In putative Transcription Factor Binding Sites (TFBSs) identification from sequence/alignments, we are interested in the significance of certain match scores. TFMPvalue provides the accurate calculation of a p-value with a score threshold for position weight matrices, or the score with a given p-value. It is an interface to code originally made available by Helene Touzet and Jean-Stephane Varre, 2007, Algorithms Mol Biol:2, 15. Touzet and Varre (2007).
In repeated measures studies with extreme large or small values it is common that the subjects measurements on average are closer to the mean of the basic population. Interpreting possible changes in the mean in such situations can lead to biased results since the values were not randomly selected, they come from truncated sampling. This method allows to estimate the range of means where treatment effects are likely to occur when regression toward the mean is present. Ostermann, T., Willich, Stefan N. & Luedtke, Rainer. (2008). Regression toward the mean - a detection method for unknown population mean based on Mee and Chua's algorithm. BMC Medical Research Methodology.<doi:10.1186/1471-2288-8-52>. Acknowledgments: We would like to acknowledge "Lena Roth" and "Nico Steckhan" for the package's initial updates (Q3 2024) and continued supervision and guidance. Both have contributed to discussing and integrating these methods into the package, ensuring they are up-to-date and contextually relevant.
An interface to the AutoDesk API Platform including the Authentication API for obtaining authentication to the AutoDesk Forge Platform, Data Management API for managing data across the platform's cloud services, Design Automation API for performing automated tasks on design files in the cloud, Model Derivative API for translating design files into different formats, sending them to the viewer app, and extracting design data, and Viewer for rendering 2D and 3D models.
Indicators and measures by country and time describe what happens at economic and social levels. This package provides functions to calculate several measures of convergence after imputing missing values. The automated downloading of Eurostat data, followed by the production of country fiches and indicator fiches, makes possible to produce automated reports. The Eurofound report (<doi:10.2806/68012>) "Upward convergence in the EU: Concepts, measurements and indicators", 2018, is a detailed presentation of convergence.
Rcpp implementation of the multivariate Kim filter, which combines the Kalman and Hamilton filters for state probability inference. The filter is designed for state space models and can handle missing values and exogenous data in the observation and state equations. Kim, Chang-Jin and Charles R. Nelson (1999) "State-Space Models with Regime Switching: Classical and Gibbs-Sampling Approaches with Applications" <doi:10.7551/mitpress/6444.001.0001><http://econ.korea.ac.kr/~cjkim/>.
Without imposing stringent distributional assumptions or shape restrictions, nonparametric estimation has been popular in economics and other social sciences for counterfactual analysis, program evaluation, and policy recommendations. This package implements a novel density (and derivatives) estimator based on local polynomial regressions, documented in Cattaneo, Jansson and Ma (2022) <doi:10.18637/jss.v101.i02>: lpdensity() to construct local polynomial based density (and derivatives) estimator, and lpbwdensity() to perform data-driven bandwidth selection.
Compute power and sample size for linear models of longitudinal data. Supported models include mixed-effects models and models fit by generalized least squares and generalized estimating equations. The package is described in Iddi and Donohue (2022) <DOI:10.32614/RJ-2022-022>. Relevant formulas are derived by Liu and Liang (1997) <DOI:10.2307/2533554>, Diggle et al (2002) <ISBN:9780199676750>, and Lu, Luo, and Chen (2008) <DOI:10.2202/1557-4679.1098>.
Clean the MS/MS spectrum, calculate spectral entropy, unweighted entropy similarity, and entropy similarity for mass spectrometry data. The entropy similarity is a novel similarity measure for MS/MS spectra which outperform the widely used dot product similarity in compound identification. For more details, please refer to the paper: Yuanyue Li et al. (2021) "Spectral entropy outperforms MS/MS dot product similarity for small-molecule compound identification" <doi:10.1038/s41592-021-01331-z>.
Use morphological image processing and edge detection algorithms to automatically measure tree ring widths on digital images. Users can also manually mark tree rings on species with complex anatomical structures. The arcs of inner-rings and angles of successive inclined ring boundaries are used to correct ring-width series. The package provides a Shiny-based application, allowing R beginners to easily analyze tree ring images and export ring-width series in standard file formats.
Data analysis based on panel partially-observed Markov process (PanelPOMP) models. To implement such models, simulate them and fit them to panel data, panelPomp extends some of the facilities provided for time series data by the pomp package. Implemented methods include filtering (panel particle filtering) and maximum likelihood estimation (Panel Iterated Filtering) as proposed in Breto, Ionides and King (2020) "Panel Data Analysis via Mechanistic Models" <doi:10.1080/01621459.2019.1604367>.
This package implements two differentially private algorithms for estimating L2-regularized logistic regression coefficients. A randomized algorithm F is epsilon-differentially private (C. Dwork, Differential Privacy, ICALP 2006 <DOI:10.1007/11681878_14>), if |log(P(F(D) in S)) - log(P(F(D') in S))| <= epsilon for any pair D, D of datasets that differ in exactly one record, any measurable set S, and the randomness is taken over the choices F makes.
