Efficient Frequentist profiling and Bayesian marginalization of parameters for which the conditional likelihood is that of a multivariate linear regression model. Arbitrary inter-observation error correlations are supported, with optimized calculations provided for independent-heteroskedastic and stationary dependence structures.

When building complex models, it is often difficult to explain why the model should be trusted. While global measures such as accuracy are useful, they cannot be used for explaining why a model made a specific prediction. lime (a port of the lime Python package) is a method for explaining the outcome of black box models by fitting a local model around the point in question an perturbations of this point. The approach is described in more detail in the article by Ribeiro et al. (2016) <doi:10.48550/arXiv.1602.04938>.

Implementations of estimation algorithm of low rank plus sparse structured VAR model by using Fast Iterative Shrinkage-Thresholding Algorithm (FISTA). It relates to the algorithm in Sumanta, Li, and Michailidis (2019) <doi:10.1109/TSP.2018.2887401>.

Set of tools for analyzing lactate thresholds from a step incremental test to exhaustion. Easily analyze the methods Log-log, Onset of Blood Lactate Accumulation (OBLA), Baseline plus (Bsln+), Dmax, Lactate Turning Point (LTP), and Lactate / Intensity ratio (LTratio) in cycling, running, or swimming. Beaver WL, Wasserman K, Whipp BJ (1985) <doi:10.1152/jappl.1985.59.6.1936>. Heck H, Mader A, Hess G, Mücke S, Müller R, Hollmann W (1985) <doi:10.1055/s-2008-1025824>. Kindermann W, Simon G, Keul J (1979) <doi:10.1007/BF00421101>. Skinner JS, Mclellan TH (1980) <doi:10.1080/02701367.1980.10609285>. Berg A, Jakob E, Lehmann M, Dickhuth HH, Huber G, Keul J (1990) PMID 2408033. Zoladz JA, Rademaker AC, Sargeant AJ (1995) <doi:10.1113/jphysiol.1995.sp020959>. Cheng B, Kuipers H, Snyder A, Keizer H, Jeukendrup A, Hesselink M (1992) <doi:10.1055/s-2007-1021309>. Bishop D, Jenkins DG, Mackinnon LT (1998) <doi:10.1097/00005768-199808000-00014>. Hughson RL, Weisiger KH, Swanson GD (1987) <doi:10.1152/jappl.1987.62.5.1975>. Jamnick NA, Botella J, Pyne DB, Bishop DJ (2018) <doi:10.1371/journal.pone.0199794>. Hofmann P, Tschakert G (2017) <doi:10.3389/fphys.2017.00337>. Hofmann P, Pokan R, von Duvillard SP, Seibert FJ, Zweiker R, Schmid P (1997) <doi:10.1097/00005768-199706000-00005>. Pokan R, Hofmann P, Von Duvillard SP, et al. (1997) <doi:10.1097/00005768-199708000-00009>. Dickhuth H-H, Yin L, Niess A, et al. (1999) <doi:10.1055/s-2007-971105>.

Calculates 3D lacunarity from voxel data. It is designed for use with point clouds generated from Light Detection And Ranging (LiDAR) scans in order to measure the spatial heterogeneity of 3-dimensional structures such as forest stands. It provides fast C++ functions to efficiently bin point cloud data into voxels and calculate lacunarity using different variants of the gliding-box algorithm originated by Allain & Cloitre (1991) <doi:10.1103/PhysRevA.44.3552>.

Non-parametric prediction of survival outcomes for mixture data that incorporates covariates and a landmark time. Details are described in Garcia (2021) <doi:10.1093/biostatistics/kxz052>.

Wrapper functions for the implementation of lagged weighted quantile sum regression, as per Gennings et al (2020) <doi:10.1016/j.envres.2020.109529>.

This package implements a local likelihood estimator for the dependence parameter in bivariate conditional copula models. Copula family and local likelihood bandwidth parameters are selected by leave-one-out cross-validation. The models are implemented in TMB', meaning that the local score function is efficiently calculated via automated differentiation (AD), such that quasi-Newton algorithms may be used for parameter estimation.

Cellular cooperation compromises the established method of calculating clonogenic activity from limiting dilution assay (LDA) data. This tool provides functions that enable robust analysis in presence or absence of cellular cooperation. The implemented method incorporates the same cooperativity module to model the non-linearity associated with cellular cooperation as known from the colony formation assay (Brix et al. (2021) <doi:10.1038/s41596-021-00615-0>: "Analysis of clonogenic growth in vitro." Nature protocols).

Dimensionality reduction techniques for binary data including logistic PCA.

Labels are a common construct in statistical software providing a human readable description of a variable. While variable names are succinct, quick to type, and follow a language's naming conventions, labels may be more illustrative and may use plain text and spaces. R does not provide native support for labels. Some packages, however, have made this feature available. Most notably, the Hmisc package provides labelling methods for a number of different object. Due to design decisions, these methods are not all exported, and so are unavailable for use in package development. The labelVector package supports labels for atomic vectors in a light-weight design that is suitable for use in other packages.

Calculation of rectifying LTPD and AOQL plans for sampling inspection by variables which minimize mean inspection cost per lot of process average quality.

