This is a analysis toolkit to streamline the analyses of minicircle sequence diversity in population-scale genome projects. rKOMICS is a user-friendly R package that has simple installation requirements and that is applicable to all 27 trypanosomatid genera. Once minicircle sequence alignments are generated, rKOMICS allows to examine, summarize and visualize minicircle sequence diversity within and between samples through the analyses of minicircle sequence clusters. We showcase the functionalities of the (r)KOMICS tool suite using a whole-genome sequencing dataset from a recently published study on the history of diversification of the Leishmania braziliensis species complex in Peru. Analyses of population diversity and structure highlighted differences in minicircle sequence richness and composition between Leishmania subspecies, and between subpopulations within subspecies. The rKOMICS package establishes a critical framework to manipulate, explore and extract biologically relevant information from mitochondrial minicircle assemblies in tens to hundreds of samples simultaneously and efficiently. This should facilitate research that aims to develop new molecular markers for identifying species-specific minicircles, or to study the ancestry of parasites for complementary insights into their evolutionary history. ***** !! WARNING: this package relies on dependencies from Bioconductor. For Mac users, this can generate errors when installing rKOMICS. Install Bioconductor and ComplexHeatmap at advance: install.packages("BiocManager"); BiocManager::install("ComplexHeatmap") *****.

Allows loading and displaying an Observable notebook (online JavaScript notebooks powered by <https://observablehq.com>) as an HTML Widget in an R session, shiny application or rmarkdown document.

This package performs species distribution modeling for rare species with unprecedented accuracy (Mondanaro et al., 2023 <doi:10.1111/2041-210X.14066>) and finds the area of origin of species and past contact between them taking climatic variability in full consideration (Mondanaro et al., 2025 <doi:10.1111/2041-210X.14478>).

Interface to the Dryad "Solr" API, their "OAI-PMH" service, and fetch datasets. Dryad (<https://datadryad.org/>) is a curated host of data underlying scientific publications.

Loads Axon Binary Files (both ABF and ABF2') created by Axon Instruments/Molecular Devices software such as pClamp'.

This package provides subsets with reference semantics, i.e. subsets which automatically reflect changes in the original object, and which optionally update the original object when they are changed.

Includes Resourcecode hindcast database (see <https://resourcecode.ifremer.fr>) configuration data: nodes locations for both the sea-state parameters and the spectra data; examples of time series of 1D and 2D surface elevation variance spectral density.

Easy-to-use functions for downloading air quality data from the Mexican National Air Quality Information System (SINAICA). Allows you to query pollution and meteorological parameters from more than a hundred monitoring stations located throughout Mexico. See <https://sinaica.inecc.gob.mx> for more information.

This package provides a set of functions to simplify reading data from files. The main function, reader(), should read most common R datafile types without needing any parameters except the filename. Other functions provide simple ways of handling file paths and extensions, and automatically detecting file format and structure.

Designed for the import, analysis, and visualization of dosimetric and volumetric data in Radiation Oncology, the tools herein enable import of dose-volume histogram information from multiple treatment planning system platforms and 3D structural representations and dosimetric information from DICOM-RT files. These tools also enable subsequent visualization and statistical analysis of these data.

Interface to integrate igraph and ggplot2 graphics in a normalized coordinate system. RGraphSpace implements new geometric objects using ggplot2 prototypes, customized for side-by-side visualization of multiple graphs. By scaling shapes and graph elements, RGraphSpace can provide a framework for layered visualizations.

Fit and simulate any kind of physiologically-based kinetic ('PBK') models whatever the number of compartments. Moreover, it allows to account for any link between pairs of compartments, as well as any link of each of the compartments with the external medium. Such generic PBK models have today applications in pharmacology (PBPK models) to describe drug effects, in toxicology and ecotoxicology (PBTK models) to describe chemical substance effects. In case of exposure to a parent compound (drug or chemical) the rPBK package allows to consider metabolites, whatever their number and their phase (I, II, ...). Last but not least, package rPBK can also be used for dynamic flux balance analysis (dFBA) to deal with metabolic networks. See also Charles et al. (2022) <doi:10.1101/2022.04.29.490045>.

Implementation of the affine-invariant method of Goodman & Weare (2010) <DOI:10.2140/camcos.2010.5.65>, a method of producing Monte-Carlo samples from a target distribution.

This package creates and maintains a build process for complex analytic tasks in R. Package allows to easily generate Makefile for the (GNU) make tool, which drives the build process by (in parallel) executing build commands in order to update results accordingly to given dependencies on changed data or updated source files.

