Time-dependent Receiver Operating Characteristic curves, Area Under the Curve, and Net Reclassification Indexes for repeated measures. It is based on methods in Barbati and Farcomeni (2017) <doi:10.1007/s10260-017-0410-2>.

Provide methods to perform customized inference at individual level by taking contextual covariates into account. Three main functions are provided in this package: (i) LASER(): it generates specially-designed artificial relevant samples for a given case; (ii) g2l.proc(): computes customized fdr(z|x); and (iii) rEB.proc(): performs empirical Bayes inference based on LASERs. The details can be found in Mukhopadhyay, S., and Wang, K (2021, <arXiv:2004.09588>).

The reference implementation of model equations and default parameters for the toxicokinetic-toxicodynamic (TKTD) model of the Lemna (duckweed) aquatic plant. Lemna is a standard test macrophyte used in ecotox effect studies. The model was described and published by the SETAC Europe Interest Group Effect Modeling. It is a refined description of the Lemna TKTD model published by Schmitt et al. (2013) <doi:10.1016/j.ecolmodel.2013.01.017>.

This package implements Latent Unknown Clusters By Integrating Multi-omics Data (LUCID; Peng (2019) <doi:10.1093/bioinformatics/btz667>) for integrative clustering with exposures, multi-omics data, and health outcomes. Supports three integration strategies: early, parallel, and serial. Provides model fitting and tuning, lasso-type regularization for exposure and omics feature selection, handling of missing data, including both sporadic and complete-case patterns, prediction, and g-computation for estimating causal effects of exposures, bootstrap inference for uncertainty estimation, and S3 summary and plot methods. For the multi-omics integration framework, see Jia (2024) <https://journal.r-project.org/articles/RJ-2024-012/RJ-2024-012.pdf>. For the missing-data imputation mechanism, see Jia (2024) <doi:10.1093/bioadv/vbae123>.

Allows you to read and change the state of LIFX smart light bulbs via the LIFX developer api <https://api.developer.lifx.com/>. Covers most LIFX api endpoints, including changing light color and brightness, selecting lights by id, group or location as well as activating effects.

Interpretable nonparametric modeling of longitudinal data using additive Gaussian process regression. Contains functionality for inferring covariate effects and assessing covariate relevances. Models are specified using a convenient formula syntax, and can include shared, group-specific, non-stationary, heterogeneous and temporally uncertain effects. Bayesian inference for model parameters is performed using Stan'. The modeling approach and methods are described in detail in Timonen et al. (2021) <doi:10.1093/bioinformatics/btab021>.

This package performs variety of viral quasispecies diversity analyses [see Pamornchainavakul et al. (2024) <doi:10.21203/rs.3.rs-4637890/v1>] based on long-read sequence alignment. Main functions include 1) sequencing error and other noise minimization and read sampling, 2) Single nucleotide variant (SNV) profiles comparison, and 3) viral quasispecies profiles comparison and visualization.

Converts video files to mp3', merges multiple audio files and trims audio files using FFmpeg', which is dynamically downloaded to avoid bundling any third-party binaries. Users must ensure compliance with the license terms of FFmpeg when using the package. See <https://github.com/BtbN/FFmpeg-Builds/releases/download/latest/ffmpeg-master-latest-win64-gpl.zip> for details.

Performing impulse-response function (IRF) analysis of relevant variables of agent-based simulation models, in particular for models described in LSD format. Based on the data produced by the simulation model, it performs both linear and state-dependent IRF analysis, providing the tools required by the Counterfactual Monte Carlo (CMC) methodology (Amendola and Pereira (2024) <doi:10.1016/j.jebo.2024.106811>), including state identification and sensitivity. CMC proposes retrieving the causal effect of shocks by exploiting the opportunity to directly observe the counterfactual in a fully controlled experimental setup. LSD (Laboratory for Simulation Development) is free software available at <https://www.labsimdev.org/>).

Fast estimation of multinomial (MNL) and mixed logit (MXL) models in R. Models can be estimated using "Preference" space or "Willingness-to-pay" (WTP) space utility parameterizations. Weighted models can also be estimated. An option is available to run a parallelized multistart optimization loop with random starting points in each iteration, which is useful for non-convex problems like MXL models or models with WTP space utility parameterizations. The main optimization loop uses the nloptr package to minimize the negative log-likelihood function. Additional functions are available for computing and comparing WTP from both preference space and WTP space models and for predicting expected choices and choice probabilities for sets of alternatives based on an estimated model. Mixed logit models can include uncorrelated or correlated heterogeneity covariances and are estimated using maximum simulated likelihood based on the algorithms in Train (2009) <doi:10.1017/CBO9780511805271>. More details can be found in Helveston (2023) <doi:10.18637/jss.v105.i10>.

