This package provides tools to assist in safely applying user generated objective and derivative function to optimization programs. These are primarily function minimization methods with at most bounds and masks on the parameters. Provides a way to check the basic computation of objective functions that the user provides, along with proposed gradient and Hessian functions, as well as to wrap such functions to avoid failures when inadmissible parameters are provided. Check bounds and masks. Check scaling or optimality conditions. Perform an axial search to seek lower points on the objective function surface. Includes forward, central and backward gradient approximation codes.

This package provides Azure Active Directory (AAD) authentication functionality for R users of Microsoft's Azure cloud <https://azure.microsoft.com/>. Use this package to obtain OAuth 2.0 tokens for services including Azure Resource Manager, Azure Storage and others. It supports both AAD v1.0 and v2.0, as well as multiple authentication methods, including device code and resource owner grant. Tokens are cached in a user-specific directory obtained using the rappdirs package. The interface is based on the OAuth framework in the httr package, but customised and streamlined for Azure. Part of the AzureR family of packages.

This package provides several functions to identify and analyse miRNA sponge, including popular methods for identifying miRNA sponge interactions, two types of global ceRNA regulation prediction methods and four types of context-specific prediction methods( Li Y et al.(2017) <doi:10.1093/bib/bbx137>), which are based on miRNA-messenger RNA regulation alone, or by integrating heterogeneous data, respectively. In addition, For predictive ceRNA relationship pairs, this package provides several downstream analysis algorithms, including regulatory network analysis and functional annotation analysis, as well as survival prognosis analysis based on expression of ceRNA ternary pair.

Easy installation, loading and management, of high-performance packages for statistical computing and data manipulation in R. The core fastverse consists of 4 packages: data.table', collapse', kit and magrittr', that jointly only depend on Rcpp'. The fastverse can be freely and permanently extended with additional packages, both globally or for individual projects. Separate package verses can also be created. Fast packages for many common tasks such as time series, dates and times, strings, spatial data, statistics, data serialization, larger-than-memory processing, and compilation of R code are listed in the README file: <https://github.com/fastverse/fastverse#suggested-extensions>.

The routine twosample_test() in this package runs the two-sample test using various test statistic for multivariate data. The user can also run several tests and then find a p value adjusted for simultaneous inference. The p values are found via permutation or via the parametric bootstrap. The routine twosample_power() allows the estimation of the power of the tests. The routine run.studies() allows a user to quickly study the power of a new method and how it compares to those included in the package. For details of the methods and references see the included vignettes.

This package provides functions and datasets to support Valliant, Dever, and Kreuter (2018), <doi:10.1007/978-3-319-93632-1>, "Practical Tools for Designing and Weighting Survey Samples". Contains functions for sample size calculation for survey samples using stratified or clustered one-, two-, and three-stage sample designs, and single-stage audit sample designs. Functions are included that will group geographic units accounting for distances apart and measures of size. Other functions compute variance components for multistage designs, sample sizes in two-phase designs, and a stopping rule for ending data collection. A number of example data sets are included.

Objects to manipulate sequential and seasonal time series. Sequential time series based on time instants and time duration are handled. Both can be regularly or unevenly spaced (overlapping duration are allowed). Only POSIX* format are used for dates and times. The following classes are provided : POSIXcti', POSIXctp', TimeIntervalDataFrame', TimeInstantDataFrame', SubtimeDataFrame ; methods to switch from a class to another and to modify the time support of series (hourly time series to daily time series for instance) are also defined. Tools provided can be used for instance to handle environmental monitoring data (not always produced on a regular time base).

It offers functions for splitting, parsing, tokenizing and creating a vocabulary for big text data files. Moreover, it includes functions for building a document-term matrix and extracting information from those (term-associations, most frequent terms). It also embodies functions for calculating token statistics (collocations, look-up tables, string dissimilarities) and functions to work with sparse matrices. Lastly, it includes functions for Word Vector Representations (i.e. GloVe', fasttext') and incorporates functions for the calculation of (pairwise) text document dissimilarities. The source code is based on C++11 and exported in R through the Rcpp', RcppArmadillo and BH packages.

19 term and 9 first trimester placental chorionic villi and matched cell-sorted samples ran on Illumina HumanMethylationEPIC DNA methylation microarrays. This data was made available on GEO accession [GSE159526](https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159526). Both the raw and processed data has been made available on \codeExperimentHub. Raw unprocessed data formatted as an RGChannelSet object for integration and normalization using minfi and other existing Bioconductor packages. Processed normalized data is also available as a DNA methylation \codematrix, with a corresponding phenotype information as a \codedata.frame object.

