Decorate functions to make them return enhanced output. The enhanced output consists in an object of type chronicle containing the result of the function applied to its arguments, as well as a log detailing when the function was run, what were its inputs, what were the errors (if the function failed to run) and other useful information. Tools to handle decorated functions are included, such as a forward pipe operator that makes chaining decorated functions possible.

Optimal design analysis algorithms for any study design that can be represented or modelled as a generalised linear mixed model including cluster randomised trials, cohort studies, spatial and temporal epidemiological studies, and split-plot designs. See <https://github.com/samuel-watson/glmmrBase/blob/master/README.md> for a detailed manual on model specification. A detailed discussion of the methods in this package can be found in Watson, Hemming, and Girling (2023) <doi:10.1177/09622802231202379>.

Measures niche breadth and overlap of microbial taxa from large matrices. Niche breadth measurements include Levins niche breadth (Bn) index, Hurlbert's Bn and Feinsinger's proportional similarity (PS) index. (Feinsinger, P., Spears, E.E., Poole, R.W. (1981) <doi:10.2307/1936664>). Niche overlap measurements include Levin's Overlap (Ludwig, J.A. and Reynolds, J.F. (1988, ISBN:0471832359)) and a Jaccard similarity index of Feinsinger's PS values between taxa pairs, as Proportional Overlap.

Learning and using the Metropolis algorithm for Bayesian fitting of a generalized linear model. The package vignette includes examples of hand-coding a logistic model using several variants of the Metropolis algorithm. The package also contains R functions for simulating posterior distributions of Bayesian generalized linear model parameters using guided, adaptive, guided-adaptive and random walk Metropolis algorithms. The random walk Metropolis algorithm was originally described in Metropolis et al (1953); <doi:10.1063/1.1699114>.

Find recursive dependencies of R packages from various sources. Solve the dependencies to obtain a consistent set of packages to install. Download packages, and install them. It supports packages on CRAN', Bioconductor and other CRAN-like repositories, GitHub', package URLs', and local package trees and files. It caches metadata and package files via the pkgcache package, and performs all HTTP requests, downloads, builds and installations in parallel. pkgdepends is the workhorse of the pak package.

This package provides tools for estimating model-agnostic prediction intervals using conformal prediction, bootstrapping, and parametric prediction intervals. The package is designed for ease of use, offering intuitive functions for both binned and full conformal prediction methods, as well as parametric interval estimation with diagnostic checks. Currently only working for continuous predictions. For details on the conformal and bin-conditional conformal prediction methods, see Randahl, Williams, and Hegre (2024) <DOI:10.48550/arXiv.2410.14507>.

This package provides a single function to fit data of an input data frame into one of the selected Weibull functions (w2, w3 and it's truncated versions), calculating the scale, location and shape parameters accordingly. The resulting plots and files are saved into the folder parameter provided by the user. References: a) John C. Nash, Ravi Varadhan (2011). "Unifying Optimization Algorithms to Aid Software System Users: optimx for R" <doi:10.18637/jss.v043.i09>.

ETS stands for Error, Trend, and Seasonality, and it is a popular time series forecasting method. Wavelet decomposition can be used for denoising, compression, and feature extraction of signals. By removing the high-frequency components, wavelet decomposition can remove noise from the data while preserving important features. A hybrid Wavelet ETS (Error Trend-Seasonality) model has been developed for time series forecasting using algorithm of Anjoy and Paul (2017) <DOI:10.1007/s00521-017-3289-9>.

Provide a sparse matrix format with data stored on disk, to be used in both R and C++. This is intended for more efficient use of sparse data in C++ and also when parallelizing, since data on disk does not need copying. Only a limited number of features will be implemented. For now, conversion can be performed from a dgCMatrix or a dsCMatrix from R package Matrix'. A new compact format is also now available.

One haplotype is a combination of SNP (Single Nucleotide Polymorphisms) within the QTL (Quantitative Trait Loci). clusterhap groups together all individuals of a population with the same haplotype. Each group contains individual with the same allele in each SNP, whether or not missing data. Thus, clusterhap groups individuals, that to be imputed, have a non-zero probability of having the same alleles in the entire sequence of SNP's. Moreover, clusterhap calculates such probability from relative frequencies.

This package provides a modified hierarchical test (Liu (2017) <doi:10.1214/17-AOS1539>) for detecting the structural difference between two Semiparametric Gaussian graphical models. The multiple testing procedure asymptotically controls the false discovery rate (FDR) at a user-specified level. To construct the test statistic, a truncated estimator is used to approximate the transformation functions and two R functions including lassoGGM() and lassoNPN() are provided to compute the lasso estimates of the regression coefficients.

This package provides a small set of tools for formatting numbers in R-markdown documents. Convert a numerical vector to character strings in power-of-ten form, decimal form, or measurement-units form; all are math-delimited for rendering as inline equations. Can also convert text into math-delimited text to match the font face and size of math-delimited numbers. Useful for rendering single numbers in inline R code chunks and for rendering columns in tables.

