This package provides a unified data layer for single-cell, spatial and bulk T-cell and B-cell immune receptor repertoire data. Think AnnData or SeuratObject, but for AIRR data, a.k.a. Adaptive Immune Receptor Repertoire, VDJ-seq, RepSeq, or VDJ sequencing data.

Use R to make requests to the US Census Bureau's International Data Base API. Results are returned as R data frames. For more information about the IDB API, visit <https://www.census.gov/data/developers/data-sets/international-database.html>.

This package provides convenient access to the German modification of the International Classification of Diagnoses, 10th revision (ICD-10-GM). It provides functionality to aid in the identification, specification and historisation of ICD-10 codes. Its intended use is the analysis of routinely collected data in the context of epidemiology, medical research and health services research. The underlying metadata are released by the German Institute for Medical Documentation and Information <https://www.dimdi.de>, and are redistributed in accordance with their license.

This package provides a port of Python's excellent itertools module to R for efficient looping.

This package provides functions to facilitate inverse estimation (e.g., calibration) in linear, generalized linear, nonlinear, and (linear) mixed-effects models. A generic function is also provided for plotting fitted regression models with or without confidence/prediction bands that may be of use to the general user. For a general overview of these methods, see Greenwell and Schubert Kabban (2014) <doi:10.32614/RJ-2014-009>.

An implementation of the initial guided analytics for parameter testing and controlband extraction framework. Functions are available for continuous and categorical target variables as well as for generating standardized reports of the conducted analysis. See <https://github.com/stefan-stein/igate> for more information on the technology.

Calculation of key bacterial growth curve parameters using fourth degree polynomial functions. Six growth curve parameters are provided including peak growth rate, doubling time, lag time, maximum growth, and etc. ipolygrowth takes time series data from individual biological samples (with technical replicates) or multiple samples.

Imputation (replacement) of missing values in univariate time series. Offers several imputation functions and missing data plots. Available imputation algorithms include: Mean', LOCF', Interpolation', Moving Average', Seasonal Decomposition', Kalman Smoothing on Structural Time Series models', Kalman Smoothing on ARIMA models'. Published in Moritz and Bartz-Beielstein (2017) <doi:10.32614/RJ-2017-009>.

Immunotherapy has revolutionized cancer treatment, but predicting patient response remains challenging. Here, we presented Intelligent Predicting Response to cancer Immunotherapy through Systematic Modeling (iPRISM), a novel network-based model that integrates multiple data types to predict immunotherapy outcomes. It incorporates gene expression, biological functional network, tumor microenvironment characteristics, immune-related pathways, and clinical data to provide a comprehensive view of factors influencing immunotherapy efficacy. By identifying key genetic and immunological factors, it provides an insight for more personalized treatment strategies and combination therapies to overcome resistance mechanisms.

An R client for the ipbase.com IP Geolocation API. The API requires registration of an API key. Basic features are free, some require a paid subscription. You can find the full API documentation at <https://ipbase.com/docs> .

This package provides a bunch of functions to deal with circular data under order restrictions.

Semiparametric regression models on the cumulative incidence function for interval-censored competing risks data as described in Bakoyannis, Yu, & Yiannoutsos (2017) /doi10.1002/sim.7350 and the models with missing event types as described in Park, Bakoyannis, Zhang, & Yiannoutsos (2021) \doi10.1093/biostatistics/kxaa052. The proportional subdistribution hazards model (Fine-Gray model), the proportional odds model, and other models that belong to the class of semiparametric generalized odds rate transformation models.

Computes the log likelihood for an inverse gamma stochastic volatility model using a closed form expression of the likelihood. The details of the computation of this closed form expression are given in Gonzalez and Majoni (2023) <http://rcea.org/RePEc/pdf/wp23-11.pdf> . The closed form expression is obtained for a stationary inverse gamma stochastic volatility model by marginalising out the volatility. This allows the user to obtain the maximum likelihood estimator for this non linear non Gaussian state space model. In addition, the user can obtain the estimates of the smoothed volatility using the exact smoothing distributions.

