Kernel density estimation with hexagonal grid for bivariate data. Hexagonal grid has many beneficial properties like equidistant neighbours and less edge bias, making it better for spatial analyses than the more commonly used rectangular grid. Carr, D. B. et al. (1987) <doi:10.2307/2289444>. Diggle, P. J. (2010) <doi:10.1201/9781420072884>. Hill, B. (2017) <https://blog.bruce-hill.com/meandering-triangles>. Jones, M. C. (1993) <doi:10.1007/BF00147776>.

Predicts any variable in any categorical dataset for given values of predictor variables. If a dataset contains 4 variables, then any variable can be predicted based on the values of the other three variables given by the user. The user can upload their own datasets and select what variable they want to predict. A handsontable is provided to enter the predictor values and also accuracy of the prediction is also shown.

Build CPMs (cumulative probability models, also known as cumulative link models) to account for detection limits (both single and multiple detection limits) in response variables. Conditional quantiles and conditional CDFs can be calculated based on fitted models. The package implements methods described in Tian, Y., Li, C., Tu, S., James, N. T., Harrell, F. E., & Shepherd, B. E. (2022). "Addressing Detection Limits with Semiparametric Cumulative Probability Models". <arXiv:2207.02815>.

This package implements the three parallel forecast combinations of Markov Switching GARCH and extreme learning machine model along with the selection of appropriate model for volatility forecasting. For method details see Hsiao C, Wan SK (2014). <doi:10.1016/j.jeconom.2013.11.003>, Hansen BE (2007). <doi:10.1111/j.1468-0262.2007.00785.x>, Elliott G, Gargano A, Timmermann A (2013). <doi:10.1016/j.jeconom.2013.04.017>.

Bayesian logistic regression model with optional EXchangeability-NonEXchangeability parameter modelling for flexible borrowing from historical or concurrent data-sources. The safety model can guide dose-escalation decisions for adaptive oncology Phase I dose-escalation trials which involve an arbitrary number of drugs. Please refer to Neuenschwander et al. (2008) <doi:10.1002/sim.3230> and Neuenschwander et al. (2016) <doi:10.1080/19466315.2016.1174149> for details on the methodology.

This package provides a framework for building enterprise, scalable and UI-standardized shiny applications. It brings enhanced features such as bootstrap v4 <https://getbootstrap.com/docs/4.0/getting-started/introduction/>, additional and enhanced shiny modules, customizable UI features, as well as an enhanced application file organization paradigm. This update allows developers to harness the ability to build powerful applications and enriches the shiny developers experience when building and maintaining applications.

Tide analysis and prediction of predominantly semi-diurnal tides with two high waters and two low waters during one lunar day (~24.842 hours, ~1.035 days). The analysis should preferably cover an observation period of at least 19 years. For shorter periods, for example, the nodal cycle can not be taken into account, which particularly affects the height calculation. The main objective of this package is to produce tide tables.

This package provides a toolkit to detect clusters from distance matrices. The distance matrices are assumed to be calculated between the cells of multiple animals ('Caenorhabditis elegans') from input time-series matrices. Some functions for generating distance matrices, performing clustering, evaluating the clustering, and visualizing the results of clustering and evaluation are available. We're also providing the download function to retrieve the calculated distance matrices from figshare <https://figshare.com>.

The Hashery is a tight collection of Hash-like classes. Included are the auto-sorting Dictionary class, the efficient LRUHash, the flexible OpenHash and the convenient KeyHash. Nearly every class is a subclass of the CRUDHash which defines a CRUD (Create, Read, Update and Delete) model on top of Ruby's standard Hash making it possible to subclass and augment to fit any specific use case.

MSstatsPTM provides general statistical methods for quantitative characterization of post-translational modifications (PTMs). Supports DDA, DIA, SRM, and tandem mass tag (TMT) labeling. Typically, the analysis involves the quantification of PTM sites (i.e., modified residues) and their corresponding proteins, as well as the integration of the quantification results. MSstatsPTM provides functions for summarization, estimation of PTM site abundance, and detection of changes in PTMs across experimental conditions.

This package provides a shiny interface to the scanMiR package. The application enables the scanning of transcripts and custom sequences for miRNA binding sites, the visualization of KdModels and binding results, as well as browsing predicted repression data. In addition contains the IndexedFst class for fast indexed reading of large GenomicRanges or data.frames, and some utilities for facilitating scans and identifying enriched miRNA-target pairs.

This package provides simple and intuitive functions for basic statistical analyses. Methods include the t-test (Student 1908 <doi:10.1093/biomet/6.1.1>), the Mann-Whitney U test (Mann and Whitney 1947 <doi:10.1214/aoms/1177730491>), Pearson's correlation (Pearson 1895 <doi:10.1098/rspl.1895.0041>), and analysis of variance (Fisher 1925, <doi:10.1007/978-1-4612-4380-9_5>). Functions are compatible with ggplot2 and dplyr'.

Construct the admissible exact intervals for the binomial proportion, the Poisson mean and the total number of subjects with a certain attribute or the total number of the subjects for the hypergeometric distribution. Both one-sided and two-sided intervals are of interest. This package can be used to calculate the intervals constructed methods developed by Wang (2014) <doi:10.5705/ss.2012.257> and Wang (2015) <doi:10.1111/biom.12360>.