Reconstruct birth-year specific probabilities of immune imprinting to influenza A, using the methods of Gostic et al. (2016) <doi:10.1126/science.aag1322>. Plot, save, or export the calculated probabilities for use in your own research. By default, the package calculates subtype-specific imprinting probabilities, but with user-provided frequency data, it is possible to calculate probabilities for arbitrary kinds of primary exposure to influenza A, including primary vaccination and exposure to specific clades, strains, etc.

This package provides a tool for visualizing numerical data (such as gene expression levels) on human organ maps. It supports custom color schemes, organ system filtering, and optional bar charts for quantitative comparison. The package integrates organ coordinate data to plot anatomical contours and map data values to specific organs, facilitating intuitive visualization of biological data distribution. The underlying method was described in the preprint by Zhou et al. (2022) <doi:10.1101/2022.09.07.506938>.

Enables small area estimation (SAE) of health and demographic indicators in low- and middle-income countries (LMICs). It powers an R shiny application for generating subnational estimates and prevalence maps of 150+ binary indicators from Demographic and Health Surveys (DHS). It builds on the SAE analysis workflow from the surveyPrev package. For documentation, visit <https://sae4health.stat.uw.edu/>. Methodological details can be found at Wu et al. (2025) <doi:10.48550/arXiv.2505.01467>.

ChromSCape - Chromatin landscape profiling for Single Cells - is a ready-to-launch user-friendly Shiny Application for the analysis of single-cell epigenomics datasets (scChIP-seq, scATAC-seq, scCUT&Tag, ...) from aligned data to differential analysis & gene set enrichment analysis. It is highly interactive, enables users to save their analysis and covers a wide range of analytical steps: QC, preprocessing, filtering, batch correction, dimensionality reduction, vizualisation, clustering, differential analysis and gene set analysis.

MPRAnalyze provides statistical framework for the analysis of data generated by Massively Parallel Reporter Assays (MPRAs), used to directly measure enhancer activity. MPRAnalyze can be used for quantification of enhancer activity, classification of active enhancers and comparative analyses of enhancer activity between conditions. MPRAnalyze construct a nested pair of generalized linear models (GLMs) to relate the DNA and RNA observations, easily adjustable to various experimental designs and conditions, and provides a set of rigorous statistical testig schemes.

Gene-regulatory network (GRN) modeling seeks to infer dependencies between genes and thereby provide insight into the regulatory relationships that exist within a cell. This package provides a computational Bayesian approach to GRN estimation from perturbation experiments using a ternary network model, in which gene expression is discretized into one of 3 states: up, unchanged, or down). The ternarynet package includes a parallel implementation of the replica exchange Monte Carlo algorithm for fitting network models, using MPI.

This package provides a number of functions to create and analyze factorial plans according to the Design of Experiments (DoE) approach, with the addition of some utility function to perform some statistical analyses. DoE approach follows the approach in "Design and Analysis of Experiments" by Douglas C. Montgomery (2019, ISBN:978-1-119-49244-3). The package also provides utilities used in the course "Analysis of Data and Statistics" at the University of Trento, Italy.

Blocks units into experimental blocks, with one unit per treatment condition, by creating a measure of multivariate distance between all possible pairs of units. Maximum, minimum, or an allowable range of differences between units on one variable can be set. Randomly assign units to treatment conditions. Diagnose potential interference between units assigned to different treatment conditions. Write outputs to .tex and .csv files. For more information on the methods implemented, see Moore (2012) <doi:10.1093/pan/mps025>.

Processing and analyzing omics data from genomics, transcriptomics, proteomics, and metabolomics platforms. It provides functions for preprocessing, normalization, visualization, and statistical analysis, as well as machine learning algorithms for predictive modeling. omicsTools is an essential tool for researchers working with high-throughput omics data in fields such as biology, bioinformatics, and medicine.The QC-RLSC (quality controlâ based robust LOESS signal correction) algorithm is used for normalization. Dunn et al. (2011) <doi:10.1038/nprot.2011.335>.

ProTracker is a popular music tracker to sequence music on a Commodore Amiga machine. This package offers the opportunity to import, export, manipulate and play ProTracker module files. Even though the file format could be considered archaic, it still remains popular to this date. This package intends to contribute to this popularity and therewith keeping the legacy of ProTracker and the Commodore Amiga alive. This package is the successor of ProTrackR providing better performance.

Standardized accuracy (staccuracy) is a framework for expressing accuracy scores such that 50% represents a reference level of performance and 100% is a perfect prediction. The staccuracy package provides tools for creating staccuracy functions as well as some recommended staccuracy measures. It also provides functions for some classic performance metrics such as mean absolute error (MAE), root mean squared error (RMSE), and area under the receiver operating characteristic curve (AUCROC), as well as their winsorized versions when applicable.

Label propagation approaches are a widely used procedure in computational biology for giving context to molecular entities using network data. Node labels, which can derive from gene expression, genome-wide association studies, protein domains or metabolomics profiling, are propagated to their neighbours in the network, effectively smoothing the scores through prior annotated knowledge and prioritising novel candidates. The R package diffuStats contains a collection of diffusion kernels and scoring approaches that facilitates their computation, characterisation and benchmarking.