This package performs drug demand forecasting by modeling drug dispensing data while taking into account predicted enrollment and treatment discontinuation dates. The gap time between randomization and the first drug dispensing visit is modeled using interval-censored exponential, Weibull, log-logistic, or log-normal distributions (Anderson-Bergman (2017) <doi:10.18637/jss.v081.i12>). The number of skipped visits is modeled using Poisson, zero-inflated Poisson, or negative binomial distributions (Zeileis, Kleiber & Jackman (2008) <doi:10.18637/jss.v027.i08>). The gap time between two consecutive drug dispensing visits given the number of skipped visits is modeled using linear regression based on least squares or least absolute deviations (Birkes & Dodge (1993, ISBN:0-471-56881-3)). The number of dispensed doses is modeled using linear or linear mixed-effects models (McCulloch & Searle (2001, ISBN:0-471-19364-X)).

Via Foundry API provides streamlined tools for interacting with and extracting data from structured responses, particularly for use cases involving hierarchical data from Foundry's API. It includes functions to fetch and parse process-level and file-level metadata, allowing users to efficiently query and manipulate nested data structures. Key features include the ability to list all unique process names, retrieve file metadata for specific or all processes, and dynamically load or download files based on their type. With built-in support for handling various file formats (e.g., tabular and non-tabular files) and seamless integration with API through authentication, this package is designed to enhance workflows involving large-scale data management and analysis. Robust error handling and flexible configuration ensure reliable performance across diverse data environments. Please consult the documentation for the API endpoint for your installation.

This package contains basic structures and operations used frequently in quantum computing. Intended to be a convenient tool to help learn quantum mechanics and algorithms. Can create arbitrarily sized kets and bras and implements quantum gates, inner products, and tensor products. Creates arbitrarily controlled versions of all gates and can simulate complete or partial measurements of kets. Has functionality to convert functions into equivalent quantum gates and model quantum noise. Includes larger applications, such as Steane error correction <DOI:10.1103/physrevlett.77.793>, Quantum Fourier Transform and Shor's algorithm (Shor 1999), Grover's algorithm (1996), Quantum Approximation Optimization Algorithm (QAOA) (Farhi, Goldstone, and Gutmann 2014) <arXiv:1411.4028>, and a variational quantum classifier (Schuld 2018) <arXiv:1804.00633>. Can be used with the gridsynth algorithm <arXiv:1212.6253> to perform decomposition into the Clifford+T set.

This package implements a set of methodological tools that enable researchers to apply matching methods to time-series cross-sectional data. Imai, Kim, and Wang (2023) <http://web.mit.edu/insong/www/pdf/tscs.pdf> proposes a nonparametric generalization of the difference-in-differences estimator, which does not rely on the linearity assumption as often done in practice. Researchers first select a method of matching each treated observation for a given unit in a particular time period with control observations from other units in the same time period that have a similar treatment and covariate history. These methods include standard matching methods based on propensity score and Mahalanobis distance, as well as weighting methods. Once matching and refinement is done, treatment effects can be estimated with standard errors. The package also offers diagnostics for researchers to assess the quality of their results.

Quantifies clustering quality by measuring both cohesion within clusters and separation between clusters. Implements advanced silhouette width computations for diverse clustering structures, including: simplified silhouette (Van der Laan et al., 2003) <doi:10.1080/0094965031000136012>, Probability of Alternative Cluster normalization methods (Raymaekers & Rousseeuw, 2022) <doi:10.1080/10618600.2022.2050249>, fuzzy clustering and silhouette diagnostics using membership probabilities (Campello & Hruschka, 2006; Bhat & Kiruthika, 2024) <doi:10.1016/j.fss.2006.07.006>, <doi:10.1080/23737484.2024.2408534>, and multi-way clustering extensions such as block and tensor clustering (Schepers et al., 2008; Bhat & Kiruthika, 2025) <doi:10.1007/s00357-008-9005-9>, <doi:10.21203/rs.3.rs-6973596/v1>. Provides tools for computation and visualization (Rousseeuw, 1987) <doi:10.1016/0377-0427(87)90125-7> to support robust and reproducible cluster diagnostics across standard, soft, and multi-way clustering settings.