This package provides classes and methods for handling networks or graphs whose nodes are geographical (i.e. locations in the globe). The functionality includes the creation of objects of class geonetwork as a graph with node coordinates, the computation of network measures, the support of spatial operations (projection to different Coordinate Reference Systems, handling of bounding boxes, etc.) and the plotting of the geonetwork object combined with supplementary cartography for spatial representation.

This package contains kidney care oriented functions. Current version contains functions for calculation of: - Estimated glomerular filtration rate by CKD-EPI (2021 and 2009), MDRD, CKiD, FAS, EKFC, etc. - Kidney Donor Risk Index and Kidney Donor Profile Index for kidney transplant donors. - Citation: Bikbov B. kidney.epi: Kidney-Related Functions for Clinical and Epidemiological Research. Scientific-Tools.Org, <https://Scientific-Tools.Org>. <doi:10.32614/CRAN.package.kidney.epi>.

Analysis of kin-cohort studies. kin.cohort provides estimates of age-specific cumulative risk of a disease for carriers and noncarriers of a mutation. The cohorts are retrospectively built from relatives of probands for whom the genotype is known. Currently the method of moments and marginal maximum likelihood are implemented. Confidence intervals are calculated from bootstrap samples. Most of the code is a translation from previous MATLAB code by N. Chatterjee.

This package provides a single function options.ifunset(...) is contained herewith, which allows the user to set a global option ONLY if it is not already set. By this token, for package maintainers this function can be used in preference to the standard options(...) function, making provision for THEIR end user to place options(...) directives within their .Rprofile file, which will not be overridden at the point when a package is loaded.

This package provides a C++ backend for multivariate phylogenetic comparative models implemented in the R-package PCMBase'. Can be used in combination with PCMBase to enable fast and parallel likelihood calculation. Implements the pruning likelihood calculation algorithm described in Mitov et al. (2020) <doi:10.1016/j.tpb.2019.11.005>. Uses the SPLITT C++ library for parallel tree traversal described in Mitov and Stadler (2018) <doi:10.1111/2041-210X.13136>.

There are three sets of functions. The first produces basic properties of a graph and generates samples from multinomial distributions to facilitate the simulation functions (they maybe used for other purposes as well). The second provides various simulation functions for a Potts model in Potts, R. B. (1952) <doi:10.1017/S0305004100027419>. The third currently includes only one function which computes the normalizing constant of a Potts model based on simulation results.

Computes normalized cycle threshold (Ct) values (delta Ct) from raw quantitative polymerase chain reaction (qPCR) Ct values and conducts test of significance using t.test(). Plots expression values based from log2(2^(-1*delta delta Ct)) across groups per gene of interest. Methods for calculation of delta delta Ct and relative expression (2^(-1*delta delta Ct)) values are described in: Livak & Schmittgen, (2001) <doi:10.1006/meth.2001.1262>.

Empowers users to fuzzily-merge data frames with millions or tens of millions of rows in minutes with low memory usage. The package uses the locality sensitive hashing algorithms developed by Datar, Immorlica, Indyk and Mirrokni (2004) <doi:10.1145/997817.997857>, and Broder (1998) <doi:10.1109/SEQUEN.1997.666900> to avoid having to compare every pair of records in each dataset, resulting in fuzzy-merges that finish in linear time.

Wrapper for widely used SUNDIALS software (SUite of Nonlinear and DIfferential/ALgebraic Equation Solvers) and more precisely to its CVODES solver. It is aiming to solve ordinary differential equations (ODE) and optionally pending forward sensitivity problem. The wrapper is made R friendly by allowing to pass custom parameters to user's callback functions. Such functions can be both written in R and in C++ ('RcppArmadillo flavor). In case of C++', performance is greatly improved so this option is highly advisable when performance matters. If provided, Jacobian matrix can be calculated either in dense or sparse format. In the latter case rmumps package is used to solve corresponding linear systems. Root finding and pending event management are optional and can be specified as R or C++ functions too. This makes them a very flexible tool for controlling the ODE system during the time course simulation. SUNDIALS library was published in Hindmarsh et al. (2005) <doi:10.1145/1089014.1089020>.

This package provides some easy-to-use functions to extract and visualize the output of multivariate data analyses, including PCA (Principal Component Analysis), CA (Correspondence Analysis), MCA (Multiple Correspondence Analysis), FAMD (Factor Analysis of Mixed Data), MFA (Multiple Factor Analysis) and HMFA (Hierarchical Multiple Factor Analysis) functions from different R packages. It contains also functions for simplifying some clustering analysis steps and provides ggplot2-based elegant data visualization.

As a successor of the packages BatchJobs and BatchExperiments, this package provides a parallel implementation of the Map function for high performance computing systems managed by various schedulers. A multicore and socket mode allow the parallelization on a local machines, and multiple machines can be hooked up via SSH to create a makeshift cluster. Moreover, the package provides an abstraction mechanism to define large-scale computer experiments in a well-organized and reproducible way.