Calculates the coverage of high-throughput short-reads against a genome of reference and summarizes it per feature of interest (e.g. exon, gene, transcript). The data can be normalized as RPKM or by the DESeq or edgeR package.

FISHalyseR provides functionality to process and analyse digital cell culture images, in particular to quantify FISH probes within nuclei. Furthermore, it extract the spatial location of each nucleus as well as each probe enabling spatial co-localisation analysis.

Easily install and load all packages and functions used in CourseKata courses. Aid teaching with helper functions and augment generic functions to provide cohesion between the network of packages. Learn more about CourseKata at <https://www.coursekata.org>.

Perform sparse estimation of a Gaussian graphical model (GGM) with node aggregation through variable clustering. Currently, the package implements the clusterpath estimator of the Gaussian graphical model (CGGM) (Touw, Alfons, Groenen & Wilms, 2025; <doi:10.48550/arXiv.2407.00644>).

This package provides Python'-style list comprehensions. List comprehension expressions use usual loops (for(), while() and repeat()) and usual if() as list producers. In many cases it gives more concise notation than standard "*apply + filter" strategy.

Modifies dot plots to have different sizes of dots mimicking violin plots and identifies modes or peaks for them based on frequency and kernel density estimates (Rosenblatt, 1956) <doi:10.1214/aoms/1177728190> (Parzen, 1962) <doi:10.1214/aoms/1177704472>.

Read Word documents containing bibliographic references, search for corresponding DOIs using the Crossref API, and append the retrieved DOIs directly to the references. Supports parallel processing for faster retrieval and produces a new Word document with numbered references including DOIs.

This package provides methods for dividing data into groups. Create balanced partitions and cross-validation folds. Perform time series windowing and general grouping and splitting of data. Balance existing groups with up- and downsampling or collapse them to fewer groups.

This package performs recursive partitioning of linear and nonlinear mixed effects models, specifically for longitudinal data. The package is an extension of the original longRPart package by Stewart and Abdolell (2013) <https://cran.r-project.org/package=longRPart>.

Interface to the open location server API of Publieke Diensten Op de Kaart (<http://www.pdok.nl>). It offers geocoding, address suggestions and lookup of geographical objects. Included is an utility function for displaying leaflet tiles restricted to the Netherlands.

The NetCoupler algorithm identifies potential direct effects of correlated, high-dimensional variables formed as a network with an external variable. The external variable may act as the dependent/response variable or as an independent/predictor variable to the network.

This package provides methods for generating, exploring and executing seamless Phase II-III designs of Lai, Lavori and Shih using generalized likelihood ratio statistics. Includes pdf and source files that describe the entire R implementation with the relevant mathematical details.

Miscellaneous functions for working with stars objects, mainly single-band rasters. Currently includes functions for: (1) focal filtering, (2) detrending of Digital Elevation Models, (3) calculating flow length, (4) calculating the Convergence Index, (5) calculating topographic aspect and topographic slope.

Blind source separation for multivariate spatial data based on simultaneous/joint diagonalization of (robust) local covariance matrices. This package is an implementation of the methods described in Bachoc, Genton, Nordhausen, Ruiz-Gazen and Virta (2020) <doi:10.1093/biomet/asz079>.

Makes data wrangling with ID-related aspects more comfortable. Provides functions that make it easy to inspect various subject-generated ID codes (SGIC) for plausibility. Also helps with inspecting other common identifiers, ensuring that your data stays clean and reliable.

This package provides simple and fast date manipulation functions operating on character strings in the format DD.MM.YYYY'. Functions include extraction of day, month, and year components, computation of differences between two dates, and addition or subtraction of months.

Analyse data from longitudinal studies to characterise changes in values of semi-quantitative outcome variables within individual subjects, using high performance C++ code to enable rapid processing of large datasets. A flexible methodology is available for codifying these state transitions.

Estimates high-dimensional multivariate normal copula regression models with the weighted composite likelihood estimating equations in Nikoloulopoulos (2023) <doi:10.1016/j.csda.2022.107654>. It provides autoregressive moving average correlation structures and binary, ordinal, Poisson, and negative binomial regressions.

With the DiagrammeR package you can create, modify, analyze, and visualize network graph diagrams. The output can be incorporated into R Markdown documents, integrated with Shiny web apps, converted to other graph formats, or exported as image files.

The Evolutionary Rate Matrix is a variance-covariance matrix which describes both the rates of trait evolution and the evolutionary correlation among multiple traits. This package has functions to estimate these parameters using Bayesian MCMC. It is possible to test if the pattern of evolutionary correlations among traits has changed between predictive regimes painted along the branches of the phylogenetic tree. Regimes can be created a priori or estimated as part of the MCMC under a joint estimation approach. The package has functions to run MCMC chains, plot results, evaluate convergence, and summarize posterior distributions.

This package contains the shared libraries and Python modules of Ren'py. While functional, they are not meaningful on their own without the launcher and common Ren'py code provided by the renpy package and are only used to bootstrap it.

IPC::Run allows you run and interact with child processes using files, pipes, and pseudo-ttys. Both system()-style and scripted usages are supported and may be mixed. Likewise, functional and OO API styles are both supported and may be mixed.

This package encapsulate many functions to conduct a differential topology analysis. It focuses on analyzing an omic dataset with multiple conditions. While the package is mostly geared toward scRNASeq, it does not place any restriction on the actual input format.

ChIP-Enrich and Poly-Enrich perform gene set enrichment testing using peaks called from a ChIP-seq experiment. The method empirically corrects for confounding factors such as the length of genes, and the mappability of the sequence surrounding genes.