High-throughput sequencing technologies allow the production of large volumes of short sequences, which can be aligned to the genome to create a set of matches to the genome. By looking for regions of the genome which to which there are high densities of matches, we can infer a segmentation of the genome into regions of biological significance. The methods in this package allow the simultaneous segmentation of data from multiple samples, taking into account replicate data, in order to create a consensus segmentation. This has obvious applications in a number of classes of sequencing experiments, particularly in the discovery of small RNA loci and novel mRNA transcriptome discovery.

Testing for parallel trends is crucial in the Difference-in-Differences framework. To this end, this package performs equivalence testing in the context of Difference-in-Differences estimation. It allows users to test if pre-treatment trends in the treated group are â equivalentâ to those in the control group. Here, â equivalenceâ means that rejection of the null hypothesis implies that a function of the pre-treatment placebo effects (maximum absolute, average or root mean squared value) does not exceed a pre-specified threshold below which trend differences are considered negligible. The package is based on the theory developed in Dette & Schumann (2024) <doi:10.1080/07350015.2024.2308121>.

Allows access to data in running instance of Microsoft Excel (e. g. xl[a1] = xl[b2]*3 and so on). Graphics can be transferred with xl[a1] = current.graphics()'. Additionally there are function for reading/writing Excel files - xl.read.file'/'xl.save.file'. They are not fast but able to read/write *.xlsb'-files and password-protected files. There is an Excel workbook with examples of calling R from Excel in the doc folder. It tries to keep things as simple as possible - there are no needs in any additional installations besides R, only VBA code in the Excel workbook. Microsoft Excel is required for this package.

This package implements an empirical approach referred to as PeakTrace which uses multiple hydrographs to detect and follow hydropower plant-specific hydropeaking waves at the sub-catchment scale and to describe how hydropeaking flow parameters change along the longitudinal flow path. The method is based on the identification of associated events and uses (linear) regression models to describe translation and retention processes between neighboring hydrographs. Several regression model results are combined to arrive at a power plant-specific model. The approach is proposed and validated in Greimel et al. (2022) <doi:10.1002/rra.3978>. The identification of associated events is based on the event detection implemented in hydropeak'.

Use standard genomics file format (BED) and a table of orthologs to illustrate synteny conservation at the genome-wide scale. Significantly conserved linkage groups are identified as described in Simakov et al. (2020) <doi:10.1038/s41559-020-1156-z> and displayed on an Oxford Grid (Edwards (1991) <doi:10.1111/j.1469-1809.1991.tb00394.x>) or a chord diagram as in Simakov et al. (2022) <doi:10.1126/sciadv.abi5884>. The package provides a function that uses a network-based greedy algorithm to find communities (Clauset et al. (2004) <doi:10.1103/PhysRevE.70.066111>) and so automatically order the chromosomes on the plot to improve interpretability.

Allows production of Microsoft corporate documents from R Markdown by reusing formatting defined in Microsoft Word documents. You can reuse table styles, list styles but also add column sections, landscape oriented pages. Table and image captions as well as cross-references are transformed into Microsoft Word fields, allowing documents edition and merging without issue with references; the syntax conforms to the bookdown cross-reference definition. Objects generated by the officer package are also supported in the knitr chunks. Microsoft PowerPoint presentations also benefit from this as well as the ability to produce editable vector graphics in PowerPoint and also to define placeholder where content is to be added.

Model-implied simulation-based power estimation (MSPE) for nonlinear (and linear) SEM, path analysis and regression analysis. A theoretical framework is used to approximate the relation between power and sample size for given type I error rates and effect sizes. The package offers an adaptive search algorithm to find the optimal N for given effect sizes and type I error rates. Plots can be used to visualize the power relation to N for different parameters of interest (POI). Theoretical justifications are given in Irmer et al. (2024a) <doi:10.31219/osf.io/pe5bj> and detailed description are given in Irmer et al. (2024b) <doi:10.3758/s13428-024-02476-3>.

This package provides a toolset for functional enrichment analysis and visualization, gene/protein/SNP identifier conversion and mapping orthologous genes across species via g:Profiler. The main tools are:

1. g:GOSt, functional enrichment analysis and visualization of gene lists;

2. g:Convert, gene/protein/transcript identifier conversion across various namespaces;

3. g:Orth, orthology search across species;

4. g:SNPense, mapping SNP rs identifiers to chromosome positions, genes and variant effects.

This package is an R interface corresponding to the 2019 update of g:Profiler and provides access to versions e94_eg41_p11 and higher.

Survival analysis using a flexible Bayesian model for individual-level right-censored data, optionally combined with aggregate data on counts of survivors in different periods of time. An M-spline is used to describe the hazard function, with a prior on the coefficients that controls over-fitting. Proportional hazards or flexible non-proportional hazards models can be used to relate survival to predictors. Additive hazards (relative survival) models, waning treatment effects, and mixture cure models are also supported. Priors can be customised and calibrated to substantive beliefs. Posterior distributions are estimated using Stan', and outputs are arranged in a tidy format. See Jackson (2023) <doi:10.1186/s12874-023-02094-1>.

