpcache provides simple tools for caching and invalidating cache. It includes the HTTP verb functions GET, PUT, PATCH, POST, and DELETE, which are drop-in replacements for those in the httr package. These functions are cache-aware and provide default settings for cache invalidation suitable for RESTful APIs; the package also enables custom cache-management strategies. Finally, httpcache includes a basic logging framework to facilitate the measurement of HTTP request time and cache performance.

High level functions for hyperplane fitting (hyper.fit()) and visualising (hyper.plot2d() / hyper.plot3d()). In simple terms this allows the user to produce robust 1D linear fits for 2D x vs y type data, and robust 2D plane fits to 3D x vs y vs z type data. This hyperplane fitting works generically for any N-1 hyperplane model being fit to a N dimension dataset. All fits include intrinsic scatter in the generative model orthogonal to the hyperplane.

This package provides a joint mixture model has been developed by Majumdar et al. (2025) <doi:10.48550/arXiv.2412.17511> that integrates information from gene expression data and methylation data at the modelling stage to capture their inherent dependency structure, enabling simultaneous identification of differentially methylated cytosine-guanine dinucleotide (CpG) sites and differentially expressed genes. The model leverages a joint likelihood function that accounts for the nested structure in the data, with parameter estimation performed using an expectation-maximisation algorithm.

It provides a generic set of tools for initializing a synthetic population with each individual in specific disease states, and making transitions between those disease states according to the rates calculated on each timestep. The new version 1.0.0 has C++ code integration to make the functions run faster. It has also a higher level function to actually run the transitions for the number of timesteps that users specify. Additional functions will follow for changing attributes on demographic, health belief and movement.