Implementation of the methodology proposed in Data-driven design of targeted gene panels for estimating immunotherapy biomarkers', Bradley and Cannings (2021) <arXiv:2102.04296>. This package allows the user to fit generative models of mutation from an annotated mutation dataset, and then further to produce tunable linear estimators of exome-wide biomarkers. It also contains functions to simulate mutation annotated format (MAF) data, as well as to analyse the output and performance of models.

Shared, dependency-light primitives for landscape-genetic network methods: a lightweight deme/landscape graph (vertex coordinates and an undirected edge list) with constructors from coordinates; genetic covariance and distance from biallelic or multiallelic data (the Yang-style normalized-dosage covariance and the Dyer-style multivariate covariance); and antisymmetric per-edge directional covariate builders (the gradient of a scalar potential, and the projection of a vector flow field). Used by terradish (symmetric resistance). No compiled code.

Helper functions that interface with the system utilities to learn about the local build environment. Lets you explore make rules to test the local configuration, or query pkg-config to find compiler flags and libs needed for building packages with external dependencies. Also contains tools to analyze which libraries that a installed R package linked to by inspecting output from ldd in combination with information from your distribution package manager, e.g. rpm or dpkg'.

Reconcile species names across datasets and phylogenetic trees for comparative biology workflows. Identifies mismatches due to formatting differences, taxonomic synonymy, and spelling errors. Produces detailed reports documenting how each name was resolved, which taxonomic authority was used, and what remains unresolved. Supports exact matching, name normalisation, synonym resolution via local taxonomic databases, and fuzzy matching for likely typos. Detects taxonomic splits and lumps. For methodological context, see Nakagawa et al. (2026) <doi:10.32942/X2468Z>.

Last.fm'<https://www.last.fm> is a music platform focussed on building a detailed profile of a users listening habits. It does this by scrobbling (recording) every track you listen to on other platforms ('spotify', youtube', soundcloud etc) and transferring them to your Last.fm database. This allows Last.fm to act as a complete record of your entire listening history. scrobbler provides helper functions to download and analyse your listening history in R.

Deciphering hierarchy of agents exhibiting observable dominance events is a crucial problem in several disciplines, in particular in behavioural analysis of social animals, but also in social sciences and game theory. This package implements an inference approach based on graph theory, namely to extract the optimal acyclic subset of a weighted graph of dominance; this allows for hierarchy estimation through topological sorting. The package also contains infrastructure to investigate partially defined hierarchies and hierarchy dynamics.

This package provides a robust toolkit designed to standardize and clean complex tabular data from commercial enterprise systems, healthcare records, logistics software, and HR databases. Features include intelligent regex parsing for domain-specific noise (currencies, percentages), gap-based block clustering, and automated messy table resolution. Methods draw on tidy data principles described in Wickham (2014) <doi:10.18637/jss.v059.i10> and the readxl parsing infrastructure described in Wickham & Bryan (2023) <https://readxl.tidyverse.org>.

This package implements a task queue system for asynchronous parallel computing using PostgreSQL <https://www.postgresql.org/> as a backend. Designed for embarrassingly parallel problems where tasks do not communicate with each other. Dynamically distributes tasks to workers, handles uneven load balancing, and allows new workers to join at any time. Particularly useful for running large numbers of independent tasks on high-performance computing (HPC) clusters with SLURM <https://slurm.schedmd.com/> job schedulers.

This package provides an R interface for using AmCharts Library. Based on htmlwidgets', it provides a global architecture to generate JavaScript source code for charts. Most of classes in the library have their equivalent in R with S4 classes; for those classes, not all properties have been referenced but can easily be added in the constructors. Complex properties (e.g. JavaScript object) can be passed as named list. See examples at <https://datastorm-open.github.io/introduction_ramcharts/> and <https://www.amcharts.com/> for more information about the library. The package includes the free version of AmCharts Library. Its only limitation is a small link to the web site displayed on your charts. If you enjoy this library, do not hesitate to refer to this page <https://www.amcharts.com/online-store/> to purchase a licence, and thus support its creators and get a period of Priority Support. See also <https://www.amcharts.com/about/> for more information about AmCharts company.

Feature selection is critical in omics data analysis to extract restricted and meaningful molecular signatures from complex and high-dimension data, and to build robust classifiers. This package implements a method to assess the relevance of the variables for the prediction performances of the classifier. The approach can be run in parallel with the PLS-DA, Random Forest, and SVM binary classifiers. The signatures and the corresponding 'restricted' models are returned, enabling future predictions on new datasets.

PAIRADISE is a method for detecting allele-specific alternative splicing (ASAS) from RNA-seq data. Unlike conventional approaches that detect ASAS events one sample at a time, PAIRADISE aggregates ASAS signals across multiple individuals in a population. By treating the two alleles of an individual as paired, and multiple individuals sharing a heterozygous SNP as replicates, PAIRADISE formulates ASAS detection as a statistical problem for identifying differential alternative splicing from RNA-seq data with paired replicates.

Tools to clean and process text. Tools are geared at checking for substrings that are not optimal for analysis and replacing or removing them (normalizing) with more analysis friendly substrings (see Sproat, Black, Chen, Kumar, Ostendorf, & Richards (2001) doi:10.1006/csla.2001.0169) or extracting them into new variables. For example, emoticons are often used in text but not always easily handled by analysis algorithms. The replace_emoticon() function replaces emoticons with word equivalents.

