Mining informative genes with certain biological meanings are important for clinical diagnosis of disease and discovery of disease mechanisms in plants and animals. This process involves identification of relevant genes and removal of redundant genes as much as possible from a whole gene set. This package selects the informative genes related to a specific trait using gene expression dataset. These trait specific genes are considered as informative genes. This package returns the informative gene set from the high dimensional gene expression data using a combination of methods SVM and MRMR (for feature selection) with bootstrapping procedure.

Perform fast and memory efficient time-weighted averaging of values measured over intervals into new arbitrary intervals. This package is useful in the context of data measured or represented as constant values over intervals on a one-dimensional discrete axis (e.g. time-integrated averages of a curve over defined periods). This package was written specifically to deal with air pollution data recorded or predicted as averages over sampling periods. Data in this format often needs to be shifted to non-aligned periods or averaged up to periods of longer duration (e.g. averaging data measured over sequential non-overlapping periods to calendar years).

Query for enriched data such as country, region, city, latitude & longitude, ZIP code, time zone, Autonomous System, Internet Service Provider, domain, net speed, International direct dialing (IDD) code, area code, weather station data, mobile data, elevation, usage type, address type, advertisement category, fraud score, and proxy data with an IP address. You can also query a list of hosted domain names for the IP address too. This package uses the IP2Location.io API to query this data. To get started with a free API key, sign up here <https://www.ip2location.io/sign-up?ref=1>.

Identify Cancer Dysfunctional Sub-pathway by integrating gene expression, DNA methylation and copy number variation, and pathway topological information. 1)We firstly calculate the gene risk scores by integrating three kinds of data: DNA methylation, copy number variation, and gene expression. 2)Secondly, we perform a greedy search algorithm to identify the key dysfunctional sub-pathways within the pathways for which the discriminative scores were locally maximal. 3)Finally, the permutation test was used to calculate statistical significance level for these key dysfunctional sub-pathways.

This package provides functions to make inference about the standardized mortality ratio (SMR) when evaluating the effect of a screening program. The package is based on methods described in Sasieni (2003) <doi: 10.1097/00001648-200301000-00026> and Talbot et al. (2011) <doi: 10.1002/sim.4334>.

This package provides a set of functions for the modeling of data derived from the Minidisc Infiltrometer device. It calculates cumulative infiltration and square root of time. Also, it calculates the A parameter based on soil physical properties.

The implement of integrative analysis methods based on a two-part penalization, which realizes dimension reduction analysis and mining the heterogeneity and association of multiple studies with compatible designs. The software package provides the integrative analysis methods including integrative sparse principal component analysis (Fang et al., 2018), integrative sparse partial least squares (Liang et al., 2021) and integrative sparse canonical correlation analysis, as well as corresponding individual analysis and meta-analysis versions. References: (1) Fang, K., Fan, X., Zhang, Q., and Ma, S. (2018). Integrative sparse principal component analysis. Journal of Multivariate Analysis, <doi:10.1016/j.jmva.2018.02.002>. (2) Liang, W., Ma, S., Zhang, Q., and Zhu, T. (2021). Integrative sparse partial least squares. Statistics in Medicine, <doi:10.1002/sim.8900>.

The Importance Index (I.I.) can determine the loss and solution sources for a system in certain knowledge areas (e.g., agronomy), when production (e.g., fruits) is known (Demolin-Leite, 2021). Events (e.g., agricultural pest) can have different magnitudes (numerical measurements), frequencies, and distributions (aggregate, random, or regular) of event occurrence, and I.I. bases in this triplet (Demolin-Leite, 2021) <https://cjascience.com/index.php/CJAS/article/view/1009/1319>. Usually, the higher the magnitude and frequency of aggregated distribution, the greater the problem or the solution (e.g., natural enemies versus pests) for the system (Demolin-Leite, 2021). However, the final production of the system is not always known or is difficult to determine (e.g., degraded area recovery). A derivation of the I.I. is the percentage of Importance Index-Production Unknown (% I.I.-PU) that can detect the loss or solution sources, when production is unknown for the system (Demolin-Leite, 2024) <DOI:10.1590/1519-6984.253218>.

This package provides a suite of functions for conducting and interpreting analysis of statistical interaction in regression models that was formerly part of the jtools package. Functionality includes visualization of two- and three-way interactions among continuous and/or categorical variables as well as calculation of "simple slopes" and Johnson-Neyman intervals (see e.g., Bauer & Curran, 2005 <doi:10.1207/s15327906mbr4003_5>). These capabilities are implemented for generalized linear models in addition to the standard linear regression context.

This package implements the procedures suggested in Esarey and Sumner (2017) <http://justinesarey.com/interaction-overconfidence.pdf> for controlling the false discovery rate when constructing marginal effects plots for models with interaction terms.

