DNA methylation of 5-methylcytosine (5mC) is the result of a multi-step, enzyme-dependent process. Predicting these sites in-vitro is laborious, time consuming as well as costly. This Gb5mC-Pred package is an in-silico pipeline for predicting DNA sequences containing the 5mC sites. It uses a machine learning approach which uses Stochastic Gradient Boosting approach for prediction of the sequences with 5mC sites. This package has been developed by using the concept of Navarez and Roxas (2022) <doi:10.1109/TCBB.2021.3082184>.

Official GenderAPI.io V2 client for R. Provides an interface to the GenderAPI.io V2 web service <https://www.genderapi.io/api-documentation> that infers gender from personal names, email addresses and usernames, runs batches of up to 50 items, reads credit usage and validates phone numbers. Responses are returned as parsed lists with all fields kept, including unknown results, confidence metadata, billing status and batch summaries; errors are raised as structured conditions. Requests are never retried and redirects are never followed. Results are inferences, not verified identity, and can be unknown.

By analyzing time series, it is possible to observe significant changes in the behavior of observations that frequently characterize events. Events present themselves as anomalies, change points, or motifs. In the literature, there are several methods for detecting events. However, searching for a suitable time series method is a complex task, especially considering that the nature of events is often unknown. This work presents Harbinger, a framework for integrating and analyzing event detection methods. Harbinger contains several state-of-the-art methods described in Salles et al. (2020) <doi:10.5753/sbbd.2020.13626>.

Plot both fixed and random effects of linear mixed models, multilevel models in a single spaghetti plot. The package allows to visualize the effect of a predictor on a criterion between different levels of a grouping variable. Additionally, confidence intervals can be displayed for fixed effects. Calculation of predicted values of random effects allows only models with one random intercept and/or one random slope to be plotted. Confidence intervals and predicted values of fixed effects are computed using the ggpredict function from the ggeffects package. Lüdecke, D. (2018) <doi:10.21105/joss.00638>.

Several tests of quantitative palaeoenvironmental reconstructions from microfossil assemblages, including the null model tests of the statistically significant of reconstructions developed by Telford and Birks (2011) <doi:10.1016/j.quascirev.2011.03.002>, and tests of the effect of spatial autocorrelation on transfer function model performance using methods from Telford and Birks (2009) <doi:10.1016/j.quascirev.2008.12.020> and Trachsel and Telford (2016) <doi:10.5194/cp-12-1215-2016>. Age-depth models with generalized mixed-effect regression from Heegaard et al (2005) <doi:10.1191/0959683605hl836rr> are also included.

For making Trellis-type conditioning plots without strip labels. This is useful for displaying the structure of results from factorial designs and other studies when many conditioning variables would clutter the display with layers of redundant strip labels. Settings of the variables are encoded by layout and spacing in the trellis array and decoded by a separate legend. The functionality is implemented by a single S3 generic strucplot() function that is a wrapper for the Lattice package's xyplot() function. This allows access to all Lattice graphics capabilities in the usual way.

Estimates the time-varying (tv) parameters of the GARCH(1,1) model, enabling the modeling of non-stationary volatilities by allowing the model parameters to change gradually over time. The estimation and prediction processes are facilitated through the application of the Kalman filter and state-space equations. This package supports the estimation of tv parameters for various deterministic functions, which can be identified through exploratory analysis of different time periods or segments of return data. The methodology is grounded in the framework presented by Ferreira et al. (2017) <doi:10.1080/00949655.2017.1334778>.

Finite mixture models are a popular technique for modelling unobserved heterogeneity or to approximate general distribution functions in a semi-parametric way. They are used in a lot of different areas such as astronomy, biology, economics, marketing or medicine. This package is the implementation of popular robust mixture regression methods based on different algorithms including: fleximix, finite mixture models and latent class regression; CTLERob, component-wise adaptive trimming likelihood estimation; mixbi, bi-square estimation; mixL, Laplacian distribution; mixt, t-distribution; TLE, trimmed likelihood estimation. The implemented algorithms includes: CTLERob stands for Component-wise adaptive Trimming Likelihood Estimation based mixture regression; mixbi stands for mixture regression based on bi-square estimation; mixLstands for mixture regression based on Laplacian distribution; TLE stands for Trimmed Likelihood Estimation based mixture regression. For more detail of the algorithms, please refer to below references. Reference: Chun Yu, Weixin Yao, Kun Chen (2017) <doi:10.1002/cjs.11310>. NeyKov N, Filzmoser P, Dimova R et al. (2007) <doi:10.1016/j.csda.2006.12.024>. Bai X, Yao W. Boyer JE (2012) <doi:10.1016/j.csda.2012.01.016>. Wennan Chang, Xinyu Zhou, Yong Zang, Chi Zhang, Sha Cao (2020) <doi:10.48550/arXiv.2005.11599>.