This package provides an interface to infer the parameters of BASiCS using the variational inference (ADVI), Markov chain Monte Carlo (NUTS), and maximum a posteriori (BFGS) inference engines in the Stan programming language. BASiCS is a Bayesian hierarchical model that uses an adaptive Metropolis within Gibbs sampling scheme. Alternative inference methods provided by Stan may be preferable in some situations, for example for particularly large data or posterior distributions with difficult geometries.

The geomeTriD (Three-Dimensional Geometry) Package provides interactive 3D visualization of chromatin structures using the WebGL-based three.js (https://threejs.org/) or the rgl rendering library. It is designed to identify and explore spatial chromatin patterns within genomic regions. The package generates dynamic 3D plots and HTML widgets that integrate seamlessly with Shiny applications, enabling researchers to visualize chromatin organization, detect spatial features, and compare structural dynamics across different conditions and data types.

Calculates population attributable fraction causal effects. The causalPAF package contains a suite of functions for causal analysis calculations of population attributable fractions (PAF) given a causal diagram which apply both: Pathway-specific population attributable fractions (PS-PAFs) Oâ Connell and Ferguson (2022) <doi:10.1093/ije/dyac079> and Sequential population attributable fractions Ferguson, Oâ Connell, and Oâ Donnell (2020) <doi:10.1186/s13690-020-00442-x>. Results are presentable in both table and plot format.

This package implements instrumental variables estimation and inference for one endogenous regressor and one-way clustered errors. Includes the cluster-jackknife IV estimator (CJIVE) of Frandsen, Leslie and McIntyre (2025) <doi:10.1162/rest.a.263> and the cluster-jackknife Anderson-Rubin and score tests of Ligtenberg (2025) <doi:10.48550/arXiv.2306.08559>, which are robust to weak and many instruments. Supports multiple excluded instruments, covariates, precision weights, and high-dimensional fixed effects.

Helping biologists to choose the most suitable approach to link their research to conservation. After answering few questions on the data available, geographic and taxonomic scope, conserveR ranks existing methods for conservation prioritization and systematic conservation planning by suitability. The methods data base of conserveR contains 133 methods for conservation prioritization based on a systematic review of > 12,000 scientific publications from the fields of spatial conservation prioritization, systematic conservation planning, biogeography and ecology.

This package provides tools for systematic assessment, validation, and reporting of data quality. The package detects common data-quality problems including missing or blank values, duplicate observations, infinite values, constant and near-zero variance variables, outliers, invalid ranges and categories, type and pattern violations, problematic dates and identifiers, sequence errors, dependency violations, and cross-variable inconsistencies. It also supports reusable validation rules, integrated audit reports, and standardized data-quality scoring for reproducible data-quality assessment workflows.

This package provides a unified framework for epidemiological data analysis and disease surveillance. The package supports descriptive epidemiology, incidence, prevalence and mortality estimation, age standardization, trend analysis, geographic summaries, disease risk prediction, and automated analytical workflows. Designed for researchers and public health professionals, it facilitates reproducible analyses of epidemiological datasets using established statistical and predictive modeling techniques. Methods are informed by standard epidemiological references including Rothman et al. (2008, ISBN:9780781755641) and Gordis (2014, ISBN:9781455737338).

This package provides a flexible framework for estimating factor models with multiple latent variables. Supports linear, probit, ordered probit, and multinomial logit model components. Features include multi-stage estimation, automatic parameter initialization, analytical gradients and Hessians, and parallel estimation. Methods are described in Heckman, Humphries, and Veramendi (2016) <doi:10.1016/j.jeconom.2015.12.001>, Heckman, Humphries, and Veramendi (2018) <doi:10.1086/698760>, and Humphries, Joensen, and Veramendi (2024) <doi:10.1257/pandp.20241026>.

Package for parametric relative survival analyses. It allows to model non-linear and non-proportional effects and both non proportional and non linear effects, using splines (B-spline and truncated power basis), Weighted Cumulative Index of Exposure effect, with correction model for the life table. Both non proportional and non linear effects are described in Remontet, L. et al. (2007) <doi:10.1002/sim.2656> and Mahboubi, A. et al. (2011) <doi:10.1002/sim.4208>.

Recent years have seen significant interest in neighborhood-based structural parameters that effectively represent the spatial characteristics of tree populations and forest communities, and possess strong applicability for guiding forestry practices. This package provides valuable information that enhances our understanding and analysis of the fine-scale spatial structure of tree populations and forest stands. Reference: Yan L, Tan W, Chai Z, et al (2019) <doi:10.13323/j.cnki.j.fafu(nat.sci.).2019.03.007>.

This package provides a simple method to select the best model or best subset of variables using different types of data (binary, Gaussian or Poisson) and applying it in different contexts (parametric or non-parametric). Implemented methodology described in: M. Sestelo, N. M. Villanueva, L. Meira-Machado and J. Roca-Pardiñas (2016). FWDselect: an R package for variable selection in regression models. The R Journal, 8 (1), 132-148. <doi:10.32614/RJ-2016-009>.

Comfortable ways to work with hyperspectral data sets. I.e. spatially or time-resolved spectra, or spectra with any other kind of information associated with each of the spectra. The spectra can be data as obtained in XRF, UV/VIS, Fluorescence, AES, NIR, IR, Raman, NMR, MS, etc. More generally, any data that is recorded over a discretized variable, e.g. absorbance = f(wavelength), stored as a vector of absorbance values for discrete wavelengths is suitable.