Estimates Variable Length Markov Chains (VLMC) models and VLMC with covariates models from discrete sequences. Supports model selection via information criteria and simulation of new sequences from an estimated model. See Bühlmann, P. and Wyner, A. J. (1999) <doi:10.1214/aos/1018031204> for VLMC and Zanin Zambom, A., Kim, S. and Lopes Garcia, N. (2022) <doi:10.1111/jtsa.12615> for VLMC with covariates.

Fit flexible (excess) hazard regression models with the possibility of including non-proportional effects of covariables and of adding a random effect at the cluster level (corresponding to a shared frailty). A detailed description of the package functionalities is provided in Charvat and Belot (2021) <doi: 10.18637/jss.v098.i14>.

These guidelines are meant to provide a pragmatic, yet rigorous, help to drug developers and decision makers, since they are shaped by three fundamental ingredients: the clinically determined margin of detriment on OS that is unacceptably high (delta null); the benefit on OS that is plausible given the mechanism of action of the novel intervention (delta alt); and the quantity of information (i.e. survival events) it is feasible to accrue given the clinical and drug development setting. The proposed guidelines facilitate transparent discussions between stakeholders focusing on the risks of erroneous decisions and what might be an acceptable trade-off between power and the false positive error rate.

An implementation of MLMC (Multi-Level Monte Carlo), Giles (2008) <doi:10.1287/opre.1070.0496>, Heinrich (1998) <doi:10.1006/jcom.1998.0471>, for R. This package builds on the original Matlab and C++ implementations by Mike Giles to provide a full MLMC driver and example level samplers. Multi-core parallel sampling of levels is provided built-in.

Multi-core replication function to make it easier to do fast Monte Carlo simulation. Based on the mcreplicate() function from the rethinking package. The rethinking package requires installing rstan', which is onerous to install, while also not adding capabilities to this function.

Unbiased estimators of overall and per-class thematic map accuracy and area published in Olofsson et al. (2014) <doi:10.1016/j.rse.2014.02.015> and Stehman (2014) <doi:10.1080/01431161.2014.930207>.

Enhances mlexperiments <https://CRAN.R-project.org/package=mlexperiments> with additional machine learning ('ML') learners for survival analysis. The package provides R6-based survival learners for the following algorithms: glmnet <https://CRAN.R-project.org/package=glmnet>, ranger <https://CRAN.R-project.org/package=ranger>, xgboost <https://CRAN.R-project.org/package=xgboost>, and rpart <https://CRAN.R-project.org/package=rpart>. These can be used directly with the mlexperiments R package.

Used for general multiple mediation analysis with big data sets.

Addressing a central challenge encountered in Mendelian randomization (MR) studies, where MR primarily focuses on discerning the effects of individual exposures on specific outcomes and establishes causal links between them. Using a network-based methodology, the intricacy involving interdependent outcomes due to numerous factors has been tackled through this routine. Based on Ni et al. (2018) <doi:10.1214/17-BA1087>, MR.RGM extends to a broader exploration of the causal landscape by leveraging on network structures and involves the construction of causal graphs that capture interactions between response variables and consequently between responses and instrument variables. The resulting Graph visually represents these causal connections, showing directed edges with effect sizes labeled. MR.RGM facilitates the navigation of various data availability scenarios effectively by accommodating three input formats, i.e., individual-level data and two types of summary-level data. The method also optionally incorporates measured covariates (when available) and allows flexible modeling of the error variance structure, including correlated errors that may reflect unmeasured confounding among responses. In the process, causal effects, adjacency matrices, and other essential parameters of the complex biological networks, are estimated. Besides, MR.RGM provides uncertainty quantification for specific network structures among response variables. Parts of the Inverse Wishart sampler are adapted from the econ722 repository by DiTraglia (GPL-2.0).

Computing transitive (and non-transitive) index numbers (Coelli et al., 2005 <doi:10.1007/b136381>) for cross-sections and panel data. For the calculation of transitive indexes, the EKS (Coelli et al., 2005 <doi:10.1007/b136381>; Rao et al., 2002 <doi:10.1007/978-1-4615-0851-9_4>) and Minimum spanning tree (Hill, 2004 <doi:10.1257/0002828043052178>) methods are implemented. Traditional fixed-base and chained indexes, and their growth rates, can also be derived using the Paasche, Laspeyres, Fisher and Tornqvist formulas.

