Generate Manhattan, Q-Q, and PCA plots from GWAS and PCA results using ggplot2'.

It is well known that the distribution of a Gaussian ratio does not follow a Gaussian distribution. The lack of awareness among users of vegetation indices about this non-Gaussian nature could lead to incorrect statistical modeling and interpretation. This package provides tools to accurately handle and analyse such ratios: density function, parameter estimation, simulation. An example on the study of chlorophyll fluorescence can be found in A. El Ghaziri et al. (2023) <doi:10.3390/rs15020528> and another method for parameter estimation is given in Bouhlel et al. (2023) <doi:10.23919/EUSIPCO58844.2023.10290111>.

Quantitative genetics tool supporting the modelling of multivariate genetic variance structures in quantitative data. It allows fitting different models through multivariate genetic-relationship-matrix (GRM) structural equation modelling (SEM) in unrelated individuals, using a maximum likelihood approach. Specifically, it combines genome-wide genotyping information, as captured by GRMs, with twin-research-based SEM techniques, St Pourcain et al. (2017) <doi:10.1016/j.biopsych.2017.09.020>, Shapland et al. (2020) <doi:10.1101/2020.08.14.251199>.

This package provides tools to download comprehensive datasets of local, state, and federal election results in Germany from 1990 to 2025. The package facilitates access to data on turnout, vote shares for major parties, and demographic information across different levels of government (municipal, state, and federal). It offers access to geographically harmonized datasets that account for changes in municipal boundaries over time and incorporate mail-in voting districts. Includes bundled county-level covariates from INKAR and municipality-level Census 2022 data. Users can easily retrieve, clean, and standardize German electoral data, making it ready for analysis. Data is sourced from <https://github.com/awiedem/german_election_data>.

We propose a fully efficient sieve maximum likelihood method to estimate genotype-specific distribution of time-to-event outcomes under a nonparametric model. We can handle missing genotypes in pedigrees. We estimate the time-dependent hazard ratio between two genetic mutation groups using B-splines, while applying nonparametric maximum likelihood estimation to the reference baseline hazard function. The estimators are calculated via an expectation-maximization algorithm.

Set of routines for making map projections (forward and inverse), topographic maps, perspective plots, geological maps, geological map symbols, geological databases, interactive plotting and selection of focus regions.

Understanding spatial association is essential for spatial statistical inference, including factor exploration and spatial prediction. Geographically optimal similarity (GOS) model is an effective method for spatial prediction, as described in Yongze Song (2022) <doi:10.1007/s11004-022-10036-8>. GOS was developed based on the geographical similarity principle, as described in Axing Zhu (2018) <doi:10.1080/19475683.2018.1534890>. GOS has advantages in more accurate spatial prediction using fewer samples and critically reduced prediction uncertainty.

Reconstruction of muscle fibers from image stacks using textural analysis. Includes functions for tracking, smoothing, cleaning, plotting and exporting muscle fibers. Also calculates basic fiber properties (e.g., length and curvature).

An engine to facilitate the orchestration and execution of metadata-driven data management workflows, in compliance with FAIR (Findable, Accessible, Interoperable and Reusable) data management principles. By means of a pivot metadata model, relying on the DublinCore standard (<https://dublincore.org/>), a unique source of metadata can be used to operate multiple and inter-connected data management actions. Users can also customise their own workflows by creating specific actions but the library comes with a set of native actions targeting common geographic information and data management, in particular actions oriented to the publication on the web of metadata and data resources to provide standard discovery and access services. At first, default actions of the library were meant to focus on providing turn-key actions for geospatial (meta)data: 1) by creating manage geospatial (meta)data complying with ISO/TC211 (<https://committee.iso.org/home/tc211>) and OGC (<https://www.ogc.org/standards/>) geographic information standards (eg 19115/19119/19110/19139) and related best practices (eg. INSPIRE'); and 2) by facilitating extraction, reading and publishing of standard geospatial (meta)data within widely used software that compound a Spatial Data Infrastructure ('SDI'), including spatial databases (eg. PostGIS'), metadata catalogues (eg. GeoNetwork', CSW servers), data servers (eg. GeoServer'). The library was then extended to actions for other domains: 1) biodiversity (meta)data standard management including handling of EML metadata, and their management with DataOne servers, 2) in situ sensors, remote sensing and model outputs (meta)data standard management by handling part of CF conventions, NetCDF data format and OPeNDAP access protocol, and their management with Thredds servers, 3) generic / domain agnostic (meta)data standard managers ('DublinCore', DataCite'), to facilitate the publication of data within (meta)data repositories such as Zenodo (<https://zenodo.org>) or DataVerse (<https://dataverse.org/>). The execution of several actions will then allow to cross-reference (meta)data resources in each action performed, offering a way to bind resources between each other (eg. reference Zenodo DOI in GeoNetwork'/'GeoServer metadata, or vice versa reference GeoNetwork'/'GeoServer links in Zenodo or EML metadata). The use of standardized configuration files ('JSON or YAML formats) allow fully reproducible workflows to facilitate the work of data and information managers.