The anota2seq package provides analysis of translational efficiency and differential expression analysis for polysome-profiling and ribosome-profiling studies (two or more sample classes) quantified by RNA sequencing or DNA-microarray. Polysome-profiling and ribosome-profiling typically generate data for two RNA sources, translated mRNA and total mRNA. Analysis of differential expression is used to estimate changes within each RNA source. Analysis of translational efficiency aims to identify changes in translation efficiency leading to altered protein levels that are independent of total mRNA levels or buffering, a mechanism regulating translational efficiency so that protein levels remain constant despite fluctuating total mRNA levels.

iheatmapr is an R package for building complex, interactive heatmaps using modular building blocks. "Complex" heatmaps are heatmaps in which subplots along the rows or columns of the main heatmap add more information about each row or column. For example, a one column additional heatmap may indicate what group a particular row or column belongs to. Complex heatmaps may also include multiple side by side heatmaps which show different types of data for the same conditions. Interactivity can improve complex heatmaps by providing tooltips with information about each cell and enabling zooming into interesting features. iheatmapr uses the plotly library for interactivity.

Access and manage the application programming interface (API) of the Armed Conflict Location & Event Data Project (ACLED) at <https://acleddata.com/>. The package makes it easy to retrieve a user-defined sample (or all of the available data) of ACLED, enabling a seamless integration of regular data updates into the research work flow. It requires a minimal number of dependencies. See the package's README file for a note on replicability when drawing on ACLED data. When using this package, you acknowledge that you have read ACLED's terms and conditions of use, and that you agree with their attribution requirements.

Verification of continually updating time series data where we expect new values, but want to ensure previous data remains unchanged. Data previously recorded could change for a number of reasons, such as discovery of an error in model code, a change in methodology or instrument recalibration. Monitoring data sources for these changes is not always possible. Other unnoticed changes could include a jump in time or measurement frequency, due to instrument failure or software updates. Functionality is provided that can be used to check and flag changes to previous data to prevent changes going unnoticed, as well as unexpected jumps in time.

Understanding the drivers of microbial diversity is an important frontier of microbial ecology, and investigating the diversity of samples from microbial ecosystems is a common step in any microbiome analysis. breakaway is the premier package for statistical analysis of microbial diversity. breakaway implements the latest and greatest estimates of species richness, described in Willis and Bunge (2015) <doi:10.1111/biom.12332>, Willis et al. (2017) <doi:10.1111/rssc.12206>, and Willis (2016) <arXiv:1604.02598>, as well as the most commonly used estimates, including the objective Bayes approach described in Barger and Bunge (2010) <doi:10.1214/10-BA527>.

Pacote para análise de delineamentos experimentais (DIC, DBC e DQL), experimentos em esquema fatorial duplo (em DIC e DBC), experimentos em parcelas subdivididas (em DIC e DBC), experimentos em esquema fatorial duplo com um tratamento adicional (em DIC e DBC), experimentos em fatorial triplo (em DIC e DBC) e experimentos em esquema fatorial triplo com um tratamento adicional (em DIC e DBC), fazendo analise de variancia e comparacao de multiplas medias (para tratamentos qualitativos), ou ajustando modelos de regressao ate a terceira potencia (para tratamentos quantitativos); analise de residuos (Ferreira, Cavalcanti and Nogueira, 2014) <doi:10.4236/am.2014.519280>.

This package provides an implementation of concurrent or varying coefficient regression methods for functional data. The implementations are done for both dense and sparsely observed functional data. Pointwise confidence bands can be constructed for each case. Further, the influence of past predictor values are modeled by a smooth history index function, while the effects on the response are described by smooth varying coefficient functions, which are very useful in analyzing real data such as COVID data. References: Yao, F., Müller, H.G., Wang, J.L. (2005) <doi:10.1214/009053605000000660>. Sentürk, D., Müller, H.G. (2010) <doi:10.1198/jasa.2010.tm09228>.

