Simulates demic diffusion building on models previously developed for the expansion of Neolithic and other food-producing economies during the Holocene (Fort et al. (2012) <doi:10.7183/0002-7316.77.2.203>, Souza et al. (2021) <doi:10.1098/rsif.2021.0499>). Growth and emigration are modelled as density-dependent processes using logistic growth and an asymptotic threshold model. Environmental and terrain layers, which can change over time, affect carrying capacity, growth and mobility. Multiple centres of origin with their respective starting times can be specified.

Differential Analysis of short RNA transcripts that can be modeled by either Poisson or Negative binomial distribution. The statistical methodology implemented in this package is based on the random selection of references genes (Desaulle et al. (2021) <arXiv:2103.09872>).

Calculates distances from point locations to features. The usual approach for eg. resource selection function analyses is to generate a complete distance to features surface then sample it with your observed and random points. Since these raster based approaches can be pretty costly with large areas, and often lead to memory issues in R, the distanceto package opts to compute these distances using efficient, vector based approaches. As a helper, there's a decidedly low-res raster based approach for visually inspecting your region's distance surface. But the workhorse is distance_to.

Detection of runs of homozygosity and of heterozygosity in diploid genomes using two methods: sliding windows (Purcell et al (2007) <doi:10.1086/519795>) and consecutive runs (Marras et al (2015) <doi:10.1111/age.12259>).

This package provides helper functions to scrape the online archive of the Deutsche Turnliga <https://www.deutsche-turnliga.de/archiv.html>. Also included is data of one competition and one matchday as test data.

Distances on dual-weighted directed graphs using priority-queue shortest paths (Padgham (2019) <doi:10.32866/6945>). Weighted directed graphs have weights from A to B which may differ from those from B to A. Dual-weighted directed graphs have two sets of such weights. A canonical example is a street network to be used for routing in which routes are calculated by weighting distances according to the type of way and mode of transport, yet lengths of routes must be calculated from direct distances.

Implementation of the double/debiased machine learning framework of Chernozhukov et al. (2018) <doi:10.1111/ectj.12097> for partially linear regression models, partially linear instrumental variable regression models, interactive regression models and interactive instrumental variable regression models. DoubleML allows estimation of the nuisance parts in these models by machine learning methods and computation of the Neyman orthogonal score functions. DoubleML is built on top of mlr3 and the mlr3 ecosystem. The object-oriented implementation of DoubleML based on the R6 package is very flexible. More information available in the publication in the Journal of Statistical Software: <doi:10.18637/jss.v108.i03>.

Algorithm to handle with optimal subset selection for distributed local principal component analysis. The philosophy of the package is described in Guo G. (2020) <doi:10.1080/02331888.2020.1823979>.

Individual gene expression patterns are encoded into a series of eigenvector patterns ('WGCNA package). Using the framework of linear model-based differential expression comparisons ('limma package), time-course expression patterns for genes in different conditions are compared and analyzed for significant pattern changes. For reference, see: Greenham K, Sartor RC, Zorich S, Lou P, Mockler TC and McClung CR. eLife. 2020 Sep 30;9(4). <doi:10.7554/eLife.58993>.

S3 classes for multivariate optimization using the desirability function by Derringer and Suich (1980).

Dose Titration Algorithm Tuning (DTAT) is a methodologic framework allowing dose individualization to be conceived as a continuous learning process that begins in early-phase clinical trials and continues throughout drug development, on into clinical practice. This package includes code that researchers may use to reproduce or extend key results of the DTAT research programme, plus tools for trialists to design and simulate a 3+3/PC dose-finding study. Please see Norris (2017a) <doi:10.12688/f1000research.10624.3> and Norris (2017c) <doi:10.1101/240846>.

This package provides S4 classes and methods for storing dense and sparse matrices in DuckDB databases. The package supports constructing database-backed matrices from base R and Matrix objects, extracting slices and summaries, performing arithmetic and selected linear algebra operations, and materializing results for larger-than-memory workflows. It integrates with dbProject to keep database paths, live connections, and lazy matrix tables synchronized across interactive analyses.

