This package provides a family of novel beta mixture models (BMMs) has been developed by Majumdar et al. (2022) <doi:10.48550/arXiv.2211.01938> to appositely model the beta-valued cytosine-guanine dinucleotide (CpG) sites, to objectively identify methylation state thresholds and to identify the differentially methylated CpG (DMC) sites using a model-based clustering approach. The family of beta mixture models employs different parameter constraints applicable to different study settings. The EM algorithm is used for parameter estimation, with a novel approximation during the M-step providing tractability and ensuring computational feasibility.

Noise filter based on determining the proportion of neighboring points. A false point will be rejected if it has only few neighbors, but accepted if the proportion of neighbors in a rectangular frame is high. The size of the rectangular frame as well as the cut-off value, i.e. of a minimum proportion of neighbor-points, may be supplied or can be calculated automatically. Originally designed for the cleaning of heart rates, but suitable for filtering any slowly-changing physiological variable.For more information see Signer (2010)<doi:10.1111/j.2041-210X.2009.00010.x>.

An implementation of the corrected sandwich variance (CSV) method for inverse probability weighted (IPW) Cox models described in Shu et al. (2021) <doi:10.1111/biom.13332>. The method accounts for the uncertainty in estimating propensity score weights to improve variance and confidence interval estimation for adjusted marginal hazard ratios (HRs) in observational and randomized studies. The package supports estimation of the average treatment effect (ATE) using conventional and stabilized ATE weights, and the average treatment effect in the treated (ATT) using ATT weights, for both independent and clustered data. Propensity scores are estimated using logistic regression.

This package provides a lightweight interface to the libcmaes C++ library for the Covariance Matrix Adaptation Evolution Strategy (CMA-ES). CMA-ES is a state-of-the-art evolutionary algorithm for the optimization of difficult non-linear, non-convex black-box functions, as described in Hansen and Ostermeier (2001) <doi:10.1162/106365601750190398>. Supports the active, separable, and VD (diagonal plus rank-one covariance) variants of the algorithm as well as the IPOP (increasing population size) and BIPOP (bi-population) restart strategies. A patched copy of libcmaes (LGPL >= 3) is bundled; see the COPYRIGHTS file for details.

Large-scale phenotypic data processing is essential in research. Researchers need to eliminate outliers from the data in order to obtain true and reliable results. Best linear unbiased prediction (BLUP) is a standard method for estimating random effects of a mixed model. This method can be used to process phenotypic data under different conditions and is widely used in animal and plant breeding. The Phenotype can remove outliers from phenotypic data and performs the best linear unbiased prediction (BLUP), help researchers quickly complete phenotypic data analysis. H.P.Piepho. (2008) <doi:10.1007/s10681-007-9449-8>.

This package provides a fast and flexible framework for agglomerative partitioning. partition uses an approach called Direct-Measure-Reduce to create new variables that maintain the user-specified minimum level of information. Each reduced variable is also interpretable: the original variables map to one and only one variable in the reduced data set. partition is flexible, as well: how variables are selected to reduce, how information loss is measured, and the way data is reduced can all be customized. partition is based on the Partition framework discussed in Millstein et al. (2020) <doi:10.1093/bioinformatics/btz661>.

Exporting shiny applications with shinylive allows you to run them entirely in a web browser, without the need for a separate R server. The traditional way of deploying shiny applications involves in a separate server and client: the server runs R and shiny', and clients connect via the web browser. When an application is deployed with shinylive', R and shiny run in the web browser (via webR'): the browser is effectively both the client and server for the application. This allows for your shiny application exported by shinylive to be hosted by a static web server.

Doubly robust estimation for the mean of an arbitrarily transformed survival time under covariate-induced dependent left truncation and noninformative right censoring. The functions truncAIPW(), truncAIPW_cen1(), and truncAIPW_cen2() compute the doubly robust estimators under the scenario without censoring and the two censoring scenarios, respectively. The package also contains three simulated data sets simu', simu_c1', and simu_c2', which are used to illustrate the usage of the functions in this package. Reference: Wang, Y., Ying, A., Xu, R. (2022) "Doubly robust estimation under covariate-induced dependent left truncation" <arXiv:2208.06836>.