This package provides a fast, interactive cross-platform, and easy to share WebGL'-based 3D brain viewer that visualizes FreeSurfer and/or AFNI/SUMA surfaces. The viewer widget can be either standalone or embedded into R-shiny applications. The standalone version only require a web browser with WebGL2 support (for example, Chrome', Firefox', Safari'), and can be inserted into any websites. The R-shiny support allows the 3D viewer to be dynamically generated from reactive user inputs. Please check the publication by Wang, Magnotti, Zhang, and Beauchamp (2023, <doi:10.1523/ENEURO.0328-23.2023>) for electrode localization. This viewer has been fully adopted by RAVE <https://openwetware.org/wiki/RAVE>, an interactive toolbox to analyze iEEG data by Magnotti, Wang, and Beauchamp (2020, <doi:10.1016/j.neuroimage.2020.117341>). Please check citation("threeBrain") for details.

This package provides functions to implement model selection and multimodel inference based on Akaike's information criterion (AIC) and the second-order AIC (AICc), as well as their quasi-likelihood counterparts (QAIC, QAICc) from various model object classes. The package implements classic model averaging for a given parameter of interest or predicted values, as well as a shrinkage version of model averaging parameter estimates or effect sizes. The package includes diagnostics and goodness-of-fit statistics for certain model types including those of unmarkedFit classes estimating demographic parameters after accounting for imperfect detection probabilities. Some functions also allow the creation of model selection tables for Bayesian models of the bugs', rjags', and jagsUI classes. Functions also implement model selection using BIC. Objects following model selection and multimodel inference can be formatted to LaTeX using xtable methods included in the package.

This package provides methods to analyse spatial units in archaeology from the relationships between refitting fragmented objects scattered in these units (e.g. stratigraphic layers). Graphs are used to model archaeological observations. The package is mainly based on the igraph package for graph analysis. Functions can: 1) create, manipulate, and simulate fragmentation graphs, 2) measure the cohesion and admixture of archaeological spatial units, and 3) characterise the topology of a specific set of refitting relationships. Empirical datasets are provided as examples. Documentation about archeofrag is provided by the vignette included in this package, by the accompanying scientific papers: Plutniak (2021, Journal of Archaeological Science, <doi:10.1016/j.jas.2021.105501>) and Plutniak (2022, Journal of Open Source Software, <doi:10.21105/joss.04335>). This package is complemented by a companion GUI application available at <https://analytics.huma-num.fr/Sebastien.Plutniak/archeofrag/>.

This package implements a class of univariate and multivariate spatio-temporal generalised linear mixed models for areal unit data, with inference in a Bayesian setting using Markov chain Monte Carlo (MCMC) simulation. The response variable can be binomial, Gaussian, or Poisson, but for some models only the binomial and Poisson data likelihoods are available. The spatio-temporal autocorrelation is modelled by random effects, which are assigned conditional autoregressive (CAR) style prior distributions. A number of different random effects structures are available, including models similar to Rushworth et al. (2014) <doi:10.1016/j.sste.2014.05.001>. Full details are given in the vignette accompanying this package. The creation and development of this package was supported by the Engineering and Physical Sciences Research Council (EPSRC) grants EP/J017442/1 and EP/T004878/1 and the Medical Research Council (MRC) grant MR/L022184/1.

Analyze data from a crossover design using generalized estimation equations (GEE), including carryover effects and various correlation structures based on the Kronecker product. It contains functions for semiparametric estimates of carry-over effects in repeated measures and allows estimation of complex carry-over effects. Related work includes: a) Cruz N.A., Melo O.O., Martinez C.A. (2023). "CrossCarry: An R package for the analysis of data from a crossover design with GEE". <doi:10.48550/arXiv.2304.02440>. b) Cruz N.A., Melo O.O., Martinez C.A. (2023). "A correlation structure for the analysis of Gaussian and non-Gaussian responses in crossover experimental designs with repeated measures". <doi:10.1007/s00362-022-01391-z> and c) Cruz N.A., Melo O.O., Martinez C.A. (2023). "Semiparametric generalized estimating equations for repeated measurements in cross-over designs". <doi:10.1177/09622802231158736>.