Optimal design analysis algorithms for any study design that can be represented or modelled as a generalised linear mixed model including cluster randomised trials, cohort studies, spatial and temporal epidemiological studies, and split-plot designs. See <https://github.com/samuel-watson/glmmrBase/blob/master/README.md> for a detailed manual on model specification. A detailed discussion of the methods in this package can be found in Watson, Hemming, and Girling (2023) <doi:10.1177/09622802231202379>.

This package implements the generalized integration model, which integrates individual-level data and summary statistics under a generalized linear model framework. It supports continuous and binary outcomes to be modeled by the linear and logistic regression models. For binary outcome, data can be sampled in prospective cohort studies or case-control studies. Described in Zhang et al. (2020)<doi:10.1093/biomet/asaa014>.

Genomic signatures represent unique features within a species DNA, enabling the differentiation of species and offering broad applications across various fields. This package provides essential tools for calculating these specific signatures, streamlining the process for researchers and offering a comprehensive and time-saving solution for genomic analysis.The amino acid contents are identified based on the work published by Sandberg et al. (2003) <doi:10.1016/s0378-1119(03)00581-x> and Xiao et al. (2015) <doi:10.1093/bioinformatics/btv042>. The Average Mutual Information Profiles (AMIP) values are calculated based on the work of Bauer et al. (2008) <doi:10.1186/1471-2105-9-48>. The Chaos Game Representation (CGR) plot visualization was done based on the work of Deschavanne et al. (1999) <doi:10.1093/oxfordjournals.molbev.a026048> and Jeffrey et al. (1990) <doi:10.1093/nar/18.8.2163>. The GC content is calculated based on the work published by Nakabachi et al. (2006) <doi:10.1126/science.1134196> and Barbu et al. (1956) <https://pubmed.ncbi.nlm.nih.gov/13363015>. The Oligonucleotide Frequency Derived Error Gradient (OFDEG) values are computed based on the work published by Saeed et al. (2009) <doi:10.1186/1471-2164-10-S3-S10>. The Relative Synonymous Codon Usage (RSCU) values are calculated based on the work published by Elek (2018) <https://urn.nsk.hr/urn:nbn:hr:217:686131>.

Discrete scales for the colorblind-friendly Okabe-Ito palette, including color', fill', and edge_colour'. ggokabeito provides ggplot2 and ggraph scales to easily use the Okabe-Ito palette in your data visualizations.

This package provides tools for geometric morphometric analyses and multidimensional data. Implements methods for morphological disparity analysis using bootstrap and rarefaction, as reviewed in Foote (1997) <doi:10.1146/annurev.ecolsys.28.1.129>. Includes integration and modularity testing, following Fruciano et al. (2013) <doi:10.1371/journal.pone.0069376>, using Escoufier's RV coefficient as test statistic as well as two-block partial least squares - PLS, Rohlf and Corti (2000) <doi:10.1080/106351500750049806>. Also includes vector angle comparisons, orthogonal projection for data correction (Burnaby (1966) <doi:10.2307/2528217>; Fruciano (2016) <doi:10.1007/s00427-016-0537-4>), and parallel analysis for dimensionality reduction (Buja and Eyuboglu (1992) <doi:10.1207/s15327906mbr2704_2>).

Implementation of global envelopes for a set of general d-dimensional vectors T in various applications. A 100(1-alpha)% global envelope is a band bounded by two vectors such that the probability that T falls outside this envelope in any of the d points is equal to alpha. Global means that the probability is controlled simultaneously for all the d elements of the vectors. The global envelopes can be used for graphical Monte Carlo and permutation tests where the test statistic is a multivariate vector or function (e.g. goodness-of-fit testing for point patterns and random sets, functional analysis of variance, functional general linear model, n-sample test of correspondence of distribution functions), for central regions of functional or multivariate data (e.g. outlier detection, functional boxplot) and for global confidence and prediction bands (e.g. confidence band in polynomial regression, Bayesian posterior prediction). See Myllymäki and MrkviÄ ka (2024) <doi:10.18637/jss.v111.i03>, Myllymäki et al. (2017) <doi:10.1111/rssb.12172>, MrkviÄ ka and Myllymäki (2023) <doi:10.1007/s11222-023-10275-7>, MrkviÄ ka et al. (2016) <doi:10.1016/j.spasta.2016.04.005>, MrkviÄ ka et al. (2017) <doi:10.1007/s11222-016-9683-9>, MrkviÄ ka et al. (2020) <doi:10.14736/kyb-2020-3-0432>, MrkviÄ ka et al. (2021) <doi:10.1007/s11009-019-09756-y>, Myllymäki et al. (2021) <doi:10.1016/j.spasta.2020.100436>, MrkviÄ ka et al. (2022) <doi:10.1002/sim.9236>, Dai et al. (2022) <doi:10.5772/intechopen.100124>, DvoŠák and MrkviÄ ka (2022) <doi:10.1007/s00180-021-01134-y>, MrkviÄ ka et al. (2023) <doi:10.48550/arXiv.2309.04746>, and Konstantinou et al. (2024) <doi: 10.1007/s00180-024-01569-z>.

