CENTIPEDE applies a hierarchical Bayesian mixture model to infer regions of the genome that are bound by particular transcription factors. It starts by identifying a set of candidate binding sites, and then aims to classify the sites according to whether each site is bound or not bound by a transcription factor. CENTIPEDE is an unsupervised learning algorithm that discriminates between two different types of motif instances using as much relevant information as possible.

In putative Transcription Factor Binding Sites (TFBSs) identification from sequence/alignments, we are interested in the significance of certain match scores. TFMPvalue provides the accurate calculation of a p-value with a score threshold for position weight matrices, or the score with a given p-value. It is an interface to code originally made available by Helene Touzet and Jean-Stephane Varre, 2007, Algorithms Mol Biol:2, 15. Touzet and Varre (2007).

Genomic analysis of model organisms often requires the use of databases based on human data or making comparisons to patient-derived resources. This requires converting genes between human and non-human analogues. The babelgene R package provides predicted gene orthologs/homologs for frequently studied model organisms in an R-friendly tidy/long format. The package integrates orthology assertion predictions sourced from multiple databases as compiled by the HGNC Comparison of Orthology Predictions (HCOP).

This package provides tools to compute marginal effects from statistical models and return the result as tidy data frames. These data frames are ready to use with the ggplot2 package. Marginal effects can be calculated for many different models. Interaction terms, splines and polynomial terms are also supported. The two main functions are ggpredict() and ggeffect(). There is a generic plot() method to plot the results using ggplot2.

The r-phylogram package is a tool for for developing phylogenetic trees as deeply-nested lists known as "dendrogram" objects. It provides functions for conversion between "dendrogram" and "phylo" class objects, as well as several tools for command-line tree manipulation and import/export via Newick parenthetic text. This improves accessibility to the comprehensive range of object-specific analytical and tree-visualization functions found across a wide array of bioinformatic R packages.

This package provides simple and intuitive functions for basic statistical analyses. Methods include the t-test (Student 1908 <doi:10.1093/biomet/6.1.1>), the Mann-Whitney U test (Mann and Whitney 1947 <doi:10.1214/aoms/1177730491>), Pearson's correlation (Pearson 1895 <doi:10.1098/rspl.1895.0041>), and analysis of variance (Fisher 1925, <doi:10.1007/978-1-4612-4380-9_5>). Functions are compatible with ggplot2 and dplyr'.

Perform parallel factor analysis (PARAFAC: Hitchcock, 1927) <doi:10.1002/sapm192761164> on fluorescence excitation-emission matrices: handle scattering signal and inner filter effect, scale the dataset, fit the model; perform split-half validation or jack-knifing. Modified approaches such as Whittaker interpolation, randomised split-half, and fluorescence and scattering model estimation are also available. The package has a low dependency footprint and has been tested on a wide range of R versions.

Derives, organizes, summarizes, and visualizes terrain metrics from bathymetric and elevation rasters for submerged-landscape geomorphometry. Tools support terra-based raster preparation, slope and aspect decomposition, terrain position, rugosity, curvature, depth-band summaries, transect extraction, isobath-corridor analysis, and model-ready summaries for seafloor classification, habitat mapping, shelf-margin analysis, and spatial modeling. Methodological context for geomorphometric terrain analysis is provided by Lindsay (2016) <doi:10.1016/j.cageo.2016.07.003>.

This package provides functions for analyzing and visualizing complex macroevolutionary dynamics on phylogenetic trees. It is a companion package to the command line program BAMM (Bayesian Analysis of Macroevolutionary Mixtures) and is entirely oriented towards the analysis, interpretation, and visualization of evolutionary rates. Functionality includes visualization of rate shifts on phylogenies, estimating evolutionary rates through time, comparing posterior distributions of evolutionary rates across clades, comparing diversification models using Bayes factors, and more.

Converts numbers to continued fractions and back again. A solver for Pell's Equation is provided. The method for calculating roots in continued fraction form is provided without published attribution in such places as Professor Emeritus Jonathan Lubin, <http://www.math.brown.edu/jlubin/> and his post to StackOverflow, <https://math.stackexchange.com/questions/2215918> , or Professor Ron Knott, e.g., <https://r-knott.surrey.ac.uk/Fibonacci/cfINTRO.html> .

This package provides functions for fitting Cox proportional hazards models for grouped time-to-event data, where the shared group-specific frailties have a discrete nonparametric distribution. The methods proposed in the package is described by Gasperoni, F., Ieva, F., Paganoni, A. M., Jackson, C. H., Sharples, L. (2018) <doi:10.1093/biostatistics/kxy071>. There are also functions for simulating from these models, with a nonparametric or a parametric baseline hazard function.

This package provides a meta-package that installs and loads a set of packages from easystats ecosystem in a single step. This collection of packages provide a unifying and consistent framework for statistical modeling, visualization, and reporting. Additionally, it provides articles targeted at instructors for teaching easystats', and a dashboard targeted at new R users for easily conducting statistical analysis by accessing summary results, model fit indices, and visualizations with minimal programming.