Linkage disequilibrium visualizations of up to several hundreds of single nucleotide polymorphisms (SNPs), annotated with chromosomic positions and gene names. Two types of plots are available for small numbers of SNPs (<40) and for large numbers (tested up to 500). Both can be extended by combining other ggplots, e.g. association studies results, and functions enable to directly visualize the effect of SNP selection methods, as minor allele frequency filtering and TagSNP selection, with a second correlation heatmap. The SNPs correlations are computed on Genotype Data objects from the GWASTools package using the SNPRelate package, and the plots are customizable ggplot2 and gtable objects and are annotated using the biomaRt package. Usage is detailed in the vignette with example data and results from up to 500 SNPs of 1,200 scans are in Charlon T. (2019) <doi:10.13097/archive-ouverte/unige:161795>.

This package provides two methods for segmentation and joint segmentation/clustering of bivariate time-series. Originally intended for ecological segmentation (home-range and behavioural modes) but easily applied on other series, the package also provides tools for analysing outputs from R packages moveHMM and marcher'. The segmentation method is a bivariate extension of Lavielle's method available in adehabitatLT (Lavielle, 1999 <doi:10.1016/S0304-4149(99)00023-X> and 2005 <doi:10.1016/j.sigpro.2005.01.012>). This method rely on dynamic programming for efficient segmentation. The segmentation/clustering method alternates steps of dynamic programming with an Expectation-Maximization algorithm. This is an extension of Picard et al (2007) <doi:10.1111/j.1541-0420.2006.00729.x> method (formerly available in cghseg package) to the bivariate case. The method is fully described in Patin et al (2018) <doi:10.1101/444794>.

This package implements a functionality to deal with RabbitMQ Streams using asyncio.

It is designed and implemented with the following qualities in mind:

• asynchronous Pythonic API with type annotations

• use of AMQP 1.0 message format to enable interoperability between RabbitMQ Stream. clients

• auto reconnection to RabbitMQ broker with lazily created connection objects

Support of many RabbitMQ Streams broker features:

• publishing single messages, or in batches, with confirmation

• subscribing to a stream at a specific point in time, from a specific offset, or using offset reference

• stream message filtering

• writing stream offset reference

• message deduplication

• integration with AMQP 1.0 ecosystem at message format level

Many clustering methods have been proposed, but most of them cannot work for longitudinal gene expression data. BClustLonG is a package that allows us to perform clustering analysis for longitudinal gene expression data. It adopts a linear-mixed effects framework to model the trajectory of genes over time, while clustering is jointly conducted based on the regression coefficients obtained from all genes. To account for the correlations among genes and alleviate the high dimensionality challenges, factor analysis models are adopted for the regression coefficients. The Dirichlet process prior distribution is utilized for the means of the regression coefficients to induce clustering. This package allows users to specify which variables to use for clustering (intercepts or slopes or both) and whether a factor analysis model is desired. More details about this method can be found in Jiehuan Sun, et al. (2017) <doi:10.1002/sim.7374>.

The Ensemble Quadratic and Affine Invariant Markov chain Monte Carlo algorithms provide an efficient way to perform Bayesian inference in difficult parameter space geometries. The Ensemble Quadratic Monte Carlo algorithm was developed by Militzer (2023) <doi:10.3847/1538-4357/ace1f1>. The Ensemble Affine Invariant algorithm was developed by Goodman and Weare (2010) <doi:10.2140/camcos.2010.5.65> and it was implemented in Python by Foreman-Mackey et al (2013) <doi:10.48550/arXiv.1202.3665>. The Quadratic Monte Carlo method was shown to perform better than the Affine Invariant method in the paper by Militzer (2023) <doi:10.3847/1538-4357/ace1f1> and the Quadratic Monte Carlo method is the default method used. The Chen-Shao Highest Posterior Density Estimation algorithm is used for obtaining credible intervals and the potential scale reduction factor diagnostic is used for checking the convergence of the chains.

