DriverNet is a package to predict functional important driver genes in cancer by integrating genome data (mutation and copy number variation data) and transcriptome data (gene expression data). The different kinds of data are combined by an influence graph, which is a gene-gene interaction network deduced from pathway data. A greedy algorithm is used to find the possible driver genes, which may mutated in a larger number of patients and these mutations will push the gene expression values of the connected genes to some extreme values.

The iNETgrate package provides functions to build a correlation network in which nodes are genes. DNA methylation and gene expression data are integrated to define the connections between genes. This network is used to identify modules (clusters) of genes. The biological information in each of the resulting modules is represented by an eigengene. These biological signatures can be used as features e.g., for classification of patients into risk categories. The resulting biological signatures are very robust and give a holistic view of the underlying molecular changes.

An interface to the AutoDesk Platform Services ('APS') API including the Authentication API for obtaining OAuth2 tokens with expiry tracking, Data Management API for managing buckets and objects across the platform's cloud services, Design Automation API for running automated tasks on design files in the cloud, Model Derivative API for translating design files into SVF', SVF2', OBJ', and STL formats and extracting model data, Reality Capture API for generating 3D models from photogrammetry image sets, and Viewer for rendering 2D and 3D models in Shiny applications.

Simulate and analyze Semi-competing Risks Data using copula-based models. The Semi-competing Risks Data consist of a terminal event time and single or multiple intermediate event times. The marginal survival functions of these event times are estimated without parametric assumptions. The association parameters measuring dependency among these event times involving the copula model are yielded from solving a concordance estimating equations or maximizing a pseudo-likelihood function. Details can be found in the article by Tonghui Yu and Liming Xiang (2026) <doi:10.1093/biomtc/ujag087>.

Paquete creado con el fin de facilitar el cálculo y distribución del à ndice Socio Material Territorial (ISMT), elaborado por el Observatorio de Ciudades UC. La metodologà a completa está disponible en "ISMT" (<https://ideocuc-ocuc.hub.arcgis.com/datasets/6ed956450cfc4293b7d90df3ce3474e4/about>) [Observatorio de Ciudades UC (2019)]. || Package created to facilitate the calculation and distribution of the Socio-Material Territorial Index by Observatorio de Ciudades UC. The full methodology is available at "ISMT" (<https://ideocuc-ocuc.hub.arcgis.com/datasets/6ed956450cfc4293b7d90df3ce3474e4/about>) [Observatorio de Ciudades UC (2019)].

The function get_parameters() is intended to be used within a docker container to read keyword arguments from a .json file automagically. A tool.yaml file contains specifications on these keyword arguments, which are then passed as input to containerized R tools in the [tool-runner framework](<https://github.com/hydrocode-de/tool-runner>). A template for a containerized R tool, which can be used as a basis for developing new tools, is available at the following URL: <https://github.com/VForWaTer/tool_template_r>.

Conducts a cointegration test for high-dimensional vector autoregressions (VARs) of order k based on the large N,T asymptotics of Bykhovskaya and Gorin, 2022 (<doi:10.48550/arXiv.2202.07150>). The implemented test is a modification of the Johansen likelihood ratio test. In the absence of cointegration the test converges to the partial sum of the Airy-1 point process. This package contains simulated quantiles of the first ten partial sums of the Airy-1 point process that are precise up to the first three digits.

Summarizes and visualizes categorical data extracted during literature reviews and evidence syntheses, starting from a data frame with one row per study. Generates publication-ready bar, stacked bar, histogram, waffle, donut, treemap, alluvial, trend, co-occurrence, UpSet', tree, and study-by-criteria matrix figures, together with world maps and formatted summary tables. Plot functions return standard ggplot2 objects that can be further customized, and an interactive Shiny application is included for building figures without writing code. Aims to help researchers report study characteristics consistently across many publications.

This package provides a set of functions to locate some programs available on the user machine. It can locate Node.js', npm', LibreOffice', Microsoft Word', Microsoft PowerPoint', Microsoft Excel', Python', pip', Mozilla Firefox', Google Chrome', Air and Pandoc'. The user can test the availability of a program, optionally with a required version, and call it with the functions system2() or system(). This allows the use of a single function to retrieve the path to a program regardless of the operating system and its configuration.

Computation of an estimation of the long-memory parameters and the long-run covariance matrix using a multivariate model (Lobato (1999) <doi:10.1016/S0304-4076(98)00038-4>; Shimotsu (2007) <doi:10.1016/j.jeconom.2006.01.003>). Two semi-parametric methods are implemented: a Fourier based approach (Shimotsu (2007) <doi:10.1016/j.jeconom.2006.01.003>) and a wavelet based approach (Achard and Gannaz (2016) <doi:10.1111/jtsa.12170>; Achard and Gannaz (2024) <doi:10.1111/jtsa.12719>). Real and complex wavelets are implemented.

This package implements the S-type estimators, novel robust estimators for general linear regression models, addressing challenges such as outlier contamination and leverage points. This package introduces robust regression techniques to provide a robust alternative to classical methods and includes diagnostic tools for assessing model fit and performance. The methodology is based on the study, "Comparison of the Robust Methods in the General Linear Regression Model" by Sazak and Mutlu (2023). This package is designed for statisticians and applied researchers seeking advanced tools for robust regression analysis.

