The nls.lm function provides an R interface to lmder and lmdif from the MINPACK library, for solving nonlinear least-squares problems by a modification of the Levenberg-Marquardt algorithm, with support for lower and upper parameter bounds. The implementation can be used via nls-like calls using the nlsLM function.

This package provides S4 classes for general nucleases, CRISPR nucleases, CRISPR nickases, and base editors.Several CRISPR-specific genome arithmetic functions are implemented to help extract genomic coordinates of spacer and protospacer sequences. Commonly-used CRISPR nuclease objects are provided that can be readily used in other packages. Both DNA- and RNA-targeting nucleases are supported.

HMP16SData is a Bioconductor ExperimentData package of the Human Microbiome Project (HMP) 16S rRNA sequencing data for variable regions 1–3 and 3–5. Raw data files are provided in the package as downloaded from the HMP Data Analysis and Coordination Center. Processed data is provided as SummarizedExperiment class objects via ExperimentHub.

ncRNAtools provides a set of basic tools for handling and analyzing non-coding RNAs. These include tools to access the RNAcentral database and to predict and visualize the secondary structure of non-coding RNAs. The package also provides tools to read, write and interconvert the file formats most commonly used for representing such secondary structures.

This package contains a set of functions to perform large-scale analysis of pharmaco-genomic data. These include the PharmacoSet object for storing the results of pharmacogenomic experiments, as well as a number of functions for computing common summaries of drug-dose response and correlating them with the molecular features in a cancer cell-line.

The ggarrow package is a ggplot2 extension that plots a variety of different arrow segments with many options to customize. The arrowheadr package makes it easy to create custom arrowheads and fins within the parameters that ggarrow functions expect. It has preset arrowheads and a collection of functions to create and transform data for customizing arrows.

An interface to Azure Queue Storage'. This is a cloud service for storing large numbers of messages, for example from automated sensors, that can be accessed remotely via authenticated calls using HTTP or HTTPS. Queue storage is often used to create a backlog of work to process asynchronously. Part of the AzureR family of packages.

Interface to the Azure Machine Learning Software Development Kit ('SDK'). Data scientists can use the SDK to train, deploy, automate, and manage machine learning models on the Azure Machine Learning service. To learn more about Azure Machine Learning visit the website: <https://docs.microsoft.com/en-us/azure/machine-learning/service/overview-what-is-azure-ml>.

Inference of protein complex states from quantitative proteomics data. The package takes information on known stable protein interactions (i.e. protein components of the same complex) and assesses how protein quantitative ratios change between different conditions. It reports protein pairs for which relative protein quantities to each other have been significantly altered in the tested condition.

Microsoft Word docx files provide an XML structure that is fairly straightforward to navigate, especially when it applies to Word tables and comments. Tools are provided to determine table count/structure, comment count and also to extract/clean tables and comments from Microsoft Word docx documents. There is also nascent support for .doc and .pptx files.

Enables users to incorporate expert opinion with parametric survival analysis using a Bayesian or frequentist approach. Expert Opinion can be provided on the survival probabilities at certain time-point(s) or for the difference in mean survival between two treatment arms. Please reference it's use as Cooney, P., White, A. (2023) <doi:10.1177/0272989X221150212>.

This package implements three complementary pipelines for causal analysis on macroeconomic time series: (1) Error-Correction Models with Multivariate Adaptive Regression Splines (ECM-MARS), (2) Bayesian Structural Time Series (BSTS), and (3) Bayesian GLM with AR(1) errors validated with Leave-Future-Out (LFO). Heavy backends (Stan) are optional and never used in examples or tests.

Play or simulate games of "Four in a Row" in the R console. This package is designed for educational purposes, encouraging users to write their own functions to play the game automatically. It contains a collection of built-in functions that play the game at various skill levels, for users to test their own functions against.

This package provides a tidy R interface for count time series analysis. It includes implementation of the INGARCH (Integer Generalized Autoregressive Conditional Heteroskedasticity) model from the tscount package and the GLARMA (Generalized Linear Autoregressive Moving Averages) model from the glarma package. Additionally, it offers automated parameter selection algorithms based on the minimization of a penalized likelihood.

Scrapes football match shots data from Understat <https://understat.com/> and visualizes it using interactive plots: - A detailed shot map displaying the location, type, and xG value of shots taken by both teams. - An xG timeline chart showing the cumulative xG for each team over time, annotated with the details of scored goals.

Fit, summarize and plot sinusoidal hysteretic processes using: two-step simple harmonic least squares, ellipse-specific non-linear least squares, the direct method, geometric least squares or linear least squares. See Yang, F and A. Parkhurst, "Efficient Estimation of Elliptical Hysteresis with Application to the Characterization of Heat Stress" <DOI:10.1007/s13253-015-0213-6>.

Generates Rd files from R source code with comments. The main features of the default syntax are that (1) docs are defined in comments near the relevant code, (2) function argument names are not repeated in comments, and (3) examples are defined in R code, not comments. It is also easy to define a new syntax.

Local explanations of machine learning models describe, how features contributed to a single prediction. This package implements an explanation method based on LIME (Local Interpretable Model-agnostic Explanations, see Tulio Ribeiro, Singh, Guestrin (2016) <doi:10.1145/2939672.2939778>) in which interpretable inputs are created based on local rather than global behaviour of each original feature.

This package provides an l1-version of the spectral clustering algorithm devoted to robustly clustering highly perturbed graphs using l1-penalty. This algorithm is described with more details in the preprint C. Champion, M. Champion, M. Blazère, R. Burcelin and J.M. Loubes, "l1-spectral clustering algorithm: a spectral clustering method using l1-regularization" (2022).

Various functions are provided to estimate parametric mixture models (with Gaussian, t, Laplace, log-concave distributions, etc.) and non-parametric mixture models. The package performs hypothesis tests and addresses label switching issues in mixture models. The package also allows for parameter estimation in mixture of regressions, proportion-varying mixture of regressions, and robust mixture of regressions.

Installs an updated version of pomdp-solve and provides a low-level interface. Pomdp-solve is a program to solve Partially Observable Markov Decision Processes (POMDPs) using a variety of exact and approximate value iteration algorithms. A convenient R infrastructure is provided in the separate package pomdp. Hahsler and Cassandra <doi:10.32614/RJ-2024-021>.

Automates the process of creating a scale bar and north arrow in any package that uses base graphics to plot in R. Bounding box tools help find and manipulate extents. Finally, there is a function to automate the process of setting margins, plotting the map, scale bar, and north arrow, and resetting graphic parameters upon completion.

This package provides a collection of highly configurable, touch-enabled knob input controls for shiny'. These components can be styled to fit in perfectly in any app, and allow users to set precise values through many input modalities. Users can touch-and-drag, click-and-drag, scroll their mouse wheel, double click, or use keyboard input.

This package provides functions to support economic modelling in R based on the methods of the Dutch guideline for economic evaluations in healthcare <https://www.zorginstituutnederland.nl/documenten/2024/01/16/richtlijn-voor-het-uitvoeren-van-economische-evaluaties-in-de-gezondheidszorg>, CBS data <https://www.cbs.nl/>, and OECD data <https://www.oecd.org/en.html>.