Core Hunter is a tool to sample diverse, representative subsets from large germplasm collections, with minimum redundancy. Such so-called core collections have applications in plant breeding and genetic resource management in general. Core Hunter can construct cores based on genetic marker data, phenotypic traits or precomputed distance matrices, optimizing one of many provided evaluation measures depending on the precise purpose of the core (e.g. high diversity, representativeness, or allelic richness). In addition, multiple measures can be simultaneously optimized as part of a weighted index to bring the different perspectives closer together. The Core Hunter library is implemented in Java 8 as an open source project (see <http://www.corehunter.org>).

This package provides tools for quantitative analysis in gender studies, including functions to calculate various gender inequality metrics such as the Gender Pay Gap, Gender Inequality Index (GII), Gender Development Index (GDI), and Gender Empowerment Measure (GEM). Also includes extracted secondary example datasets for practice and learning purposes, which were obtained from the UNDP Human Development Reports Data Center and the World Bank Gender Data Portal by the author the dataset is available on <doi:10.34740/kaggle/dsv/6359326>. References: Miller, Kevin; Vagins, Deborah J. (2021) <https://eric.ed.gov/?id=ED596219>. Jacques Charmes & Saskia Wieringa (2003) <doi:10.1080/1464988032000125773>. Gaëlle Ferrant (2010) <https://shs.hal.science/halshs-00462463/>.

This package implements various heuristics like Take The Best and unit-weight linear, which do two-alternative choice: which of two objects will have a higher criterion? Also offers functions to assess performance, e.g. percent correct across all row pairs in a data set and finding row pairs where models disagree. New models can be added by implementing a fit and predict function-- see vignette. Take The Best was first described in: Gigerenzer, G. & Goldstein, D. G. (1996) <doi:10.1037/0033-295X.103.4.650>. All of these heuristics were run on many data sets and analyzed in: Gigerenzer, G., Todd, P. M., & the ABC Group (1999). <ISBN:978-0195143812>.

This package provides methods for inference about/under complex relationships using peak height data from DNA mixtures: the most basic example would be testing whether a contributor to a mixture is the father of a child of known genotype. This provides most of the functionality of the KinMix package, but with some loss of efficiency and restriction on problem size, as the latter uses RHugin as the Bayes net engine, while this package uses gRain'. The package implements the methods introduced in Green, P. J. and Mortera, J. (2017) <doi:10.1016/j.fsigen.2017.02.001> and Green, P. J. and Mortera, J. (2021) <doi:10.1111/rssc.12498>.

With high-dimensional omics features, repeated measure ANOVA leads to longitudinal gene-environment interaction studies that have intra-cluster correlations, outlying observations and structured sparsity arising from the ANOVA design. In this package, we have developed robust sparse Bayesian mixed effect models tailored for the above studies (Fan et al. (2025) <doi:10.1093/jrsssc/qlaf027>). An efficient Gibbs sampler has been developed to facilitate fast computation. The Markov chain Monte Carlo algorithms of the proposed and alternative methods are efficiently implemented in C++'. The development of this software package and the associated statistical methods have been partially supported by an Innovative Research Award from Johnson Cancer Research Center, Kansas State University.

This package provides a framework for evaluating drug combination effects in preclinical in vivo studies. SynergyLMM provides functions to analyze longitudinal tumor growth experiments using mixed-effects models, perform time-resolved analyses of synergy and antagonism, evaluate model diagnostics and performance, and assess both post-hoc and a priori statistical power. The calculation of drug combination synergy follows the statistical framework provided by Demidenko and Miller (2019, <doi:10.1371/journal.pone.0224137>). The implementation and analysis of linear mixed-effect models is based on the methods described by Pinheiro and Bates (2000, <doi:10.1007/b98882>), and GaÅ ecki and Burzykowski (2013, <doi:10.1007/978-1-4614-3900-4>).

Computing diversity measures on tripartite graphs. This package first implements a parametrized family of such diversity measures which apply on probability distributions. Sometimes called "True Diversity", this family contains famous measures such as the richness, the Shannon entropy, the Herfindahl-Hirschman index, and the Berger-Parker index. Second, the package allows to apply these measures on probability distributions resulting from random walks between the levels of tripartite graphs. By defining an initial distribution at a given level of the graph and a path to follow between the three levels, the probability of the walker's position within the final level is then computed, thus providing a particular instance of diversity to measure.

