Contains, as a main contribution, a function to fit a regression model with possibly right, left or interval censored observations and with the error distribution expressed as a mixture of G-splines. Core part of the computation is done in compiled C++ written using the Scythe Statistical Library Version 0.3. The methods implemented in the package have been published in Komárek, Lesaffe and Hilton (2005, J. of Comp. and Graph. Stat.) <doi:10.1198/106186005X63734> and Lesaffre, Komárek and Declerck (2005, Stat. Methods in Med. Res.) <doi:10.1191/0962280205sm417oa>.

Considering an (n x m) data matrix X, this package is based on the method proposed by Gower, Groener, and Velden (2010) <doi:10.1198/jcgs.2010.07134>, and utilize the resulting matrices from the extended version of the NIPALS decomposition to determine n triangles whose areas are used to visually estimate the elements of a specific column of X. After a 90-degree rotation of the sample points, the triangles are drawn regarding the following points: 1.the origin of the axes; 2.the sample points; 3. the vector endpoint representing some variable.

CIFTI files contain brain imaging data in "grayordinates," which represent the gray matter as cortical surface vertices (left and right) and subcortical voxels (cerebellum, basal ganglia, and other deep gray matter). ciftiTools provides a unified environment for reading, writing, visualizing and manipulating CIFTI-format data. It supports the "dscalar," "dlabel," and "dtseries" intents. Grayordinate data is read in as a "xifti" object, which is structured for convenient access to the data and metadata, and includes support for surface geometry files to enable spatially-dependent functionality such as static or interactive visualizations and smoothing.

This is a one-function package that will pass only unique values to a computationally-expensive function that returns an output of the same length as the input. In importing and working with tidy data, it is common to have index columns, often including time stamps that are far from unique. Some functions to work with these such as text conversion to other variable types (e.g. as.POSIXct()), various grep()-based functions, and often the cut() function are relatively slow when working with tens of millions of rows or more.

Iterate and repel visually similar colors away in various ggplot2 plots. When many groups are plotted at the same time on multiple axes, for instance stacked bars or scatter plots, effectively ordering colors becomes difficult. This tool iterates through color combinations to find the best solution to maximize visual distinctness of nearby groups, so plots are more friendly toward colorblind users. This is achieved by two distance measurements, distance between groups within the plot, and CIELAB color space distances between colors as described in Carter et al., (2018) <doi:10.25039/TR.015.2018>.

Fits the hierarchical summary receiver operating characteristic (HSROC) model of Rutter and Gatsonis (2001) <doi:10.1002/sim.942>, the bivariate binomial-normal model of Reitsma et al. (2005) <doi:10.1016/j.jclinepi.2005.02.022>, the threshold-based bivariate time-to-event model of Hoyer et al. (2018) <doi:10.1002/jrsm.1273>, and the latent class extensions of Liu et al. (2015) <doi:10.1111/biom.12264> for diagnostic studies with an imperfect reference standard. Provides subgroup analyses, HSROC meta-regression, likelihood-ratio tests, summary ROC plots, and coupled forest plots.

We provide an R implementation of Deep Significance Clustering (DICE), a self-supervised learning framework designed to identify clinically meaningful and risk-stratified patient subgroups from electronic health record (EHR) data. DICE jointly optimizes deep representation learning, clustering, and outcome prediction while enforcing statistical significance between predicted outcomes and cluster membership. This integrated optimization produces subgroups that are both clinically coherent and predictive, addressing a gap where traditional unsupervised clustering methods and supervised risk prediction models alone may fail to generate actionable clinical groupings. See Huang et al. (2021) <doi:10.1093/jamia/ocab203>.

This package provides a clean, unified interface for training, predicting, and evaluating ensemble machine learning models including Random Forest, Gradient Boosting ('XGBoost'), AdaBoost', and Bagging'. All algorithms share a consistent API: em_fit(), em_predict(), em_evaluate(), and em_tune(). Includes built-in cross-validation, feature importance, calibration diagnostics, partial dependence plots, and model comparison utilities. Methods: Breiman (2001) <doi:10.1023/A:1010933404324>; Chen and Guestrin (2016) <doi:10.1145/2939672.2939785>; Freund and Schapire (1997) <doi:10.1006/jcss.1997.1504>; Breiman (1996) <doi:10.1007/BF00058655>.

