The accurate annotation of genes and Quantitative Trait Loci (QTLs) located within candidate markers and/or regions (haplotypes, windows, CNVs, etc) is a crucial step the most common genomic analyses performed in livestock, such as Genome-Wide Association Studies or transcriptomics. The Genomic Annotation in Livestock for positional candidate LOci (GALLO) is an R package designed to provide an intuitive and straightforward environment to annotate positional candidate genes and QTLs from high-throughput genetic studies in livestock. Moreover, GALLO allows the graphical visualization of gene and QTL annotation results, data comparison among different grouping factors (e.g., methods, breeds, tissues, statistical models, studies, etc.), and QTL enrichment in different livestock species including cattle, pigs, sheep, and chicken, among others.

This package provides a coherent interface and implementation for creating grouped date classes.

Extremely efficient procedures for fitting regularization path with l0, l1, and truncated lasso penalty for linear regression and logistic regression models. This version is a completely new version compared with our previous version, which was mainly based on R. New core algorithms are developed and are now written in C++ and highly optimized.

Plot density and distribution functions with automatic selection of suitable regions. Numerically invert (compute quantiles) distribution functions. Simulate real and complex numbers from distributions of their magnitude and arguments. Optionally, the magnitudes and/or arguments may be fixed in almost arbitrary ways. Create polynomials from roots given in Cartesian or polar form. Small programming utilities: check if an object is identical to NA, count positional arguments in a call, set intersection of more than two sets, check if an argument is unnamed, compute the graph of S4 classes in packages.

This package provides a function for fitting a penalized constrained continuation ratio model using the glmpath algorithm and methods for extracting coefficient estimates, predicted class, class probabilities, and plots as described by Archer and Williams (2012) <doi:10.1002/sim.4484>.

This package provides a native R implementation of grammatical evolution (GE). GE facilitates the discovery of programs that can achieve a desired goal. This is done by performing an evolutionary optimisation over a population of R expressions generated via a user-defined context-free grammar (CFG) and cost function.

Bindings to the GeographicLib C++ library <https://geographiclib.sourceforge.io/> for precise geodetic calculations including geodesic computations (distance, bearing, paths, intersections), map projections (UTM/UPS, Transverse Mercator, Lambert Conformal Conic, and more), grid reference systems (MGRS, Geohash, GARS, Georef), coordinate conversions (geocentric, local Cartesian), and polygon area on the WGS84 ellipsoid. All functions are fully vectorized.

Implementation of the Generalized Score Matching estimator in Yu et al. (2019) <https://jmlr.org/papers/v20/18-278.html> for non-negative graphical models (truncated Gaussian, exponential square-root, gamma, a-b models) and univariate truncated Gaussian distributions. Also includes the original estimator for untruncated Gaussian graphical models from Lin et al. (2016) <doi:10.1214/16-EJS1126>, with the addition of a diagonal multiplier.

This package contains the Gene ontology terms and skeleton for the reduced GO directed acyclic graph (DAG) for the organisms Rat and Mouse. The methods are explicitly discussed in the following article : Manjang et al (2020) <doi:10.1038/s41598-020-73326-3>.

Collect marketing data from Google Ads using the Windsor.ai API <https://windsor.ai/api-fields/>.

Enables users to create simple plots of biological culture plates as well as microplates. Both continuous and discrete values can be plotted onto the plate layout.

This package provides methods to analyse experimental agriculture data, from data synthesis to model selection and visualisation. The package is named after W.S. Gosset aka â Studentâ , a pioneer of modern statistics in small sample experimental design and analysis.

Combining a generalized linear model with an additional tree part on the same scale. A four-step procedure is proposed to fit the model and test the joint effect of the selected tree part while adjusting on confounding factors. We also proposed an ensemble procedure based on the bagging to improve prediction accuracy and computed several scores of importance for variable selection. See Cyprien Mbogning et al.'(2014)<doi:10.1186/2043-9113-4-6> and Cyprien Mbogning et al.'(2015)<doi:10.1159/000380850> for an overview of all the methods implemented in this package.

