The basic idea of this package is provides some tools to help the researcher to work with geostatistics. Initially, we present a collection of functions that allow the researchers to deal with spatial data using bootstrap procedure. There are five methods available and two ways to display them: bootstrap confidence interval - provides a two-sided bootstrap confidence interval; bootstrap plot - a graphic with the original variogram and each of the B bootstrap variograms.

This package provides functions to conduct robust inference in difference-in-differences and event study designs by implementing the methods developed in Rambachan & Roth (2023) <doi:10.1093/restud/rdad018>, "A More Credible Approach to Parallel Trends" [Previously titled "An Honest Approach..."]. Inference is conducted under a weaker version of the parallel trends assumption. Uniformly valid confidence sets are constructed based upon conditional confidence sets, fixed-length confidence sets and hybridized confidence sets.

This package provides functions and classes to compute, handle and visualise incidence from dated events for a defined time interval. Dates can be provided in various standard formats. The class incidence is used to store computed incidence and can be easily manipulated, subsetted, and plotted. In addition, log-linear models can be fitted to incidence objects using fit'. This package is part of the RECON (<https://www.repidemicsconsortium.org/>) toolkit for outbreak analysis.

Utility functions for mutational signature analysis as described in Alexandrov, L. B. (2020) <doi:10.1038/s41586-020-1943-3>. This package provides two groups of functions. One is for dealing with mutational signature "exposures" (i.e. the counts of mutations in a sample that are due to each mutational signature). The other group of functions is for matching or comparing sets of mutational signatures. mSigTools stands for mutational Signature analysis Tools.

Computation of an estimation of the long-memory parameters and the long-run covariance matrix using a multivariate model (Lobato (1999) <doi:10.1016/S0304-4076(98)00038-4>; Shimotsu (2007) <doi:10.1016/j.jeconom.2006.01.003>). Two semi-parametric methods are implemented: a Fourier based approach (Shimotsu (2007) <doi:10.1016/j.jeconom.2006.01.003>) and a wavelet based approach (Achard and Gannaz (2016) <doi:10.1111/jtsa.12170>).

Psychometric mixture models based on flexmix infrastructure. At the moment Rasch mixture models with different parameterizations of the score distribution (saturated vs. mean/variance specification), Bradley-Terry mixture models, and MPT mixture models are implemented. These mixture models can be estimated with or without concomitant variables. See Frick et al. (2012) <doi:10.18637/jss.v048.i07> and Frick et al. (2015) <doi:10.1177/0013164414536183> for details on the Rasch mixture models.

Enhanced RTF wrapper written in R for use with existing R tables packages such as Huxtable or GT'. This package fills a gap where tables in certain packages can be written out to RTF, but cannot add certain metadata or features to the document that are required/expected in a report for a regulatory submission, such as multiple levels of titles and footnotes, making the document landscape, and controlling properties such as margins.

We implement an adaptation of Jiang & Zeng's (1995) <https://www.genetics.org/content/140/3/1111> likelihood ratio test for testing the null hypothesis of pleiotropy against the alternative hypothesis, two separate quantitative trait loci. The test differs from that in Jiang & Zeng (1995) <https://www.genetics.org/content/140/3/1111> and that in Tian et al. (2016) <doi:10.1534/genetics.115.183624> in that our test accommodates multiparental populations.

The steepness package computes steepness as a property of dominance hierarchies. Steepness is defined as the absolute slope of the straight line fitted to the normalized David's scores. The normalized David's scores can be obtained on the basis of dyadic dominance indices corrected for chance or by means of proportions of wins. Given an observed sociomatrix, it computes hierarchy's steepness and estimates statistical significance by means of a randomization test.

Generate synthetic time series from commonly used statistical models, including linear, nonlinear and chaotic systems. Applications to testing methods can be found in Jiang, Z., Sharma, A., & Johnson, F. (2019) <doi:10.1016/j.advwatres.2019.103430> and Jiang, Z., Sharma, A., & Johnson, F. (2020) <doi:10.1029/2019WR026962> associated with an open-source tool by Jiang, Z., Rashid, M. M., Johnson, F., & Sharma, A. (2020) <doi:10.1016/j.envsoft.2020.104907>.

Implementation of the BLEU-Score in C++ to evaluate the quality of generated text. The BLEU-Score, introduced by Papineni et al. (2002) <doi:10.3115/1073083.1073135>, is a metric for evaluating the quality of generated text. It is based on the n-gram overlap between the generated text and reference texts. Additionally, the package provides some smoothing methods as described in Chen and Cherry (2014) <doi:10.3115/v1/W14-3346>.

Obtain parameters of Svensson's Method, including percentage agreement, systematic change and individual change. Also, the contingency table can be generated. Svensson's Method is a rank-invariant nonparametric method for the analysis of ordered scales which measures the level of change both from systematic and individual aspects. For the details, please refer to Svensson E. Analysis of systematic and random differences between paired ordinal categorical data [dissertation]. Stockholm: Almqvist & Wiksell International; 1993.

