This package provides functions that calculate appropriate sample sizes for one-sample t-tests, two-sample t-tests, and F-tests for microarray experiments based on desired power while controlling for false discovery rates. For all tests, the standard deviations (variances) among genes can be assumed fixed or random. This is also true for effect sizes among genes in one-sample and two sample experiments. Functions also output a chart of power versus sample size, a table of power at different sample sizes, and a table of critical test values at different sample sizes.

In order to make it easy to use variance reduction algorithms for any simulation, this framework can help you. We propose user friendly and easy to extend framework. Antithetic Variates, Inner Control Variates, Outer Control Variates and Importance Sampling algorithms are available in the framework. User can write its own simulation function and use the Variance Reduction techniques in this package to obtain more efficient simulations. An implementation of Asian Option simulation is already available within the package. See Kemal Dinçer Dingeç & Wolfgang Hörmann (2012) <doi:10.1016/j.ejor.2012.03.046>.

EDIRquery provides a tool to search for genes of interest within the Exome Database of Interspersed Repeats (EDIR). A gene name is a required input, and users can additionally specify repeat sequence lengths, minimum and maximum distance between sequences, and whether to allow a 1-bp mismatch. Outputs include a summary of results by repeat length, as well as a dataframe of query results. Example data provided includes a subset of the data for the gene GAA (ENSG00000171298). To query the full database requires providing a path to the downloaded database files as a parameter.

This package provides functionality to combine the existing pieces of the transcriptome data and results, making it easier to generate insightful observations and hypothesis. Its usage is made easy with a Shiny application, combining the benefits of interactivity and reproducibility e.g. by capturing the features and gene sets of interest highlighted during the live session, and creating an HTML report as an artifact where text, code, and output coexist. Using the GeneTonicList as a standardized container for all the required components, it is possible to simplify the generation of multiple visualizations and summaries.

Pigengene package provides an efficient way to infer biological signatures from gene expression profiles. The signatures are independent from the underlying platform, e.g., the input can be microarray or RNA Seq data. It can even infer the signatures using data from one platform, and evaluate them on the other. Pigengene identifies the modules (clusters) of highly coexpressed genes using coexpression network analysis, summarizes the biological information of each module in an eigengene, learns a Bayesian network that models the probabilistic dependencies between modules, and builds a decision tree based on the expression of eigengenes.

After using this, a publication-ready correlation table with p-values indicated will be created. The input can be a full data frame; any string and Boolean terms will be dropped as part of functionality. Correlations and p-values are calculated using the Hmisc framework. Output of the correlation_matrix() function is a table of strings; this gets saved out to a .csv2 with the save_correlation_matrix() function for easy insertion into a paper. For more details about the process, consult <https://paulvanderlaken.com/2020/07/28/publication-ready-correlation-matrix-significance-r/>.

Takes a .state file generated by IQ-TREE as an input and, for each ancestral node present in the file, generates a FASTA-formatted maximum likelihood (ML) sequence as well as an âAltAllâ sequence in which uncertain sites, determined by the two parameters thres_1 and thres_2, have the maximum likelihood state swapped with the next most likely state as described in Geeta N. Eick, Jamie T. Bridgham, Douglas P. Anderson, Michael J. Harms, and Joseph W. Thornton (2017), "Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty" <doi:10.1093/molbev/msw223>.

This package provides functions to retrieve the location of R scripts loaded through the source() function or run from the command line using the Rscript command. This functionality is analogous to the Bash shell's $BASH_SOURCE[0]. Users can first set the project root's path relative to the script path and then all subsequent paths relative to the root. This system ensures that all paths lead to the same location regardless of where any script is executed/loaded from without resorting to the use of setwd() at the top of the scripts.

This package provides interface to the Spectator Earth API <https://api.spectator.earth/>, mainly for obtaining the acquisition plans and satellite overpasses for Sentinel-1, Sentinel-2, Landsat-8 and Landsat-9 satellites. Current position and trajectory can also be obtained for a much larger set of satellites. It is also possible to search the archive for available images over the area of interest for a given (past) period, get the URL links to download the whole image tiles, or alternatively to download the image for just the area of interest based on selected spectral bands.

