Fits non-homogeneous Markov multistate models and misclassification-type hidden Markov models in continuous time to intermittently observed data. Implements the methods in Titman (2011) <doi:10.1111/j.1541-0420.2010.01550.x>. Uses direct numerical solution of the Kolmogorov forward equations to calculate the transition probabilities.

nlmixr2 often has long runtimes. A pipeline toolkit tailored to nlmixr2 workflows leverages targets and nlmixr2 to ease reproducible workflows. nlmixr2targets ensures minimal rework in model development with nlmixr2 and targets by simplifying and standardizing models and datasets.

Quantifies and removes technical noise from high-throughput sequencing data. Two approaches are used, one based on the count matrix, and one using the alignment BAM files directly. Contains several options for every step of the process, as well as tools to quality check and assess the stability of output.

Ensemble functions for outlier/anomaly detection. There is a new ensemble method proposed using Item Response Theory. Existing outlier ensemble methods from Schubert et al (2012) <doi:10.1137/1.9781611972825.90>, Chiang et al (2017) <doi:10.1016/j.jal.2016.12.002> and Aggarwal and Sathe (2015) <doi:10.1145/2830544.2830549> are also included.

This package provides functions to construct confidence intervals for the Overlap Coefficient (OVL). OVL measures the similarity between two distributions through the overlapping area of their distribution functions. Given its intuitive description and ease of visual representation by the straightforward depiction of the amount of overlap between the two corresponding histograms based on samples of measurements from each one of the two distributions, the development of accurate methods for confidence interval construction can be useful for applied researchers. Implements methods based on the work of Franco-Pereira, A.M., Nakas, C.T., Reiser, B., and Pardo, M.C. (2021) <doi:10.1177/09622802211046386> as well as extensions for multimodal distributions proposed by Alcaraz-Peñalba, A., Franco-Pereira, A., and Pardo, M.C. (2025) <doi:10.1007/s10182-025-00545-2>.

Supplemental functions and data for OpenIntro resources, which includes open-source textbooks and resources for introductory statistics (<https://www.openintro.org/>). The package contains datasets used in our open-source textbooks along with custom plotting functions for reproducing book figures. Note that many functions and examples include color transparency; some plotting elements may not show up properly (or at all) when run in some versions of Windows operating system.

It is a computer tool to estimate the item-sum score's reliability (composite reliability, CR) in multidimensional scales with overlapping items. An item that measures more than one domain construct is called an overlapping item. The estimation is based on factor models allowing unlimited cross-factor loadings such as exploratory structural equation modeling (ESEM) and Bayesian structural equation modeling (BSEM). The factor models include correlated-factor models and bi-factor models. Specifically for bi-factor models, a type of hierarchical factor model, the package estimates the CR hierarchical subscale/hierarchy and CR subscale/scale total. The CR estimator Omega-generic was proposed by Mai, Srivastava, and Krull (2021) <https://whova.com/embedded/subsession/enars_202103/1450751/1452993/>. The current version can only handle continuous data. Yujiao Mai contributes to the algorithms, R programming, and application example. Deo Kumar Srivastava contributes to the algorithms and the application example. Kevin R. Krull contributes to the application example. The package OmegaG was sponsored by American Lebanese Syrian Associated Charities (ALSAC). However, the contents of OmegaG do not necessarily represent the policy of the ALSAC.

Optimal Subset Cardinality Regression (OSCAR) models offer regularized linear regression using the L0-pseudonorm, conventionally known as the number of non-zero coefficients. The package estimates an optimal subset of features using the L0-penalization via cross-validation, bootstrapping and visual diagnostics. Effective Fortran implementations are offered along the package for finding optima for the DC-decomposition, which is used for transforming the discrete L0-regularized optimization problem into a continuous non-convex optimization task. These optimization modules include DBDC ('Double Bundle method for nonsmooth DC optimization as described in Joki et al. (2018) <doi:10.1137/16M1115733>) and LMBM ('Limited Memory Bundle Method for large-scale nonsmooth optimization as in Haarala et al. (2004) <doi:10.1080/10556780410001689225>). The OSCAR models are comprehensively exemplified in Halkola et al. (2023) <doi:10.1371/journal.pcbi.1010333>). Multiple regression model families are supported: Cox, logistic, and Gaussian.

This package provides a set of tools to extract bibliographic content from OpenAlex database using API <https://docs.openalex.org>.

Supports the definition of sets of properties on objects. Observers can listen to changes on individual properties or the set as a whole. The properties are meant to be fully self-describing. In support of this, there is a framework for defining enumerated types, as well as other bounded types, as S4 classes.

Empirical or simulated disease outbreak data, provided either as RData or as text files.

This package provides a collection of aesthetically appealing color palettes for effective data visualization with ggplot2'. Palettes support both discrete and continuous data.

