This package provides tools for the analysis of reverse-phase protein arrays (RPPAs), which are also known as tissue lysate arrays or simply lysate arrays'. The package's primary purpose is to input a set of quantification files representing dilution series of samples and control points taken from scanned RPPA slides and determine a relative log concentration value for each valid dilution series present in each slide and provide graphical visualization of the input and output data and their relationships. Other optional features include generation of quality control scores for judging the quality of the input data, spatial adjustment of sample points based on controls added to the slides, and various types of normalization of calculated values across a set of slides. The package was derived from a previous package named SuperCurve. For a detailed description of data inputs and outputs, usage information, and a list of related papers describing methods used in the package please review the vignette Guide_to_RPPASPACE'. RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data'. Bioinformatics Nov 15;38(22):5131-5133. <doi: 10.1093/bioinformatics/btac665>.

Calculates several entropy metrics for spatial data inspired by Boltzmann's entropy formula. It includes metrics introduced by Cushman for landscape mosaics (Cushman (2015) <doi:10.1007/s10980-015-0305-2>), and landscape gradients and point patterns (Cushman (2021) <doi:10.3390/e23121616>); by Zhao and Zhang for landscape mosaics (Zhao and Zhang (2019) <doi:10.1007/s10980-019-00876-x>); and by Gao et al. for landscape gradients (Gao et al. (2018) <doi:10.1111/tgis.12315>; Gao and Li (2019) <doi:10.1007/s10980-019-00854-3>).

Noise in the time-series data significantly affects the accuracy of the Machine Learning (ML) models (Artificial Neural Network and Support Vector Regression are considered here). Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) decomposes the time series data into sub-series and help to improve the model performance. The models can achieve higher prediction accuracy than the traditional ML models. Two models have been provided here for time series forecasting. More information may be obtained from Garai and Paul (2023) <doi:10.1016/j.iswa.2023.200202>.

Please note: active development has moved to packages validate and errorlocate'. Facilitates reading and manipulating (multivariate) data restrictions (edit rules) on numerical and categorical data. Rules can be defined with common R syntax and parsed to an internal (matrix-like format). Rules can be manipulated with variable elimination and value substitution methods, allowing for feasibility checks and more. Data can be tested against the rules and erroneous fields can be found based on Fellegi and Holt's generalized principle. Rules dependencies can be visualized with using the igraph package.

Power analysis is used in the estimation of sample sizes for experimental designs. Most programs and R packages will only output the highest recommended sample size to the user. Often the user input can be complicated and computing multiple power analyses for different treatment comparisons can be time consuming. This package simplifies the user input and allows the user to view all of the sample size recommendations or just the ones they want to see. The calculations used to calculate the recommended sample sizes are from the pwr package.

Data-driven fMRI denoising with projection scrubbing (Pham et al (2022) <doi:10.1016/j.neuroimage.2023.119972>). Also includes routines for DVARS (Derivatives VARianceS) (Afyouni and Nichols (2018) <doi:10.1016/j.neuroimage.2017.12.098>), motion scrubbing (Power et al (2012) <doi:10.1016/j.neuroimage.2011.10.018>), aCompCor (anatomical Components Correction) (Muschelli et al (2014) <doi:10.1016/j.neuroimage.2014.03.028>), detrending, and nuisance regression. Projection scrubbing is also applicable to other outlier detection tasks involving high-dimensional data.

The goal of gsDesign2 is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, gsDesign2 offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the gsDesign package is intended for selecting boundaries.

This package provides a set of tools for writing documents according to Geneva Graduate Institute conventions and regulations. The most common use is for writing and compiling theses or thesis chapters, as drafts or for examination with correct preamble formatting. However, the package also offers users to create HTML presentation slides with xaringan', complete problem sets, format posters, and, for course instructors, prepare a syllabus. The package includes additional functions for institutional color palettes, an institutional ggplot theme, a function for counting manuscript words, and a bibliographical analysis toolkit.