The past decade has demonstrated an increased need to better understand risks leading to systemic crises. This framework offers scholars, practitioners and policymakers a useful toolbox to explore such risks in financial systems. Specifically, this framework provides popular econometric and network measures to monitor systemic risk and to measure the consequences of regulatory decisions. These systemic risk measures are based on the frameworks of Adrian and Brunnermeier (2016) <doi:10.1257/aer.20120555> and Billio, Getmansky, Lo and Pelizzon (2012) <doi:10.1016/j.jfineco.2011.12.010>.

Once initialized, the package leaves a tiny trail of human- and AI-readable text that makes it effortless to keep track of small to medium-sized projects. The package is lightweight (hence tiny') and maintains a YAML trail file recording which scripts produced which output files. Call tinytrail() once at the top of each script to record metadata, wrap any save call with tinytrail_write() to log the output path, and optionally use tinytrail_dict() to capture a data dictionary for each input data frame.

This package creates a local Lightning Memory-Mapped Database ('LMDB') of many commonly used taxonomic authorities and provides functions that can quickly query this data. Supported taxonomic authorities include the Integrated Taxonomic Information System ('ITIS'), National Center for Biotechnology Information ('NCBI'), Global Biodiversity Information Facility ('GBIF'), Catalogue of Life ('COL'), and Open Tree Taxonomy ('OTT'). Name and identifier resolution using LMDB can be hundreds of times faster than either relational databases or internet-based queries. Precise data provenance information for data derived from naming providers is also included.

The googleVis package provides an interface between R and the Google Charts API. Google Charts offer interactive charts which can be embedded into web pages. The functions of the googleVis package allow the user to visualise data stored in R data frames with Google Charts without uploading the data to Google. The output of a googleVis function is HTML code that contains the data and references to JavaScript functions hosted by Google. googleVis makes use of the internal R HTTP server to display the output locally.

This package provides an R Client for the Europe PubMed Central RESTful Web Service. It gives access to both metadata on life science literature and open access full texts. Europe PMC indexes all PubMed content and other literature sources including Agricola, a bibliographic database of citations to the agricultural literature, or Biological Patents. In addition to bibliographic metadata, the client allows users to fetch citations and reference lists. Links between life-science literature and other EBI databases, including ENA, PDB or ChEMBL are also accessible.

This package contains the function to find marker genes for image-based spatial transcriptomics data. There are functions to create spatial vectors from the cell and transcript coordiantes, which are passed as inputs to find marker genes. Marker genes are detected for every cluster by two approaches. The first approach is by permtuation testing, which is implmented in parallel for finding marker genes for one sample study. The other approach is to build a linear model for every gene. This approach can account for multiple samples and backgound noise.

Calculates several entropy metrics for spatial data inspired by Boltzmann's entropy formula. It includes metrics introduced by Cushman for landscape mosaics (Cushman (2015) <doi:10.1007/s10980-015-0305-2>), and landscape gradients and point patterns (Cushman (2021) <doi:10.3390/e23121616>); by Zhao and Zhang for landscape mosaics (Zhao and Zhang (2019) <doi:10.1007/s10980-019-00876-x>); and by Gao et al. for landscape gradients (Gao et al. (2018) <doi:10.1111/tgis.12315>; Gao and Li (2019) <doi:10.1007/s10980-019-00854-3>).

Noise in the time-series data significantly affects the accuracy of the Machine Learning (ML) models (Artificial Neural Network and Support Vector Regression are considered here). Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (CEEMDAN) decomposes the time series data into sub-series and help to improve the model performance. The models can achieve higher prediction accuracy than the traditional ML models. Two models have been provided here for time series forecasting. More information may be obtained from Garai and Paul (2023) <doi:10.1016/j.iswa.2023.200202>.

Power analysis is used in the estimation of sample sizes for experimental designs. Most programs and R packages will only output the highest recommended sample size to the user. Often the user input can be complicated and computing multiple power analyses for different treatment comparisons can be time consuming. This package simplifies the user input and allows the user to view all of the sample size recommendations or just the ones they want to see. The calculations used to calculate the recommended sample sizes are from the pwr package.

Please note: active development has moved to packages validate and errorlocate'. Facilitates reading and manipulating (multivariate) data restrictions (edit rules) on numerical and categorical data. Rules can be defined with common R syntax and parsed to an internal (matrix-like format). Rules can be manipulated with variable elimination and value substitution methods, allowing for feasibility checks and more. Data can be tested against the rules and erroneous fields can be found based on Fellegi and Holt's generalized principle. Rules dependencies can be visualized with using the igraph package.

Data-driven fMRI denoising with projection scrubbing (Pham et al (2022) <doi:10.1016/j.neuroimage.2023.119972>). Also includes routines for DVARS (Derivatives VARianceS) (Afyouni and Nichols (2018) <doi:10.1016/j.neuroimage.2017.12.098>), motion scrubbing (Power et al (2012) <doi:10.1016/j.neuroimage.2011.10.018>), aCompCor (anatomical Components Correction) (Muschelli et al (2014) <doi:10.1016/j.neuroimage.2014.03.028>), detrending, and nuisance regression. Projection scrubbing is also applicable to other outlier detection tasks involving high-dimensional data.

The goal of gsDesign2 is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, gsDesign2 offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the gsDesign package is intended for selecting boundaries.

Estimation of joint models for multivariate longitudinal markers (with various distributions available) and survival outcomes (possibly accounting for competing risks) with Integrated Nested Laplace Approximations (INLA). The flexible and user friendly function joint() facilitates the use of the fast and reliable inference technique implemented in the INLA package for joint modeling. More details are given in the help page of the joint() function (accessible via ?joint in the R console) and the vignette associated to the joint() function (accessible via vignette("INLAjoint") in the R console).