This package provides a client for the OmniPath web service and many other resources. It also includes functions to transform and pretty print some of the downloaded data, functions to access a number of other resources such as BioPlex, ConsensusPathDB, EVEX, Gene Ontology, Guide to Pharmacology (IUPHAR/BPS), Harmonizome, HTRIdb, Human Phenotype Ontology, InWeb InBioMap, KEGG Pathway, Pathway Commons, Ramilowski et al. 2015, RegNetwork, ReMap, TF census, TRRUST and Vinayagam et al. 2011. Furthermore, OmnipathR features a close integration with the NicheNet method for ligand activity prediction from transcriptomics data, and its R implementation nichenetr.

EDIRquery provides a tool to search for genes of interest within the Exome Database of Interspersed Repeats (EDIR). A gene name is a required input, and users can additionally specify repeat sequence lengths, minimum and maximum distance between sequences, and whether to allow a 1-bp mismatch. Outputs include a summary of results by repeat length, as well as a dataframe of query results. Example data provided includes a subset of the data for the gene GAA (ENSG00000171298). To query the full database requires providing a path to the downloaded database files as a parameter.

This package provides functionality to combine the existing pieces of the transcriptome data and results, making it easier to generate insightful observations and hypothesis. Its usage is made easy with a Shiny application, combining the benefits of interactivity and reproducibility e.g. by capturing the features and gene sets of interest highlighted during the live session, and creating an HTML report as an artifact where text, code, and output coexist. Using the GeneTonicList as a standardized container for all the required components, it is possible to simplify the generation of multiple visualizations and summaries.

Pigengene package provides an efficient way to infer biological signatures from gene expression profiles. The signatures are independent from the underlying platform, e.g., the input can be microarray or RNA Seq data. It can even infer the signatures using data from one platform, and evaluate them on the other. Pigengene identifies the modules (clusters) of highly coexpressed genes using coexpression network analysis, summarizes the biological information of each module in an eigengene, learns a Bayesian network that models the probabilistic dependencies between modules, and builds a decision tree based on the expression of eigengenes.

This package provides an R6-based project container for managing DuckDB connections, reconnecting lazy database tables after session restarts, and storing metadata for database-backed objects used by packages in the dbverse'. The package supplies S4 base classes and generics for database-backed data, helpers for validating DuckDB connections and table names, utilities for creating persistent database views, and methods for writing and restoring pinned lazy tables through the pins package. These tools help package authors and analysts keep database paths, cached connections, and table references synchronized across interactive sessions and project directories.

This package provides database-backed spatial geometry classes and methods for working with vector spatial data in DuckDB'. The package supports loading, converting, querying, joining, and measuring spatial geometries through familiar sf'-style interfaces while keeping geometry columns lazy inside the database. It integrates with dbProject to preserve database paths, live connections, and spatial table metadata across interactive sessions. The package follows the Simple Features framework described by Pebesma (2018) <doi:10.32614/RJ-2018-009> and uses DuckDB's spatial extension <https://duckdb.org/docs/stable/core_extensions/spatial/overview.html>.

Conduct one- and two-sample goodness-of-fit tests for univariate data. In the one-sample case, normal, uniform, exponential, Bernoulli, binomial, geometric, beta, Poisson, lognormal, Laplace, asymmetric Laplace, inverse Gaussian, half-normal, chi-squared, gamma, F, Weibull, Cauchy, and Pareto distributions are supported. egof.test() can also test goodness-of-fit to any distribution with a continuous distribution function. A subset of the available distributions can be tested for the composite goodness-of-fit hypothesis, that is, one can test for distribution fit with unknown parameters. P-values are calculated via parametric bootstrap.