This package provides a set of functions providing several outlier (i.e., studies with extreme findings) and influential detection measures and methodologies in network meta-analysis : - simple outlier and influential detection measures - outlier and influential detection measures by considering study deletion (shift the mean) - plots for outlier and influential detection measures - Q-Q plot for network meta-analysis - Forward Search algorithm in network meta-analysis. - forward plots to monitor statistics in each step of the forward search algorithm - forward plots for summary estimates and their confidence intervals in each step of forward search algorithm.

Calculates performance criteria measures and associated Monte Carlo standard errors for simulation results. Includes functions to help run simulation studies, following a general simulation workflow that closely aligns with the approach described by Morris, White, and Crowther (2019) <DOI:10.1002/sim.8086>. Also includes functions for calculating bootstrap confidence intervals (including normal, basic, studentized, percentile, bias-corrected, and bias-corrected-and-accelerated) with tidy output, as well as for extrapolating confidence interval coverage rates and hypothesis test rejection rates following techniques suggested by Boos and Zhang (2000) <DOI:10.1080/01621459.2000.10474226>.

This package provides a graphics output device for R that records plots in a LaTeX-friendly format. The device transforms plotting commands issued by R functions into LaTeX code blocks. When included in a LaTeX document, these blocks are interpreted with the help of TikZ'---a graphics package for TeX and friends written by Till Tantau. Using the tikzDevice', the text of R plots can contain LaTeX commands such as mathematical formula. The device also allows arbitrary LaTeX code to be inserted into the output stream.

This package support non-robust and robust computations of the sample autocovariance (ACOVF) and sample autocorrelation functions (ACF) of univariate and multivariate processes. The methodology consists in reversing the diagonalization procedure involving the periodogram or the cross-periodogram and the Fourier transform vectors, and, thus, obtaining the ACOVF or the ACF as discussed in Fuller (1995) doi:10.1002/9780470316917. The robust version is obtained by fitting robust M-regressors to obtain the M-periodogram or M-cross-periodogram as discussed in Reisen et al. (2017) doi:10.1016/j.jspi.2017.02.008.

In the framework of Symbolic Data Analysis, a relatively new approach to the statistical analysis of multi-valued data, we consider histogram-valued data, i.e., data described by univariate histograms. The methods and the basic statistics for histogram-valued data are mainly based on the L2 Wasserstein metric between distributions, i.e., the Euclidean metric between quantile functions. The package contains unsupervised classification techniques, least square regression and tools for histogram-valued data and for histogram time series. An introducing paper is Irpino A. Verde R. (2015) <doi: 10.1007/s11634-014-0176-4>.

Generate Mermaid syntax for a pedigree flowchart from a pedigree data frame. Mermaid syntax is commonly used to generate plots, charts, diagrams, and flowcharts. It is a textual syntax for creating reproducible illustrations. This package generates Mermaid syntax from a pedigree data frame to visualize a pedigree flowchart. The Mermaid syntax can be embedded in a Markdown or R Markdown file, or viewed on Mermaid editors and renderers. Links shape, style, and orientation can be customized via function arguments, and nodes shapes and styles can be customized via optional columns in the pedigree data frame.

We aim for fitting a multinomial regression model with Lasso penalty and doing statistical inference (calculating confidence intervals of coefficients and p-values for individual variables). It implements 1) the coordinate descent algorithm to fit an l1-penalized multinomial regression model (parameterized with a reference level); 2) the debiasing approach to obtain the inference results, which is described in "Tian, Y., Rusinek, H., Masurkar, A. V., & Feng, Y. (2024). L1â Penalized Multinomial Regression: Estimation, Inference, and Prediction, With an Application to Risk Factor Identification for Different Dementia Subtypes. Statistics in Medicine, 43(30), 5711-5747.".

It is a framework to fit semiparametric regression estimators for the total parameter of a finite population when the interest variable is asymmetric distributed. The main references for this package are Sarndal C.E., Swensson B., and Wretman J. (2003,ISBN: 978-0-387-40620-6, "Model Assisted Survey Sampling." Springer-Verlag) Cardozo C.A, Paula G.A. and Vanegas L.H. (2022) "Generalized log-gamma additive partial linear mdoels with P-spline smoothing", Statistical Papers. Cardozo C.A and Alonso-Malaver C.E. (2022). "Semi-parametric model assisted estimation in finite populations." In preparation.

