Identify and visualize individuals with unusual association patterns of genetics and geography using the approach of Chang and Schmid (2023) <doi:10.1101/2023.04.06.535838>. It detects potential outliers that violate the isolation-by-distance assumption using the K-nearest neighbor approach. You can obtain a table of outliers with statistics and visualize unusual geo-genetic patterns on a geographical map. This is useful for landscape genomics studies to discover individuals with unusual geography and genetics associations from a large biological sample.

Large language models are readily accessible via API. This package lowers the barrier to use the API inside of your development environment. For more on the API, see <https://platform.openai.com/docs/introduction>.

The goal of gsDesign2 is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, gsDesign2 offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the gsDesign package is intended for selecting boundaries.

Supply implementation to model generalized multivariate functional data using Bayesian additive mixed models of R package bamlss via a latent Gaussian process (see Umlauf, Klein, Zeileis (2018) <doi:10.1080/10618600.2017.1407325>).

This package provides a procedure that uses target-decoy competition (or knockoffs) to reject multiple hypotheses in the presence of group structure. The procedure controls the false discovery rate (FDR) at a user-specified threshold.

This package provides functions to specify and fit generalized nonlinear models, including models with multiplicative interaction terms such as the UNIDIFF model from sociology and the AMMI model from crop science, and many others. Over-parameterized representations of models are used throughout; functions are provided for inference on estimable parameter combinations, as well as standard methods for diagnostics etc.

Includes the ga.lts() function that estimates LTS (Least Trimmed Squares) parameters using genetic algorithms and C-steps. ga.lts() constructs a genetic algorithm to form a basic subset and iterates C-steps as defined in Rousseeuw and van-Driessen (2006) to calculate the cost value of the LTS criterion. OLS (Ordinary Least Squares) regression is known to be sensitive to outliers. A single outlying observation can change the values of estimated parameters. LTS is a resistant estimator even the number of outliers is up to half of the data. This package is for estimating the LTS parameters with lower bias and variance in a reasonable time. Version >=1.3 includes the function medmad for fast outlier detection in linear regression.

Extended techniques for generalized linear models (GLMs), especially for binary responses, including parametric links and heteroscedastic latent variables.

Create what we call Elemental Graphics for display of anova results. The term elemental derives from the fact that each function is aimed at construction of graphical displays that afford direct visualizations of data with respect to the fundamental questions that drive the particular anova methods. This package represents a modification of the original granova package; the key change is to use ggplot2', Hadley Wickham's package based on Grammar of Graphics concepts (due to Wilkinson). The main function is granovagg.1w() (a graphic for one way ANOVA); two other functions (granovagg.ds() and granovagg.contr()) are to construct graphics for dependent sample analyses and contrast-based analyses respectively. (The function granova.2w(), which entails dynamic displays of data, is not currently part of granovaGG'.) The granovaGG functions are to display data for any number of groups, regardless of their sizes (however, very large data sets or numbers of groups can be problematic). For granovagg.1w() a specialized approach is used to construct data-based contrast vectors for which anova data are displayed. The result is that the graphics use a straight line to facilitate clear interpretations while being faithful to the standard effect test in anova. The graphic results are complementary to standard summary tables; indeed, numerical summary statistics are provided as side effects of the graphic constructions. granovagg.ds() and granovagg.contr() provide graphic displays and numerical outputs for a dependent sample and contrast-based analyses. The graphics based on these functions can be especially helpful for learning how the respective methods work to answer the basic question(s) that drive the analyses. This means they can be particularly helpful for students and non-statistician analysts. But these methods can be of assistance for work-a-day applications of many kinds, as they can help to identify outliers, clusters or patterns, as well as highlight the role of non-linear transformations of data. In the case of granovagg.1w() and granovagg.ds() several arguments are provided to facilitate flexibility in the construction of graphics that accommodate diverse features of data, according to their corresponding display requirements. See the help files for individual functions.

Simulating, visualizing and comparing tumor clonal data by using simple commands. This aims at providing a tool to help researchers to easily simulate tumor data and analyze the results of their approaches for studying the composition and the evolutionary history of tumors.

This package implements statistical methods for group factor analysis, focusing on estimating the number of global and local factors and extracting them. Several algorithms are implemented, including Canonical Correlation-based Estimation by Choi et al. (2021) <doi:10.1016/j.jeconom.2021.09.008>, Generalised Canonical Correlation Estimation by Lin and Shin (2023) <doi:10.2139/ssrn.4295429>, Circularly Projected Estimation by Chen (2022) <doi:10.1080/07350015.2022.2051520>, and the Aggregated Projection Method by Hu et al. (2025) <doi:10.1080/01621459.2025.2491154>.