Miscellaneous R functions (for graphics, data import, data transformation, and general utilities) and templates (for exploratory analysis, Bayesian modeling, and crafting scientific manuscripts).

Lipid annotation in untargeted LC-MS lipidomics based on fragmentation rules. Alcoriza-Balaguer MI, Garcia-Canaveras JC, Lopez A, Conde I, Juan O, Carretero J, Lahoz A (2019) <doi:10.1021/acs.analchem.8b03409>.

This package provides an interface to the financial data platform <https://datahub.limex.com/>., enabling users to retrieve real-time and historical financial data. Functions within the package allow access to instruments, candlestick charts, fundamentals, news, events, models, and trading signals. Authentication is managed through user-specific API tokens, which are securely handled via environment variables.

Fast implementations to compute the genetic covariance matrix, the Jaccard similarity matrix, the s-matrix (the weighted Jaccard similarity matrix), and the (classic or robust) genomic relationship matrix of a (dense or sparse) input matrix (see Hahn, Lutz, Hecker, Prokopenko, Cho, Silverman, Weiss, and Lange (2020) <doi:10.1002/gepi.22356>). Full support for sparse matrices from the R-package Matrix'. Additionally, an implementation of the power method (von Mises iteration) to compute the largest eigenvector of a matrix is included, a function to perform an automated full run of global and local correlations in population stratification data, a function to compute sliding windows, and a function to invert minor alleles and to select those variants/loci exceeding a minimal cutoff value. New functionality in locStra allows one to extract the k leading eigenvectors of the genetic covariance matrix, Jaccard similarity matrix, s-matrix, and genomic relationship matrix via fast PCA without actually computing the similarity matrices. The fast PCA to compute the k leading eigenvectors can now also be run directly from bed'+'bim'+'fam files.

This package provides a set of functions for analyzing the structure of forests based on the leaf area density (LAD) and leaf area index (LAI) measures calculated from Airborne Laser Scanning (ALS), i.e., scanning lidar (Light Detection and Ranging) data. The methodology is discussed and described in Almeida et al. (2019) <doi:10.3390/rs11010092> and Stark et al. (2012) <doi:10.1111/j.1461-0248.2012.01864.x>.

An interface for NetLogo <https://www.netlogo.org> that enables programmatic setup and execution of simulations. Designed to facilitate integrating NetLogo models into reproducible workflows by creating and running BehaviorSpace experiments and retrieving their results.

This computes Lipinski Rule of Five parameters and offers visualization for drug discovery. It analyzes molecular properties like molecular weight, hydrogen bond donors, acceptors, and ALogP, providing histograms and pass/fail status plots for efficient compound evaluation, aiding in drug development.

This package provides functionality to train and evaluate algorithm selection models for portfolios.

Combines Latent Dirichlet Allocation (LDA) and Bayesian multinomial time series methods in a two-stage analysis to quantify dynamics in high-dimensional temporal data. LDA decomposes multivariate data into lower-dimension latent groupings, whose relative proportions are modeled using generalized Bayesian time series models that include abrupt changepoints and smooth dynamics. The methods are described in Blei et al. (2003) <doi:10.1162/jmlr.2003.3.4-5.993>, Western and Kleykamp (2004) <doi:10.1093/pan/mph023>, Venables and Ripley (2002, ISBN-13:978-0387954578), and Christensen et al. (2018) <doi:10.1002/ecy.2373>.

Some simple objects and functions to do statistics using linear models and a Bayesian framework.

Diagnostics and visualization tools for latent variable models fitted with lavaan (Rosseel, 2012 <doi:10.18637/jss.v048.i02>). The package provides fast, parallel-safe factor-score prediction (lavPredict_parallel()), data augmentation with model predictions, residuals, delta-method standard errors and confidence intervals (augment()), and model-based latent grids for continuous, ordinal, or mixed indicators (prepare()). It offers item-level empirical versus model curve comparison using generalized additive models for both continuous and ordinal indicators (item_data(), item_plot()) via mgcv (Wood, 2017, ISBN:9781498728331), residual diagnostics including residual correlation tables and plots (resid_cor(), resid_corrplot()) using corrplot (Wei and Simko, 2021 <https://github.com/taiyun/corrplot>), and Qâ Q checks of residual z-statistics (resid_qq()), optionally with non-overlapping labels from ggrepel (Slowikowski, 2024 <https://CRAN.R-project.org/package=ggrepel>). Heavy computations are parallelized via future'/'furrr (Bengtsson, 2021 <doi:10.32614/RJ-2021-048>; Vaughan and Dancho, 2018 <https://CRAN.R-project.org/package=furrr>). Methods build on established literature and packages listed above.

Probabilistic record linkage without direct identifiers using only diagnosis codes. Method is detailed in: Hejblum, Weber, Liao, Palmer, Churchill, Szolovits, Murphy, Kohane & Cai (2019) <doi: 10.1038/sdata.2018.298> ; Zhang, Hejblum, Weber, Palmer, Churchill, Szolovits, Murphy, Liao, Kohane & Cai (2021) <doi: 10.1093/jamia/ocab187>.