This package provides a system to implement the Q-Q boxplot. It is implemented as an extension to ggplot2'. The Q-Q boxplot is an amalgam of the boxplot and the Q-Q plot and allows the user to rapidly examine summary statistics and tail behavior for multiple distributions in the same pane. As an extension of the ggplot2 implementation of the boxplot, possible modifications to the boxplot extend to the Q-Q boxplot.
An easy to use tool that can compare splicing events in tumor and normal tissue samples using either a user generated matrix, or data from The Cancer Genome Atlas (TCGA). This package generates a matrix of splicing outliers that are significantly over or underexpressed in tumors samples compared to normal denoted by chromosome location. The package also will calculate the splicing burden in each tumor and characterize the types of splicing events that occur.
Self-Attention algorithm helper functions and demonstration vignettes of increasing depth on how to construct the Self-Attention algorithm, this is based on Vaswani et al. (2017) <doi:10.48550/arXiv.1706.03762>, Dan Jurafsky and James H. Martin (2022, ISBN:978-0131873216) <https://web.stanford.edu/~jurafsky/slp3/> "Speech and Language Processing (3rd ed.)" and Alex Graves (2020) <https://www.youtube.com/watch?v=AIiwuClvH6k> "Attention and Memory in Deep Learning".
Effortless multicollinearity management in data frames with both numeric and categorical variables for statistical and machine learning applications. The package simplifies multicollinearity analysis by combining four robust methods: 1) target encoding for categorical variables (Micci-Barreca, D. 2001 <doi:10.1145/507533.507538>); 2) automated feature prioritization to prevent key variable loss during filtering; 3) pairwise correlation for all variable combinations (numeric-numeric, numeric-categorical, categorical-categorical); and 4) fast computation of variance inflation factors.
The goal of corrarray is to create a multi-sample correlation array by combining the correlation matrices of a data set stratified by a grouping variable. For two specified levels of the variable, corrarray displays one level's correlation matrix in the lower triangular matrix and the other level's correlation matrix in the upper triangular matrix. Such an output can enable visualization of correlations from two samples in a single correlation matrix or corrgram.
Several tools for handling block-matrix diagonals and similar constructs are implemented. Block-diagonal matrices can be extracted or removed using two small functions implemented here. In addition, non-square matrices are supported. Block diagonal matrices occur when two dimensions of a data set are combined along one edge of a matrix. For example, trade-flow data in the decompr and gvc packages have each country-industry combination occur along both edges of the matrix.
An implementation of a clustering algorithm for functional data based on adaptive density peak detection technique, in which the density is estimated by functional k-nearest neighbor density estimation based on a proposed semi-metric between functions. The proposed functional data clustering algorithm is computationally fast since it does not need iterative process. (Alex Rodriguez and Alessandro Laio (2014) <doi:10.1126/science.1242072>; Xiao-Feng Wang and Yifan Xu (2016) <doi:10.1177/0962280215609948>).
Identifies potential data outliers and their impact on estimates and analyses. Tool for evaluation of study credibility. Uses the forward search approach of Atkinson and Riani, "Robust Diagnostic Regression Analysis", 2000,<ISBN: o-387-95017-6> to prepare descriptive statistics of a dataset that is to be analyzed by functions lm stats, glm stats, nls stats, lme nlme, or coxph survival, or their equivalent in another language. Includes graphics functions to display the descriptive statistics.
Implementation of the methodology proposed in Data-driven design of targeted gene panels for estimating immunotherapy biomarkers', Bradley and Cannings (2021) <arXiv:2102.04296>. This package allows the user to fit generative models of mutation from an annotated mutation dataset, and then further to produce tunable linear estimators of exome-wide biomarkers. It also contains functions to simulate mutation annotated format (MAF) data, as well as to analyse the output and performance of models.
Helper functions that interface with the system utilities to learn about the local build environment. Lets you explore make rules to test the local configuration, or query pkg-config to find compiler flags and libs needed for building packages with external dependencies. Also contains tools to analyze which libraries that a installed R package linked to by inspecting output from ldd in combination with information from your distribution package manager, e.g. rpm or dpkg'.
This package provides a user-friendly tool for estimating both total and directional connectedness spillovers based on Diebold and Yilmaz (2009, 2012). It also provides the user with rolling estimation for total and net indices. User can find both orthogonalized and generalized versions for each kind of measures. See Diebold and Yilmaz (2009, 2012) find them at <doi:10.1111/j.1468-0297.2008.02208.x> and <doi:10.1016/j.ijforecast.2011.02.006>.
Last.fm'<https://www.last.fm> is a music platform focussed on building a detailed profile of a users listening habits. It does this by scrobbling (recording) every track you listen to on other platforms ('spotify', youtube', soundcloud etc) and transferring them to your Last.fm database. This allows Last.fm to act as a complete record of your entire listening history. scrobbler provides helper functions to download and analyse your listening history in R.
We present a statistical simulator, scDesign3, to generate realistic single-cell and spatial omics data, including various cell states, experimental designs, and feature modalities, by learning interpretable parameters from real data. Using a unified probabilistic model for single-cell and spatial omics data, scDesign3 infers biologically meaningful parameters; assesses the goodness-of-fit of inferred cell clusters, trajectories, and spatial locations; and generates in silico negative and positive controls for benchmarking computational tools.