This package provides functions for preparing and analyzing animal tracking data, with the intention of identifying areas which are potentially important at the population level and therefore of conservation interest. Areas identified using this package may be checked against global or regionally-defined criteria, such as those set by the Key Biodiversity Area program. The method published herein is described in full in Beal et al. 2021 <doi:10.1111/2041-210X.13713>.

GladiaTOX R package is an open-source, flexible solution to high-content screening data processing and reporting in biomedical research. GladiaTOX takes advantage of the tcpl core functionalities and provides a number of extensions: it provides a web-service solution to fetch raw data; it computes severity scores and exports ToxPi formatted files; furthermore it contains a suite of functionalities to generate pdf reports for quality control and data processing.

An implementation, which takes input data and makes it available for proper batch effect removal by ComBat or Limma. The implementation appropriately handles missing values by dissecting the input matrix into smaller matrices with sufficient data to feed the ComBat or limma algorithm. The adjusted data is returned to the user as a rebuild matrix. The implementation is meant to make as much data available as possible with minimal data loss.

timeOmics is a generic data-driven framework to integrate multi-Omics longitudinal data measured on the same biological samples and select key temporal features with strong associations within the same sample group. The main steps of timeOmics are: 1. Plaform and time-specific normalization and filtering steps; 2. Modelling each biological into one time expression profile; 3. Clustering features with the same expression profile over time; 4. Post-hoc validation step.

This package implements a variety of methods for batch correction of single-cell (RNA sequencing) data. This includes methods based on detecting mutually nearest neighbors, as well as several efficient variants of linear regression of the log-expression values. Functions are also provided to perform global rescaling to remove differences in depth between batches, and to perform a principal components analysis that is robust to differences in the numbers of cells across batches.

CENTIPEDE applies a hierarchical Bayesian mixture model to infer regions of the genome that are bound by particular transcription factors. It starts by identifying a set of candidate binding sites, and then aims to classify the sites according to whether each site is bound or not bound by a transcription factor. CENTIPEDE is an unsupervised learning algorithm that discriminates between two different types of motif instances using as much relevant information as possible.

This package provides tools to compute marginal effects from statistical models and return the result as tidy data frames. These data frames are ready to use with the ggplot2 package. Marginal effects can be calculated for many different models. Interaction terms, splines and polynomial terms are also supported. The two main functions are ggpredict() and ggeffect(). There is a generic plot() method to plot the results using ggplot2.

The r-phylogram package is a tool for for developing phylogenetic trees as deeply-nested lists known as "dendrogram" objects. It provides functions for conversion between "dendrogram" and "phylo" class objects, as well as several tools for command-line tree manipulation and import/export via Newick parenthetic text. This improves accessibility to the comprehensive range of object-specific analytical and tree-visualization functions found across a wide array of bioinformatic R packages.

In putative Transcription Factor Binding Sites (TFBSs) identification from sequence/alignments, we are interested in the significance of certain match scores. TFMPvalue provides the accurate calculation of a p-value with a score threshold for position weight matrices, or the score with a given p-value. It is an interface to code originally made available by Helene Touzet and Jean-Stephane Varre, 2007, Algorithms Mol Biol:2, 15. Touzet and Varre (2007).

Genomic analysis of model organisms often requires the use of databases based on human data or making comparisons to patient-derived resources. This requires converting genes between human and non-human analogues. The babelgene R package provides predicted gene orthologs/homologs for frequently studied model organisms in an R-friendly tidy/long format. The package integrates orthology assertion predictions sourced from multiple databases as compiled by the HGNC Comparison of Orthology Predictions (HCOP).

In repeated measures studies with extreme large or small values it is common that the subjects measurements on average are closer to the mean of the basic population. Interpreting possible changes in the mean in such situations can lead to biased results since the values were not randomly selected, they come from truncated sampling. This method allows to estimate the range of means where treatment effects are likely to occur when regression toward the mean is present. Ostermann, T., Willich, Stefan N. & Luedtke, Rainer. (2008). Regression toward the mean - a detection method for unknown population mean based on Mee and Chua's algorithm. BMC Medical Research Methodology.<doi:10.1186/1471-2288-8-52>. Acknowledgments: We would like to acknowledge "Lena Roth" and "Nico Steckhan" for the package's initial updates (Q3 2024) and continued supervision and guidance. Both have contributed to discussing and integrating these methods into the package, ensuring they are up-to-date and contextually relevant.

An interface to the AutoDesk API Platform including the Authentication API for obtaining authentication to the AutoDesk Forge Platform, Data Management API for managing data across the platform's cloud services, Design Automation API for performing automated tasks on design files in the cloud, Model Derivative API for translating design files into different formats, sending them to the viewer app, and extracting design data, and Viewer for rendering 2D and 3D models.