Lake temperature records, metadata, and climate drivers for 291 global lakes during the time period 1985-2009. Temperature observations were collected using satellite and in situ methods. Climatic drivers and geomorphometric characteristics were also compiled and are included for each lake. Data are part of the associated publication from the Global Lake Temperature Collaboration project (http://www.laketemperature.org). See citation('laketemps') for dataset attribution.

This package provides a comprehensive analysis tool for metabolomics data. It consists a variety of functional modules, including several new modules: a pre-processing module for normalization and imputation, an exploratory data analysis module for dimension reduction and source of variation analysis, a classification module with the new deep-learning method and other machine-learning methods, a prognosis module with cox-PH and neural-network based Cox-nnet methods, and pathway analysis module to visualize the pathway and interpret metabolite-pathway relationships. References: H. Paul Benton <http://www.metabolomics-forum.com/index.php?topic=281.0> Jeff Xia <https://github.com/cangfengzhe/Metabo/blob/master/MetaboAnalyst/website/name_match.R> Travers Ching, Xun Zhu, Lana X. Garmire (2018) <doi:10.1371/journal.pcbi.1006076>.

An easy-to-use ndjson (newline-delimited JSON') logger. It provides a set of wrappers for base R's message(), warning(), and stop() functions that maintain identical functionality, but also log the handler message to an ndjson log file. No change in existing code is necessary to use this package, and only a few additional adjustments are needed to fully utilize its potential.

The lognormal distribution (Limpert et al. (2001) <doi:10.1641/0006-3568(2001)051%5B0341:lndats%5D2.0.co;2>) can characterize uncertainty that is bounded by zero. This package provides estimation of distribution parameters, computation of moments and other basic statistics, and an approximation of the distribution of the sum of several correlated lognormally distributed variables (Lo 2013 <doi:10.12988/ams.2013.39511>) and the approximation of the difference of two correlated lognormally distributed variables (Lo 2012 <doi:10.1155/2012/838397>).

This package provides tools for fast and accurate evaluation of skew stable distributions (CDF, PDF and quantile functions), random number generation, and parameter estimation. This is libstableR as per Royuela del Val, Simmross-Wattenberg, and Alberola López (2017) <doi:10.18637/jss.v078.i01> under a new maintainer.

LINCS L1000 is a high-throughput technology that allows the gene expression measurement in a large number of assays. However, to fit the measurements of ~1000 genes in the ~500 color channels of LINCS L1000, every two landmark genes are designed to share a single channel. Thus, a deconvolution step is required to infer the expression values of each gene. Any errors in this step can be propagated adversely to the downstream analyses. We present a LINCS L1000 data peak calling R package l1kdeconv based on a new outlier detection method and an aggregate Gaussian mixture model. Upon the remove of outliers and the borrowing information among similar samples, l1kdeconv shows more stable and better performance than methods commonly used in LINCS L1000 data deconvolution.

This package provides two methods of estimating income inequality statistics from binned income data, such as the income data provided in the Census. These methods use different interpolation techniques to infer the distribution of incomes within income bins. One method is an implementation of Jargowsky and Wheeler's mean-constrained integration over brackets (MCIB). The other method is based on a new technique, Lorenz interpolation, which estimates income inequality by constructing an interpolated Lorenz curve based on the binned income data. These methods can be used to estimate three income inequality measures: the Gini (the default measure returned), the Theil, and the Atkinson's index. Jargowsky and Wheeler (2018) <doi:10.1177/0081175018782579>.

This package provides S3 classes to represent low rank matrix decompositions.

An emulator designed for rapid sequential emulation (e.g., Markov chain Monte Carlo applications). Works via extension of the laGP approach by Gramacy and Apley (2015 <doi:10.1080/10618600.2014.914442>). Details are given in Rumsey et al. (2023 <doi:10.1002/sta4.576>).

This package provides a single analysis path that includes distance-based ordination, global tests of any effect of the microbiome, and tests of the effects of individual taxa with false-discovery-rate (FDR) control. It accommodates both continuous and discrete covariates as well as interaction terms to be tested either singly or in combination, allows for adjustment of confounding covariates, and uses permutation-based p-values that can control for sample correlations. It can be applied to transformed data, and an omnibus test can combine results from analyses conducted on different transformation scales. It can also be used for testing presence-absence associations based on infinite number of rarefaction replicates, testing mediation effects of the microbiome, analyzing censored time-to-event outcomes, and for compositional analysis by fitting linear models to centered-log-ratio taxa count data.

Effectively simulates the discretization process inherent to Likert scales while minimizing distortion. It converts continuous latent variables into ordinal categories to generate Likert scale item responses. Particularly useful for accurately modeling and analyzing survey data that use Likert scales, especially when applying statistical techniques that require metric data.

Interactive visualization of effects, response functions and marginal effects for different kinds of regression models. In this version linear regression models, generalized linear models, generalized additive models and linear mixed-effects models are supported. Major features are the interactive approach and the handling of the effects of categorical covariates: if two or more factors are used as covariates every combination of the levels of each factor is treated separately. The automatic calculation of marginal effects and a number of possibilities to customize the graphical output are useful features as well.