Implementation of the Johnson Quantile-Parameterised Distribution in R. The Johnson Quantile-Parameterised Distribution (J-QPD) is a flexible distribution system that is parameterised by a symmetric percentile triplet of quantile values (typically the 10th-50th-90th) along with known support bounds for the distribution. The J-QPD system was developed by Hadlock and Bickel (2017) <doi:10.1287/deca.2016.0343>. This package implements the density, quantile, CDF and random number generator functions.

This package provides a RESTful API wrapper for accessing the GENESIS database of the German Federal Statistical Office (Destatis) as well as its Census Database and the database of Germany's regional statistics. Supports data search functions, credential management, result caching, and handling remote background jobs for large datasets.

Conduct simulations of the Response Adaptive Block Randomization (RABR) design to evaluate its type I error rate, power and operating characteristics for binary and continuous endpoints. For more details of the proposed method, please refer to Zhan et al. (2021) <doi:10.1002/sim.9104>.

This package provides functions to access, search and download spacetime earth observation data via SpatioTemporal Asset Catalog (STAC). This package supports the version 1.0.0 (and older) of the STAC specification (<https://github.com/radiantearth/stac-spec>). For further details see Simoes et al. (2021) <doi:10.1109/IGARSS47720.2021.9553518>.

This package provides several metrics for assessing relative importance in linear models. These can be printed, plotted and bootstrapped. The recommended metric is lmg, which provides a decomposition of the model explained variance into non-negative contributions. There is a version of this package available that additionally provides a new and also recommended metric called pmvd. If you are a non-US user, you can download this extended version from Ulrike Groempings web site.

This package implements methods described by the paper Robins and Tsiatis (1991) <DOI:10.1080/03610929108830654>. These use g-estimation to estimate the causal effect of a treatment in a two-armed randomised control trial where non-compliance exists and is measured, under an assumption of an accelerated failure time model and no unmeasured confounders.

Mass rollup for a Bill of Materials is an example of a class of computations in which elements are arranged in a tree structure and some property of each element is a computed function of the corresponding values of its child elements. Leaf elements, i.e., those with no children, have values assigned. In many cases, the combining function is simple arithmetic sum; in other cases (e.g., mass properties), the combiner may involve other information such as the geometric relationship between parent and child, or statistical relations such as root-sum-of-squares (RSS). This package implements a general function for such problems. It is adapted to specific recursive computations by functional programming techniques; the caller passes a function as the update parameter to rollup() (or, at a lower level, passes functions as the get, set, combine, and override parameters to update_prop()) at runtime to specify the desired operations. The implementation relies on graph-theoretic algorithms from the igraph package of Csárdi, et al. (2006 <doi:10.5281/zenodo.7682609>).

PADRINO houses textual representations of Integral Projection Models which can be converted from their table format into full kernels to reproduce or extend an already published analysis. Rpadrino is an R interface to this database. For more information on Integral Projection Models, see Easterling et al. (2000) <doi:10.1890/0012-9658(2000)081[0694:SSSAAN]2.0.CO;2>, Merow et al. (2013) <doi:10.1111/2041-210X.12146>, Rees et al. (2014) <doi:10.1111/1365-2656.12178>, and Metcalf et al. (2015) <doi:10.1111/2041-210X.12405>. See Levin et al. (2021) for more information on ipmr', the engine that powers model reconstruction <doi:10.1111/2041-210X.13683>.

An integrated solution to perform a series of text mining tasks such as importing and cleaning a corpus, and analyses like terms and documents counts, lexical summary, terms co-occurrences and documents similarity measures, graphs of terms, correspondence analysis and hierarchical clustering. Corpora can be imported from spreadsheet-like files, directories of raw text files, as well as from Dow Jones Factiva', LexisNexis', Europresse and Alceste files.

JDemetra+ (<https://github.com/jdemetra/jdemetra-app>) is the seasonal adjustment software officially recommended to the members of the European Statistical System and the European System of Central Banks. Seasonal adjustment models performed with JDemetra+ can be stored into workspaces. JWSACruncher (<https://github.com/jdemetra/jwsacruncher/releases> for v2 and <https://github.com/jdemetra/jdplus-main/releases> for v3) is a console tool that re-estimates all the multi-processing defined in a workspace and to export the result. rjwsacruncher allows to launch easily the JWSACruncher'.