This package provides methods and classes for adding m-activation ("multiplicative activation") layers to MLR or multivariate logistic regression models. M-activation layers created in this library detect and add input interaction (polynomial) effects into a predictive model. M-activation can detect high-order interactions -- a traditionally non-trivial challenge. Details concerning application, methodology, and relevant survey literature can be found in this library's vignette, "About.".

In the case of multivariate ordinal responses, parameter estimates can be severely biased if personal response styles are ignored. This packages provides methods to account for personal response styles and to explain the effects of covariates on the response style, as proposed by Schauberger and Tutz 2021 <doi:10.1177/1471082X20978034>. The method is implemented both for the multivariate cumulative model and the multivariate adjacent categories model.

The nonparametric two-stage Bayesian adaptive design is a novel phase II clinical trial design for finding the minimum effective dose (MinED). This design is motivated by the top priority and concern of clinicians when testing a new drug, which is to effectively treat patients and minimize the chance of exposing them to subtherapeutic or overly toxic doses. It is used to design single-agent trials.

Bayesian multivariate age-period-cohort (MAPC) models for analyzing health data, with support for model fitting, visualization, stratification, and model comparison. Inference focuses on identifiable cross-strata differences, as described by Riebler and Held (2010) <doi:10.1093/biostatistics/kxp037>. Methods for handling complex survey data via the survey package are included, as described in Mercer et al. (2014) <doi:10.1016/j.spasta.2013.12.001>.

Enables correction for technical variance in raw quantitative reverse transcription polymerase chain reaction (qRT-PCR) data using the least squares-based NORMAgene data-driven normalization algorithm originally described by Heckmann et al. (2011) <doi:10.1186/1471-2105-12-250>. Performs normalization of raw crossing threshold values (CT) and also calculates relative variability metrics that can be used to assess the impact of normalization on variance.

This package provides a native R implementation of neural simulation-based inference, focused on Neural Posterior Estimation. Given a prior over parameters and a simulator, neuralsbi trains a conditional neural density estimator to approximate the Bayesian posterior, enabling amortized, likelihood-free inference. Neural estimators run on the torch back end. It targets applied researchers who want an approachable interface with sensible defaults and built-in posterior diagnostics.

Power and sample size calculation for bulk tissue and single-cell eQTL analysis based on ANOVA, simple linear regression, or linear mixed effects model. It can also calculate power/sample size for testing the association of a SNP to a continuous type phenotype. Please see the reference: Dong X, Li X, Chang T-W, Scherzer CR, Weiss ST, Qiu W. (2021) <doi:10.1093/bioinformatics/btab385>.

ProTracker is a popular music tracker to sequence music on a Commodore Amiga machine. This package offers the opportunity to import, export, manipulate and play ProTracker module files. Even though the file format could be considered archaic, it still remains popular to this date. This package intends to contribute to this popularity and therewith keeping the legacy of ProTracker and the Commodore Amiga alive.

Programmatic interface to the PhenoCam web services (<https://phenocam.nau.edu/webcam>). Allows for easy downloading of PhenoCam data directly to your R workspace or your computer and provides post-processing routines for consistent and easy timeseries outlier detection, smoothing and estimation of phenological transition dates. Methods for this package are described in detail in Hufkens et. al (2018) <doi:10.1111/2041-210X.12970>.

This package provides a consistent interface for constructing commonly used spatial covariates from polygon data. Computes polygon areas, distances to reference features, point and line intersection counts, line lengths within polygons, polygon overlap areas and shares, and raster zonal summaries. Handles coordinate reference system validation, geometry repair, unit conversion, row preservation, and standardised missing value semantics while relying on established spatial libraries for the underlying geometry operations.

Using a time-varying random parameters model developed in Koutchade et al., (2024) <https://hal.science/hal-04318163>, this package allows allocating variable input costs among crops produced by farmers based on panel data including information on input expenditure aggregated at the farm level and acreage shares. It also considers in fairly way the weighting data and can allow integrating time-varying and time-constant control variables.

Analytical computation of rolling optimization for time-series data. The rolloptim package solves constrained quadratic and linear programs in closed form by applying Lagrangian multipliers and the Karush-Kuhn-Tucker conditions (Kuhn and Tucker, 1951, <doi:10.1525/9780520411586-036>) to perform mean-variance portfolio optimization (Markowitz, 1952, <doi:10.1111/j.1540-6261.1952.tb01525.x>) over rolling windows. For each window, the analytical solution computes the optimal weights that minimize variance, maximize expected return, minimize residual sum of squares, or maximize quadratic utility, subject to a total-weight equality constraint and box bounds on each weight. Use cases include mean-variance portfolio optimization, expected-return maximization, and constrained regression. The package supports rolling optimizations with constraints via the total, lower, and upper arguments. The implementation accepts rolling moments computed via the roll package and uses RcppArmadillo for linear algebra, with parallelism across windows provided by RcppParallel'.