Mobile Motor Activity Research Consortium for Health (mMARCH) is a collaborative network of studies of clinical and community samples that employ common clinical, biological, and digital mobile measures across involved studies. One of the main scientific goals of mMARCH sites is developing a better understanding of the inter-relationships between accelerometry-measured physical activity (PA), sleep (SL), and circadian rhythmicity (CR) and mental and physical health in children, adolescents, and adults. Currently, there is no consensus on a standard procedure for a data processing pipeline of raw accelerometry data, and few open-source tools to facilitate their development. The R package GGIR is the most prominent open-source software package that offers great functionality and tremendous user flexibility to process raw accelerometry data. However, even with GGIR', processing done in a harmonized and reproducible fashion requires a non-trivial amount of expertise combined with a careful implementation. In addition, novel accelerometry-derived features of PA/SL/CR capturing multiscale, time-series, functional, distributional and other complimentary aspects of accelerometry data being constantly proposed and become available via non-GGIR R implementations. To address these issues, mMARCH developed a streamlined harmonized and reproducible pipeline for loading and cleaning raw accelerometry data, extracting features available through GGIR as well as through non-GGIR R packages, implementing several data and feature quality checks, merging all features of PA/SL/CR together, and performing multiple analyses including Joint Individual Variation Explained (JIVE), an unsupervised machine learning dimension reduction technique that identifies latent factors capturing joint across and individual to each of three domains of PA/SL/CR. In detail, the pipeline generates all necessary R/Rmd/shell files for data processing after running GGIR for accelerometer data. In module 1, all csv files in the GGIR output directory were read, transformed and then merged. In module 2, the GGIR output files were checked and summarized in one excel sheet. In module 3, the merged data was cleaned according to the number of valid hours on each night and the number of valid days for each subject. In module 4, the cleaned activity data was imputed by the average Euclidean norm minus one (ENMO) over all the valid days for each subject. Finally, a comprehensive report of data processing was created using Rmarkdown, and the report includes few exploratory plots and multiple commonly used features extracted from minute level actigraphy data. Reference: Guo W, Leroux A, Shou S, Cui L, Kang S, Strippoli MP, Preisig M, Zipunnikov V, Merikangas K (2022) Processing of accelerometry data with GGIR in Motor Activity Research Consortium for Health (mMARCH) Journal for the Measurement of Physical Behaviour, 6(1): 37-44.

Constructs genetic linkage maps in autopolyploid full-sib populations. Uses pairwise recombination fraction estimation as the first source of information to sequentially position allelic variants in specific homologous chromosomes. For situations where pairwise analysis has limited power, the algorithm relies on the multilocus likelihood obtained through a hidden Markov model (HMM). Methods are described in Mollinari and Garcia (2019) <doi:10.1534/g3.119.400378> and Mollinari et al. (2020) <doi:10.1534/g3.119.400620>.

The word Meme was originated from the book, The Selfish Gene', authored by Richard Dawkins (1976). It is a unit of culture that is passed from one generation to another and correlates to the gene, the unit of physical heredity. The internet memes are captioned photos that are intended to be funny, ridiculous. Memes behave like infectious viruses and travel from person to person quickly through social media. The meme package allows users to make custom memes.

This package provides a procedure for comparing multivariate samples associated with different groups. It uses principal component analysis to convert multivariate observations into a set of linearly uncorrelated statistical measures, which are then compared using a number of statistical methods. The procedure is independent of the distributional properties of samples and automatically selects features that best explain their differences, avoiding manual selection of specific points or summary statistics. It is appropriate for comparing samples of time series, images, spectrometric measures or similar multivariate observations. This package is described in Fachada et al. (2016) <doi:10.32614/RJ-2016-055>.

66 data sets that were imported using read.table() where appropriate but more commonly after converting to a csv file for importing via read.csv().

