Predicts anticancer peptides using random forests trained on the n-gram encoded peptides. The implemented algorithm can be accessed from both the command line and shiny-based GUI. The CancerGram model is too large for CRAN and it has to be downloaded separately from the repository: <https://github.com/BioGenies/CancerGramModel>. For more information see: Burdukiewicz et al. (2020) <doi:10.3390/pharmaceutics12111045>.

Functionality for analyzing dose-volume histograms (DVH) in radiation oncology: Read DVH text files, calculate DVH metrics as well as generalized equivalent uniform dose (gEUD), biologically effective dose (BED), equivalent dose in 2 Gy fractions (EQD2), normal tissue complication probability (NTCP), and tumor control probability (TCP). Show DVH diagrams, check and visualize quality assurance constraints for the DVH. Includes web-based graphical user interface.

Initially designed to distribute code for estimating the Gaussian graphical model with Lasso regularization, also known as the graphical lasso (glasso), using an Expectation-Maximization (EM) algorithm based on work by Städler and Bühlmann (2012) <doi:10.1007/s11222-010-9219-7>. As a byproduct, code for estimating means and covariances (or the precision matrix) under a multivariate normal (Gaussian) distribution is also available.

Method and tool for generating time series forecasts using an ensemble wavelet-based auto-regressive neural network architecture. This method provides additional support of exogenous variables and also generates confidence interval. This package provides EWNet model for time series forecasting based on the algorithm by Panja, et al. (2022) and Panja, et al. (2023) <arXiv:2206.10696> <doi:10.1016/j.chaos.2023.113124>.

For functions that take and return vectors (or scalars), this package provides 8 algorithms for finding fixed point vectors (vectors for which the inputs and outputs to the function are the same vector). These algorithms include Anderson (1965) acceleration <doi:10.1145/321296.321305>, epsilon extrapolation methods (Wynn 1962 <doi:10.2307/2004051>) and minimal polynomial methods (Cabay and Jackson 1976 <doi:10.1137/0713060>).

Providing C implementation for the computing of monotonic spline bases, including M-splines, I-splines, and C-splines, denoted by MIC splines. The definitions of the spline bases are described in Meyer (2008) <doi: 10.1214/08-AOAS167>. The package also provides the computing of constrained least-squares estimates when a subset of or all of the regression coefficients are constrained to be non-negative.

Frequently one needs a convenient way to build and tune several models in one go.The goal is to provide a number of machine learning convenience functions. It provides the ability to build, tune and obtain predictions of several models in one function. The models are built using functions from caret with easier to read syntax. Kuhn(2014) <doi:10.48550/arXiv.1405.6974>.

Using this package, one can determine the minimum sample size required so that the absolute deviation of the sample mean and the population mean of a distribution becomes less than some pre-determined epsilon, i.e. it helps the user to determine the minimum sample size required to attain the pre-fixed precision level by minimizing the difference between the sample mean and population mean.

Analysis functions to quantify inputs importance in neural network models. Functions are available for calculating and plotting the inputs importance and obtaining the activation function of each neuron layer and its derivatives. The importance of a given input is defined as the distribution of the derivatives of the output with respect to that input in each training data point <doi:10.18637/jss.v102.i07>.

This package provides access to the PlanScore Application Programming Interface (<https://github.com/PlanScore/PlanScore/blob/main/API.md>) for scoring redistricting plans. Allows for upload of plans from block assignment files and shape files. For shapes in memory, such as from sf or redist', it processes them to save and upload. Includes tools for tidying responses and saving output from the website.

Producing the time-dependent receiver operating characteristic (ROC) curve through parametric approaches. Tools for generating random data, fitting, predicting and check goodness of fit are prepared. The methods are developed from the theoretical framework of proportional hazard model and copula functions. Using this package, users can now simulate parametric time-dependent ROC and run experiment to understand the behavior of the curve under different scenario.

Label, recode, rename, and convert datasets and ASCII files more efficiently. speedycode automates the code necessary for labeling variables with the labelled package, recoding and renaming variables with dplyr syntax, and converting ASCII files with the readroper package. Most functions require only the name of the dataset and the code will be automatically written. Some convenience functions useful for converting ASCII files are also included.

