Offers an interactive RStudio gadget interface for communicating with OpenAI large language models (e.g., gpt-5', gpt-5-mini', gpt-5-nano') (<https://platform.openai.com/docs/api-reference>). Enables users to conduct multiple chat conversations simultaneously in separate tabs. Supports uploading local files (R, PDF, DOCX) to provide context for the models. Allows per-conversation configuration of system messages (where supported by the model). API interactions via the httr package are performed asynchronously using promises and future to avoid blocking the R console. Useful for tasks like code generation, text summarization, and document analysis directly within the RStudio environment. Requires an OpenAI API key set as an environment variable.

Analysis tools to investigate changes in intercellular communication from scRNA-seq data. Using a Seurat object as input, the package infers which cell-cell interactions are present in the dataset and how these interactions change between two conditions of interest (e.g. young vs old). It relies on an internal database of ligand-receptor interactions (available for human, mouse and rat) that have been gathered from several published studies. Detection and differential analyses rely on permutation tests. The package also contains several tools to perform over-representation analysis and visualize the results. See Lagger, C. et al. (2023) <doi:10.1038/s43587-023-00514-x> for a full description of the methodology.

Many methods allow us to extract biological activities from omics data using information from prior knowledge resources, reducing the dimensionality for increased statistical power and better interpretability. decoupleR is a Bioconductor package containing different statistical methods to extract these signatures within a unified framework. decoupleR allows the user to flexibly test any method with any resource. It incorporates methods that take into account the sign and weight of network interactions. decoupleR can be used with any omic, as long as its features can be linked to a biological process based on prior knowledge. For example, in transcriptomics gene sets regulated by a transcription factor, or in phospho-proteomics phosphosites that are targeted by a kinase.

Training and predict functions for Single Hidden-layer Feedforward Neural Networks (SLFN) using the Extreme Learning Machine (ELM) algorithm. The ELM algorithm differs from the traditional gradient-based algorithms for very short training times (it doesn't need any iterative tuning, this makes learning time very fast) and there is no need to set any other parameters like learning rate, momentum, epochs, etc. This is a reimplementation of the elmNN package using RcppArmadillo after the elmNN package was archived. For more information, see "Extreme learning machine: Theory and applications" by Guang-Bin Huang, Qin-Yu Zhu, Chee-Kheong Siew (2006), Elsevier B.V, <doi:10.1016/j.neucom.2005.12.126>.

Models integrate environmental DNA (eDNA) detection data and traditional survey data to jointly estimate species catch rate (see package vignette: <https://ednajoint.netlify.app/>). Models can be used with count data via traditional survey methods (i.e., trapping, electrofishing, visual) and replicated eDNA detection/nondetection data via polymerase chain reaction (i.e., PCR or qPCR) from multiple survey locations. Estimated parameters include probability of a false positive eDNA detection, a site-level covariates that scale the sensitivity of eDNA surveys relative to traditional surveys, and gear scaling coefficients for traditional gear types. Models are implemented with a Bayesian framework (Markov chain Monte Carlo) using the Stan probabilistic programming language.

This package provides a toolbox for implementing the Ecological Dynamic Regime framework (Sánchez-Pinillos et al., 2023 <doi:10.1002/ecm.1589>) to characterize and compare groups of ecological trajectories in multidimensional spaces defined by state variables. The package includes the RETRA-EDR algorithm to identify representative trajectories, functions to generate, summarize, and visualize representative trajectories, and several metrics to quantify the distribution and heterogeneity of trajectories in an ecological dynamic regime and quantify the dissimilarity between two or more ecological dynamic regimes. The package also includes a set of functions to assess ecological resilience based on ecological dynamic regimes (Sánchez-Pinillos et al., 2024 <doi:10.1016/j.biocon.2023.110409>).