Computes chlorophyll a fluorescence transient parameters from fluorescence summary data, including minimum and maximum fluorescence, selected transient steps, and area. Provides standard photosynthetic performance indices and fluxes per reaction center and per cross section. Includes helpers to read exported trace tables in supported csv formats and validation workflows based on bundled example files, as well as visualization tools and an interactive shiny interface. The implemented calculations are based on Strasser et al. (2004) <doi:10.1007/978-1-4020-3218-9_12> and Stirbet and Govindjee (2011) <doi:10.1016/j.jphotobiol.2010.12.010>.

Gives a Stan'-based R package one interface for fitting its models through either rstan or cmdstanr', neither of which is required to install this package (install whichever you use). Collects and validates sampler options, guarding against mixing one backend's argument vocabulary into the other, dispatches the fit to the chosen backend, and exposes backend-agnostic accessors for reading posterior draws, extracting parameters, and running generated quantities. The host package supplies its own compiled models; flexstanr resolves them from the calling package at run time, so the same code works whichever backend is installed.

Reproducible, programmatic retrieval of datasets from the GESIS Data Archive. The GESIS Data Archive <https://search.gesis.org> makes available thousands of invaluable datasets, but researchers using these datasets are caught in a bind. The archive's terms and conditions bar dissemination of downloaded datasets to third parties, but to ensure that one's work can be reproduced, assessed, and built upon by others, one must provide access to the raw data one has employed. The gesisdata package cuts this knot by providing registered users with programmatic, reproducible access to GESIS datasets from within R'.

This package provides methods include converting series of event names to strings, finding common patterns in a group of strings, discovering "unique" patterns when comparing two groups of strings as well as the number and starting position of each pattern in each string, obtaining transition matrix, computing transition entropy, statistically comparing the difference between two groups of strings, and clustering string groups. Event names can be any action names or labels such as events in log files or areas of interest (AOIs) in eye tracking research. An R Shiny application is available on GitHub.

Template R package with minimal setup to use Rust code in R without hacks or frameworks. Includes basic examples of importing cargo dependencies, spawning threads and passing numbers or strings from Rust to R. Cargo crates are automatically vendored in the R source package to support offline installation. The GitHub repository for this package has more details and also explains how to set up CI. This project was first presented at Erum2018 to showcase R-Rust integration <https://jeroen.github.io/erum2018/>; for a real world use-case, see the gifski package on CRAN'.

Genome-wide gene insertion and deletion rates can be modelled in a maximum likelihood framework with the additional flexibility of modelling potential missing data using the models included within. These models simultaneously estimate insertion and deletion (indel) rates of gene families and proportions of "missing" data for (multiple) taxa of interest. The likelihood framework is utilized for parameter estimation. A phylogenetic tree of the taxa and gene presence/absence patterns (with data ordered by the tips of the tree) are required. See Dang et al. (2016) <doi:10.1534/genetics.116.191973> for more details.

This package provides a graphical user interface with an integrated diagrammer for latent variable models from the lavaan package. It offers two core functions: first, lavaangui() launches a web application that allows users to specify models by drawing path diagrams, fitting them, assessing model fit, and more; second, plot_lavaan() creates interactive path diagrams from models specified in lavaan'. After customizing a diagram interactively, export_plot() saves it to a file, enabling reproducible scripts without sacrificing fine-grained control over appearance. Karch (2024) <doi: 10.1080/10705511.2024.2420678> contains a tutorial.

DNA methylation is an important epigenetic process that regulates gene activity through chemical modifications of DNA without changing its sequence. OpEnCAMeO is a organism based ensemble model for prediction of 4mC, 6mA and No methylation sites directly from DNA sequences. It combines multiple machine learning algorithms trained on Bacteria (Escherichia coli), Fungi (Saccharomyces cerevisiae) and Nematode (Caenorhabditis elegans) as reference models to deliver accurate predictions. This methodology is being inspired by the ensemble algorithm for methylation prediction developed by Sinha et al. (2025) <doi:10.1101/2025.11.10.687509>.

This package provides a quantum computer simulator framework with up to 24 qubits. It allows to define general single qubit gates and general controlled single qubit gates. For convenience, it currently provides the most common gates (X, Y, Z, H, Z, S, T, Rx, Ry, Rz, CNOT, SWAP, Toffoli or CCNOT, Fredkin or CSWAP). qsimulatR also implements noise models. qsimulatR supports plotting of circuits and is able to export circuits to Qiskit <https://qiskit.org/>, a python package which can be used to run on IBM's hardware <https://quantum-computing.ibm.com/>.