This package provides a comprehensive framework for model fitting and simulation of drug release kinetics, pharmacokinetics (PK), and pharmacodynamics (PD). The package implements widely used mechanistic and empirical models for in vitro drug release, including zero-order, first-order, Higuchi, Korsmeyer-Peppas, Hixson-Crowell, and Weibull models. Pharmacokinetic functionality includes linear and nonlinear functions for one- and two-compartment models for intravenous bolus and oral administration, Michaelis-Menten kinetics, and non-compartmental analysis (NCA). Pharmacodynamic and dose-response modeling is supported through Emax-based models, including stimulatory (sigmoid Emax) and inhibitory (sigmoid Imax) Hill models, four- and five-parameter logistic models, as well as median toxic dose (TD50) and lethal dose (LD50) models. The package is intended to support parameter estimation, simulation, and model comparison in pharmaceutical research, drug development, and pharmacometrics education. For more details, see Gabrielsson & Weiner (2000) <ISBN:9186274929>, Holford & Sheiner (1981) <doi:10.2165/00003088-198106060-00002>, and Manlapaz (2025) <doi:10.32614/CRAN.package.adsoRptionCMF>.

The t-designs represent a generalized class of balanced incomplete block designs in which the number of blocks in which any t-tuple of treatments (t >= 2) occur together is a constant. When the focus of an experiment lies in grading and selecting treatment subgroups, t-designs would be preferred over the conventional ones, as they have the additional advantage of t-tuple balance. t-designs can be advantageously used in identifying the best crop-livestock combination for a particular location in Integrated Farming Systems that will help in generating maximum profit. But as the number of components increases, the number of possible t-component combinations will also increase. Most often, combinations derived from specific components are only practically feasible, for example, in a specific locality, farmers may not be interested in keeping a pig or goat and hence combinations involving these may not be of any use in that locality. In such situations partially balanced t-designs with few selected combinations appearing in a constant number of blocks (while others not at all appearing) may be useful (Sayantani Karmakar, Cini Varghese, Seema Jaggi & Mohd Harun (2021)<doi:10.1080/03610918.2021.2008436>). Further, every location may not have the resources to form equally sized homogeneous blocks. Partially balanced t-designs with unequal block sizes (Damaraju Raghavarao & Bei Zhou (1998)<doi:10.1080/03610929808832657>. Sayantani Karmakar, Cini Varghese, Seema Jaggi & Mohd Harun (2022)." Partially Balanced t-designs with unequal block sizes") prove to be more suitable for such situations.This package generates three series of partially balanced t-designs namely Series 1, Series 2 and Series 3. Series 1 and Series 2 are designs having equal block sizes and with treatment structures 4(t + 1) and a prime number, respectively. Series 3 consists of designs with unequal block sizes and with treatment structure n(n-1)/2. This package is based on the function named PBtD() for generating partially balanced t-designs along with their parameters, information matrices, average variance factors and canonical efficiency factors.

This package provides tools to interact with the Pangaea Database (<https://www.pangaea.de>), including functions for searching for data, fetching datasets by dataset ID', and working with the Pangaea OAI-PMH service.

Spectral response data for broadband ultraviolet and visible radiation sensors. Angular response data for broadband ultraviolet and visible radiation sensors and diffusers used as entrance optics. Data obtained from multiple sources were used: author-supplied data from scientific research papers, sensor-manufacturer supplied data, and published sensor specifications. Part of the r4photobiology suite Aphalo P. J. (2015) <doi:10.19232/uv4pb.2015.1.14>.

Producing the time-dependent receiver operating characteristic (ROC) curve through parametric approaches. Tools for generating random data, fitting, predicting and check goodness of fit are prepared. The methods are developed from the theoretical framework of proportional hazard model and copula functions. Using this package, users can now simulate parametric time-dependent ROC and run experiment to understand the behavior of the curve under different scenario.

This package provides tools for visual exploratory data analysis with nested data. Includes functions for creating bivariate plots, dot plots, histograms, and violin plots for each group or unit in nested data. Methods are described in Crabtree and Nelson (2017) "Plotrr: Functions for making visual exploratory data analysis with nested data easier" <doi:10.21105/joss.00190>.

This package implements projected sparse Gaussian process Kriging ('Ingram et. al.', 2008, <doi:10.1007/s00477-007-0163-9>) as an additional method for the intamap package. More details on implementation ('Barillec et. al.', 2010, <doi:10.1016/j.cageo.2010.05.008>).

Designed for prediction error estimation through resampling techniques, possibly accelerated by parallel execution on a compute cluster. Newly developed model fitting routines can be easily incorporated. Methods used in the package are detailed in Porzelius Ch., Binder H. and Schumacher M. (2009) <doi:10.1093/bioinformatics/btp062> and were used, for instance, in Porzelius Ch., Schumacher M. and Binder H. (2011) <doi:10.1007/s00180-011-0236-6>.

Simulation functions to assess or explore the power of a dataset to estimates significant random effects (intercept or slope) in a mixed model. The functions are based on the "lme4" and "lmerTest" packages.

This package implements novel tools for estimating sample sizes needed for phylogenetic studies, including studies focused on estimating the probability of true pathogen transmission between two cases given phylogenetic linkage and studies focused on tracking pathogen variants at a population level. Methods described in Wohl, Giles, and Lessler (2021) and in Wohl, Lee, DiPrete, and Lessler (2023).

