This package provides analytical methods for analyzing CRISPR screen data at different levels of gene expression. Multi-component normal mixture models and EM algorithms are used for modeling.

This package provides functions to check whether a vector of p-values respects the assumptions of FDR (false discovery rate) control procedures and to compute adjusted p-values.

Fixation and saccade detection in eye movement recordings. This package implements a dispersion-based algorithm (I-DT) proposed by Salvucci & Goldberg (2000) which detects fixation duration and position.

Real capture frequencies will be fitted to various distributions which provide the basis of estimating population sizes, their standard error, and symmetric as well as asymmetric confidence intervalls.

Enables calculation of image textures (Haralick 1973) <doi:10.1109/TSMC.1973.4309314> from grey-level co-occurrence matrices (GLCMs). Supports processing images that cannot fit in memory.

Providing various equations to calculate Gini coefficients. The methods used in this package can be referenced from Brown MC (1994) <doi: 10.1016/0277-9536(94)90189-9>.

Perform gene set enrichment analyses using the Gene set Ordinal Association Test (GOAT) algorithm and visualize your results. Koopmans, F. (2024) <doi:10.1038/s42003-024-06454-5>.

An efficient algorithm inspired by majorization-minimization principle for solving the entire solution path of a flexible nonparametric expectile regression estimator constructed in a reproducing kernel Hilbert space.

This package provides functions for simulating missing morphometric data randomly, with taxonomic bias and with anatomical bias. LOST also includes functions for estimating linear and geometric morphometric data.

Fits semi-confirmatory structural equation modeling (SEM) via penalized likelihood (PL) or penalized least squares (PLS). For details, please see Huang (2020) <doi:10.18637/jss.v093.i07>.

Providing a method for Local Discrimination via Latent Class Models. The approach is described in <https://www.r-project.org/conferences/useR-2009/abstracts/pdf/Bucker.pdf>.

Model evaluation based on a modified version of the recursive feature elimination algorithm. This package is designed to determine the optimal model(s) by leveraging all available features.

This package provides routines to compute normalised prediction distribution errors, a metric designed to evaluate non-linear mixed effect models such as those used in pharmacokinetics and pharmacodynamics.

This package provides functions for fitting a sparse partial least squares (SPLS) regression and classification (Chun and Keles (2010) <doi:10.1111/j.1467-9868.2009.00723.x>).

Este paquete tiene la finalidad de ayudar a aprender de una forma interactiva, teniendo ejemplos y la posibilidad de resolver nuevos al mismo tiempo. Apuntes de clase interactivos.

Makes research involving EMDAT and related datasets easier. These Datasets are manually filled and have several formatting and compatibility issues. Weed aims to resolve these with its functions.

Implementation of an alternating direction method of multipliers algorithm for fitting a linear model with tree-based lasso regularization, which is proposed in Algorithm 1 of Yan and Bien (2020) <doi:10.1080/01621459.2020.1796677>. The package allows efficient model fitting on the entire 2-dimensional regularization path for large datasets. The complete set of functions also makes the entire process of tuning regularization parameters and visualizing results hassle-free.

This package provides functions to construct efficient row-column designs for 3-level factorial experiments in 3 rows. The designs ensure the estimation of all main effects (full efficiency) and two factor interactions in minimum replications. For more details, see Dey, A. and Mukerjee, R. (2012) <doi:10.1016/j.spl.2012.06.014> and Dash, S., Parsad, R., and Gupta, V. K. (2013) <doi:10.1007/s40003-013-0059-5>.

Implementation of the Robust Exponential Decreasing Index (REDI), proposed in the article by Issa Moussa, Arthur Leroy et al. (2019) <https://bmjopensem.bmj.com/content/bmjosem/5/1/e000573.full.pdf>. The REDI represents a measure of cumulated workload, robust to missing data, providing control of the decreasing influence of workload over time. Various functions are provided to format data, compute REDI, and visualise results in a simple and convenient way.

Personalized assignment to one of many treatment arms via regularized and clustered joint assignment forests as described in Ladhania, Spiess, Ungar, and Wu (2023) <doi:10.48550/arXiv.2311.00577>. The algorithm pools information across treatment arms: it considers a regularized forest-based assignment algorithm based on greedy recursive partitioning that shrinks effect estimates across arms; and it incorporates a clustering scheme that combines treatment arms with consistently similar outcomes.

Generates pseudo-random vectors that follow an arbitrary von Mises-Fisher distribution on a sphere. This method is fast and efficient when generating a large number of pseudo-random vectors. Functions to generate random variates and compute density for the distribution of an inner product between von Mises-Fisher random vector and its mean direction are also provided. Details are in Kang and Oh (2024) <doi:10.1007/s11222-024-10419-3>.

Rdfind is a command line tool that finds duplicate files based on their content instead of their file names. It is useful for compressing backup directories or just finding duplicate files.

This package provides a Perl interface (Perl::Rename) as well as a command-line utility (rename) that can rename multiple files at once based on a Perl regular expression.

This package provides an interface to Amazon Web Services, including storage, database, and compute services, such as Simple Storage Service (S3), DynamoDB NoSQL database, and Lambda functions-as-a-service.