Simple and integrated tool that automatically extracts and folds all hairpin sequences from raw genome-wide data. It predicts the secondary structure of several overlapped segments, with longer length than the mean length of sequences of interest for the species under processing, ensuring that no one is lost nor inappropriately cut.

This package implements transformations of p-values to the smallest possible Bayes factor within the specified class of alternative hypotheses, as described in Held & Ott (2018, <doi:10.1146/annurev-statistics-031017-100307>). Covers several common testing scenarios such as z-tests, t-tests, likelihood ratio tests and the F-test.

Detecting markers of politeness in English natural language. This package allows researchers to easily visualize and quantify politeness between groups of documents. This package combines prior research on the linguistic markers of politeness. We thank the Spencer Foundation, the Hewlett Foundation, and Harvard's Institute for Quantitative Social Science for support.

Offers markdown output formats designed with various styles, allowing users to generate HTML reports tailored for scientific or machine learning showcase. The output has a contemporary appearance with vibrant visuals, providing numerous styles for effective highlighting. Created using the tufte <https://rstudio.github.io/tufte/> package code as a starting point.

Improves the interpretation of the Standardized Precipitation Index under changing climate conditions. The package uses the nonstationary approach proposed in Blain et al. (2022) <doi:10.1002/joc.7550> to detect trends in rainfall quantities and to quantify the effect of such trends on the probability of a drought event occurring.

Routines for creating, manipulating, and performing Bayesian inference about Gaussian processes in one and two dimensions using the Fourier basis approximation: simulation and plotting of processes, calculation of coefficient variances, calculation of process density, coefficient proposals (for use in MCMC). It uses R environments to store GP objects as references/pointers.

This package provides a set of functions to interpret changes in compositional data based on a network representation of all pairwise ratio comparisons: computation of all pairwise ratio, construction of a p-value matrix of all pairwise tests of these ratios between conditions, conversion of this matrix to a network.

The maximum likelihood classifier (MLC) is one of the most common classifiers used for remote sensing imagery. This package uses RcppArmadillo to provide a fast implementation of the MLC to train and predict over tabular data (data.frame). The algorithms were based on Mather (1985) <doi:10.1080/01431168508948456> method.

This application provides exploratory and confirmatory factor analysis, classical test theory, unidimensional and multidimensional item response theory, and continuous item response model analysis, through the shiny interactive interface. In addition, it offers rich functionalities for visualizing and downloading results. Users can download figures, tables, and analysis reports via the interactive interface.

Constructs a virtual population from fertility and mortality rates for any country, calendar year and birth cohort in the Human Mortality Database <https://www.mortality.org> and the Human Fertility Database <https://www.humanfertility.org>. Fertility histories are simulated for every individual and their offspring, producing a multi-generation virtual population.

Scalable methods for learning causal graphical models from mixed data, including continuous, discrete, and censored variables. The package implements CausalMGM, which combines a convex, score-based approach for learning an initial moralized graph with a producer-consumer scheme that enables efficient parallel conditional independence testing in constraint-based causal discovery algorithms. The implementation supports high-dimensional datasets and provides individual access to core components of the workflow, including MGM and the PC-Stable and FCI-Stable causal discovery algorithms. To support practical applications, the package includes multiple model selection strategies, including information criteria based on likelihood and model complexity, cross-validation for out-of-sample likelihood estimation, and stability-based approaches that assess graph robustness across subsamples.

This package provides tools to query the U.S. National Library of Medicine's Clinical Trials database. Functions are provided for a variety of techniques for searching the data using range queries, categorical filtering, and by searching for full-text keywords. Minimal graphical tools are also provided for interactively exploring the constructed data.

Fast annotation of genomic peaks using DNA interaction data by constructing interaction networks with igraph, where peaks overlapping any node in a connected subgraph are annotated with all genes in that subgraph. The annotation evidence could be visualized as either a network graph or a genomic track integrated with gene annotation information.

This package finds and filters artificial chimeric reads specifically generated in next-generation sequencing (NGS) process of formalin-fixed paraffin-embedded (FFPE) tissues. These artificial chimeric reads can lead to a large number of false positive structural variation (SV) calls. The required input is an indexed BAM file of a FFPE sample.

Kataegis refers to the occurrence of regional hypermutation and is a phenomenon observed in a wide range of malignancies. Using changepoint detection katdetectr aims to identify putative kataegis foci from common data-formats housing genomic variants. Katdetectr has shown to be a robust package for the detection, characterization and visualization of kataegis.

pairedGSEA makes it simple to run a paired Differential Gene Expression (DGE) and Differencital Gene Splicing (DGS) analysis. The package allows you to store intermediate results for further investiation, if desired. pairedGSEA comes with a wrapper function for running an Over-Representation Analysis (ORA) and functionalities for plotting the results.

Simplify creating multiple, related leaflet maps across tabs for a shiny application. Users build lists of any polygons, points, and polylines needed for the project, use the map_server() function to assign built lists and other chosen aesthetics into each tab, and the package leverages modules to generate all map tabs.

This package contains the probability density function, cumulative distribution function, quantile function, and random number generator for composite and discrete composite distributions with Pareto tails. The detailed description of the methods and the applications of the methods can be found in Bowen Liu, Malwane M.A. Ananda (2023) <arXiv:2309.16443>.

Work with controlled vocabularies; a predefined set of terms intended to be used in in a specific context. This package introduces the control verb, which recodes values in a vector using a lookup table of preferred and variant terms (a thesaurus'). It also includes functions for reading controlled vocabularies from standard formats.

This package implements estimation methods for parameters of common distribution families. The common d, p, q, r function family for each distribution is enriched with the ll, e, and v counterparts, computing the log-likelihood, performing estimation, and calculating the asymptotic variance - covariance matrix, respectively. Parameter estimation is performed analytically whenever possible.

This package contains a set of clustering methods and evaluation metrics to select the best number of the clusters based on clustering stability. Two references describe the methodology: Fahimeh Nezhadmoghadam, and Jose Tamez-Pena (2021)<doi:10.1016/j.compbiomed.2021.104753>, and Fahimeh Nezhadmoghadam, et al.(2021)<doi:10.2174/1567205018666210831145825>.

Satellite data collected between 2003 and 2022, in conjunction with gridded bathymetric data (50-150 m resolution), are used to estimate the irradiance reaching the bottom of a series of representative EU Arctic fjords. An Earth System Science Data (ESSD) manuscript, Schlegel et al. (2024), provides a detailed explanation of the methodology.

We propose two distribution-free test statistics based on between-sample edge counts and measure the degree of relevance by standardized counts. Users can set edge costs in the graph to compare the parameters of the distributions. Methods for comparing distributions are as described in: Xiaoping Shi (2021) <arXiv:2107.00728>.

This package provides a set of tools to create georeferenced hillshade relief raster maps using ray-tracing and other advanced hill-shading techniques. It includes a wrapper function to create a georeferenced, ray-traced hillshade map from a digital elevation model, and other functions that can be used in a rayshader pipeline.