This package provides a collection of functions to simulate, estimate and forecast a wide range of regression based dynamic models for positive time series. This package implements the results presented in Prass, T.S.; Pumi, G.; Taufemback, C.G. and Carlos, J.H. (2025). "Positive time series regression models: theoretical and computational aspects". Computational Statistics 40, 1185â 1215. <doi:10.1007/s00180-024-01531-z>.

This package provides a semi-parametric estimation method for the Cox model with left-truncated data using augmented information from the marginal of truncation times.

This package performs genomic prediction of hybrid performance using eight GS methods including GBLUP, BayesB, RKHS, PLS, LASSO, Elastic net, XGBoost and LightGBM. GBLUP: genomic best liner unbiased prediction, RKHS: reproducing kernel Hilbert space, PLS: partial least squares regression, LASSO: least absolute shrinkage and selection operator, XGBoost: extreme gradient boosting, LightGBM: light gradient boosting machine. It also provides fast cross-validation and mating design scheme for training population (Xu S et al (2016) <doi:10.1111/tpj.13242>; Xu S (2017) <doi:10.1534/g3.116.038059>). A complete manual for this package is provided in the manual folder of the package installation directory. You can locate the manual by running the following command in R: system.file("manual", package = "predhy.GUI").

Tests for a comparison of two partially overlapping samples. A comparison of means using the partially overlapping samples t-test: See Derrick, Russ, Toher and White (2017), Test statistics for the comparison of means for two samples which include both paired observations and independent observations, Journal of Modern Applied Statistical Methods, 16(1). A comparison of proportions using the partially overlapping samples z-test: See Derrick, Dobson-Mckittrick, Toher and White (2015), Test statistics for comparing two proportions with partially overlapping samples. Journal of Applied Quantitative Methods, 10(3).

Functional claims reserving methods based on aggregated chain-ladder data, also known as a run-off triangle, implemented in three nonparametric algorithms (PARALLAX, REACT, and MACRAME) proposed in Maciak, Mizera, and Pešta (2022) <doi:10.1017/asb.2022.4>. Additional methods including permutation bootstrap for completed run-off triangles are also provided.

Implementation of an oligonucleotide primer and probe design algorithm using a linearly scaling approximation of set coverage. A detailed description available at Smolander and Tamminen, 2021; <doi:10.1101/2021.09.06.459073>.

This package provides a collection of R functions that are widely used by the Petersen Lab. Included are functions for various purposes, including evaluating the accuracy of judgments and predictions, performing scoring of assessments, generating correlation matrices, conversion of data between various types, data management, psychometric evaluation, extensions related to latent variable modeling, various plotting capabilities, and other miscellaneous useful functions. By making the package available, we hope to make our methods reproducible and replicable by others and to help others perform their data processing and analysis methods more easily and efficiently. The codebase is provided in Petersen (2025) <doi:10.5281/zenodo.7602890> and on CRAN': <doi: 10.32614/CRAN.package.petersenlab>. The package is described in "Principles of Psychological Assessment: With Applied Examples in R" (Petersen, 2024, 2025a) <doi:10.1201/9781003357421>, <doi:10.25820/work.007199>, <doi:10.5281/zenodo.6466589> and in "Fantasy Football Analytics: Statistics, Prediction, and Empiricism Using R" (Petersen, 2025b).

Automatic estimation of number of principal components in PCA with PEnalized SEmi-integrated Likelihood (PESEL). See Piotr Sobczyk, Malgorzata Bogdan, Julie Josse "Bayesian dimensionality reduction with PCA using penalized semi-integrated likelihood" (2017) <doi:10.1080/10618600.2017.1340302>.

Adds different kinds of brackets to a plot, including braces, chevrons, parentheses or square brackets.

Fit linear mixed models dedicated to the genetic study of plant mixtures, such as those based on general and specific mixing abilities (GMA-SMA) as well as direct and social breeding values (DBV-SBV), also known as direct and indirect genetic effects (DGE-IGE). More details in Forst et al (2019, <doi:10.1016/j.fcr.2019.107571>) for GMA-SMA models, and Salomon et al (2026, <doi:10.64898/2026.03.27.714849>) for DBV-SBV models. The package also provides functions to optimize experimental designs, simulate data sets and compute interaction indices.

Conducts maximum likelihood analysis and simulation of the protracted birth-death model of diversification. See Etienne, R.S. & J. Rosindell 2012 <doi:10.1093/sysbio/syr091>; Lambert, A., H. Morlon & R.S. Etienne 2014, <doi:10.1007/s00285-014-0767-x>; Etienne, R.S., H. Morlon & A. Lambert 2014, <doi:10.1111/evo.12433>.

There are three sets of functions. The first produces basic properties of a graph and generates samples from multinomial distributions to facilitate the simulation functions (they maybe used for other purposes as well). The second provides various simulation functions for a Potts model in Potts, R. B. (1952) <doi:10.1017/S0305004100027419>. The third currently includes only one function which computes the normalizing constant of a Potts model based on simulation results.

This package provides an R interface to the PCATS API <https://pcats.research.cchmc.org/api/__docs__/>, allowing R users to submit tasks and retrieve results.

This package provides tools for processing, analyzing, and visualizing spectral data collected from 3D laser-based scanning systems. Supports applications in agriculture, forestry, environmental monitoring, industrial quality control, and biomedical research. Enables evaluation of plant growth, productivity, resource efficiency, disease management, and pest monitoring. Includes statistical methods for extracting insights from multispectral and hyperspectral data and generating publication-ready visualizations. See Zieschank & Junker (2023) <doi:10.3389/fpls.2023.1141554> and Saric et al. (2022) <doi:10.1016/J.TPLANTS.2021.12.003> for related work.