This package implements a novel method for privatizing network data using differential privacy. Provides functions for generating synthetic networks based on LSM (Latent Space Model), applying differential privacy to network latent positions to achieve overall network privatization, and evaluating the utility of privatized networks through various network statistics. The privatize and evaluate functions support both LSM and RDPG (Random Dot Product Graph). For generating RDPG networks, users are encouraged to use the randnet package <https://CRAN.R-project.org/package=randnet>. For more details, see the "proposed method" section of Liu, Bi, and Li (2025) <doi:10.48550/arXiv.2507.00402>.

This package implements the high-dimensional two-sample test proposed by Zhang (2019) <http://hdl.handle.net/2097/40235>. It also implements the test proposed by Srivastava, Katayama, and Kano (2013) <doi:10.1016/j.jmva.2012.08.014>. These tests are particularly suitable to high dimensional data from two populations for which the classical multivariate Hotelling's T-square test fails due to sample sizes smaller than dimensionality. In this case, the ZWL and ZWLm tests proposed by Zhang (2019) <http://hdl.handle.net/2097/40235>, referred to as zwl_test() in this package, provide a reliable and powerful test.

Estimates the intraclass correlation coefficient (ICC) for count data to assess repeatability (intra-methods concordance) and concordance (between-method concordance). In the concordance setting, the ICC is equivalent to the concordance correlation coefficient estimated by variance components. The ICC is estimated using the estimates from generalized linear mixed models. The within-subjects distributions considered are: Poisson; Negative Binomial with additive and proportional extradispersion; Zero-Inflated Poisson; and Zero-Inflated Negative Binomial with additive and proportional extradispersion. The statistical methodology used to estimate the ICC with count data can be found in Carrasco (2010) <doi:10.1111/j.1541-0420.2009.01335.x>.

This package provides maximum likelihood estimates of the performance parameters that drive a binomial distribution of observed errors, and takes full advantage of zero error observations. High performance communications systems typically have inherent noise sources and other performance limitations that need to be estimated. Measurements made at high signal to noise ratios typically result in zero errors due to limitation in available measurement time. Package includes theoretical performance functions for common modulation schemes (Proakis, "Digital Communications" (1995, <ISBN:0-07-051726-6>)), polarization shifted QPSK (Agrell & Karlsson (2009, <DOI:10.1109/JLT.2009.2029064>)), and utility functions to work with the performance functions.

CODATA internationally recommended values of the fundamental physical constants, provided as symbols for direct use within the R language. Optionally, the values with uncertainties and/or units are also provided if the errors', units and/or quantities packages are installed. The Committee on Data for Science and Technology (CODATA) is an interdisciplinary committee of the International Council for Science which periodically provides the internationally accepted set of values of the fundamental physical constants. This package contains the "2022 CODATA" version, published on May 2024: Eite Tiesinga, Peter J. Mohr, David B. Newell, and Barry N. Taylor (2024) <https://physics.nist.gov/cuu/Constants/>.

Modeling periodic mortality (or other time-to event) processes from right-censored data. Given observations of a process with a known period (e.g. 365 days, 24 hours), functions determine the number, intensity, timing, and duration of peaks of periods of elevated hazard within a period. The underlying model is a mixed wrapped Cauchy function fitted using maximum likelihoods (details in Gurarie et al. (2020) <doi:10.1111/2041-210X.13305>). The development of these tools was motivated by the strongly seasonal mortality patterns observed in many wild animal populations. Thus, the respective periods of higher mortality can be identified as "mortality seasons".

The user must supply a matrix filled with similarity values. The software will search for significant differences between similarity values at different hierarchical levels. The algorithm will return a Loess-smoothed plot of the similarity values along with the inflection point, if there are any. There is the option to search for an inflection point within a specified range. The package also has a function that will return the matrix components at a specified cutoff. References: Mullner. <ArXiv:1109.2378>; Cserhati, Carter. (2020, Journal of Creation 34(3):41-50), <https://dl0.creation.com/articles/p137/c13759/j34-3_64-73.pdf>.

This package provides a generalised workflow for Matching-Adjusted Indirect Comparison (MAIC) analysis, which supports both anchored and non-anchored MAIC methods. In MAIC, unbiased trial outcome comparison is achieved by weighting the subject-level outcomes of the intervention trial so that the weighted aggregate measures of prognostic or effect-modifying variables match those of the comparator trial. Measurements supported include time-to-event (e.g., overall survival) and binary (e.g., objective tumor response). The method is described in Signorovitch et al. (2010) <doi:10.2165/11538370-000000000-00000> and Signorovitch et al. (2012) <doi:10.1016/j.jval.2012.05.004>.