Estimation of joint models for multivariate longitudinal markers (with various distributions available) and survival outcomes (possibly accounting for competing risks) with Integrated Nested Laplace Approximations (INLA). The flexible and user friendly function joint() facilitates the use of the fast and reliable inference technique implemented in the INLA package for joint modeling. More details are given in the help page of the joint() function (accessible via ?joint in the R console) and the vignette associated to the joint() function (accessible via vignette("INLAjoint") in the R console).

In breeding experiments, mating environmental (ME) designs are very popular as mating designs are directly implemented in the field environment using block or row-column designs. Here, three functions are given related to three new methods which will generate mating diallel cross designs (Hinkelmann and Kempthorne, 1963<doi:10.2307/2333899>) or mating environmental (ME) designs along with design parameters, C matrix, eigenvalues (EVs), degree of fractionations (DF) and canonical efficiency factor (CEF). Another one function is added to check the properties of a given ME diallel cross design.

This package provides a minimalistic but flexible framework that facilitates the creation, management and training of multiple caret models. A model grid consists of two components, (1) a set of settings that is shared by all models by default, and (2) specifications that apply only to the individual models. When the model grid is trained, model and training specifications are first consolidated from the shared and the model specific settings into complete caret model configurations. These models are then trained with the train() function from the caret package.

This package provides methods for plotting potentially large (raster) images interactively on a plain HTML canvas. In contrast to package mapview data are plotted without background map, but data can be projected to any spatial coordinate reference system. Supports plotting of classes RasterLayer', RasterStack', RasterBrick (from package raster') as well as png files located on disk. Interactivity includes zooming, panning, and mouse location information. In case of multi-layer RasterStacks or RasterBricks', RGB image plots are created (similar to raster::plotRGB - but interactive).

Spatial forecast verification refers to verifying weather forecasts when the verification set (forecast and observations) is on a spatial field, usually a high-resolution gridded spatial field. Most of the functions here require the forecast and observed fields to be gridded and on the same grid. For a thorough review of most of the methods in this package, please see Gilleland et al. (2009) <doi: 10.1175/2009WAF2222269.1> and for a tutorial on some of the main functions available here, see Gilleland (2022) <doi: 10.5065/4px3-5a05>.

Adds some functions to help in your coding etiquette. tinycodet primarily focuses on 4 aspects. 1) Safer decimal (in)equality testing, standard-evaluated alternatives to with() and aes(), and other functions for safer coding. 2) A new package import system, that attempts to combine the benefits of using a package without attaching it, with the benefits of attaching a package. 3) Extending the string manipulation capabilities of the stringi R package. 4) Reducing repetitive code. Besides linking to Rcpp', tinycodet has only one other dependency, namely stringi'.

Dunn's test computes stochastic dominance & reports pairwise comparisons. This is done following a Kruskal-Wallis test (Kruskal and Wallis, 1952). It employs Dunn's z-test-statistic approximations for rank statistics, conducting k(k-1)/2 comparisons. The null hypothesis assumes that the probability of a randomly selected value from the first group being larger than one from the second group is one half, similar to the Wilcoxon-Mann-Whitney test. Dunn's test serves as a test for median difference and takes into account tied ranks.

This package performs a spatial Bayesian general linear model (GLM) for task functional magnetic resonance imaging (fMRI) data on the cortical surface. Additional models include group analysis and inference to detect thresholded areas of activation. Includes direct support for the CIFTI neuroimaging file format. For more information see A. F. Mejia, Y. R. Yue, D. Bolin, F. Lindgren, M. A. Lindquist (2020) <doi:10.1080/01621459.2019.1611582> and D. Spencer, Y. R. Yue, D. Bolin, S. Ryan, A. F. Mejia (2022) <doi:10.1016/j.neuroimage.2022.118908>.

