Estimates micro effects on macro structures (MEMS) and average micro mediated effects (AMME). URL: <https://github.com/sduxbury/netmediate>. BugReports: <https://github.com/sduxbury/netmediate/issues>. Robins, Garry, Phillipa Pattison, and Jodie Woolcock (2005) <doi:10.1086/427322>. Snijders, Tom A. B., and Christian E. G. Steglich (2015) <doi:10.1177/0049124113494573>. Imai, Kosuke, Luke Keele, and Dustin Tingley (2010) <doi:10.1037/a0020761>. Duxbury, Scott (2023) <doi:10.1177/00811750231209040>. Duxbury, Scott (2024) <doi:10.1177/00811750231220950>.

Fast, lightweight toolkit for data splitting. Data sets can be partitioned into disjoint groups (e.g. into training, validation, and test) or into (repeated) k-folds for subsequent cross-validation. Besides basic splits, the package supports stratified, grouped as well as blocked splitting. Furthermore, cross-validation folds for time series data can be created. See e.g. Hastie et al. (2001) <doi:10.1007/978-0-387-84858-7> for the basic background on data partitioning and cross-validation.

With given inputs that include number of points, discrete design space, a measure of skewness, models and parameter value, this package calculates the objective value, optimal designs and plot the equivalence theory under A- and D-optimal criteria under the second-order Least squares estimator. This package is based on the paper "Properties of optimal regression designs under the second-order least squares estimator" by Chi-Kuang Yeh and Julie Zhou (2021) <doi:10.1007/s00362-018-01076-6>.

Privacy protected raster maps can be created from spatial point data. Protection methods include smoothing of dichotomous variables by de Jonge and de Wolf (2016) <doi:10.1007/978-3-319-45381-1_9>, continuous variables by de Wolf and de Jonge (2018) <doi:10.1007/978-3-319-99771-1_23>, suppressing revealing values and a generalization of the quad tree method by Suñé, Rovira, Ibáñez and Farré (2017) <doi:10.2901/EUROSTAT.C2017.001>.

The function generates and plots random snowflakes. Each snowflake is defined by a given diameter, width of the crystal, color, and random seed. Snowflakes are plotted in such way that they always remain round, no matter what the aspect ratio of the plot is. Snowflakes can be created using transparent colors, which creates a more interesting, somewhat realistic, image. Images of the snowflakes can be separately saved as svg files and used in websites as static or animated images.

This package provides a multi-task learning approach to variable selection regression with highly correlated predictors and sparse effects, based on frequentist statistical inference. It provides statistical evidence to identify which subsets of predictors have non-zero effects on which subsets of response variables, motivated and designed for colocalization analysis across genome-wide association studies (GWAS) and quantitative trait loci (QTL) studies. The ColocBoost model is described in Cao et. al. (2025) <doi:10.1101/2025.04.17.25326042>.

Shows color patches for encoding fold changes (e.g. log ratios) together with confidence values within a single diagram. This is especially useful for rendering gene expression data as well as other types of differential experiments. In addition to different rendering methods (ggplot extensions) functionality for perceptually optimizing color palettes are provided. Furthermore the package provides extension methods of the colorspace color-class in order to simplify the work with palettes (a.o. length, as.list, and append are supported).

Useful tools for conveniently downloading FHIR resources in xml format and converting them to R data.frames. The package uses FHIR-search to download bundles from a FHIR server, provides functions to save and read xml-files containing such bundles and allows flattening the bundles to data.frames using XPath expressions. FHIR® is the registered trademark of HL7 and is used with the permission of HL7. Use of the FHIR trademark does not constitute endorsement of this product by HL7.

It provides an interesting solution for handling a high number of segmentation variables in partial least squares structural equation modeling. The package implements the "Pathmox" algorithm (Lamberti, Sanchez, and Aluja,(2016)<doi:10.1002/asmb.2168>) including the F-coefficient test (Lamberti, Sanchez, and Aluja,(2017)<doi:10.1002/asmb.2270>) to detect the path coefficients responsible for the identified differences). The package also allows running the hybrid multi-group approach (Lamberti (2021) <doi:10.1007/s11135-021-01096-9>).

Prototypes for construction of a Gaussian Stochastic Process emulator (GASP) of a computer model. This is done within the objective Bayesian implementation of the GASP. The package allows for construction of a linked GASP of the composite computer model. Computational implementation follows the mathematical exposition given in publication: Ksenia N. Kyzyurova, James O. Berger, Robert L. Wolpert. Coupling computer models through linking their statistical emulators. SIAM/ASA Journal on Uncertainty Quantification, 6(3): 1151-1171, (2018).<DOI:10.1137/17M1157702>.

Enable operationalized evaluation of disease outcomes in multiple sclerosis. â MSoutcomesâ requires longitudinally recorded clinical data structured in long format. The package is based on the research developed at Clinical Outcomes Research unit (CORe), University of Melbourne and Neuroimmunology Centre, Royal Melbourne Hospital. Kalincik et al. (2015) <doi:10.1093/brain/awv258>. Lorscheider et al. (2016) <doi:10.1093/brain/aww173>. Sharmin et al. (2022) <doi:10.1111/ene.15406>. Dzau et al. (2023) <doi:10.1136/jnnp-2023-331748>.