This package provides a multidimensional dataset of students performance assessment in high school physics. The SPHERE dataset was collected from 497 students in four public high schools specifically measuring their conceptual understanding, scientific ability, and attitude toward physics [see Santoso et al. (2024) <doi:10.17632/88d7m2fv7p.1>]. The data collection was conducted using some research based assessments established by the physics education research community. They include the Force Concept Inventory, the Force and Motion Conceptual Evaluation, the Rotational and Rolling Motion Conceptual Survey, the Fluid Mechanics Concept Inventory, the Mechanical Waves Conceptual Survey, the Thermal Concept Evaluation, the Survey of Thermodynamic Processes and First and Second Laws, the Scientific Abilities Assessment Rubrics, and the Colorado Learning Attitudes about Science Survey. Students attributes related to gender, age, socioeconomic status, domicile, literacy, physics identity, and test results administered using teachers developed items are also reported in this dataset.

Fit latent variable models with the GEV distribution as the data likelihood and the GEV parameters following latent Gaussian processes. The models in this package are built using the template model builder TMB in R, which has the fast ability to integrate out the latent variables using Laplace approximation. This package allows the users to choose in the fit function which GEV parameter(s) is considered as a spatially varying random effect following a Gaussian process, so the users can fit spatial GEV models with different complexities to their dataset without having to write the models in TMB by themselves. This package also offers methods to sample from both fixed and random effects posteriors as well as the posterior predictive distributions at different spatial locations. Methods for fitting this class of models are described in Chen, Ramezan, and Lysy (2024) <doi:10.48550/arXiv.2110.07051>.

The natural increase in the complexity of current research experiments and data demands better tools to enhance productivity in Data Analytics. The package is a framework designed to address the modern challenges in data analytics workflows. The package is inspired by Experiment Line concepts. It aims to provide seamless support for users in developing their data mining workflows by offering a uniform data model and method API. It enables the integration of various data mining activities, including data preprocessing, classification, regression, clustering, and time series prediction. It also offers options for hyper-parameter tuning and supports integration with existing libraries and languages. Overall, the package provides researchers with a comprehensive set of functionalities for data science, promoting ease of use, extensibility, and integration with various tools and libraries. Information on Experiment Line is based on Ogasawara et al. (2009) <doi:10.1007/978-3-642-02279-1_20>.

Facilitates the testing of causal relationships among lineage-pair traits in a phylogenetically informed context. Lineage-pair traits are characters that are defined for pairs of lineages instead of individual taxa. Examples include the strength of reproductive isolation, range overlap, competition coefficient, diet niche similarity, and relative hybrid fitness. Users supply a lineage-pair dataset and a phylogeny. phylopairs calculates a covariance matrix for the pairwise-defined data and provides built-in models to test for relationships among variables while taking this covariance into account. Bayesian sampling is run through built-in Stan programs via the rstan package. The various models and methods that this package makes available are described in Anderson et al. (In Review), Coyne and Orr (1989) <doi:10.1111/j.1558-5646.1989.tb04233.x>, Fitzpatrick (2002) <doi:10.1111/j.0014-3820.2002.tb00860.x>, and Castillo (2007) <doi:10.1002/ece3.3093>.

Generate programmable surveys using markdown and R code chunks. Surveys are composed of two files: a survey.qmd Quarto file defining the survey content (pages, questions, etc), and an app.R file defining a shiny app with global settings (libraries, database configuration, etc.) and server configuration options (e.g., conditional skipping / display, etc.). Survey data collected from respondents is stored in a PostgreSQL database. Features include controls for conditional skip logic (skip to a page based on an answer to a question), conditional display logic (display a question based on an answer to a question), a customizable progress bar, and a wide variety of question types, including multiple choice (single choice and multiple choices), select, text, numeric, multiple choice buttons, text area, and dates. Because the surveys render into a shiny app, designers can also leverage the reactive capabilities of shiny to create dynamic and interactive surveys.

