We provide extensions to the classical dataset "Example 4: Death by the kick of a horse in the Prussian Army" first used by Ladislaus von Bortkeiwicz in his treatise on the Poisson distribution "Das Gesetz der kleinen Zahlen", <DOI:10.1017/S0370164600019453>. As well as an extended time series for the horse-kick death data, we also provide, in parallel, deaths by falling from a horse and by drowning.

This package provides functions to assess and test for heterogeneity in the utility of a surrogate marker with respect to a baseline covariate using censored (survival data), and to test for heterogeneity across multiple time points. More details are available in Parast et al (2024) <doi:10.1002/sim.10122>.

The Gene Ontology (GO) Consortium <https://geneontology.org/> organizes genes into hierarchical categories based on biological process (BP), molecular function (MF) and cellular component (CC, i.e., subcellular localization). Tools such as GoMiner (see Zeeberg, B.R., Feng, W., Wang, G. et al. (2003) <doi:10.1186/gb-2003-4-4-r28>) can leverage GO to perform ontological analysis of microarray and proteomics studies, typically generating a list of significant functional categories. Microarray studies are usually analyzed with BP, whereas proteomics researchers often prefer CC. To capture the benefit of both of those ontologies, I now present an enhancement of the existing two-dimensional version of High-Throughput GoMiner ('HTGM2D'), which is called HTGM4D'. The original HTGM2D is augmented by adding two instances of the original GoMiner genes versus categories heatmaps, aligned with the categories axes of the HTGM2D heatmap.

This package provides a procedure that fits derivative curves based on a sequence of quotient differences. In a hierarchical setting the package produces estimates of subject-specific and group-specific derivative curves. In a non-hierarchical setting the package produces a single derivative curve.

This package provides a consistent API for hypothesis testing built on principles from Structure and Interpretation of Computer Programs': data abstraction, closure (combining tests yields tests), and higher-order functions (transforming tests). Implements z-tests, Wald tests, likelihood ratio tests, Fisher's method for combining p-values, and multiple testing corrections. Designed for use by other packages that want to wrap their hypothesis tests in a consistent interface.

Implementation of selected high-dimensional statistical and econometric methods for estimation and inference. Efficient estimators and uniformly valid confidence intervals for various low-dimensional causal/ structural parameters are provided which appear in high-dimensional approximately sparse models. Including functions for fitting heteroscedastic robust Lasso regressions with non-Gaussian errors and for instrumental variable (IV) and treatment effect estimation in a high-dimensional setting. Moreover, the methods enable valid post-selection inference and rely on a theoretically grounded, data-driven choice of the penalty. Chernozhukov, Hansen, Spindler (2016) <arXiv:1603.01700>.

This package provides a method for identifying responses to experimental stimulation in mass or flow cytometry that uses high dimensional analysis of measured parameters and can be performed with an end-to-end unsupervised approach. In the context of in vitro stimulation assays where high-parameter cytometry was used to monitor intracellular response markers, using cell populations annotated either through automated clustering or manual gating for a combined set of stimulated and unstimulated samples, HDStIM labels cells as responding or non-responding. The package also provides auxiliary functions to rank intracellular markers based on their contribution to identifying responses and generating diagnostic plots.

High throughput toxicokinetics ("HTTK") is the combination of 1) chemical-specific in vitro measurements or in silico predictions and 2) generic mathematical models, to predict absorption, distribution, metabolism, and excretion by the body. HTTK methods have been described by Pearce et al. (2017) (<doi:10.18637/jss.v079.i04>) and Breen et al. (2021) (<doi:10.1080/17425255.2021.1935867>). Here we provide examples (vignettes) applying HTTK to solve various problems in bioinformatics, toxicology, and exposure science. In accordance with Davidson-Fritz et al. (2025) (<doi:10.1371/journal.pone.0321321>), whenever a new HTTK model is developed, the code to generate the figures evaluating that model is added as a new vignettte.

Historical borrowing in clinical trials can improve precision and operating characteristics. This package supports a longitudinal hierarchical model to borrow historical control data from other studies to better characterize the control response of the current study. It also quantifies the amount of borrowing through longitudinal benchmark models (independent and pooled). The hierarchical model approach to historical borrowing is discussed by Viele et al. (2013) <doi:10.1002/pst.1589>.

Tracks elapsed clock time using a `hms::hms()` scalar. It was was originally developed to time Bayesian model runs. It should not be used to estimate how long extremely fast code takes to execute as the package code adds a small time cost.

This package provides a shiny interface for a free, open-source managerial accounting-like system for health care practices. This package allows health care administrators to project revenue with monthly adjustments and procedure-specific boosts up to a 3-year period. Granular data (patient-level) to aggregated data (department- or hospital-level) can all be used as valid inputs provided historical volume and revenue data is available. For more details on managerial accounting techniques, see Brewer et al. (2015, ISBN:9780078025792).