This is the central location for data and tools for the development, maintenance, analysis, and deployment of the International Soil Radiocarbon Database (ISRaD). ISRaD was developed as a collaboration between the U.S. Geological Survey Powell Center and the Max Planck Institute for Biogeochemistry. This R package provides tools for accessing and manipulating ISRaD data, compiling local data using the ISRaD data structure, and simple query and reporting functions for ISRaD. For more detailed information visit the ISRaD website at: <https://soilradiocarbon.org/>.

Sieve semiparametric likelihood methods for analyzing interval-censored failure time data from an outcome-dependent sampling (ODS) design and from a case-cohort design. Zhou, Q., Cai, J., and Zhou, H. (2018) <doi:10.1111/biom.12744>; Zhou, Q., Zhou, H., and Cai, J. (2017) <doi:10.1093/biomet/asw067>.

This package provides functions and classes to compute, handle and visualise incidence from dated events for a defined time interval. Dates can be provided in various standard formats. The class incidence is used to store computed incidence and can be easily manipulated, subsetted, and plotted. In addition, log-linear models can be fitted to incidence objects using fit'. This package is part of the RECON (<https://www.repidemicsconsortium.org/>) toolkit for outbreak analysis.

This package provides a simplified version of the IDSL.UFA package to calculate isotopic profiles and adduct formulas from molecular formulas with no dependency on other R packages for online tools and educational mass spectrometry courses. The IDSL.SUFA package also provides an ancillary module to process user-defined adduct formulas.

Some basic functions to implement belief functions including: transformation between belief functions using the method introduced by Philippe Smets <arXiv:1304.1122>, evidence combination, evidence discounting, decision-making, and constructing masses. Currently, thirteen combination rules and six decision rules are supported. It can also be used to generate different types of random masses when working on belief combination and conflict management.

This package implements approximate Bayesian inference for Structural Equation Models (SEM) using a custom adaptation of the Integrated Nested Laplace Approximation as described in Rue et al. (2009) <doi:10.1111/j.1467-9868.2008.00700.x>. Provides a computationally efficient alternative to Markov Chain Monte Carlo (MCMC) for Bayesian estimation, allowing users to fit latent variable models using the lavaan syntax.

This package implements a nonparametric maximum likelihood method for assessing potentially time-varying vaccine efficacy (VE) against SARS-CoV-2 infection under staggered enrollment and time-varying community transmission, allowing crossover of placebo volunteers to the vaccine arm. Lin, D. Y., Gu, Y., Zeng, D., Janes, H. E., and Gilbert, P. B. (2021) <doi:10.1093/cid/ciab630>.

Interactive dendrogram that enables the user to select and color clusters, to zoom and pan the dendrogram, and to visualize the clustered data not only in a built-in heat map, but also in GGobi interactive plots and user-supplied plots. This is a backport of Qt-based idendro (<https://github.com/tsieger/idendro>) to base R graphics and Tcl/Tk GUI.

Computes intervention in prediction measure for assessing variable importance for random forests. See details at I. Epifanio (2017) <DOI:10.1186/s12859-017-1650-8>.

Compute missing values on a training data set and impute them on a new data set. Current available options are median/mode and random forest.

This package provides composable invertible transforms for (sparse) matrices.

This package provides a comprehensive toolkit for clinical Human Leukocyte Antigen (HLA) informatics, built on tidyverse <https://tidyverse.tidyverse.org/> principles and making use of genotype list string (GL string, Mack et al. (2023) <doi:10.1111/tan.15126>) for storing and computing HLA genotype data. Specific functionalities include: coercion of HLA data in tabular format to and from GL string; calculation of matching and mismatching in all directions, with multiple output formats; automatic formatting of HLA data for searching within a GL string; truncation of molecular HLA data to a specific number of fields; and reading HLA genotypes in HML files and extracting the GL string. This library is intended for research use. Any application making use of this package in a clinical setting will need to be independently validated according to local regulations.

Pre-processing and basic analytical tasks for working with Eurostat's symmetric inputâ output tables, and basic inputâ output economics calculations. Part of rOpenGov <https://ropengov.github.io/> for open source open government initiatives.

Helps with the thoughtful saving, reading, and management of result files (using rds files). The core functions take a list of parameters that are used to generate a unique hash to save results under. Then, the same parameter list can be used to read those results back in. This is helpful to avoid clunky file naming when running a large number of simulations. Additionally, helper functions are available for compiling a flat file of parameters of saved results, monitoring result usage, and cleaning up unwanted or unused results. For more information, visit the indexr homepage <https://lharris421.github.io/indexr/>.