This package implements the algorithm described in Barron, M., and Li, J. (Not yet published). This algorithm clusters samples from multiple ordered populations, links the clusters across the conditions and identifies marker genes for these changes. The package was designed for scRNA-Seq data but is also applicable to many other data types, just replace cells with samples and genes with variables. The package also contains functions for estimating the parameters for SparseMDC as outlined in the paper. We recommend that users further select their marker genes using the magnitude of the cluster centers.

This package provides methods for handling the missing values outliers are introduced in this package. The recognized missing values and outliers are replaced using a model-based approach. The model may consist of both autoregressive components and external regressors. The methods work robust and efficient, and they are fully tunable. The primary motivation for writing the package was preprocessing of the energy systems data, e.g. power plant production time series, but the package could be used with any time series data. For details, see Narajewski et al. (2021) <doi:10.1016/j.softx.2021.100809>.

This package provides functions for Estimating a (c)DCC-GARCH Model in large dimensions based on a publication by Engle et,al (2017) <doi:10.1080/07350015.2017.1345683> and Nakagawa et,al (2018) <doi:10.3390/ijfs6020052>. This estimation method is consist of composite likelihood method by Pakel et al. (2014) <http://paneldataconference2015.ceu.hu/Program/Cavit-Pakel.pdf> and (Non-)linear shrinkage estimation of covariance matrices by Ledoit and Wolf (2004,2015,2016). (<doi:10.1016/S0047-259X(03)00096-4>, <doi:10.1214/12-AOS989>, <doi:10.1016/j.jmva.2015.04.006>).

This package provides a client for the OmniPath web service and many other resources. It also includes functions to transform and pretty print some of the downloaded data, functions to access a number of other resources such as BioPlex, ConsensusPathDB, EVEX, Gene Ontology, Guide to Pharmacology (IUPHAR/BPS), Harmonizome, HTRIdb, Human Phenotype Ontology, InWeb InBioMap, KEGG Pathway, Pathway Commons, Ramilowski et al. 2015, RegNetwork, ReMap, TF census, TRRUST and Vinayagam et al. 2011. Furthermore, OmnipathR features a close integration with the NicheNet method for ligand activity prediction from transcriptomics data, and its R implementation nichenetr.

This package provides an automatic aggregation tool to manage point data privacy, intended to be helpful for the production of official spatial data and for researchers. The package pursues the data accuracy at the smallest possible areas preventing individual information disclosure. The methodology, based on hierarchical geographic data structures performs aggregation and local suppression of point data to ensure privacy as described in Lagonigro, R., Oller, R., Martori J.C. (2017) <doi:10.2436/20.8080.02.55>. The data structures are created following the guidelines for grid datasets from the European Forum for Geography and Statistics.

Estimate the Å estákâ Berggren kinetic model (degradation model) from experimental data. A closed-form (analytic) solution to the degradation model is implemented as a non-linear fit, allowing for the extrapolation of the degradation of a drug product - both in time and temperature. Parametric bootstrap, with kinetic parameters drawn from the multivariate t-distribution, and analytical formulae (the delta method) are available options to calculate the confidence and prediction intervals. The results (modelling, extrapolations and statistical intervals) can be visualised with multiple plots. The examples illustrate the accelerated stability modelling in drugs and vaccines development.

This package provides a family of novel beta mixture models (BMMs) has been developed by Majumdar et al. (2022) <doi:10.48550/arXiv.2211.01938> to appositely model the beta-valued cytosine-guanine dinucleotide (CpG) sites, to objectively identify methylation state thresholds and to identify the differentially methylated CpG (DMC) sites using a model-based clustering approach. The family of beta mixture models employs different parameter constraints applicable to different study settings. The EM algorithm is used for parameter estimation, with a novel approximation during the M-step providing tractability and ensuring computational feasibility.