Fits structural equation modeling via penalized likelihood.

The leader clustering algorithm provides a means for clustering a set of data points. Unlike many other clustering algorithms it does not require the user to specify the number of clusters, but instead requires the approximate radius of a cluster as its primary tuning parameter. The package provides a fast implementation of this algorithm in n-dimensions using Lp-distances (with special cases for p=1,2, and infinity) as well as for spatial data using the Haversine formula, which takes latitude/longitude pairs as inputs and clusters based on great circle distances.

Local Individual Conditional Expectation ('localICE') is a local explanation approach from the field of eXplainable Artificial Intelligence (XAI). localICE is a model-agnostic XAI approach which provides three-dimensional local explanations for particular data instances. The approach is proposed in the master thesis of Martin Walter as an extension to ICE (see Reference). The three dimensions are the two features at the horizontal and vertical axes as well as the target represented by different colors. The approach is applicable for classification and regression problems to explain interactions of two features towards the target. For classification models, the number of classes can be more than two and each class is added as a different color to the plot. The given instance is added to the plot as two dotted lines according to the feature values. The localICE-package can explain features of type factor and numeric of any machine learning model. Automatically supported machine learning packages are mlr', randomForest', caret or all other with an S3 predict function. For further model types from other libraries, a predict function has to be provided as an argument in order to get access to the model. Reference to the ICE approach: Alex Goldstein, Adam Kapelner, Justin Bleich, Emil Pitkin (2013) <arXiv:1309.6392>.

Supervised classification methods, which (if asked) can provide step-by-step explanations of the algorithms used, as described in PK Josephine et. al., (2021) <doi:10.59176/kjcs.v1i1.1259>; and datasets to test them on, which highlight the strengths and weaknesses of each technique.

Computation of linkage disequilibrium of ancestry (LDA) and linkage disequilibrium of ancestry score (LDAS). LDA calculates the pairwise linkage disequilibrium of ancestry between single nucleotide polymorphisms (SNPs). LDAS calculates the LDA score of SNPs. The methods are described in Barrie W, Yang Y, Irving-Pease E.K, et al (2024) <doi:10.1038/s41586-023-06618-z>.

Regression analysis of mixed sparse synchronous and asynchronous longitudinal covariates. Please cite the manuscripts corresponding to this package: Sun, Z. et al. (2023) <arXiv:2305.17715> and Liu, C. et al. (2023) <arXiv:2305.17662>.

Recursive partition algorithms designed for fitting survival trees with left-truncated and right-censored (LTRC) data, as well as interval-censored data. The LTRC trees can also be used to fit survival trees with time-varying covariates.

This package contains functions for a flexible varying-coefficient landmark model by incorporating multiple short-term events into the prediction of long-term survival probability. For more information about landmark prediction please see Li, W., Ning, J., Zhang, J., Li, Z., Savitz, S.I., Tahanan, A., Rahbar.M.H., (2023+). "Enhancing Long-term Survival Prediction with Multiple Short-term Events: Landmarking with A Flexible Varying Coefficient Model".

Locally sparse estimator of generalized varying coefficient model for asynchronous longitudinal data by kernel-weighted estimating equation.

Helper functions to implement univariate and bivariate latent change score models in R using the lavaan package. For details about Latent Change Score Modeling (LCSM) see McArdle (2009) <doi:10.1146/annurev.psych.60.110707.163612> and Grimm, An, McArdle, Zonderman and Resnick (2012) <doi:10.1080/10705511.2012.659627>. The package automatically generates lavaan syntax for different model specifications and varying timepoints. The lavaan syntax generated by this package can be returned and further specifications can be added manually. Longitudinal plots as well as simplified path diagrams can be created to visualise data and model specifications. Estimated model parameters and fit statistics can be extracted as data frames. Data for different univariate and bivariate LCSM can be simulated by specifying estimates for model parameters to explore their effects. This package combines the strengths of other R packages like lavaan', broom', and semPlot by generating lavaan syntax that helps these packages work together.

Time series analysis based on lambda transformer and variational seq2seq, built on Torch'.

An easy tool to transform 2D longitudinal data into 3D arrays suitable for Long short-term memory neural networks training. The array output can be used by the keras package. Long short-term memory neural networks are described in: Hochreiter, S., & Schmidhuber, J. (1997) <doi:10.1162/neco.1997.9.8.1735>.

Four measures of linkage disequilibrium are provided: the usual r^2 measure, the r^2_S measure (r^2 corrected by the structure sample), the r^2_V (r^2 corrected by the relatedness of genotyped individuals), the r^2_VS measure (r^2 corrected by both the relatedness of genotyped individuals and the structure of the sample).

This package provides a collection of colour palettes inspired by some of our dearest butterfly species. This package provides continuous and categorical palettes, including some colour blind friendly options.