Identity by Descent (IBD) distributions in pedigrees. A Hidden Markov Model is used to compute identity coefficients, simulate IBD segments and to derive the distribution of total IBD sharing and segment count across chromosomes. The methods are applied in Kruijver (2025) <doi:10.3390/genes16050492>. The probability that the total IBD sharing is zero can be computed using the method of Donnelly (1983) <doi:10.1016/0040-5809(83)90004-7>.

This package provides a joint mixture model has been developed by Majumdar et al. (2025) <doi:10.48550/arXiv.2412.17511> that integrates information from gene expression data and methylation data at the modelling stage to capture their inherent dependency structure, enabling simultaneous identification of differentially methylated cytosine-guanine dinucleotide (CpG) sites and differentially expressed genes. The model leverages a joint likelihood function that accounts for the nested structure in the data, with parameter estimation performed using an expectation-maximisation algorithm.

An implementation of the MaxLFQ algorithm by Cox et al. (2014) <doi:10.1074/mcp.M113.031591> in a comprehensive pipeline for processing proteomics data in data-independent acquisition mode (Pham et al. 2020 <doi:10.1093/bioinformatics/btz961>). It offers additional options for protein quantification using the N most intense fragment ions, using all fragment ions, the median polish algorithm by Tukey (1977, ISBN:0201076160), and a robust linear model. In general, the tool can be used to integrate multiple proportional observations into a single quantitative value.

This package contains a number of infix binary operators that may be useful in day to day practices.

This package provides advanced functions for image processing based on the package imager'.

Convert historical monetary values into their present-day equivalents using bundled CPI (Consumer Price Index) and GDP deflator data sourced from the World Bank Development Indicators. Supports British pounds (GBP), Australian dollars (AUD), US dollars (USD), Euro (EUR), Canadian dollars (CAD), Japanese yen (JPY), Chinese yuan (CNY), Swiss francs (CHF), New Zealand dollars (NZD), Indian rupees (INR), South Korean won (KRW), Brazilian reais (BRL), and Norwegian krone (NOK). Currency codes and country names are both accepted as input.

You can access to open data published in Instituto Canario De Estadistica (ISTAC) APIs at <https://datos.canarias.es/api/estadisticas/>.

This package implements the compartment model from Tokars (2018) <doi:10.1016/j.vaccine.2018.10.026>. This enables quantification of population-wide impact of vaccination against vaccine-preventable diseases such as influenza.

This package provides a suite of functions to use with regression models, including summaries, residual plots, and factor comparisons. Used as part of the Model Fitting module of iNZight', a graphical user interface providing easy exploration and visualisation of data for students of statistics, available in both desktop and online versions.

Evaluating if values of vectors are within different open/closed intervals (`x %[]% c(a, b)`), or if two closed intervals overlap (`c(a1, b1) %[]o[]% c(a2, b2)`). Operators for negation and directional relations also implemented.

This package provides tools for estimating uncertainty in individual polygenic risk scores (PRSs) using both sampling-based and analytical methods, as well as the Best Linear Unbiased Estimator (BLUE). These methods quantify variability in PRS estimates for both binary and quantitative traits. See Henderson (1975) <doi:10.2307/2529430> for more details.

Manage a GitHub problem using R: wrangle issues, labels and milestones. It includes functions for storing, prioritizing (sorting), displaying, adding, deleting, and selecting (filtering) issues based on qualitative and quantitative information. Issues (labels and milestones) are written in lists and categorized into the S3 class to be easily manipulated as datasets in R.

This package performs Goodness of Fit for regression models using Integrated Regression method. Works for several different fitting techniques.

Prepare objects to implement models over spatial and spacetime domains with the INLA package (<https://www.r-inla.org>). These objects contain data to for the cgeneric interface in INLA', enabling fast parallel computations. We implemented the spatial barrier model, see Bakka et. al. (2019) <doi:10.1016/j.spasta.2019.01.002>, and some of the spatio-temporal models proposed in Lindgren et. al. (2024) <https://raco.cat/index.php/SORT/article/view/428665>. Details are provided in the available vignettes and from the URL bellow.

We provide the collection of data-sets used in the book An Introduction to Statistical Learning with Applications in R'.

Calculates fundamental IO matrices (Leontief, Wassily W. (1951) <doi:10.1038/scientificamerican1051-15>); within period analysis via various rankings and coefficients (Sonis and Hewings (2006) <doi:10.1080/09535319200000013>, Blair and Miller (2009) <ISBN:978-0-521-73902-3>, Antras et al (2012) <doi:10.3386/w17819>, Hummels, Ishii, and Yi (2001) <doi:10.1016/S0022-1996(00)00093-3>); across period analysis with impact analysis (Dietzenbacher, van der Linden, and Steenge (2006) <doi:10.1080/09535319300000017>, Sonis, Hewings, and Guo (2006) <doi:10.1080/09535319600000002>); and a variety of table operators.

This package provides access to core inflation functions. Four different core inflation functions are provided. The well known trimmed means, exclusion and double weighing methods, alongside the new Triple Filter method introduced in Ferreira et al. (2016) <https://goo.gl/UYLhcj>.

The proportion of cancer cells in solid tumor sample, known as the tumor purity, has adverse impact on a variety of data analyses if not properly accounted for. We develop InfiniumPurify', which is a comprehensive R package for estimating and accounting for tumor purity based on DNA methylation Infinium 450k array data. InfiniumPurify provides functionalities for tumor purity estimation. In addition, it can perform differential methylation detection and tumor sample clustering with the consideration of tumor purities.

Chi-square tests are computed with corrections.

Calculate B-spline basis functions with a given set of knots and order, or a B-spline function with a given set of knots and order and set of de Boor points (coefficients), or the integral of a B-spline function.

Calculate the injury severity score (ISS) based on the dictionary in ICDPIC from <https://ideas.repec.org/c/boc/bocode/s457028.html>. The original code was written in STATA 11'. The original STATA code was written by David Clark, Turner Osler and David Hahn. I implement the same logic for easier access. Ref: David E. Clark & Turner M. Osler & David R. Hahn, 2009. "ICDPIC: Stata module to provide methods for translating International Classification of Diseases (Ninth Revision) diagnosis codes into standard injury categories and/or scores," Statistical Software Components S457028, Boston College Department of Economics, revised 29 Oct 2010.

Iterated Function Systems Estimator as in Iacus and La Torre (2005) <doi:10.1155/JAMDS.2005.33>.

This package provides a suite for identifying causal models using relative concordances and identifying causal polymorphisms in case-control genetic association data, especially with large controls re-sequenced data.

Multi-data type subtyping, which is data type agnostic and accepts missing data. Subtyping is performed using intermediary assessments created with autoencoders and similarity calculations. See Fox et al. (2024) <doi:10.1016/j.crmeth.2024.100884> for details.