This package provides a collection of general optimization routines based on variants of the One Side Cut Accelerated Random Search (OSCARS-II) algorithm (Price et al., 2020, <doi:10.1007/s10898-020-00928-6>). The main function , oscars()', performs black-box optimization of a general (including nonsmooth or discontinuous) function subject to simple bounds on the unknowns. If all bounds are finite, oscars searches globally. The main method implements a stochastic direct search method and is derivative free. Testing shows the OSCARS-II algorithm usually finds extrema with fewer function evaluations than similar global derivative-free methods.

Retrieve data from the Our World in Data (OWID) Chart API <https://docs.owid.io/projects/etl/api/>. OWID provides public access to more than 5,000 charts focusing on global problems such as poverty, disease, hunger, climate change, war, existential risks, and inequality.

Optimal testing under general dependence. The R package implements procedures proposed in Wang, Han, and Tong (2022). The package includes parameter estimation procedures, the computation for the posterior probabilities, and the testing procedure.

This package provides an interface to OpenCL, allowing R to leverage computing power of GPUs and other HPC accelerator devices.

The restricted optimal design method is implemented to optimally allocate a set of items that require calibration to a group of examinees. The optimization process is based on the method described in detail by Ul Hassan and Miller in their works published in (2019) <doi:10.1177/0146621618824854> and (2021) <doi:10.1016/j.csda.2021.107177>. To use the method, preliminary item characteristics must be provided as input. These characteristics can either be expert guesses or based on previous calibration with a small number of examinees. The item characteristics should be described in the form of parameters for an Item Response Theory (IRT) model. These models can include the Rasch model, the 2-parameter logistic model, the 3-parameter logistic model, or a mixture of these models. The output consists of a set of rules for each item that determine which examinees should be assigned to each item. The efficiency or gain achieved through the optimal design is quantified by comparing it to a random allocation. This comparison allows for an assessment of how much improvement or advantage is gained by using the optimal design approach. This work was supported by the Swedish Research Council (Vetenskapsrådet) Grant 2019-02706.

Solves linear systems of form Ax=b via Gauss elimination, LU decomposition, Gauss-Seidel, Conjugate Gradient Method (CGM) and Cholesky methods.

Bayesian logistic regression model with optional EXchangeability-NonEXchangeability parameter modelling for flexible borrowing from historical or concurrent data-sources. The safety model can guide dose-escalation decisions for adaptive oncology Phase I dose-escalation trials which involve an arbitrary number of drugs. Please refer to Neuenschwander et al. (2008) <doi:10.1002/sim.3230> and Neuenschwander et al. (2016) <doi:10.1080/19466315.2016.1174149> for details on the methodology.

This is a tool to find the optimal rerandomization threshold in non-sequential experiments. We offer three procedures based on assumptions made on the residuals distribution: (1) normality assumed (2) excess kurtosis assumed (3) entire distribution assumed. Illustrations are included. Also included is a routine to unbiasedly estimate Frobenius norms of variance-covariance matrices. Details of the method can be found in "Optimal Rerandomization via a Criterion that Provides Insurance Against Failed Experiments" Adam Kapelner, Abba M. Krieger, Michael Sklar and David Azriel (2020) <arXiv:1905.03337>.

This package provides tools for processing and analyzing data from the O-GlcNAcAtlas database <https://oglcnac.org/>, as described in Ma (2021) <doi:10.1093/glycob/cwab003>. It integrates UniProt <https://www.uniprot.org/> API calls to retrieve additional information. It is specifically designed for research workflows involving O-GlcNAcAtlas data, providing a flexible and user-friendly interface for customizing and downloading processed results. Interactive elements allow users to easily adjust parameters and handle various biological datasets.

Classify Open Street Map (OSM) features into meaningful functional or analytical categories. Designed for OSM PBF files, e.g. from <https://download.geofabrik.de/> imported as spatial data frames. A classification consists of a list of categories that are related to certain OSM tags and values. Given a layer from an OSM PBF file and a classification, the main osm_classify() function returns a classification data table giving, for each feature, the primary and alternative categories (if there is overlap) assigned, and the tag(s) and value(s) matched on. The package also contains a classification of OSM features by economic function/significance, following Krantz (2023) <https://www.ssrn.com/abstract=4537867>.

This package provides functions to design and simulate optimal two-stage randomized controlled trials (RCTs) with ordered categorical outcomes, supporting rank-based tests and group-sequential decision rules. Methods build on classical and modern rank tests and two-stage/Group-Sequential designs, e.g., Park (2025) <doi: 10.1371/journal.pone.0318211>. Please see the package reference manual and vignettes for details.

Calculates D-, Ds-, A-, I- and L-optimal designs, weighted combinations of these via a Compound criterion, and KL-optimal designs for model discrimination, for non-linear single- and multi-factor models, via an implementation of the cocktail algorithm (Yu, 2011, <doi:10.1007/s11222-010-9183-2>). Multi-factor models use design variables x1, x2, â ¦ with a named-list design space; single-factor models remain backward compatible. Compares designs via their efficiency, augments any design with a controlled efficiency loss, and provides efficient rounding functions to convert approximate designs to exact ones.