The genetic algorithm is designed to optimize wind farms of any shape. Each layout is encoded as n unique grid-cell identifiers. It requires a predefined amount of turbines, a unified rotor radius and an average wind speed value for each incoming wind direction. A terrain effect model can be included that downloads an SRTM elevation model and loads a Corine Land Cover raster to approximate surface roughness.

This package provides a random-effects stochastic model that allows quick detection of clonal dominance events from clonal tracking data collected in gene therapy studies. Starting from the Ito-type equation describing the dynamics of cells duplication, death and differentiation at clonal level, we first considered its local linear approximation as the base model. The parameters of the base model, which are inferred using a maximum likelihood approach, are assumed to be shared across the clones. Although this assumption makes inference easier, in some cases it can be too restrictive and does not take into account possible scenarios of clonal dominance. Therefore we extended the base model by introducing random effects for the clones. In this extended formulation the dynamic parameters are estimated using a tailor-made expectation maximization algorithm. Further details on the methods can be found in L. Del Core et al., (2022) <doi:10.1101/2022.05.31.494100>.

Implementations of several robust nonparametric two-sample tests for location or scale differences. The test statistics are based on robust location and scale estimators, e.g. the sample median or the Hodges-Lehmann estimators as described in Fried & Dehling (2011) <doi:10.1007/s10260-011-0164-1>. The p-values can be computed via the permutation principle, the randomization principle, or by using the asymptotic distributions of the test statistics under the null hypothesis, which ensures (approximate) distribution independence of the test decision. To test for a difference in scale, we apply the tests for location difference to transformed observations; see Fried (2012) <doi:10.1016/j.csda.2011.02.012>. Random noise on a small range can be added to the original observations in order to hold the significance level on data from discrete distributions. The location tests assume homoscedasticity and the scale tests require the location parameters to be zero.

Imputation of missing numerical outcomes for a longitudinal trial with protocol deviations. The package uses distinct treatment arm-based assumptions for the unobserved data, following the general algorithm of Carpenter, Roger, and Kenward (2013) <doi:10.1080/10543406.2013.834911>, and the causal model of White, Royes and Best (2020) <doi:10.1080/10543406.2019.1684308>. Sensitivity analyses to departures from these assumptions can be done by the Delta method of Roger. The program uses the same algorithm as the mimix Stata package written by Suzie Cro, with additional coding for the causal model and delta method. The reference-based methods are jump to reference (J2R), copy increments in reference (CIR), copy reference (CR), and the causal model, all of which must specify the reference treatment arm. Other methods are missing at random (MAR) and the last mean carried forward (LMCF). Individual-specific imputation methods (and their reference groups) can be specified.

JASPAR is an open-access database containing manually curated, non-redundant transcription factor (TF) binding profiles for TFs across six taxonomic groups. In this 9th release, we expanded the CORE collection with 341 new profiles (148 for plants, 101 for vertebrates, 85 for urochordates, and 7 for insects), which corresponds to a 19% expansion over the previous release. To search thisdatabases, please use the package TFBSTools (>= 1.31.2).

Set of functions for analyzing Atomic Force Microscope (AFM) force-distance curves. It allows to obtain the contact and unbinding points, perform the baseline correction, estimate the Young's modulus, fit up to two exponential decay function to a stress-relaxation / creep experiment, obtain adhesion energies. These operations can be done either over a single F-d curve or over a set of F-d curves in batch mode.

Synthesizing joint distributions from marginal densities, focusing on controlling key statistical properties such as correlation for continuous data, mutual information for categorical data, and inducing Simpson's Paradox. Generate datasets with specified correlation structures for continuous variables, adjust mutual information between categorical variables, and manipulate subgroup correlations to intentionally create Simpson's Paradox. Joe (1997) <doi:10.1201/b13150> Sklar (1959) <https://en.wikipedia.org/wiki/Sklar%27s_theorem>.

Providing a set of functions to easily generate and iterate complex networks. The functions can be used to generate realistic networks with a wide range of different clustering, density, and average path length. For more information consult research articles by Amiyaal Ilany and Erol Akcay (2016) <doi:10.1093/icb/icw068> and Ilany and Erol Akcay (2016) <doi:10.1101/026120>, which have inspired many methods in this package.

This package provides functions for the clustering of variables around Latent Variables, for 2-way or 3-way data. Each cluster of variables, which may be defined as a local or directional cluster, is associated with a latent variable. External variables measured on the same observations or/and additional information on the variables can be taken into account. A "noise" cluster or sparse latent variables can also be defined.

Circumplex models, which organize constructs in a circle around two underlying dimensions, are popular for studying interpersonal functioning, mood/affect, and vocational preferences/environments. This package provides tools for analyzing and visualizing circular data, including scoring functions for relevant instruments and a generalization of the bootstrapped structural summary method from Zimmermann & Wright (2017) <doi:10.1177/1073191115621795> and functions for creating publication-ready tables and figures from the results.

This package provides the necessary functions to identify and extract a selection of already available barcode constructs (Cornils, K. et al. (2014) <doi:10.1093/nar/gku081>) and freely choosable barcode designs from next generation sequence (NGS) data. Furthermore, it offers the possibility to account for sequence errors, the calculation of barcode similarities and provides a variety of visualisation tools (Thielecke, L. et al. (2017) <doi:10.1038/srep43249>).