Estimates statistically significant marker combination values within which one immunologically distinctive group (i.e., disease case) is more associated than another group (i.e., healthy control), successively, using various combinations (i.e., "gates") of markers to examine features of cells that may be different between groups. For a two-group comparison, the gateR package uses the spatial relative risk function estimated using the sparr package. Details about the sparr package methods can be found in the tutorial: Davies et al. (2018) <doi:10.1002/sim.7577>. Details about kernel density estimation can be found in J. F. Bithell (1990) <doi:10.1002/sim.4780090616>. More information about relative risk functions using kernel density estimation can be found in J. F. Bithell (1991) <doi:10.1002/sim.4780101112>.

This package provides helpers to add Git links to shiny applications, rmarkdown documents, and other HTML based resources. This is most commonly used for GitHub ribbons.

Discrete scales for the colorblind-friendly Okabe-Ito palette, including color', fill', and edge_colour'. ggokabeito provides ggplot2 and ggraph scales to easily use the Okabe-Ito palette in your data visualizations.

Duct tape the quanteda ecosystem (Benoit et al., 2018) <doi:10.21105/joss.00774> to modern Transformer-based text classification models (Wolf et al., 2020) <doi:10.18653/v1/2020.emnlp-demos.6>, in order to facilitate supervised machine learning for textual data. This package mimics the behaviors of quanteda.textmodels and provides a function to setup the Python environment to use the pretrained models from Hugging Face <https://huggingface.co/>. More information: <doi:10.5117/CCR2023.1.003.CHAN>.

Utilizes methods of the PyMongo Python library to initialize, insert and query GeoJson data (see <https://github.com/mongodb/mongo-python-driver> for more information on PyMongo'). Furthermore, it allows the user to validate GeoJson objects and to use the console for MongoDB (bulk) commands. The reticulate package provides the R interface to Python modules, classes and functions.

Helps find meaningful patterns in complex genetic experiments. First gimap takes data from paired CRISPR (Clustered regularly interspaced short palindromic repeats) screens that has been pre-processed to counts table of paired gRNA (guide Ribonucleic Acid) reads. The input data will have cell counts for how well cells grow (or don't grow) when different genes or pairs of genes are disabled. The output of the gimap package is genetic interaction scores which are the distance between the observed CRISPR score and the expected CRISPR score. The expected CRISPR scores are what we expect for the CRISPR values to be for two unrelated genes. The further away an observed CRISPR score is from its expected score the more we suspect genetic interaction. The work in this package is based off of original research from the Alice Berger lab at Fred Hutchinson Cancer Center (2021) <doi:10.1016/j.celrep.2021.109597>.

This package provides tools to build and work with bilateral generalized-mean price indexes (and by extension quantity indexes), and indexes composed of generalized-mean indexes (e.g., superlative quadratic-mean indexes, GEKS). Covers the core mathematical machinery for making bilateral price indexes, computing price relatives, detecting outliers, and decomposing indexes, with wrappers for all common (and many uncommon) index-number formulas. Implements and extends many of the methods in Balk (2008, <doi:10.1017/CBO9780511720758>), von der Lippe (2007, <doi:10.3726/978-3-653-01120-3>), and the CPI manual (2020, <doi:10.5089/9781484354841.069>).

It provides an effective, efficient, and fast way to explore the Gene Ontology (GO). Given a set of genes, the package contains functions to assess the GO and obtain the terms associated with the genes and the levels of the GO terms. The package provides functions for the three different GO ontology. We discussed the methods explicitly in the following article <doi:10.1038/s41598-020-73326-3>.

R version of G-Series', Statistics Canada's generalized system devoted to the benchmarking and reconciliation of time series data. The methods used in G-Series essentially come from Dagum, E. B., and P. Cholette (2006) <doi:10.1007/0-387-35439-5>.

Data from multi environment agronomic trials, which are often carried out by plant breeders, can be analyzed with the tools offered by this package such as the Additive Main effects and Multiplicative Interaction model or AMMI ('Gauch 1992, ISBN:9780444892409) and the Site Regression model or SREG ('Cornelius 1996, <doi:10.1201/9780367802226>). Since these methods present a poor performance under the presence of outliers and missing values, this package includes robust versions of the AMMI model ('Rodrigues 2016, <doi:10.1093/bioinformatics/btv533>), and also imputation techniques specifically developed for this kind of data ('Arciniegas-Alarcón 2014, <doi:10.2478/bile-2014-0006>).

This package implements methods to plot periodic data in any arbitrary range on the fly.

Application of multi-site models for daily precipitation and temperature data. This package is designed for an application to 105 precipitation and 26 temperature gauges located in Switzerland. It applies fitting procedures and provides weather generators described in the following references: - Evin, G., A.-C. Favre, and B. Hingray. (2018) <doi:10.5194/hess-22-655-2018>. - Evin, G., A.-C. Favre, and B. Hingray. (2018) <doi:10.1007/s00704-018-2404-x>.

This package provides functions for graph matching via nodes degree profiles are provided in this package. The models we can handle include Erdos-Renyi random graphs and stochastic block models(SBM). More details are in the reference paper: Yaofang Hu, Wanjie Wang and Yi Yu (2020) <arXiv:2006.03284>.