This package provides a dynamic model of the big-picture, whole ecosystem effects of hydrodynamics, temperature, nutrients, and fishing on continental shelf marine food webs. The package is described in: Heath, M.R., Speirs, D.C., Thurlbeck, I. and Wilson, R.J. (2020) <doi:10.1111/2041-210X.13510> StrathE2E2: An R package for modelling the dynamics of marine food webs and fisheries. 8pp.

An enterprise-targeted scalable and customizable shiny module providing an easy way to incorporate free-form note taking or discussion boards into applications. The package includes a shiny module that can be included in any shiny application to create a panel containing searchable, editable text broken down by section headers. Can be used with a local SQLite database, or a compatible remote database of choice.

This package provides a clinically meaningful measures of treatment effects for right-censored data are provided, based on the concept of Kendall's tau, along with the corresponding inference procedures. Two plots of tau processes, with the option to account for the cure fraction or not, are available. The plots of tau processes serve as useful graphical tools for monitoring the relative performances over time.

Vasicek density, cumulative distribution, quantile functions and random deviate generation of Vasicek distribution. In addition, there are two functions for fitting the Generalized Additive Models for Location Scale and Shape introduced by Rigby and Stasinopoulos (2005, <doi:10.1111/j.1467-9876.2005.00510.x>). Some functions are written in C++ using Rcpp', developed by Eddelbuettel and Francois (2011, <doi:10.18637/jss.v040.i08>).

This package provides a streamlined workflow for the quanTIseq method, developed to perform the quantification of the Tumor Immune contexture from RNA-seq data. The quantification is performed against the TIL10 signature (dissecting the contributions of ten immune cell types), carefully crafted from a collection of human RNA-seq samples. The TIL10 signature has been extensively validated using simulated, flow cytometry, and immunohistochemistry data.

This package provides tools for clustering and enhancing the resolution of spatial gene expression experiments. BayesSpace clusters a low-dimensional representation of the gene expression matrix, incorporating a spatial prior to encourage neighboring spots to cluster together. The method can enhance the resolution of the low-dimensional representation into "sub-spots", for which features such as gene expression or cell type composition can be imputed.

This package provides a set of low-level utilities to retrieve data from the UCSC Genome Browser. Most functions in the package access the data via the UCSC REST API but some of them query the UCSC MySQL server directly. Note that the primary purpose of the package is to support higher-level functionalities implemented in downstream packages like GenomeInfoDb or txdbmaker.

This package provides supporting annotation and test data for SeSAMe package. This includes chip tango addresses, mapping information, performance annotation, and trained predictor for Infinium array data. This package provides user access to essential annotation data for working with many generations of the Infinium DNA methylation array. It currently supports human array (HM27, HM450, EPIC), mouse array (MM285) and the HorvathMethylChip40 (Mammal40) array.

This package provides efficient routines for manipulation of date-time objects while accounting for time-zones and daylight saving times. The package includes utilities for updating of date-time components (year, month, day etc.), modification of time-zones, rounding of date-times, period addition and subtraction etc. Parts of the CCTZ source code, released under the Apache 2.0 License, are included in this package.

This package provides tools used by organizational researchers for the analysis of multilevel data. It includes four broad sets of tools.

1. functions for estimating within-group agreement and reliability indices.

2. functions for manipulating multilevel and longitudinal (panel) data.

3. simulations for estimating power and generating multilevel data.

4. miscellaneous functions for estimating reliability and performing simple calculations and data transformations.

This package provides arithmetic functions for R matrix and big.matrix objects as well as functions for QR factorization, Cholesky factorization, General eigenvalue, and Singular value decomposition (SVD). A method matrix multiplication and an arithmetic method -for matrix addition, matrix difference- allows for mixed type operation -a matrix class object and a big.matrix class object- and pure type operation for two big.matrix class objects.

The binomialRF is a new feature selection technique for decision trees that aims at providing an alternative approach to identify significant feature subsets using binomial distributional assumptions (Rachid Zaim, S., et al. (2019)) <doi:10.1101/681973>. Treating each splitting variable selection as a set of exchangeable correlated Bernoulli trials, binomialRF then tests whether a feature is selected more often than by random chance.