Provide methods to perform customized inference at individual level by taking contextual covariates into account. Three main functions are provided in this package: (i) LASER(): it generates specially-designed artificial relevant samples for a given case; (ii) g2l.proc(): computes customized fdr(z|x); and (iii) rEB.proc(): performs empirical Bayes inference based on LASERs. The details can be found in Mukhopadhyay, S., and Wang, K (2021, <arXiv:2004.09588>).

This package provides a utility to facilitate the logging and review of R programs in clinical trial programming workflows.

Estimate model parameters to determine whether two compounds have synergy, antagonism, or Loewe's Additivity.

Extracts and creates an analysis pipeline for the JSON data files from Brain Sense sessions using Medtronic's Deep Brain Stimulation surgery electrode implants.

Outlier detection using leave-one-out kernel density estimates and extreme value theory. The bandwidth for kernel density estimates is computed using persistent homology, a technique in topological data analysis. Using peak-over-threshold method, a generalized Pareto distribution is fitted to the log of leave-one-out kde values to identify outliers.

This package provides functions to access and test results from a linear model.

Estimation of the local false discovery rate using the method of moments.

This package provides drill down functionality for leaflet choropleths in shiny apps.

Print vectors (and data frames) of floating point numbers using a non-scientific format optimized for human readers. Vectors of numbers are rounded using significant digits, aligned at the decimal point, and all zeros trailing the decimal point are dropped. See: Wright (2016). Lucid: An R Package for Pretty-Printing Floating Point Numbers. In JSM Proceedings, Statistical Computing Section. Alexandria, VA: American Statistical Association. 2270-2279.

This package implements Lagrangian multiplier smoothing splines for flexible nonparametric regression and function estimation. Provides tools for fitting, prediction, and inference using a constrained optimization approach to enforce smoothness. Supports generalized linear models, Weibull accelerated failure time (AFT) models, quadratic programming constraints, and customizable working-correlation structures, with options for parallel fitting. The core spline construction builds on Ezhov et al. (2018) <doi:10.1515/jag-2017-0029>. Quadratic-programming and SQP details follow Goldfarb & Idnani (1983) <doi:10.1007/BF02591962> and Nocedal & Wright (2006) <doi:10.1007/978-0-387-40065-5>. For smoothing spline and penalized spline background, see Wahba (1990) <doi:10.1137/1.9781611970128> and Wood (2017) <doi:10.1201/9781315370279>. For variance-component and correlation-parameter estimation, see Searle et al. (2006) <ISBN:978-0470009598>. The default multivariate partitioning step uses k-means clustering as in MacQueen (1967).

Auxiliary package for better/faster analytics, visualization, data mining, and machine learning tasks. With a wide variety of family functions, like Machine Learning, Data Wrangling, Marketing Mix Modeling (Robyn), Exploratory, API, and Scrapper, it helps the analyst or data scientist to get quick and robust results, without the need of repetitive coding or advanced R programming skills.

Estimate covariance matrices that contain low rank and sparse components.

Plots empty Lexis grids, adds lifelines and highlights certain areas of the grid, like cohorts and age groups.

Miscellaneous R functions (for graphics, data import, data transformation, and general utilities) and templates (for exploratory analysis, Bayesian modeling, and crafting scientific manuscripts).

Genome-wide association (GWAS) analyses of a biomarker that account for the limit of detection.

This package performs approximate GP regression for large computer experiments and spatial datasets. The approximation is based on finding small local designs for prediction (independently) at particular inputs. OpenMP and SNOW parallelization are supported for prediction over a vast out-of-sample testing set; GPU acceleration is also supported for an important subroutine. OpenMP and GPU features may require special compilation. An interface to lower-level (full) GP inference and prediction is provided. Wrapper routines for blackbox optimization under mixed equality and inequality constraints via an augmented Lagrangian scheme, and for large scale computer model calibration, are also provided. For details and tutorial, see Gramacy (2016 <doi:10.18637/jss.v072.i01>.