Topological data analysis (TDA) is a method of data analysis that uses techniques from topology to analyze high-dimensional data. Here we implement Mapper, an algorithm from this area developed by Singh, Mémoli and Carlsson (2007) which generalizes the concept of a Reeb graph <https://en.wikipedia.org/wiki/Reeb_graph>.

We introduce factor models designed to jointly analyze high-dimensional count data from multiple studies by extracting study-shared and specified factors. Our factor models account for heterogeneous noises and overdispersion among counts with augmented covariates. We propose an efficient and speedy variational estimation procedure for estimating model parameters, along with a novel criterion for selecting the optimal number of factors and the rank of regression coefficient matrix. More details can be referred to Liu et al. (2024) <doi:10.48550/arXiv.2402.15071>.

Enables us to use the functions of the package magick interactively.

This package implements a novel density-based approach for estimating unknown parameters, distribution visualisations and meta-analyses of quantiles and ther functions. A detailed vignettes with example datasets and code to prepare data and analyses is available at <https://bookdown.org/a2delivera/metaquant/>. The methods are described in the pre-print by De Livera, Prendergast and Kumaranathunga (2024, <doi:10.48550/arXiv.2411.10971>).

This package provides methods for model-based clustering of multinomial counts under the presence of covariates using mixtures of multinomial logit models, as implemented in Papastamoulis (2023) <DOI:10.1007/s11634-023-00547-5>. These models are estimated under a frequentist as well as a Bayesian setup using the Expectation-Maximization algorithm and Markov chain Monte Carlo sampling (MCMC), respectively. The (unknown) number of clusters is selected according to the Integrated Completed Likelihood criterion (for the frequentist model), and estimating the number of non-empty components using overfitting mixture models after imposing suitable sparse prior assumptions on the mixing proportions (in the Bayesian case), see Rousseau and Mengersen (2011) <DOI:10.1111/j.1467-9868.2011.00781.x>. In the latter case, various MCMC chains run in parallel and are allowed to switch states. The final MCMC output is suitably post-processed in order to undo label switching using the Equivalence Classes Representatives (ECR) algorithm, as described in Papastamoulis (2016) <DOI:10.18637/jss.v069.c01>.

Computationally efficient functions to provide direct likelihood-based inference for partially-observed multivariate birth-death processes. Such processes range from a simple Yule model to the complex susceptible-infectious-removed model in disease dynamics. Efficient likelihood evaluation facilitates maximum likelihood estimation and Bayesian inference.

Allows users to produce estimates and MSE for multivariate variables using Linear Mixed Model. The package follows the approach of Datta, Day and Basawa (1999) <doi:10.1016/S0378-3758(98)00147-5>.

Tool for easy prior construction and visualization. It helps to formulates joint prior distributions for variance parameters in latent Gaussian models. The resulting prior is robust and can be created in an intuitive way. A graphical user interface (GUI) can be used to choose the joint prior, where the user can click through the model and select priors. An extensive guide is available in the GUI. The package allows for direct inference with the specified model and prior. Using a hierarchical variance decomposition, we formulate a joint variance prior that takes the whole model structure into account. In this way, existing knowledge can intuitively be incorporated at the level it applies to. Alternatively, one can use independent variance priors for each model components in the latent Gaussian model. Details can be found in the accompanying scientific paper: Hem, Fuglstad, Riebler (2024, Journal of Statistical Software, <doi:10.18637/jss.v110.i03>).

Climate-sensitive, single-tree forest simulator based on data-driven machine learning. It simulates the main forest processesâ radial growth, height growth, mortality, crown recession, regeneration, and harvestingâ so users can assess stand development under climate and management scenarios. The height model is described by Skudnik and JevÅ¡enak (2022) <doi:10.1016/j.foreco.2022.120017>, the basal-area increment model by JevÅ¡enak and Skudnik (2021) <doi:10.1016/j.foreco.2020.118601>, and an overview of the MLFS package, workflow, and applications is provided by JevÅ¡enak, ArniÄ , Krajnc, and Skudnik (2023), Ecological Informatics <doi:10.1016/j.ecoinf.2023.102115>.