This package provides the design of multi-group phase II clinical trials with binary outcomes using the hierarchical Bayesian classification and information sharing (BaCIS) model. Subgroups are classified into two clusters on the basis of their outcomes mimicking the hypothesis testing framework. Subsequently, information sharing takes place within subgroups in the same cluster, rather than across all subgroups. This method can be applied to the design and analysis of multi-group clinical trials with binary outcomes. Reference: Nan Chen and J. Jack Lee (2019) <doi:10.1002/bimj.201700275>.

Reproducible and automated analysis of multiplex bead assays such as CBA (Morgan et al. 2004; <doi: 10.1016/j.clim.2003.11.017>), LEGENDplex (Yu et al. 2015; <doi: 10.1084/jem.20142318>), and MACSPlex (Miltenyi Biotec 2014; Application note: Data acquisition and analysis without the MACSQuant analyzer; <https://www.miltenyibiotec.com/upload/assets/IM0021608.PDF>). The package provides functions for streamlined reading of fcs files, and identification of bead clusters and analyte expression. The package eases the calculation of standard curves and the subsequent calculation of the analyte concentration.

Quickly estimate the net growth rate of a population or clone whose growth can be approximated by a birth-death branching process. Input should be phylogenetic tree(s) of clone(s) with edge lengths corresponding to either time or mutations. Based on coalescent results in Johnson et al. (2023) <doi:10.1093/bioinformatics/btad561>. Simulation techniques as well as growth rate methods build on prior work from Lambert A. (2018) <doi:10.1016/j.tpb.2018.04.005> and Stadler T. (2009) <doi:10.1016/j.jtbi.2009.07.018>.

Computation of direct, chain and average (bisector) equating coefficients with standard errors using Item Response Theory (IRT) methods for dichotomous items (Battauz (2013) <doi:10.1007/s11336-012-9316-y>, Battauz (2015) <doi:10.18637/jss.v068.i07>). Test scoring can be performed by true score equating and observed score equating methods. DIF detection can be performed using a Wald-type test (Battauz (2019) <doi:10.1007/s10260-018-00442-w>). The package includes tests to assess the stability of the equating transformations (Battauz(2022) <doi:10.1111/stan.12277>).

Data-driven approach for arriving at person-specific time series models from within a Graphical Vector Autoregression (VAR) framework. The method first identifies which relations replicate across the majority of individuals to detect signal from noise. These group-level relations are then used as a foundation for starting the search for person-specific (or individual-level) relations. All estimates are obtained uniquely for each individual in the final models. The method for the graphicalVAR approach is found in Epskamp, Waldorp, Mottus & Borsboom (2018) <doi:10.1080/00273171.2018.1454823>.

Set of tools for descriptive analysis of metaproteomics data generated from high-throughput mass spectrometry instruments. These tools allow to cluster peptides and proteins abundance, expressed as spectral counts, and to manipulate them in groups of metaproteins. This information can be represented using multiple visualization functions to portray the global metaproteome landscape and to differentiate samples or conditions, in terms of abundance of metaproteins, taxonomic levels and/or functional annotation. The provided tools allow to implement flexible analytical pipelines that can be easily applied to studies interested in metaproteomics analysis.

Given a sample with additive measurement error, the package estimates the deconvolution density - that is, the density of the underlying distribution of the sample without measurement error. The method maximises the log-likelihood of the estimated density, plus a quadratic smoothness penalty. The distribution of the measurement error can be either a known family, or can be estimated from a "pure error" sample. For known error distributions, the package supports Normal, Laplace or Beta distributed error. For unknown error distribution, a pure error sample independent from the data is used.

Reads/write binary genotype file compatible with PLINK <https://www.cog-genomics.org/plink/1.9/input#bed> into/from a R matrix; traverse genotype data one windows of variants at a time, like apply() or a for loop; reads/writes genotype relatedness/kinship matrices created by PLINK <https://www.cog-genomics.org/plink/1.9/distance#make_rel> or GCTA <https://cnsgenomics.com/software/gcta/#MakingaGRM> into/from a R square matrix. It is best used for bringing data produced by PLINK and GCTA into R workflow.