This package provides a unified interface to a variety of GSEA techniques from different bioconductor packages. Results are harmonized into a single object and can be interrogated uniformly for quick exploration and interpretation of results. Interactive exploration of GSEA results is enabled through a shiny app provided by a sparrow.shiny sibling package.

The Spectra package defines an efficient infrastructure for storing and handling mass spectrometry spectra and functionality to subset, process, visualize and compare spectra data. It provides different implementations (backends) to store mass spectrometry data. These comprise backends tuned for fast data access and processing and backends for very large data sets ensuring a small memory footprint.

This package provides analysis of high-dimensional single-cell splicing data. Offers a framework to extract and work with ratio-based data structures derived from single-cell RNA sequencing experiments. Provides both a modern R6 object-oriented interface and direct matrix manipulation functions. Core functionalities are implemented in C++ via Rcpp to ensure high performance and scalability on large datasets.

This package performs a gene expression data analysis to detect condition-specific genes. Such genes are significantly up- or down-regulated in a small number of conditions. It does so by fitting a mixture of normal distributions to the expression values. Conditions can be environmental conditions, different tissues, organs or any other sources that you wish to compare in terms of gene expression.

SpNeigh provides methods for neighborhood-aware analysis of spatial transcriptomics data. It supports boundary detection, spatial weighting (centroid- and boundary-based), spatially informed differential expression using spline-based models, and spatial enrichment analysis via the Spatial Enrichment Index (SEI). Designed for compatibility with Seurat objects, SpatialExperiment objects and spatial data frames, SpNeigh enables interpretable, publication-ready analysis of spatial gene expression patterns.

Detects spatial and temporal groups in GPS relocations (Robitaille et al. (2019) <doi:10.1111/2041-210X.13215>). It can be used to convert GPS relocations to gambit-of-the-group format to build proximity-based social networks, and perform data-stream randomization methods suitable for GPS data. Also provides measures of intragroup social dynamics including distance and direction to leaders, centroids and nearest neighbours.

This package contains an R Markdown template for a clinical trial protocol adhering to the SPIRIT statement. The SPIRIT (Standard Protocol Items for Interventional Trials) statement outlines recommendations for a minimum set of elements to be addressed in a clinical trial protocol. Also contains functions to create a xml document from the template and upload it to clinicaltrials.gov<https://www.clinicaltrials.gov/> for trial registration.

Perform analysis of variance when the experimental units are spatially correlated. There are two methods to deal with spatial dependence: Spatial autoregressive models (see Rossoni, D. F., & Lima, R. R. (2019) <doi:10.28951/rbb.v37i2.388>) and geostatistics (see Pontes, J. M., & Oliveira, M. S. D. (2004) <doi:10.1590/S1413-70542004000100018>). For both methods, there are three multicomparison procedure available: Tukey, multivariate T, and Scott-Knott.

This package provides a collection of functions to deal with spatial and spatiotemporal autoregressive conditional heteroscedasticity (spatial ARCH and GARCH models) by Otto, Schmid, Garthoff (2018, Spatial Statistics) <doi:10.1016/j.spasta.2018.07.005>: simulation of spatial ARCH-type processes (spARCH, log/exponential-spARCH, complex-spARCH); quasi-maximum-likelihood estimation of the parameters of spARCH models and spatial autoregressive models with spARCH disturbances, diagnostic checks, visualizations.

Fit, summarize, and predict for a variety of spatial statistical models applied to point-referenced and areal (lattice) data. Parameters are estimated using various methods. Additional modeling features include anisotropy, non-spatial random effects, partition factors, big data approaches, and more. Model-fit statistics are used to summarize, visualize, and compare models. Predictions at unobserved locations are readily obtainable. For additional details, see Dumelle et al. (2023) <doi:10.1371/journal.pone.0282524>.

Spaniel includes a series of tools to aid the quality control and analysis of Spatial Transcriptomics data. Spaniel can import data from either the original Spatial Transcriptomics system or 10X Visium technology. The package contains functions to create a SingleCellExperiment Seurat object and provides a method of loading a histologial image into R. The spanielPlot function allows visualisation of metrics contained within the S4 object overlaid onto the image of the tissue.

Utility functions that help with common base-R problems relating to lists. Lists in base-R are very flexible. This package provides functions to quickly and easily characterize types of lists. That is, to identify if all elements in a list are null, data.frames, lists, or fully named lists. Other functionality is provided for the handling of lists, such as the easy splitting of lists into equally sized groups, and the unnesting of data.frames within fully named lists.

We propose a novel two-step procedure to combine epidemiological data obtained from diverse sources with the aim to quantify risk factors affecting the probability that an individual develops certain disease such as cancer. See Hui Huang, Xiaomei Ma, Rasmus Waagepetersen, Theodore R. Holford, Rong Wang, Harvey Risch, Lloyd Mueller & Yongtao Guan (2014) A New Estimation Approach for Combining Epidemiological Data From Multiple Sources, Journal of the American Statistical Association, 109:505, 11-23, <doi:10.1080/01621459.2013.870904>.

This package provides tools to convert from specific formats to more general forms of spatial data. Using tables to store the actual entities present in spatial data provides flexibility, and the functions here deliberately minimize the level of interpretation applied, leaving that for specific applications. Includes support for simple features, round-trip for Spatial classes and long-form tables, analogous to ggplot2::fortify'. There is also a more normal form representation that decomposes simple features and their kin to tables of objects, parts, and unique coordinates.