This package provides functions for forest objects detection, structure metrics computation, model calibration and mapping with airborne laser scanning: co-registration of field plots (Monnet and Mermin (2014) <doi:10.3390/f5092307>); tree detection (method 1 in Eysn et al. (2015) <doi:10.3390/f6051721>) and segmentation; forest parameters estimation with the area-based approach: model calibration with ground reference, and maps export (Aussenac et al. (2023) <doi:10.12688/openreseurope.15373.2>); extraction of both physical (gaps, edges, trees) and statistical features useful for e.g. habitat suitability modeling (Glad et al. (2020) <doi:10.1002/rse2.117>) and forest maturity mapping (Fuhr et al. (2022) <doi:10.1002/rse2.274>).

This package provides a comprehensive analysis tool for metabolomics data. It consists a variety of functional modules, including several new modules: a pre-processing module for normalization and imputation, an exploratory data analysis module for dimension reduction and source of variation analysis, a classification module with the new deep-learning method and other machine-learning methods, a prognosis module with cox-PH and neural-network based Cox-nnet methods, and pathway analysis module to visualize the pathway and interpret metabolite-pathway relationships. References: H. Paul Benton <http://www.metabolomics-forum.com/index.php?topic=281.0> Jeff Xia <https://github.com/cangfengzhe/Metabo/blob/master/MetaboAnalyst/website/name_match.R> Travers Ching, Xun Zhu, Lana X. Garmire (2018) <doi:10.1371/journal.pcbi.1006076>.

This package provides modular, graph-based agents powered by large language models (LLMs) for intelligent task execution in R. Supports structured workflows for tasks such as forecasting, data visualization, feature engineering, data wrangling, data cleaning, SQL', code generation, weather reporting, and research-driven question answering. Each agent performs iterative reasoning: recommending steps, generating R code, executing, debugging, and explaining results. Includes built-in support for packages such as tidymodels', modeltime', plotly', ggplot2', and prophet'. Designed for analysts, developers, and teams building intelligent, reproducible AI workflows in R. Compatible with LLM providers such as OpenAI', Anthropic', Groq', and Ollama'. Inspired by the Python package langagent'.

It uses phenological and productivity-related variables derived from time series of vegetation indexes, such as the Normalized Difference Vegetation Index, to assess ecosystem dynamics and change, which eventually might drive to land degradation. The final result of the Land Productivity Dynamics indicator is a categorical map with 5 classes of land productivity dynamics, ranging from declining to increasing productivity. See www.sciencedirect.com/science/article/pii/S1470160X21010517/ for a description of the methods used in the package to calculate the indicator.

Computing statistical hypothesis testing for loading in principal component analysis (PCA) (Yamamoto, H. et al. (2014) <doi:10.1186/1471-2105-15-51>), orthogonal smoothed PCA (OS-PCA) (Yamamoto, H. et al. (2021) <doi:10.3390/metabo11030149>), one-sided kernel PCA (Yamamoto, H. (2023) <doi:10.51094/jxiv.262>), partial least squares (PLS) and PLS discriminant analysis (PLS-DA) (Yamamoto, H. et al. (2009) <doi:10.1016/j.chemolab.2009.05.006>), PLS with rank order of groups (PLS-ROG) (Yamamoto, H. (2017) <doi:10.1002/cem.2883>), regularized canonical correlation analysis discriminant analysis (RCCA-DA) (Yamamoto, H. et al. (2008) <doi:10.1016/j.bej.2007.12.009>), multiset PLS and PLS-ROG (Yamamoto, H. (2022) <doi:10.1101/2022.08.30.505949>).

This package provides a toolbox for R arrays. Flexibly split, bind, reshape, modify, subset and name arrays.

Robust test(s) for model diagnostics in regression. The current version contains a robust test for functional specification (linearity). The test is based on the robust bounded-influence test by Heritier and Ronchetti (1994) <doi:10.1080/01621459.1994.10476822>.

This package provides a class that links matrix-like objects (nodes) by rows or by columns while behaving similarly to a base R matrix. Very large matrices are supported if the nodes are file-backed matrices.