Provide estimation and data generation tools for new multivariate frailty models. This version includes the gamma, inverse Gaussian, weighted Lindley, Birnbaum-Saunders, truncated normal, mixture of inverse Gaussian, mixture of Birnbaum-Saunders, generalized exponential and Jorgensen-Seshadri-Whitmore as the distribution for frailty terms. For the basal model, it is considered a parametric approach based on the exponential, Weibull and the piecewise exponential distributions as well as a semiparametric approach. For details, see Gallardo et al. (2024) <doi:10.1007/s11222-024-10458-w>, Gallardo et al. (2025) <doi:10.1002/bimj.70044>, Kiprotich et al. (2025) <doi:10.1177/09622802251338984> and Gallardo et al. (2025) <doi:10.1038/s41598-025-15903-y>.

This package provides functions for joining data frames based on inexact criteria, including string distance, Manhattan distance, Euclidean distance, and interval overlap. This API is designed as a modern, performance-oriented alternative to the fuzzyjoin package (Robinson 2026) <doi:10.32614/CRAN.package.fuzzyjoin>. String distance functions utilizing q-grams are adapted with permission from the textdistance Rust crate (Orsinium 2024) <https://docs.rs/textdistance/latest/textdistance/>. Other string distance calculations rely on the rapidfuzz Rust crate (Bachmann 2023) <https://docs.rs/rapidfuzz/0.5.0/rapidfuzz/>. Interval joins are backed by a Adelson-Velsky and Landis tree as implemented by the interavl Rust crate <https://docs.rs/interavl/0.5.0/interavl/>.

This package provides tools for preprocessing, feature extraction, and segmentation of three-dimensional forest point clouds derived from terrestrial laser scanning. Functions support creating height-above-ground (HAG) metrics, tiling, and sampling point clouds, generating training datasets, applying trained models to new point clouds, and producing per-point fuel classes such as stems, branches, foliage, and surface fuels. These tools support workflows for forest structure analysis, wildfire behavior modeling, and fuel complexity assessment. Deep learning segmentation relies on the PointNeXt architecture described by Qian et al. (2022) <doi:10.48550/arXiv.2206.04670>, while ground classification utilizes the Cloth Simulation Filter algorithm by Zhang et al. (2016) <doi:10.3390/rs8060501>.

Web front end for your R functions producing plots or tables. If you have a function or set of related functions, you can make them available over the internet through a web browser. This is the same motivation as the shiny package, but note that the development of shinylight is not in any way linked to that of shiny (beyond the use of the httpuv package). You might prefer shinylight to shiny if you want a lighter weight deployment with easier horizontal scaling, or if you want to develop your front end yourself in JavaScript and HTML just using a lightweight remote procedure call interface to your R code on the server.

Generates publication-ready summary tables for clinical research, supporting descriptive summaries and comparisons across two or three groups. The package streamlines the analytical workflow by detecting variable types and applying appropriate statistical tests (Welch t-test, Wilcoxon rank-sum, Welch ANOVA, Kruskal-Wallis, Chi-squared, or Fisher's exact test). Results are formatted as tibble objects and can be exported to Word or Excel using the officer', flextable', and writexl packages. Optional pairwise post-hoc testing for three-group comparisons (Games-Howell and Dunn's test) is available via the rstatix package. Example data are derived from the landmark adjuvant colon cancer trial described in Moertel et al. (1990) <doi:10.1056/NEJM199002083220602>.

Intense parallel workloads can be difficult to monitor. Packages crew.cluster, clustermq, and future.batchtools distribute hundreds of worker processes over multiple computers. If a worker process exhausts its available memory, it may terminate silently, leaving the underlying problem difficult to detect or troubleshoot. Using the autometric package, a worker can proactively monitor itself in a detached background thread. The worker process itself runs normally, and the thread writes to a log every few seconds. If the worker terminates unexpectedly, autometric can read and visualize the log file to reveal potential resource-related reasons for the crash. The autometric package borrows heavily from the methods of packages ps and psutil.

Simulation of species diversification, fossil records, and phylogenies. While the literature on species birth-death simulators is extensive, including important software like paleotree and APE', we concluded there were interesting gaps to be filled regarding possible diversification scenarios. Here we strove for flexibility over focus, implementing a large array of regimens for users to experiment with and combine. In this way, paleobuddy can be used in complement to other simulators as a flexible jack of all trades, or, in the case of scenarios implemented only here, can allow for robust and easy simulations for novel situations. Environmental data modified from that in RPANDA': Morlon H. et al (2016) <doi:10.1111/2041-210X.12526>.

This package provides a set of functions to support experimentation in the utility of partially synthetic data sets. All functions compare an observed data set to one or a set of partially synthetic data sets derived from the observed data to (1) check that data sets have identical attributes, (2) calculate overall and specific variable perturbation rates, (3) check for potential logical inconsistencies, and (4) calculate confidence intervals and standard errors of desired variables in multiple imputed data sets. Confidence interval and standard error formulas have options for either synthetic data sets or multiple imputed data sets. For more information on the formulas and methods used, see Reiter & Raghunathan (2007) <doi:10.1198/016214507000000932>.