Fast scalable Gaussian process approximations, particularly well suited to spatial (aerial, remote-sensed) and environmental data, described in more detail in Katzfuss and Guinness (2017) <doi:10.48550/arXiv.1708.06302>. Package also contains a fast implementation of the incomplete Cholesky decomposition (IC0), based on Schaefer et al. (2019) <doi:10.48550/arXiv.1706.02205> and MaxMin ordering proposed in Guinness (2018) <doi:10.48550/arXiv.1609.05372>.

Fits explanatory generalized partial credit models and related ordinal item response models with global and item-specific covariate effects. Penalized marginal maximum likelihood estimation is used for variable selection, detection of differential item functioning, and clustering of item-specific covariate effects by fusion penalties. The package extends the regularization approach for differential item functioning in generalized partial credit models proposed by Schauberger and Mair (2020) <doi:10.3758/s13428-019-01224-2>.

This package provides functions to calculate indices used to score immunoglobulin A (IgA) binding of bacteria in IgA sequencing (IgA-Seq) experiments. This includes the original Kau and Palm indices and more recent methods as described in Jackson et al. (2020) <doi:10.1101/2020.08.19.257501>. Additionally the package contains a function to simulate IgA-Seq data and an example experimental data set for method testing.

Defines predict function that transforms output from a Tweedie Generalized Linear Mixed Model (using glmmTMB'), Generalized Additive Model (using mgcv'), or spatio-temporal Generalized Linear Mixed Model (using package tinyVAST'), and returns predicted proportions (and standard errors) across a grouping variable from an equivalent multivariate-logit Tweedie model. These predicted proportions can then be used for standard plotting and diagnostics. See Thorson et al. 2022 <doi:10.1002/ecy.3637>.

This package provides sampling and density functions for matrix variate normal, t, and inverted t distributions; ML estimation for matrix variate normal and t distributions using the EM algorithm, including some restrictions on the parameters; and classification by linear and quadratic discriminant analysis for matrix variate normal and t distributions described in Thompson et al. (2019) <doi:10.1080/10618600.2019.1696208>. Performs clustering with matrix variate normal and t mixture models.

This package provides methods for quality control and exploratory analysis of surface water quality data collected in Massachusetts, USA. Functions are developed to facilitate data formatting for the Water Quality Exchange Network <https://www.epa.gov/waterdata/water-quality-data-upload-wqx> and reporting of data quality objectives to state agencies. Quality control methods are from Massachusetts Department of Environmental Protection (2020) <https://www.mass.gov/orgs/massachusetts-department-of-environmental-protection>.

Send requests to the PurpleAir Application Programming Interface (API; <https://community.purpleair.com/c/data/api/18>). Check a PurpleAir API key and get information about the related organization. Download real-time data from a single PurpleAir sensor or many sensors by sensor identifier, geographical bounding box, or time since modified. Download historical data from a single sensor. Stream real time data from monitors on a local area network.

Speeds up the process of loading raw data from MBA (Multiplex Bead Assay) examinations, performs quality control checks, and automatically normalises the data, preparing it for more advanced, downstream tasks. The main objective of the package is to create a simple environment for a user, who does not necessarily have experience with R language. The package is developed within the project PvSTATEM', which is an international project aiming for malaria elimination.

Implementation of sequential trial emulation for the analysis of observational databases. The SEQTaRget software accommodates time-varying treatments and confounders, as well as binary and failure time outcomes. SEQTaRget allows to compare both static and dynamic strategies, can be used to estimate observational analogs of intention-to-treat and per-protocol effects, and can adjust for potential selection bias induced by losses-to-follow-up. (Paper to come).

Computes confidence intervals for variance using the Chi-Square distribution, without requiring raw data. Wikipedia (2025) <https://en.wikipedia.org/wiki/Chi-squared_distribution>. All-in-One Chi Distribution CI provides functions to calculate confidence intervals for the population variance based on a chi-squared distribution, utilizing a sample variance and sample size. It offers only a simple all-in-one method for quick calculations to find the CI for Chi Distribution.

Perform spatial analysis on network. Implement several methods for spatial analysis on network: Network Kernel Density estimation, building of spatial matrices based on network distance ('listw objects from spdep package), K functions estimation for point pattern analysis on network, k nearest neighbours on network, reachable area calculation, and graph generation References: Okabe et al (2019) <doi:10.1080/13658810802475491>; Okabe et al (2012, ISBN:978-0470770818);Baddeley et al (2015, ISBN:9781482210200).

This package provides a synthetic control offers a way of evaluating the effect of an intervention in comparative case studies. The package makes a number of improvements when implementing the method in R. These improvements allow users to inspect, visualize, and tune the synthetic control more easily. A key benefit of a tidy implementation is that the entire preparation process for building the synthetic control can be accomplished in a single pipe.