This package provides a transparent, rule-based framework for detecting changes between successive data cuts of clinical trial datasets, classifying those changes into clinically meaningful categories, tracing user-defined data lineage, and assessing which downstream analyses and outputs may be affected. The package is designed to complement existing low-level data frame comparison tools by adding clinical-trial-specific classification, lineage and impact-assessment layers on top of deterministic comparison. The rule-based classification is similar in spirit to the data validation infrastructure of van der Loo and de Jonge (2021) <doi:10.18637/jss.v097.i10>.

An implementation of methods related to sparse clustering and variable importance in clustering. The package currently allows to perform sparse k-means clustering with a group penalty, so that it automatically selects groups of numerical features. It also allows to perform sparse clustering and variable selection on mixed data (categorical and numerical features), by preprocessing each categorical feature as a group of numerical features. Several methods for visualizing and exploring the results are also provided. M. Chavent, J. Lacaille, A. Mourer and M. Olteanu (2020)<https://www.esann.org/sites/default/files/proceedings/2020/ES2020-103.pdf>.

An interactive HTML widget of the perspective plot for generalized additive models; an alternative solution of the function mgcv::vis.gam(). This R package author has retired from academic research. Accordingly, this package should not be considered a validated tool for use in peer-reviewed publications or as the basis for grant applications. Backward compatibility with user-code published in <doi:10.1093/bioinformatics/btaf182> and <doi:10.1093/bioinformatics/btaf430> is not maintained in versions >= 0.3.0 (June 2026) of this package. The authors of those publications are the appropriate contacts for reproducibility inquiries.

Provide sets of functions and methods to learn and practice data science using idea of algorithmic trading. Main goal is to process information within "Decision Support System" to come up with analysis or predictions. There are several utilities such as dynamic and adaptive risk management using reinforcement learning and even functions to generate predictions of price changes using pattern recognition deep regression learning. Summary of Methods used: Awesome H2O tutorials: <https://github.com/h2oai/awesome-h2o>, Market Type research of Van Tharp Institute: <https://vantharp.com/>, Reinforcement Learning R package: <https://CRAN.R-project.org/package=ReinforcementLearning>.

Estimate, compare, and analyze dynamic and psychological networks using a unified interface. Provides transition network analysis estimation (transition, frequency, co-occurrence, attention-weighted) Saqr et al. (2025) <doi:10.1145/3706468.3706513>, psychological network methods (correlation, partial correlation, graphical lasso', Ising') Saqr, Beck, and Lopez-Pernas (2024) <doi:10.1007/978-3-031-54464-4_19>, and higher-order network methods including higher-order networks, higher-order network embedding, hyper-path anomaly, and multi-order generative model. Supports bootstrap inference, permutation testing, split-half reliability, centrality stability analysis, mixed Markov models, multi-cluster multi-layer networks and clustering.

This package provides a phylogenetic comparative method for finding associations between biological traits and molecular evolutionary rates. The method samples pairs from a phylogeny such that each pair has non-overlapping edge paths, and can therefore be treated as statistically independent observations. Linear regression is performed on the pair contrasts. This approach is similar to phylogenetically independent contrasts (PIC) but without reconstructing the traits at internal nodes, and is better suited for finding trait-rate associations than phylogenetic generalised least squares (PGLS). Refer to Douglas and Bromham (2026) <doi:10.64898/2026.08.13.744736> for further details.

This package provides an interactive RStudio gadget for working with an AI assistant during package and script development. The gadget can use selected editor text, the active source file, package metadata, and uploaded files as context for code explanation, code generation, documentation, and review workflows. It offers model presets, assistant behavior settings, responsive code-focused output, and explicit copy, insert, and replace actions for the active source editor. API interactions via the httr package are performed asynchronously using promises and future to avoid blocking the R console. The backend is configured via the OPENAI_API_KEY environment variable.

It includes test for multivariate normality, test for uniformity on the d-dimensional Sphere, non-parametric two- and k-sample tests, random generation of points from the Poisson kernel-based density and clustering algorithm for spherical data. For more information see Saraceno G., Markatou M., Mukhopadhyay R. and Golzy M. (2024) <doi:10.48550/arXiv.2402.02290> Markatou, M. and Saraceno, G. (2024) <doi:10.48550/arXiv.2407.16374>, Ding, Y., Markatou, M. and Saraceno, G. (2023) <doi:10.5705/ss.202022.0347>, and Golzy, M. and Markatou, M. (2020) <doi:10.1080/10618600.2020.1740713>.