Método simples e eficiente de geolocalizar dados no Brasil. O pacote é baseado em conjuntos de dados espaciais abertos de endereços brasileiros, utilizando como fonte principal o Cadastro Nacional de Endereços para Fins Estatà sticos (CNEFE). O CNEFE é publicado pelo Instituto Brasileiro de Geografia e Estatà stica (IBGE), órgão oficial de estatà sticas e geografia do Brasil. (A simple and efficient method for geolocating data in Brazil. The package is based on open spatial datasets of Brazilian addresses, primarily using the Cadastro Nacional de Endereços para Fins Estatà sticos (CNEFE), published by the Instituto Brasileiro de Geografia e Estatà stica (IBGE), Brazil's official statistics and geography agency.).

Raman and (FT)IR spectral analysis tool for plastic particles and other environmental samples (Cowger et al. 2021, <doi:10.1021/acs.analchem.1c00123>). With read_any(), Open Specy provides a single function for reading individual, batch, or map spectral data files like .asp, .csv, .jdx, .spc, .spa, .0, and .zip. process_spec() simplifies processing spectra, including smoothing, baseline correction, range restriction and flattening, intensity conversions, wavenumber alignment, and min-max normalization. Spectra can be identified in batch using an onboard reference library (Cowger et al. 2020, <doi:10.1177/0003702820929064>) using match_spec(). A Shiny app is available via run_app() or online at <https://www.openanalysis.org/openspecy/>.

Launch an application by a simple click without opening R or RStudio. The package has 3 functions of which only one is essential in its use, `shiny.exe()`. It generates a script in the open shiny project then create a shortcut in the same folder that allows you to launch the app by clicking.If you set `host = public'`, the application will be launched on the public server to which you are connected. Thus, all other devices connected to the same server will be able to access the application through the link of your `IPv4` extended by the port. You can stop the application by leaving the terminal opened by the shortcut.

This package provides elastic net penalized maximum likelihood estimator for structural equation models (SEM). The package implements `lasso` and `elastic net` (l1/l2) penalized SEM and estimates the model parameters with an efficient block coordinate ascent algorithm that maximizes the penalized likelihood of the SEM. Hyperparameters are inferred from cross-validation (CV). A Stability Selection (STS) function is also available to provide accurate causal effect selection. The software achieves high accuracy performance through a `Network Generative Pre-trained Transformer` (Network GPT) Framework with two steps: 1) pre-trains the model to generate a complete (fully connected) graph; and 2) uses the complete graph as the initial state to fit the `elastic net` penalized SEM.

Systematic 3D interaction calls and differential analysis for Hi-C and HiChIP. The HiC-DC+ (Hi-C/HiChIP direct caller plus) package enables principled statistical analysis of Hi-C and HiChIP data sets – including calling significant interactions within a single experiment and performing differential analysis between conditions given replicate experiments – to facilitate global integrative studies. HiC-DC+ estimates significant interactions in a Hi-C or HiChIP experiment directly from the raw contact matrix for each chromosome up to a specified genomic distance, binned by uniform genomic intervals or restriction enzyme fragments, by training a background model to account for random polymer ligation and systematic sources of read count variation.

Utility functions to download and process data produced by the ALARM Project, including 2020 redistricting files Kenny and McCartan (2021) <https://alarm-redist.org/posts/2021-08-10-census-2020/> and the 50-State Redistricting Simulations of McCartan, Kenny, Simko, Garcia, Wang, Wu, Kuriwaki, and Imai (2022) <doi:10.7910/DVN/SLCD3E>. The package extends the data introduced in McCartan, Kenny, Simko, Garcia, Wang, Wu, Kuriwaki, and Imai (2022) <doi:10.1038/s41597-022-01808-2> to also include states with only a single district. The package also includes the Japanese 2022 redistricting files from the 47-Prefecture Redistricting Simulations of Miyazaki, Yamada, Yatsuhashi, and Imai (2022) <doi:10.7910/DVN/Z9UKSH>.