Software to support the introductory *MOSAIC Calculus* textbook <https://www.mosaic-web.org/MOSAIC-Calculus/>), one of many data- and modeling-oriented educational resources developed by Project MOSAIC (<https://www.mosaic-web.org/>). Provides symbolic and numerical differentiation and integration, as well as support for applied linear algebra (for data science), and differential equations/dynamics. Includes grammar-of-graphics-based functions for drawing vector fields, trajectories, etc. The software is suitable for general use, but intended mainly for teaching calculus.

This package provides tools for monitoring progress during parallel processing. Lightweight package which acts as a wrapper around mclapply() and adds a progress bar to it in RStudio or Linux environments. Simply replace your original call to mclapply() with pmclapply(). A progress bar can also be displayed during parallelisation via the foreach package. Also included are functions to safely print messages (including error messages) from within parallelised code, which can be useful for debugging parallelised R code.

This package provides tools for checking that the output of an optimization algorithm is indeed at a local mode of the objective function. This is accomplished graphically by calculating all one-dimensional "projection plots" of the objective function, i.e., varying each input variable one at a time with all other elements of the potential solution being fixed. The numerical values in these plots can be readily extracted for the purpose of automated and systematic unit-testing of optimization routines.

This package provides a robust framework for analyzing the extent to which differential survival with respect to higher level trait variation is reducible to lower level variation. In addition to its primary test, it also provides functions for simulation-based power analysis, reading in common data set formats, and visualizing results. Temporarily contains an edited version of function hr.mcp() from package wild1', written by Glen Sargeant. For tutorial see: http://evolve.zoo.ox.ac.uk/Evolve/Perspectev.html.

This package provides methods for extracting various features from time series data. The features provided are those from Hyndman, Wang and Laptev (2013) <doi:10.1109/ICDMW.2015.104>, Kang, Hyndman and Smith-Miles (2017) <doi:10.1016/j.ijforecast.2016.09.004> and from Fulcher, Little and Jones (2013) <doi:10.1098/rsif.2013.0048>. Features include spectral entropy, autocorrelations, measures of the strength of seasonality and trend, and so on. Users can also define their own feature functions.

eudysbiome a package that permits to annotate the differential genera as harmful/harmless based on their ability to contribute to host diseases (as indicated in literature) or unknown based on their ambiguous genus classification. Further, the package statistically measures the eubiotic (harmless genera increase or harmful genera decrease) or dysbiotic(harmless genera decrease or harmful genera increase) impact of a given treatment or environmental change on the (gut-intestinal, GI) microbiome in comparison to the microbiome of the reference condition.

The h5Seurat file format is specifically designed for the storage and analysis of multi-modal single-cell and spatially-resolved expression experiments, for example, from CITE-seq or 10X Visium technologies. It holds all molecular information and associated metadata, including (for example) nearest-neighbor graphs, dimensional reduction information, spatial coordinates and image data, and cluster labels. This package also supports rapid and on-disk conversion between h5Seurat and AnnData objects, with the goal of enhancing interoperability between Seurat and Scanpy.

This package provides methods for interpreting CoDa (Compositional Data) regression models along the lines of "Pairwise share ratio interpretations of compositional regression models" (Dargel and Thomas-Agnan 2024) <doi:10.1016/j.csda.2024.107945>. The new methods include variation scenarios, elasticities, elasticity differences and share ratio elasticities. These tools are independent of log-ratio transformations and allow an interpretation in the original space of shares. CoDaImpact is designed to be used with the compositions package and its ecosystem.

This package provides a single function that supports the installation of all packages belonging to the dartRverse'. The dartRverse is a set of packages that work together to analyse SNP (single nuclear polymorphism) data. All packages aim to have a similar look and feel and are based on the same type of data structure ('genlight'), with additional metadata for loci and individuals (samples). For more information visit the GitHub pages <https://github.com/green-striped-gecko/dartRverse>.

Compare variables of interest between (potentially large numbers of) spatial interactions and meta-variables. Spatial variables are summarized using K, or other, functions, and projected for use in a modified random forest model. The model allows comparison of functional and non-functional variables to each other and to noise, giving statistical significance to the results. Included are preparation, modeling, and interpreting tools along with example datasets, as described in VanderDoes et al., (2023) <doi:10.1101/2023.07.18.549619>.

The main function of this package allows numerical vector objects to be displayed with their values in vulgar fractional form. This is convenient if patterns can then be more easily detected. In some cases replacing the components of a numeric vector by a rational approximation can also be expected to remove some component of round-off error. The main functions form a re-implementation of the functions fractions and rational of the MASS package, but using a radically improved programming strategy.

This package provides S4 classes and methods for reading and manipulating aligned DNA sequences, supporting an indel coding methods (only simple indel coding method is available in the current version), showing base substitutions and indels, calculating absolute pairwise distances between DNA sequences, and collapses identical DNA sequences into haplotypes or inferring haplotypes using user provided absolute pairwise character difference matrix. This package also includes S4 classes and methods for estimating genealogical relationships among haplotypes using statistical parsimony and plotting parsimony networks.

Implementation of Kmeans clustering algorithm and a supervised KNN (K Nearest Neighbors) learning method. It allows users to perform unsupervised clustering and supervised classification on their datasets. Additional features include data normalization, imputation of missing values, and the choice of distance metric. The package also provides functions to determine the optimal number of clusters for Kmeans and the best k-value for KNN: knn_Function(), find_Knn_best_k(), KMEANS_FUNCTION(), and find_Kmeans_best_k().