This package provides functions and data sets inspired by data sharpening - data perturbation to achieve improved performance in nonparametric estimation, as described in Choi, E., Hall, P. and Rousson, V. (2000). Capabilities for enhanced local linear regression function and derivative estimation are included, as well as an asymptotically correct iterated data sharpening estimator for any degree of local polynomial regression estimation. A cross-validation-based bandwidth selector is included which, in concert with the iterated sharpener, will often provide superior performance, according to a median integrated squared error criterion. Sample data sets are provided to illustrate function usage.

Detrending multivariate time-series to approximate stationarity when dealing with intensive longitudinal data, prior to Vector Autoregressive (VAR) or multilevel-VAR estimation. Classical VAR assumes weak stationarity (constant first two moments), and deterministic trends inflate spurious autocorrelation, biasing Granger-causality and impulse-response analyses. All functions operate on raw panel data and write detrended columns back to the data set, but differ in the level at which the trend is estimated. See, for instance, Wang & Maxwell (2015) <doi:10.1037/met0000030>; Burger et al. (2022) <doi:10.4324/9781003111238-13>; Epskamp et al. (2018) <doi:10.1177/2167702617744325>.

This package provides methods for generating modelled parametric Tropical Cyclone (TC) spatial hazard fields and time series output at point locations from TC tracks. R's compatibility to simply use fast cpp code via the Rcpp package and the wide range spatial analysis tools via the terra package makes it an attractive open source environment to study TCs'. This package estimates TC vortex wind and pressure fields using parametric equations originally coded up in python by TCRM <https://github.com/GeoscienceAustralia/tcrm> and then coded up in Cuda cpp by TCwindgen <https://github.com/CyprienBosserelle/TCwindgen>.

The package ptairData contains two raw datasets from Proton-Transfer-Reaction Time-of-Flight mass spectrometer acquisitions (PTR-TOF-MS), in the HDF5 format. One from the exhaled air of two volunteer healthy individuals with three replicates, and one from the cell culture headspace from two mycobacteria species and one control (culture medium only) with two replicates. Those datasets are used in the examples and in the vignette of the ptairMS package (PTR-TOF-MS data pre-processing). There are also used to gererate the ptrSet in the ptairMS data : exhaledPtrset and mycobacteriaSet.

This package provides a common task faced by researchers is the creation of APA style (i.e., American Psychological Association style) tables from statistical output. In R a large number of function calls are often needed to obtain all of the desired information for a single APA style table. As well, the process of manually creating APA style tables in a word processor is prone to transcription errors. This package creates Word files (.doc files) containing APA style tables for several types of analyses. Using this package minimizes transcription errors and reduces the number commands needed by the user.

Gene Symbols or Ensembl Gene IDs are converted using the Bimap interface in AnnotationDbi in convertId2() for the most common use cases in data analysis. The main function in the package is convert.bm() which queries BioMart using the full capacity of the API provided through the biomaRt package. Presets and defaults are provided for convenience but all "marts", "filters" and "attributes" can be set by the user. Function convert.alias() converts Gene Symbols to Aliases and vice versa and function likely_symbol() attempts to determine the most likely current Gene Symbol.

This package provides tools for converting and imputing date values to the ISO 8601 standard format and for reconciling differences between two versions of a data set. The package automatically detects date patterns within data frame columns and converts them to consistent ISO-formatted dates, with optional imputation of missing day or month components based on user-defined rules. It also includes functionality to identify inserted, deleted, and updated records, as well as column- and value-level changes, when comparing old and new versions of a data frame. Only one date format may be applied within a single column.

Fast C++ implementation of Dynamic Time Warping for time series dissimilarity analysis, with applications in environmental monitoring and sensor data analysis, climate science, signal processing and pattern recognition, and financial data analysis. Built upon the ideas presented in Benito and Birks (2020) <doi:10.1111/ecog.04895>, provides tools for analyzing time series of varying lengths and structures, including irregular multivariate time series. Key features include individual variable contribution analysis, restricted permutation tests for statistical significance, and imputation of missing data via GAMs. Additionally, the package provides an ample set of tools to prepare and manage time series data.