Enable users to evaluate long-term trends using a Generalized Additive Modeling (GAM) approach. The model development includes selecting a GAM structure to describe nonlinear seasonally-varying changes over time, incorporation of hydrologic variability via either a river flow or salinity, the use of an intervention to deal with method or laboratory changes suspected to impact data values, and representation of left- and interval-censored data. The approach has been applied to water quality data in the Chesapeake Bay, a major estuary on the east coast of the United States to provide insights to a range of management- and research-focused questions. Methodology described in Murphy (2019) <doi:10.1016/j.envsoft.2019.03.027>.

Fits Bayesian dose-response model-based network meta-analysis (MBNMA) that incorporate multiple doses within an agent by modelling different dose-response functions, as described by Mawdsley et al. (2016) <doi:10.1002/psp4.12091>. By modelling dose-response relationships this can connect networks of evidence that might otherwise be disconnected, and can improve precision on treatment estimates. Several common dose-response functions are provided; others may be added by the user. Various characteristics and assumptions can be flexibly added to the models, such as shared class effects. The consistency of direct and indirect evidence in the network can be assessed using unrelated mean effects models and/or by node-splitting at the treatment level.

This package provides functions used to fit and test the phenology of species based on counts. Based on Girondot, M. (2010) <doi:10.3354/esr00292> for the phenology function, Girondot, M. (2017) <doi:10.1016/j.ecolind.2017.05.063> for the convolution of negative binomial, Girondot, M. and Rizzo, A. (2015) <doi:10.2993/etbi-35-02-337-353.1> for Bayesian estimate, Pfaller JB, ..., Girondot M (2019) <doi:10.1007/s00227-019-3545-x> for tag-loss estimate, Hancock J, ..., Girondot M (2019) <doi:10.1016/j.ecolmodel.2019.04.013> for nesting history, Laloe J-O, ..., Girondot M, Hays GC (2020) <doi:10.1007/s00227-020-03686-x> for aggregating several seasons.

A workflow is an object that can bundle together your pre-processing, modeling, and post-processing requests. For example, if you have a recipe and parsnip model, these can be combined into a workflow. The advantages are:

1. You don’t have to keep track of separate objects in your workspace.

2. The recipe prepping and model fitting can be executed using a single call to fit().

3. If you have custom tuning parameter settings, these can be defined using a simpler interface when combined with tune.

4. In the future, workflows will be able to add post-processing operations, such as modifying the probability cutoff for two-class models.

In the single cell World, which includes flow cytometry, mass cytometry, single-cell RNA-seq (scRNA-seq), and others, there is a need to improve data visualisation and to bring analysis capabilities to researchers even from non-technical backgrounds. scDataviz attempts to fit into this space, while also catering for advanced users. Additonally, due to the way that scDataviz is designed, which is based on SingleCellExperiment, it has a plug and play feel, and immediately lends itself as flexibile and compatibile with studies that go beyond scDataviz. Finally, the graphics in scDataviz are generated via the ggplot engine, which means that users can add on features to these with ease.

Dual Scaling, developed by Professor Shizuhiko Nishisato (1994, ISBN: 0-9691785-3-6), is a fundamental technique in multivariate analysis used for data scaling and correspondence analysis. Its utility lies in its ability to represent multidimensional data in a lower-dimensional space, making it easier to visualize and understand underlying patterns in complex data. This technique has been implemented to handle various types of data, including Contingency and Frequency data (CF), Multiple-Choice data (MC), Sorting data (SO), Paired-Comparison data (PC), and Rank-Order data (RO), providing users with a powerful tool to explore relationships between variables and observations in various fields, from sociology to ecology, enabling deeper and more efficient analysis of multivariate datasets.

This package implements two estimations related to the foundations of info metrics applied to ecological inference. These methodologies assess the lack of disaggregated data and provide an approach to obtaining disaggregated territorial-level data. For more details, see the following references: Fernández-Vázquez, E., Dà az-Dapena, A., Rubiera-Morollón, F. et al. (2020) "Spatial Disaggregation of Social Indicators: An Info-Metrics Approach." <doi:10.1007/s11205-020-02455-z>. Dà az-Dapena, A., Fernández-Vázquez, E., Rubiera-Morollón, F., & Vinuela, A. (2021) "Mapping poverty at the local level in Europe: A consistent spatial disaggregation of the AROPE indicator for France, Spain, Portugal and the United Kingdom." <doi:10.1111/rsp3.12379>.