Define and compute with generalized spherical distributions - multivariate probability laws that are specified by a star shaped contour (directional behavior) and a radial component. The methods are described in Nolan (2016) <doi:10.1186/s40488-016-0053-0>.

This is an add-on package to gamlss'. The purpose of this package is to allow users to fit GAMLSS (Generalised Additive Models for Location Scale and Shape) models when the response variable is defined either in the intervals [0,1), (0,1] and [0,1] (inflated at zero and/or one distributions), or in the positive real line including zero (zero-adjusted distributions). The mass points at zero and/or one are treated as extra parameters with the possibility to include a linear predictor for both. The package also allows transformed or truncated distributions from the GAMLSS family to be used for the continuous part of the distribution. Standard methods and GAMLSS diagnostics can be used with the resulting fitted object.

This package provides a grammar of graphics approach for visualizing summary statistics from multiple Genome-wide Association Studies (GWAS). It offers geneticists, bioinformaticians, and researchers a powerful yet flexible tool for illustrating complex genetic associations using data from various GWAS datasets. The visualizations can be extensively customized, facilitating detailed comparative analysis across different genetic studies. Reference: Uffelmann, E. et al. (2021) <doi:10.1038/s43586-021-00056-9>.

Allows you to retrieve information from the Google Knowledge Graph API <https://www.google.com/intl/bn/insidesearch/features/search/knowledge.html> and process it in R in various forms. The Knowledge Graph Search API lets you find entities in the Google Knowledge Graph'. The API uses standard schema.org types and is compliant with the JSON-LD specification.

Estimation, forecasting, and simulation of generalized autoregressive score (GAS) models of Creal, Koopman, and Lucas (2013) <doi:10.1002/jae.1279> and Harvey (2013) <doi:10.1017/cbo9781139540933>. Model specification allows for various data types and distributions, different parametrizations, exogenous variables, joint and separate modeling of exogenous variables and dynamics, higher score and autoregressive orders, custom and unconditional initial values of time-varying parameters, fixed and bounded values of coefficients, and missing values. Model estimation is performed by the maximum likelihood method.

This package provides functions to estimate the disparities across categories (e.g. Black and white) that persists if a treatment variable (e.g. college) is equalized. Makes estimates by treatment modeling, outcome modeling, and doubly-robust augmented inverse probability weighting estimation, with standard errors calculated by a nonparametric bootstrap. Cross-fitting is supported. Survey weights are supported for point estimation but not for standard error estimation; those applying this package with complex survey samples should consult the data distributor to select an appropriate approach for standard error construction, which may involve calling the functions repeatedly for many sets of replicate weights provided by the data distributor. The methods in this package are described in Lundberg (2021) <doi:10.31235/osf.io/gx4y3>.

This package provides a method to predict and report gender from Brazilian first names using the Brazilian Institute of Geography and Statistics Census data.

Fits linear regression, logistic and multinomial regression models, Poisson regression, Cox model via Global Adaptive Generative Adjustment Algorithm. For more detailed information, see Bin Wang, Xiaofei Wang and Jianhua Guo (2022) <arXiv:1911.00658>. This paper provides the theoretical properties of Gaga linear model when the load matrix is orthogonal. Further study is going on for the nonorthogonal cases and generalized linear models. These works are in part supported by the National Natural Foundation of China (No.12171076).

This package provides methods for recursive partitioning based on the Graded Response Model ('GRM'), extending the MOB algorithm from the partykit package. The package allows for fitting GRM trees that partition the population into homogeneous subgroups based on item response patterns and covariates. Includes specialized plotting functions for visualizing GRM trees with different terminal node displays (threshold regions, parameter profiles, and factor score distributions). For more details on the methods, see Samejima (1969) <doi:10.1002/J.2333-8504.1968.TB00153.X>, Komboz et al. (2018) <doi:10.1177/0013164416664394> and Arimoro et al. (2025) <doi:10.1007/s11136-025-04018-6>.