This package provides nonparametric permutation tests for testing all or any subset of random effects in linear and nonlinear mixed-effects models, without requiring normality or other distributional assumptions on random effects or errors. Three distribution-free variance-component estimators are implemented: Variance Least Squares ('VLS'), Method of Moments ('MM'), and Method of Moments with First-Order Approximation ('MMF'). A permutation procedure is used to obtain finite-sample p-values. Plotting functions support data exploration, model evaluation, and communication of results. Methods are described in Uwimpuhwe, Drikvandi, and Blozis (2026) <doi:10.1002/sim.70605>.

Gene symbols, ontology terms, variant formats, and database accessions are validated through one small application programming interface (API), either offline against identifier patterns and bundled snapshots or live against a source web service. Results are designed to match those of the companion Python package for the same inputs. Input order and length are preserved, and errors are reported explicitly rather than as a silent failure. Identifier patterns follow the registry and nomenclature described in Hoyt et al. (2022) <doi:10.1038/s41597-022-01807-3> and den Dunnen et al. (2016) <doi:10.1002/humu.22981>.

This package provides tools for extracting segment paths from Graphical Fragment Assembly ('GFA') and Graph Alignment Format ('GAF') files. parse_paths_gfa() reads P (path) and W (walk) records and returns a named list of segment identifiers for each accession. parse_paths_gaf() parses the path string from each alignment and returns a named list of segments traversed by each query. parse_segment_lengths_gfa() reads S records and returns a named list of segment lengths keyed by segment identifier. These tools are intended to simplify downstream interpretation and analysis of pangenome graphs.

This package provides a pipeline-friendly toolkit for assembling stop motion animations from sequences of still images. Provides functions to read image directories, restructure frame sequences (duplicate, splice, arrange), apply per-frame pixel transformations (rotate, wiggle, flip, flop, blur, scale, crop, trim, border, background), and export the result as a GIF. All transformation functions accept a frames argument to target any subset of frames, bridging the gap between magick functions that operate on an entire image stack and fine-grained stop motion editing. Image processing is performed via ImageMagick Studio LLC (2024) <https://imagemagick.org>.

This package implements functions to retrieve the nearest genes around the peak, annotate genomic region of the peak, statstical methods for estimate the significance of overlap among ChIP peak data sets, and incorporate GEO database for user to compare the own dataset with those deposited in database. The comparison can be used to infer cooperative regulation and thus can be used to generate hypotheses. Several visualization functions are implemented to summarize the coverage of the peak experiment, average profile and heatmap of peaks binding to TSS regions, genomic annotation, distance to TSS, and overlap of peaks or genes.

This package provides an efficient implementation of Kernel SHAP (Lundberg and Lee, 2017, <doi:10.48550/arXiv.1705.07874>) permutation SHAP, and additive SHAP for model interpretability. For Kernel SHAP and permutation SHAP, if the number of features is too large for exact calculations, the algorithms iterate until the SHAP values are sufficiently precise in terms of their standard errors. The package integrates smoothly with meta-learning packages such as tidymodels, caret or mlr3. It supports multi-output models, case weights, and parallel computations. Visualizations can be done using the R package shapviz.

Interactive R package with an intuitive Shiny-based graphical interface for alternative splicing quantification and integrative analyses of alternative splicing and gene expression based on The Cancer Genome Atlas (TCGA), the Genotype-Tissue Expression project (GTEx), Sequence Read Archive (SRA) and user-provided data. The tool interactively performs survival, dimensionality reduction and median- and variance-based differential splicing and gene expression analyses that benefit from the incorporation of clinical and molecular sample-associated features (such as tumour stage or survival). Interactive visual access to genomic mapping and functional annotation of selected alternative splicing events is also included.

Supports the analysis of oceanographic data recorded by Argo autonomous drifting profiling floats. Functions are provided to (a) download and cache data files, (b) subset data in various ways, (c) handle quality-control flags and (d) plot the results according to oceanographic conventions. A shiny app is provided for easy exploration of datasets. The package is designed to work well with the oce package, providing a wide range of processing capabilities that are particular to oceanographic analysis. See Kelley, Harbin, and Richards (2021) <doi:10.3389/fmars.2021.635922> for more on the scientific context and applications.