This package provides a function toolkit to facilitate reproducible RNA-Seq Differential Gene Expression (DGE) analysis (Law (2015) <doi:10.12688/f1000research.9005.3>). The tools include both analysis work-flow and utility functions: mapping/unit conversion, count normalization, accounting for unknown covariates, and more. This is a complement/cohort to the DGEobj package that provides a flexible container to manage and annotate Differential Gene Expression analysis results.

This package provides vectorised functions for computing p-values of various common discrete statistical tests, as described e.g. in Agresti (2002) <doi:10.1002/0471249688>, including their distributions. Exact and approximate computation methods are provided. For exact ones, several procedures of determining two-sided p-values are included, which are outlined in more detail in Hirji (2006) <doi:10.1201/9781420036190>.

Fits constrained and unrestricted meta-analytic location-scale models in which residual between-study heterogeneity is modeled as an exponential function of a prespecified design-robustness score. The package supports maximum-likelihood (ML) and restricted maximum-likelihood (REML) estimation, location moderators, the conventional random-effects model as a nested special case, exact estimation at the nonnegative scale-gradient boundary, design-indexed heterogeneity summaries, scale-attenuation measures, prediction of fitted heterogeneity, leave-one-out influence diagnostics, and parametric-bootstrap inference for the scale gradient. Because the scale-gradient null lies on the boundary of the constrained parameter space, standard chi-square likelihood-ratio references do not apply (Self and Liang, 1987, <doi:10.1080/01621459.1987.10478472>). The general location-scale parent model is described in Viechtbauer and Lopez-Lopez (2022, <doi:10.1002/jrsm.1562>). A scale model reweights studies and does not adjust the mean for design-linked bias.

Computes dynamical correlation estimates and percentile bootstrap confidence intervals for pairs of longitudinal responses, including consideration of lags and derivatives.

Allows to perform the dynamic mixture estimation with state-space components and normal regression components, and clustering with normal mixture. Quasi-Bayesian estimation, as well as, that based on the Kerridge inaccuracy approximation are implemented. Main references: Nagy and Suzdaleva (2013) <doi:10.1016/j.apm.2013.05.038>; Nagy et al. (2011) <doi:10.1002/acs.1239>.

This package provides a collection of tests to analyze the causal direction of dependence in linear models (Wiedermann, W., & von Eye, A., 2025, ISBN: 9781009381390). The package includes functions to perform Direction Dependence Analysis for variable distributions, residual distributions, and independence properties of predictors and residuals in competing causal models. In addition, the package contains functions to test the causal direction of dependence in conditional models (i.e., models with interaction terms) For more information see <https://www.ddaproject.com>.

Distribution (S4-)classes for elliptically contoured distributions (based on package distr').

Employ time-calibrated phylogenies and trait/range data to test for differences in diversification rates over evolutionary time. Extend the STRAPP test from BAMMtools::traitDependentBAMM() to any time step along phylogenies. See inst/COPYRIGHTS for details on third-party code.

This package performs calculations with tree taper (or stem profile) equations, including model fitting. The package implements the methods from Garcà a, O. (2015) "Dynamic modelling of tree form" <http://mcfns.net/index.php/Journal/article/view/MCFNS7.1_2>. The models are parsimonious, describe well the tree bole shape over its full length, and are consistent with wood formation mechanisms through time.

This package provides an easy to use implementation of life expectancy decomposition formulas for age bands, derived from Ponnapalli, K. (2005). A comparison of different methods for decomposition of changes in expectation of life at birth and differentials in life expectancy at birth. Demographic Research, 12, pp.141â 172. <doi:10.4054/demres.2005.12.7> In addition, there is a decomposition function for disease cause breakdown and a couple helpful plot functions.

This package contains data sets, examples and software from the Second Edition of "Design of Observational Studies"; see Rosenbaum, P.R. (2010) <doi:10.1007/978-1-4419-1213-8>.

Overload utils::'? to build unary and binary operators from existing functions, piping operators of different precedence, and flexible syntaxes.