The Piece-wise exponential (Additive Mixed) Model (PAMM; Bender and others (2018) <doi: 10.1177/1471082X17748083>) is a powerful model class for the analysis of survival (or time-to-event) data, based on Generalized Additive (Mixed) Models (GA(M)Ms). It offers intuitive specification and robust estimation of complex survival models with stratified baseline hazards, random effects, time-varying effects, time-dependent covariates and cumulative effects (Bender and others (2019)), as well as support for left-truncated data as well as competing risks, recurrent events and multi-state settings. pammtools provides tidy workflow for survival analysis with PAMMs, including data simulation, transformation and other functions for data preprocessing and model post-processing as well as visualization.

Automatic generation and selection of spatial predictors for Random Forest models fitted to spatially structured data. Spatial predictors are constructed from a distance matrix among training samples using Moran's Eigenvector Maps (MEMs; Dray, Legendre, and Peres-Neto 2006 <DOI:10.1016/j.ecolmodel.2006.02.015>) or the RFsp approach (Hengl et al. <DOI:10.7717/peerj.5518>). These predictors are used alongside user-supplied explanatory variables in Random Forest models. The package provides functions for model fitting, multicollinearity reduction, interaction identification, hyperparameter tuning, evaluation via spatial cross-validation, and result visualization using partial dependence and interaction plots. Model fitting relies on the ranger package (Wright and Ziegler 2017 <DOI:10.18637/jss.v077.i01>).

This package provides a suite of Bayesian MI-LASSO for variable selection methods for multiply-imputed datasets. The package includes four Bayesian MI-LASSO models using shrinkage (Multi-Laplace, Horseshoe, ARD) and Spike-and-Slab (Spike-and-Laplace) priors, along with tools for model fitting via MCMC, four-step projection predictive variable selection, and hyperparameter calibration. Methods are suitable for both continuous and binary covariates under missing-at-random or missing-completely-at-random assumptions. See Zou, J., Wang, S. and Chen, Q. (2025), Bayesian MI-LASSO for Variable Selection on Multiply-Imputed Data. ArXiv, 2211.00114. <doi:10.48550/arXiv.2211.00114> for more details. We also provide the frequentist`s MI-LASSO function.

Enables off-the-shelf functionality for fully Bayesian, nonstationary Gaussian process modeling. The approach to nonstationary modeling involves a closed-form, convolution-based covariance function with spatially-varying parameters; these parameter processes can be specified either deterministically (using covariates or basis functions) or stochastically (using approximate Gaussian processes). Stationary Gaussian processes are a special case of our methodology, and we furthermore implement approximate Gaussian process inference to account for very large spatial data sets (Finley, et al (2017) <doi:10.48550/arXiv.1702.00434>). Bayesian inference is carried out using Markov chain Monte Carlo methods via the "nimble" package, and posterior prediction for the Gaussian process at unobserved locations is provided as a post-processing step.

This package provides a toolbox to facilitate the calculation of political system indicators for researchers. This package offers a variety of basic indicators related to electoral systems, party systems, elections, and parliamentary studies, as well as others. Main references are: Loosemore and Hanby (1971) <doi:10.1017/S000712340000925X>; Gallagher (1991) <doi:10.1016/0261-3794(91)90004-C>; Laakso and Taagepera (1979) <doi:10.1177/001041407901200101>; Rae (1968) <doi:10.1177/001041406800100305>; HirschmaÅ (1945) <ISBN:0-520-04082-1>; Kesselman (1966) <doi:10.2307/1953769>; Jones and Mainwaring (2003) <doi:10.1177/13540688030092002>; Rice (1925) <doi:10.2307/2142407>; Pedersen (1979) <doi:10.1111/j.1475-6765.1979.tb01267.x>; SANTOS (2002) <ISBN:85-225-0395-8>.