This package performs archetypal analysis by using Principal Convex Hull Analysis under a full control of all algorithmic parameters. It contains a set of functions for determining the initial solution, the optimal algorithmic parameters and the optimal number of archetypes. Post run tools are also available for the assessment of the derived solution. Morup, M., Hansen, LK (2012) <doi:10.1016/j.neucom.2011.06.033>. Hochbaum, DS, Shmoys, DB (1985) <doi:10.1287/moor.10.2.180>. Eddy, WF (1977) <doi:10.1145/355759.355768>. Barber, CB, Dobkin, DP, Huhdanpaa, HT (1996) <doi:10.1145/235815.235821>. Christopoulos, DT (2016) <doi:10.2139/ssrn.3043076>. Falk, A., Becker, A., Dohmen, T., Enke, B., Huffman, D., Sunde, U. (2018), <doi:10.1093/qje/qjy013>. Christopoulos, DT (2015) <doi:10.1016/j.jastp.2015.03.009> . Murari, A., Peluso, E., Cianfrani, Gaudio, F., Lungaroni, M., (2019), <doi:10.3390/e21040394>.

Mapas terrestres con topologias simplificadas. Estos mapas no tienen precision geodesica, por lo que aplica el DFL-83 de 1979 de la Republica de Chile y se consideran referenciales sin validez legal. No se incluyen los territorios antarticos y bajo ningun evento estos mapas significan que exista una cesion u ocupacion de territorios soberanos en contra del Derecho Internacional por parte de Chile. Esta paquete esta documentado intencionalmente en castellano asciificado para que funcione sin problema en diferentes plataformas. (Terrestrial maps with simplified toplogies. These maps lack geodesic precision, therefore DFL-83 1979 of the Republic of Chile applies and are considered to have no legal validity. Antartic territories are excluded and under no event these maps mean there is a cession or occupation of sovereign territories against International Laws from Chile. This package was intentionally documented in asciified spanish to make it work without problem on different platforms.).

An interface for performing climate matching using the Euclidean "Climatch" algorithm. Functions provide a vector of climatch scores (0-10) for each location (i.e., grid cell) within the recipient region, the percent of climatch scores >= a threshold value, and mean climatch score. Tools for parallelization and visualizations are also provided. Note that the floor function that rounds the climatch score down to the nearest integer has been removed in this implementation and the â Climatchâ algorithm, also referred to as the â Climateâ algorithm, is described in: Crombie, J., Brown, L., Lizzio, J., & Hood, G. (2008). â Climatch user manualâ . The method for the percent score is described in: Howeth, J.G., Gantz, C.A., Angermeier, P.L., Frimpong, E.A., Hoff, M.H., Keller, R.P., Mandrak, N.E., Marchetti, M.P., Olden, J.D., Romagosa, C.M., and Lodge, D.M. (2016). <doi:10.1111/ddi.12391>.

An algorithm for flexible conditional density estimation based on application of pooled hazard regression to an artificial repeated measures dataset constructed by discretizing the support of the outcome variable. To facilitate non/semi-parametric estimation of the conditional density, the highly adaptive lasso, a nonparametric regression function shown to reliably estimate a large class of functions at a fast convergence rate, is utilized. The pooled hazards data augmentation formulation implemented was first described by DÃ az and van der Laan (2011) <doi:10.2202/1557-4679.1356>. To complement the conditional density estimation utilities, tools for efficient nonparametric inverse probability weighted (IPW) estimation of the causal effects of stochastic shift interventions (modified treatment policies), directly utilizing the density estimation technique for construction of the generalized propensity score, are provided. These IPW estimators utilize undersmoothing (sieve estimation) of the conditional density estimators in order to achieve the non/semi-parametric efficiency bound.