This package provides a unified framework for sparse-group regularization and precision matrix estimation in Gaussian graphical models. It implements multiple sparse-group penalties, including sparse-group lasso, sparse-group adaptive lasso, sparse-group SCAD, and sparse-group MCP, and solves them efficiently using ADMM-based optimization. The package is designed for high-dimensional network inference where both sparsity and group structure are present.

Simplify your R data analysis and data visualization workflow by turning your data frame into an interactive Tableau'-like interface, leveraging the graphic-walker JavaScript library and the htmlwidgets package.

This package provides one-liner functions for common legend and guide operations in ggplot2'. Simplifies legend positioning, styling, wrapping, and collection across multi-panel plots created with patchwork or cowplot'.

Audits ggplot2 visualizations for accessibility issues, misleading practices, and readability problems. Checks for color accessibility concerns including colorblind-unfriendly palettes, misleading scale manipulations such as truncated axes and dual y-axes, text readability issues like small fonts and overlapping labels, and general accessibility barriers. Provides comprehensive audit reports with actionable suggestions for improvement. Color vision deficiency simulation uses methods from the colorspace package Zeileis et al. (2020) <doi:10.18637/jss.v096.i01>. Contrast calculations follow WCAG 2.1 guidelines (W3C 2018 <https://www.w3.org/WAI/WCAG21/Understanding/contrast-minimum>).

This package provides a novel PRS model is introduced to enhance the prediction accuracy by utilising GxE effects. This package performs Genome Wide Association Studies (GWAS) and Genome Wide Environment Interaction Studies (GWEIS) using a discovery dataset. The package has the ability to obtain polygenic risk scores (PRSs) for a target sample. Finally it predicts the risk values of each individual in the target sample. Users have the choice of using existing models (Li et al., 2015) <doi:10.1093/annonc/mdu565>, (Pandis et al., 2013) <doi:10.1093/ejo/cjt054>, (Peyrot et al., 2018) <doi:10.1016/j.biopsych.2017.09.009> and (Song et al., 2022) <doi:10.1038/s41467-022-32407-9>, as well as newly proposed models for genomic risk prediction (refer to the URL for more details).

Helper functions provide an accurate imputation algorithm for reconstructing the missing segment in a multi-variate data streams. Inspired by single-shot learning, it reconstructs the missing segment by identifying the first similar segment in the stream. Nevertheless, there should be one column of data available, i.e. a constraint column. The values of columns can be characters (A, B, C, etc.). The result of the imputed dataset will be returned a .csv file. For more details see Reza Rawassizadeh (2019) <doi:10.1109/TKDE.2019.2914653>.

This package provides functions to compute the Generalized Dynamic Principal Components introduced in Peña and Yohai (2016) <DOI:10.1080/01621459.2015.1072542>. The implementation includes an automatic procedure proposed in Peña, Smucler and Yohai (2020) <DOI:10.18637/jss.v092.c02> for the identification of both the number of lags to be used in the generalized dynamic principal components as well as the number of components required for a given reconstruction accuracy.

An implementation of Gini-based weighting approaches in constructing composite indicators, providing functionalities for normalization, aggregation, and ranking comparison.

This package provides a GraphQL client, with an R6 interface for initializing a connection to a GraphQL instance, and methods for constructing queries, including fragments and parameterized queries. Queries are checked with the libgraphqlparser C++ parser via the graphql package.

Likelihood-based boosting approaches for generalized mixed models are provided.

Create plots that combine a phylogeny and frequency dynamics. Phylogenetic input can be a generic adjacency matrix or a tree of class "phylo". Inspired by similar plots in publications of the labs of RE Lenski and JE Barrick. Named for HJ Muller (who popularised such plots) and H Wickham (whose code this package exploits).