Express meta-analyses of continuous trial outcomes in terms of responder risks, following the interpretability tutorial of Thorlund, Walter, Johnston, Furukawa and Guyatt (2011) <doi:10.1002/jrsm.46>. Given the mean change, standard deviation and sample size per arm across studies, respondeR estimates the proportion of patients who cross a minimal important difference (MID) threshold under a parametric model for the change scores, and contrasts the arms as a risk difference, risk ratio, odds ratio or number needed to treat. It provides median, unweighted-mean, weighted-mean and per-study (fixed- or random-effects) pooling, the standardized-mean-difference to odds-ratio bridge of Anzures-Cabrera, Sarpatwari and Higgins (2011) <doi:10.1002/sim.4298>, a threshold-free common-language effect size, and a point-and-click Shiny application. The estimation methods were evaluated in a simulation study by Sofi-Mahmudi (2024) <https://hdl.handle.net/11375/30210>.

This package implements an R interface to the Leiden algorithm, an iterative community detection algorithm on networks. The algorithm is designed to converge to a partition in which all subsets of all communities are locally optimally assigned, yielding communities guaranteed to be connected. The implementation proves to be fast, scales well, and can be run on graphs of millions of nodes (as long as they can fit in memory).

Umbrella for the alabaster suite, providing a single-line import for all alabaster.* packages. Installing this package ensures that all known alabaster.* packages are also installed, avoiding problems with missing packages when a staging method or loading function is dynamically requested. Obviously, this comes at the cost of needing to install more packages, so advanced users and application developers may prefer to install the required alabaster.* packages individually.

This package can generate a synthetic map with reads covering the nucleosome regions as well as a synthetic map with forward and reverse reads emulating next-generation sequencing. The synthetic hybridization data of “Tiling Arrays” can also be generated. The user has choice between three different distributions for the read positioning: Normal, Student and Uniform. In addition, a visualization tool is provided to explore the synthetic nucleosome maps.

Dot plots of single-cell RNA-seq data allow for an examination of the relationships between cell groupings (e.g. clusters) and marker gene expression. The scDotPlot package offers a unified approach to perform a hierarchical clustering analysis and add annotations to the columns and/or rows of a scRNA-seq dot plot. It works with SingleCellExperiment and Seurat objects as well as data frames.

Differential expression analysis of RNA-seq using the Poisson-Tweedie (PT) family of distributions. PT distributions are described by a mean, a dispersion and a shape parameter and include Poisson and NB distributions, among others, as particular cases. An important feature of this family is that, while the Negative Binomial (NB) distribution only allows a quadratic mean-variance relationship, the PT distributions generalizes this relationship to any orde.

One and two sample mean and variance tests (differences and ratios) are considered. The test statistics are all expressed in the same form as the Student t-test, which facilitates their presentation in the classroom. This contribution also fills the gap of a robust (to non-normality) alternative to the chi-square single variance test for large samples, since no such procedure is implemented in standard statistical software.

This package provides the ability to display something analogous to Python's docstrings within R. By allowing the user to document their functions as comments at the beginning of their function without requiring putting the function into a package we allow more users to easily provide documentation for their functions. The documentation can be viewed just like any other help files for functions provided by packages as well.

Calculation and plotting of instantaneous unavailabilities of basic events along with the top event of fault trees are issues important in reliability analysis of complex systems. Here, a fault tree is provided in terms of its minimal cut sets, along with reliability and maintainability distribution functions of the basic events. All the methods are derived from Horton (2002, ISBN: 3-936150-21-4), Niloofar and Lazarova-Molnar (2022).

This package provides utility functions that are simply, frequently used, but may require higher performance that what can be obtained from base R. Incidentally provides support for reverse geocoding', such as matching a point with its nearest neighbour in another array. Used as a complement to package hutils by sacrificing compilation or installation time for higher running speeds. The name is a portmanteau of the author and Rcpp'.

This package provides a systematic framework for integrating multiple modalities of assays profiled on the same set of samples. The goal is to identify genes that are altered in cancer either marginally or consistently across different assays. The heterogeneity among different platforms and different samples are automatically adjusted so that the overall alteration magnitude can be accurately inferred. See Tong and Coombes (2012) <doi:10.1093/bioinformatics/bts561>.

This package provides tools for easily and flexibly creating ggplot2 maps with inset maps. One crucial feature of maps is that they have fixed coordinate ratios, i.e., they cannot be distorted, which makes it difficult to manually place inset maps. This package provides functions to automatically position inset maps based on user-defined parameters, making it extremely easy to create maps with inset maps with minimal code.