We provide extensions to the classical dataset "Example 4: Death by the kick of a horse in the Prussian Army" first used by Ladislaus von Bortkeiwicz in his treatise on the Poisson distribution "Das Gesetz der kleinen Zahlen", <DOI:10.1017/S0370164600019453>. As well as an extended time series for the horse-kick death data, we also provide, in parallel, deaths by falling from a horse and by drowning.

This package provides tools to fit joinpoint regression models with a log-linear specification by levels of a categorical variable. The package acts as a wrapper around the segmented package, facilitating model fitting, selection, and interpretation. It includes functions to estimate the Annual Percent Change (APC) and the Average Annual Percent Change (AAPC), along with their 95% confidence intervals, and to generate formatted summary tables and plots of results.

This package provides a generalization of the Synth package that is designed for data at a more granular level (e.g., micro-level). Provides functions to construct weights (including propensity score-type weights) and run analyses for synthetic control methods with micro- and meso-level data; see Robbins, Saunders, and Kilmer (2017) <doi:10.1080/01621459.2016.1213634> and Robbins and Davenport (2021) <doi:10.18637/jss.v097.i02>.

This package creates and manages a provenance graph corresponding to the provenance created by the rdtLite package, which collects provenance from R scripts. rdtLite is available on CRAN. The provenance format is an extension of the W3C PROV JSON format (<https://www.w3.org/Submission/2013/SUBM-prov-json-20130424/>). The extended JSON provenance format is described in <https://github.com/End-to-end-provenance/ExtendedProvJson>.

This package provides a collection of easy-to-use tools for regression analysis of survival data with a cure fraction proposed in Su et al. (2022) <doi:10.1177/09622802221108579>. The modeling framework is based on the Cox proportional hazards mixture cure model and the bounded cumulative hazard (promotion time cure) model. The pseudo-observations approach is utilized to assess covariate effects and embedded in the variable selection procedure.

Parametric linkage analysis of monogenic traits in medical pedigrees. Features include singlepoint analysis, multipoint analysis via MERLIN (Abecasis et al. (2002) <doi:10.1038/ng786>), visualisation of log of the odds (LOD) scores and summaries of linkage peaks. Disease models may be specified to accommodate phenocopies, reduced penetrance and liability classes. paramlink2 is part of the pedsuite package ecosystem, presented in Pedigree Analysis in R (Vigeland, 2021, ISBN:9780128244302).

This package provides a unified set of helper functions to access datasets from the San Francisco Open Data platform <https://data.sfgov.org/>. Functions return results as tidy tibbles and support optional filtering, sorting, and row limits via the Socrata API. The package provides a consistent interface for discovering and downloading datasets from the San Francisco Open Data Portal using human-readable dataset keys or official Socrata dataset identifiers.

Modelling the yield curve with some parametric models. The models implemented are: Nelson, C.R., and A.F. Siegel (1987) <doi: 10.1086/296409>, Diebold, F.X. and Li, C. (2006) <doi: 10.1016/j.jeconom.2005.03.005> and Svensson, L.E. (1994) <doi: 10.3386/w4871>. The package also includes the data of the term structure of interest rate of Federal Reserve Bank and European Central Bank.

Casting metadata for REDCap database creation and handling of castellated data using repeated instruments and longitudinal projects in REDCap'. Keeps a focused data export approach, by allowing to only export required data from the database. Also for casting new REDCap databases based on datasets from other sources. Originally forked from the R part of REDCapRITS by Paul Egeler. See <https://github.com/pegeler/REDCapRITS>. REDCap (Research Electronic Data Capture) is a secure, web-based software platform designed to support data capture for research studies, providing 1) an intuitive interface for validated data capture; 2) audit trails for tracking data manipulation and export procedures; 3) automated export procedures for seamless data downloads to common statistical packages; and 4) procedures for data integration and interoperability with external sources (Harris et al (2009) <doi:10.1016/j.jbi.2008.08.010>; Harris et al (2019) <doi:10.1016/j.jbi.2019.103208>).

This package implements an approximate string matching version of R's native match function. It can calculate various string distances based on edits (Damerau-Levenshtein, Hamming, Levenshtein, optimal string alignment), qgrams (q- gram, cosine, jaccard distance) or heuristic metrics (Jaro, Jaro-Winkler). An implementation of soundex is provided as well. Distances can be computed between character vectors while taking proper care of encoding or between integer vectors representing generic sequences.

The fonts provide uppercase formal script letters for use as symbols in scientific and mathematical typesetting (in contrast to the informal script fonts such as that used for the calligraphic symbols in the TeX maths symbol font). The fonts are provided as Metafont source, and as derived Adobe Type 1 format. LaTeX support, for using these fonts in mathematics, is available via one of the packages calrsfs and mathrsfs.

This package implements inferential methods to compare gene lists in terms of their biological meaning as expressed in the GO. The compared gene lists are characterized by cross-tabulation frequency tables of enriched GO items. Dissimilarity between gene lists is evaluated using the Sorensen-Dice index. The fundamental guiding principle is that two gene lists are taken as similar if they share a great proportion of common enriched GO items.

This package provides a set of tools for performing graph theory analysis of brain MRI data. It works with data from a Freesurfer analysis (cortical thickness, volumes, local gyrification index, surface area), diffusion tensor tractography data (e.g., from FSL) and resting-state fMRI data (e.g., from DPABI). It contains a graphical user interface for graph visualization and data exploration, along with several functions for generating useful figures.