This package creates lowpass filters which are commonly used in ion channel recordings. It supports generation of random numbers that are filtered, i.e. follow a model for ion channel recordings, see <doi:10.1109/TNB.2018.2845126>. Furthermore, time continuous convolutions of piecewise constant signals with the kernel of lowpass filters can be computed.

Probabilistic record linkage without direct identifiers using only diagnosis codes. Method is detailed in: Hejblum, Weber, Liao, Palmer, Churchill, Szolovits, Murphy, Kohane & Cai (2019) <doi: 10.1038/sdata.2018.298> ; Zhang, Hejblum, Weber, Palmer, Churchill, Szolovits, Murphy, Liao, Kohane & Cai (2021) <doi: 10.1093/jamia/ocab187>.

Estimating causal parameters in the presence of treatment spillover is of great interest in statistics. This package provides tools for instrumental variables estimation of average causal effects under network interference of unknown form. The target parameters are the local average direct effect, the local average indirect effect, the local average overall effect, and the local average spillover effect. The methods are developed by Hoshino and Yanagi (2023) <doi:10.48550/arXiv.2108.07455>.

Efficient implementation of Friedman's boosting algorithm with l2-loss function and coordinate direction (design matrix columns) basis functions.

Lexical response data is a package that can be used for processing cued-recall, free-recall, and sentence responses from memory experiments.

This package performs power and sample size calculation for non-proportional hazards model using the Fleming-Harrington family of weighted log-rank tests. The sequentially calculated log-rank test score statistics are assumed to have independent increments as characterized in Anastasios A. Tsiatis (1982) <doi:10.1080/01621459.1982.10477898>. The mean and variance of log-rank test score statistics are calculated based on Kaifeng Lu (2021) <doi:10.1002/pst.2069>. The boundary crossing probabilities are calculated using the recursive integration algorithm described in Christopher Jennison and Bruce W. Turnbull (2000, ISBN:0849303168). The package can also be used for continuous, binary, and count data. For continuous data, it can handle missing data through mixed-model for repeated measures (MMRM). In crossover designs, it can estimate direct treatment effects while accounting for carryover effects. For binary data, it can design Simon's 2-stage, modified toxicity probability-2 (mTPI-2), and Bayesian optimal interval (BOIN) trials. For count data, it can design group sequential trials for negative binomial endpoints with censoring. Additionally, it facilitates group sequential equivalence trials for all supported data types. Moreover, it can design adaptive group sequential trials for changes in sample size, error spending function, number and spacing or future looks. Finally, it offers various options for adjusted p-values, including graphical and gatekeeping procedures.

This package provides functions for normalizing standard laboratory measurements (e.g. hemoglobin, cholesterol levels) according to age and sex, based on the algorithms described in "Personalized lab test models to quantify disease potentials in healthy individuals" (Netta Mendelson Cohen, Omer Schwartzman, Ram Jaschek, Aviezer Lifshitz, Michael Hoichman, Ran Balicer, Liran I. Shlush, Gabi Barbash & Amos Tanay, <doi:10.1038/s41591-021-01468-6>). Allows users to easily obtain normalized values for standard lab results, and to visualize their distributions. See more at <https://tanaylab.weizmann.ac.il/labs/>.

Various plots and functions that make use of the lattice/trellis plotting framework. The plots, which include loaPlot(), loaMapPlot() and trianglePlot(), and use panelPal(), a function that extends lattice and hexbin package methods to automate plot subscript and panel-to-panel and panel-to-key synchronization/management.

This package provides a set of functions for analyzing the structure of forests based on the leaf area density (LAD) and leaf area index (LAI) measures calculated from Airborne Laser Scanning (ALS), i.e., scanning lidar (Light Detection and Ranging) data. The methodology is discussed and described in Almeida et al. (2019) <doi:10.3390/rs11010092> and Stark et al. (2012) <doi:10.1111/j.1461-0248.2012.01864.x>.

This package contains Lioness Algorithm (LA) for finding optimal designs over continuous design space, optimal Latin hypercube designs, and optimal order-of-addition designs. LA is a brand new nature-inspired meta-heuristic optimization algorithm. Detailed methodologies of LA and its implementation on numerical simulations can be found at Hongzhi Wang, Qian Xiao and Abhyuday Mandal (2021) <doi:10.48550/arXiv.2010.09154>.

"Learning with Subset Stacking" is a supervised learning algorithm that is based on training many local estimators on subsets of a given dataset, and then passing their predictions to a global estimator. You can find the details about LESS in our manuscript at <arXiv:2112.06251>.

Detect feedback loops (cycles, circuits) between species (nodes) in ordinary differential equation (ODE) models. Feedback loops are paths from a node to itself without visiting any other node twice, and they have important regulatory functions. Loops are reported with their order of participating nodes and their length, and whether the loop is a positive or a negative feedback loop. An upper limit of the number of feedback loops limits runtime (which scales with feedback loop count). Model parametrizations and values of the modelled variables are accounted for. Computation uses the characteristics of the Jacobian matrix as described e.g. in Thomas and Kaufman (2002) <doi:10.1016/s1631-0691(02)01452-x>. Input can be the Jacobian matrix of the ODE model or the ODE function definition; in the latter case, the Jacobian matrix is determined using numDeriv'. Graph-based algorithms from igraph are employed for path detection.