Noise filter based on determining the proportion of neighboring points. A false point will be rejected if it has only few neighbors, but accepted if the proportion of neighbors in a rectangular frame is high. The size of the rectangular frame as well as the cut-off value, i.e. of a minimum proportion of neighbor-points, may be supplied or can be calculated automatically. Originally designed for the cleaning of heart rates, but suitable for filtering any slowly-changing physiological variable.For more information see Signer (2010)<doi:10.1111/j.2041-210X.2009.00010.x>.

Large-scale phenotypic data processing is essential in research. Researchers need to eliminate outliers from the data in order to obtain true and reliable results. Best linear unbiased prediction (BLUP) is a standard method for estimating random effects of a mixed model. This method can be used to process phenotypic data under different conditions and is widely used in animal and plant breeding. The Phenotype can remove outliers from phenotypic data and performs the best linear unbiased prediction (BLUP), help researchers quickly complete phenotypic data analysis. H.P.Piepho. (2008) <doi:10.1007/s10681-007-9449-8>.

This package provides a fast and flexible framework for agglomerative partitioning. partition uses an approach called Direct-Measure-Reduce to create new variables that maintain the user-specified minimum level of information. Each reduced variable is also interpretable: the original variables map to one and only one variable in the reduced data set. partition is flexible, as well: how variables are selected to reduce, how information loss is measured, and the way data is reduced can all be customized. partition is based on the Partition framework discussed in Millstein et al. (2020) <doi:10.1093/bioinformatics/btz661>.

An adaptation of classical region/gene-based association analysis techniques to the use of summary statistics (P values and effect sizes) and correlations between genetic variants as input. It is a tool to perform the most popular and efficient gene-based tests using the results of genome-wide association (meta-)analyses without having the original genotypes and phenotypes at hand. See for details: Svishcheva et al (2019) Gene-based association tests using GWAS summary statistics. Bioinformatics. Belonogova et al (2022) SumSTAAR: A flexible framework for gene-based association studies using GWAS summary statistics. PLOS Comp Biol.

Exporting shiny applications with shinylive allows you to run them entirely in a web browser, without the need for a separate R server. The traditional way of deploying shiny applications involves in a separate server and client: the server runs R and shiny', and clients connect via the web browser. When an application is deployed with shinylive', R and shiny run in the web browser (via webR'): the browser is effectively both the client and server for the application. This allows for your shiny application exported by shinylive to be hosted by a static web server.

Doubly robust estimation for the mean of an arbitrarily transformed survival time under covariate-induced dependent left truncation and noninformative right censoring. The functions truncAIPW(), truncAIPW_cen1(), and truncAIPW_cen2() compute the doubly robust estimators under the scenario without censoring and the two censoring scenarios, respectively. The package also contains three simulated data sets simu', simu_c1', and simu_c2', which are used to illustrate the usage of the functions in this package. Reference: Wang, Y., Ying, A., Xu, R. (2022) "Doubly robust estimation under covariate-induced dependent left truncation" <arXiv:2208.06836>.

An implementation of methods related to sparse clustering and variable importance in clustering. The package currently allows to perform sparse k-means clustering with a group penalty, so that it automatically selects groups of numerical features. It also allows to perform sparse clustering and variable selection on mixed data (categorical and numerical features), by preprocessing each categorical feature as a group of numerical features. Several methods for visualizing and exploring the results are also provided. M. Chavent, J. Lacaille, A. Mourer and M. Olteanu (2020)<https://www.esann.org/sites/default/files/proceedings/2020/ES2020-103.pdf>.

This package enables you to create interactive cluster heatmaps that can be saved as a stand-alone HTML file, embedded in R Markdown documents or in a Shiny app, and made available in the RStudio viewer pane. Hover the mouse pointer over a cell to show details or drag a rectangle to zoom. A heatmap is a popular graphical method for visualizing high-dimensional data, in which a table of numbers is encoded as a grid of colored cells. The rows and columns of the matrix are ordered to highlight patterns and are often accompanied by dendrograms.