Partitioning clustering algorithms divide data sets into k subsets or partitions so-called clusters. They require some initialization procedures for starting the algorithms. Initialization of cluster prototypes is one of such kind of procedures for most of the partitioning algorithms. Cluster prototypes are the centers of clusters, i.e. centroids or medoids, representing the clusters in a data set. In order to initialize cluster prototypes, the package inaparc contains a set of the functions that are the implementations of several linear time-complexity and loglinear time-complexity methods in addition to some novel techniques. Initialization of fuzzy membership degrees matrices is another important task for starting the probabilistic and possibilistic partitioning algorithms. In order to initialize membership degrees matrices required by these algorithms, a number of functions based on some traditional and novel initialization techniques are also available in the package inaparc'.

Programmatic connection to the OpenAltimetry API <https://openaltimetry.earthdatacloud.nasa.gov/data/openapi/swagger-ui/index.html/> to download and process ATL03 (Global Geolocated Photon Data), ATL06 (Land Ice Height), ATL07 (Sea Ice Height), ATL08 (Land and Vegetation Height), ATL10 (Sea Ice Freeboard), ATL12 (Ocean Surface Height) and ATL13 (Inland Water Surface Height) ICESat-2 Altimeter Data. The user has the option to download the data by selecting a bounding box from a 1- or 5-degree grid globally utilizing a shiny application. The ICESat-2 mission collects altimetry data of the Earth's surface. The sole instrument on ICESat-2 is the Advanced Topographic Laser Altimeter System (ATLAS) instrument that measures ice sheet elevation change and sea ice thickness, while also generating an estimate of global vegetation biomass. ICESat-2 continues the important observations of ice-sheet elevation change, sea-ice freeboard, and vegetation canopy height begun by ICESat in 2003.

This package implements the standard D-Scoring algorithm (Greenwald, Banaji, & Nosek, 2003) for Implicit Association Test (IAT) data and includes plotting capabilities for exploring raw IAT data.

Compute permutation- based performance measures and create partial dependence plots for (cross-validated) randomForest and ada models.

Converts matrices and lists of matrices into a single vector by interleaving their values. That is, each element of the result vector is filled from the input matrices one row at a time. This is the same as transposing a matrix, then removing the dimension attribute, but is designed to operate on matrices in nested list structures.

This package provides a collection of wrapper functions for common variable and dataset manipulation workflows primarily used by iNZight', a graphical user interface providing easy exploration and visualisation of data for students of statistics, available in both desktop and online versions. Additionally, many of the functions return the tidyverse code used to obtain the result in an effort to bridge the gap between GUI and coding.

Neural network has potential in forestry modelling. This package is designed to create and assess Artificial Intelligence based Neural Networks with varying architectures for prediction of volume of forest trees using two input features: height and diameter at breast height, as they are the key factors in predicting volume, therefore development and validation of efficient volume prediction neural network model is necessary. This package has been developed using the algorithm of Tabassum et al. (2022) <doi:10.18805/ag.D-5555>.

Carries out instrumental variable estimation of causal effects, including power analysis, sensitivity analysis, and diagnostics. See Kang, Jiang, Zhao, and Small (2020) <http://pages.cs.wisc.edu/~hyunseung/> for details.

This package provides a dataframe validation framework for package builders who use dataframes as function parameters. It performs checks on column names, coerces data-types, and checks grouping to make sure user inputs conform to a specification provided by the package author. It provides a mechanism for package authors to automatically document supported dataframe inputs and selectively dispatch to functions depending on the format of a dataframe much like S3 does for classes. It also contains some developer tools to make working with and documenting dataframe specifications easier. It helps package developers to improve their documentation and simplifies parameter validation where dataframes are used as function parameters.

This package provides functions to to compute a continuum of information-based measures for quantifying the temporal stability of populations, communities, and ecosystems, as well as their associated synchrony, based on species (or species assemblage) biomass or other key variables. When biodiversity data are available, the package also enables the assessment of the corresponding diversityâ stability relationships. All measures are applicable in both temporal and spatial contexts. The theoretical and methodological background is detailed in Chao et al. (2025) <doi:10.1101/2025.08.20.671203>.

This package provides composable invertible transforms for (sparse) matrices.