Univariate agglomerative hierarchical clustering with a comprehensive list of choices of a linkage function in O(n*log n) time. The better algorithmic time complexity is paired with an efficient C++ implementation.

This package provides a unified, extensible interface to discover hydrologic stations and download daily time series (e.g., water discharge, water level, water temperature, and several other water quality parameter) from national and regional public APIs. Includes a provider registry, S3 generics stations and timeseries', licensing metadata, date-range and complete history modes, rate limiting and retries, optional authentication via environment variables, tidy outputs, UTF-8 to ASCII transliteration, and WGS84 coordinates. Designed for reproducible workflows and straightforward addition of new providers. Background and use cases are described in Farber et al. (2025) <doi:10.5194/essd-17-4613-2025> and Farber et al. (2023) <doi:10.57757/IUGG23-2838>.

Template R package with minimal setup to use Rust code in R without hacks or frameworks. Includes basic examples of importing cargo dependencies, spawning threads and passing numbers or strings from Rust to R. Cargo crates are automatically vendored in the R source package to support offline installation. The GitHub repository for this package has more details and also explains how to set up CI. This project was first presented at Erum2018 to showcase R-Rust integration <https://jeroen.github.io/erum2018/>; for a real world use-case, see the gifski package on CRAN'.

This package provides functions for the management and treatment of hydrology and meteorology time-series stored in a Sqlite data base.

This package provides a utility to quickly obtain clean and tidy men's basketball play by play data. Provides functions to access live play by play and box score data from ESPN<https://www.espn.com> with shot locations when available. It is also a full NBA Stats API<https://www.nba.com/stats/> wrapper. It is also a scraping and aggregating interface for Ken Pomeroy's men's college basketball statistics website<https://kenpom.com>. It provides users with an active subscription the capability to scrape the website tables and analyze the data for themselves.

This package provides functions to download, parse, and tidy statistical data published by HM Revenue and Customs ('HMRC') on GOV.UK'. Returns annotated hmrc_tbl data frames with provenance metadata (source URL, fetch time, vintage, cell methods) for reproducible fiscal research. Covers monthly tax receipts (41 tax heads from 2008), VAT (from 1973), fuel duties (from 1990), tobacco duties (from 1991), annual Corporation Tax receipts, stamp duty, research and development tax credit statistics (from 2000), tax gap estimates, Income Tax liabilities by income range, and monthly property transaction counts. File URLs are resolved at runtime via the GOV.UK Content API <https://www.gov.uk/api/content>, so data is always current without hardcoded URLs. Files are cached locally between sessions.

This package implements an estimation method for Hawkes processes when count data are only observed in discrete time, using a spectral approach derived from the Bartlett spectrum, see Cheysson and Lang (2020) <arXiv:2003.04314>. Some general use functions for Hawkes processes are also included: simulation of (in)homogeneous Hawkes process, maximum likelihood estimation, residual analysis, etc.

This package provides tools for accessing various open data APIs in the Helsinki region in Finland. Current data sources include the Service Map API, Linked Events API, and Helsinki Region Infoshare statistics API.

This package contains functions for fitting hierarchical versions of EVSD, UVSD, DPSD, DPSD with d restricted to be positive, and our gamma signal detection model to recognition memory confidence-ratings data.

Computes specialist biomarker indices and risk scores for metabolic, cardiovascular, renal, hepatic, inflammatory, frailty, and psychiatric health assessment. Includes fasting and OGTT insulin sensitivity/resistance indices, ASCVD/QRISK3/KFRE risk equations, liver and kidney markers, frailty and comorbidity indices, biofluid marker panels, and utilities for column mapping, normalization, imputation, and combined marker dispatch.

Comfortable ways to work with hyperspectral data sets. I.e. spatially or time-resolved spectra, or spectra with any other kind of information associated with each of the spectra. The spectra can be data as obtained in XRF, UV/VIS, Fluorescence, AES, NIR, IR, Raman, NMR, MS, etc. More generally, any data that is recorded over a discretized variable, e.g. absorbance = f(wavelength), stored as a vector of absorbance values for discrete wavelengths is suitable.

Pfafstetter Hydrological Codes as cited in Verdin and Verdin (1999) <doi: 10.1016/S0022-1694(99)00011-6> are decoded for upstream or downstream queries.

This package implements the sample size methods for hierarchical 2x2 factorial trials under two choices of effect estimands and a series of hypothesis tests proposed in "Sample size calculation in hierarchical 2x2 factorial trials with unequal cluster sizes" (under review), and provides the table and plot generators for the sample size estimations.