Flexible nonlinear extension of spatial autoregressive (SAR), spatial error (SEM), and spatial autoregressive with autoregressive disturbances (SARAR) models with multiple regression engines (generalized additive models ('mgcv'), gradient boosting ('mboost'), multivariate adaptive regression splines ('earth'), and xgboost') and two families of spatial-parameter estimators: maximum likelihood and the determinant-free Closed-Form Estimator of Smirnov (2020) <doi:10.1111/gean.12268>. See Geniaux G. (2026). "Flexible nonlinear spatial autoregressive models: a gradient boosting approach with closed-form estimation." Presented at Spatial Econometrics World Congress (SEA/SEW 2026, Paris), unpublished.

Providing convenience functions to connect R with the Spotify application programming interface ('API'). At first it aims to help setting up the OAuth2.0 Authentication flow. The default output of the get_*() functions is tidy, but optionally the functions could return the raw response from the API as well. The search_*() and get_*() functions can be combined. See the vignette for more information and examples and the official Spotify for Developers website <https://developer.spotify.com/documentation/web-api/> for information about the Web API'.

SpikeLI is a package that performs the analysis of the Affymetrix spike-in data using the Langmuir Isotherm. The aim of this package is to show the advantages of a physical-chemistry based analysis of the Affymetrix microarray data compared to the traditional methods. The spike-in (or Latin square) data for the HGU95 and HGU133 chipsets have been downloaded from the Affymetrix web site. The model used in the spikeLI package is described in details in E. Carlon and T. Heim, Physica A 362, 433 (2006).

Inspired by space-time regressions often performed to assess the expansion of the Neolithic from the Near East to Europe (Pinhasi et al. 2005 <doi:10.1371/journal.pbio.0030410>). Test for significant correlations between the (earliest) radiocarbon dates of archaeological sites and their respective distances from a hypothetical center of origin. Both ordinary least squares (OLS) and reduced major axis (RMA) methods are supported (Russell et al. 2014 <doi:10.1371/journal.pone.0087854>). It is also possible to iterate over many sites to identify the most likely origin.

Fits spatial mixture models, including spatial Gaussian mixtures and mixtures of spatial factor analyzers, to complete or incomplete data. Spatial decay can be represented by monotone I-splines or a normalized sigmoid. Missing entries are handled using a built-in partial expectation-maximization procedure for matrix-variate data. The spatial covariance and spatial factor analyzer models are described in Lu and colleagues (2026a) "Spatial Covariance Constraints for Gaussian Mixture Models" <doi:10.48550/arXiv.2601.07979> and Lu and colleagues (2026b) "Mixtures of spatial factor analyzers for tensor-variate data" <doi:10.48550/arXiv.2607.07887>.

The speckle package contains functions for the analysis of single cell RNA-seq data. The speckle package currently contains functions to analyse differences in cell type proportions. There are also functions to estimate the parameters of the Beta distribution based on a given counts matrix, and a function to normalise a counts matrix to the median library size. There are plotting functions to visualise cell type proportions and the mean-variance relationship in cell type proportions and counts. As our research into specialised analyses of single cell data continues we anticipate that the package will be updated with new functions.

This package provides statistical process control tools for stochastic textured surfaces. The current version supports the following tools: (1) generic modeling of stochastic textured surfaces. (2) local defect monitoring and diagnostics in stochastic textured surfaces, which was proposed by Bui and Apley (2018a) <doi:10.1080/00401706.2017.1302362>. (3) global change monitoring in the nature of stochastic textured surfaces, which was proposed by Bui and Apley (2018b) <doi:10.1080/00224065.2018.1507559>. (4) computation of dissimilarity matrix of stochastic textured surface images, which was proposed by Bui and Apley (2019b) <doi:10.1016/j.csda.2019.01.019>.

Fits Bayesian hierarchical spatial and spatial-temporal process models for point-referenced Gaussian, Poisson, binomial, and binary data using stacking of predictive densities. It involves sampling from analytically available posterior distributions conditional upon candidate values of the spatial process parameters and, subsequently assimilate inference from these individual posterior distributions using Bayesian predictive stacking. Our algorithm is highly parallelizable and hence, much faster than traditional Markov chain Monte Carlo algorithms while delivering competitive predictive performance. See Zhang, Tang, and Banerjee (2025) <doi:10.1080/01621459.2025.2566449>, and, Pan, Zhang, Bradley, and Banerjee (2025) <doi:10.1214/25-BA1582> for details.

This package performs predictions of totals and weighted sums, or finite population block kriging, on spatial data using the methods in Ver Hoef (2008) <doi:10.1007/s10651-007-0035-y>. The primary outputs are an estimate of the total, mean, or weighted sum in the region, an estimated prediction variance, and a plot of the predicted and observed values. This is useful primarily to users with ecological data that are counts or densities measured on some sites in a finite area of interest. Spatial prediction for the total count or average density in the entire region can then be done using the functions in this package.

This package provides a collection of functions for estimating spatial and spatio-temporal regression models. Moran eigenvectors are used as spatial basis functions to efficiently approximate spatially dependent Gaussian processes (i.e., random effects eigenvector spatial filtering; see Murakami and Griffith 2015 <doi: 10.1007/s10109-015-0213-7>). The implemented models include linear regression with residual spatial dependence, spatially/spatio-temporally varying coefficient models (Murakami et al., 2017, 2024; <doi:10.1016/j.spasta.2016.12.001>,<doi:10.48550/arXiv.2410.07229>), spatially filtered unconditional quantile regression (Murakami and Seya, 2019 <doi:10.1002/env.2556>), Gaussian and non-Gaussian spatial mixed models through compositionally-warping (Murakami et al. 2021, <doi:10.1016/j.spasta.2021.100520>).