Interfaces the Python library zuko implementing Masked Autoregressive Flows. See Rozet, Divo and Schnake (2023) <doi:10.5281/zenodo.7625672> and Papamakarios, Pavlakou and Murray (2017) <doi:10.48550/arXiv.1705.07057>.

This package provides a suite of utility functions providing functionality commonly needed for production level projects such as logging, error handling, cache management and date-time parsing. Functions for date-time parsing and formatting require that time zones be specified explicitly, avoiding a common source of error when working with environmental time series.

Extends the mlr3 package with a connector to the package batchtools'. This allows to run large-scale benchmark experiments on scheduled high-performance computing clusters.

This package implements a novel density-based approach for estimating unknown parameters, distribution visualisations and meta-analyses of quantiles and ther functions. A detailed vignettes with example datasets and code to prepare data and analyses is available at <https://bookdown.org/a2delivera/metaquant/>. The methods are described in the pre-print by De Livera, Prendergast and Kumaranathunga (2024, <doi:10.48550/arXiv.2411.10971>).

The Molecular Signatures Database ('MSigDB') is one of the most widely used and comprehensive databases of gene sets for performing gene set enrichment analysis <doi:10.1016/j.cels.2015.12.004>. The msig package provides you with powerful, easy-to-use and flexible query functions for the MsigDB database. There are 2 query modes in the msig package: online query and local query. Both queries contain 2 steps: gene set name and gene. The online search is divided into 2 modes: registered search and non-registered browse. For registered search, email that you registered should be provided. Local queries can be made from local database, which can be updated by msig_update() function.

The MSiP is a computational approach to predict protein-protein interactions from large-scale affinity purification mass spectrometry (AP-MS) data. This approach includes both spoke and matrix models for interpreting AP-MS data in a network context. The "spoke" model considers only bait-prey interactions, whereas the "matrix" model assumes that each of the identified proteins (baits and prey) in a given AP-MS experiment interacts with each of the others. The spoke model has a high false-negative rate, whereas the matrix model has a high false-positive rate. Although, both statistical models have merits, a combination of both models has shown to increase the performance of machine learning classifiers in terms of their capabilities in discrimination between true and false positive interactions.

This package contains functions for converting existing HTML/JavaScript source into equivalent shiny functions. Bootstraps the process of making new shiny functions by allowing us to turn HTML snippets directly into R functions.

The ultimate goal is to support 2-2-1, 2-1-1, and 1-1-1 models for multilevel mediation, the option of a moderating variable for either the a, b, or both paths, and covariates. Currently the 1-1-1 model is supported and several options of random effects; the initial code for bootstrapping was evaluated in simulations by Falk, Vogel, Hammami, and MioÄ eviÄ (2024) <doi:10.3758/s13428-023-02079-4>. Support for Bayesian estimation using brms comprises ongoing work. Currently only continuous mediators and outcomes are supported. Factors for any predictors must be numerically represented.

This package provides estimation and leave-one-cluster-out jackknife standard errors for four longitudinal cluster-randomized trial estimands: horizontal individual average treatment effect (h-iATE), horizontal cluster average treatment effect (h-cATE), vertical individual average treatment effect (v-iATE), and vertical cluster-period average treatment effect (v-cATE), using unadjusted and augmented (model-robust standardization) estimators. The working model may be fit using linear mixed models for continuous outcomes or generalized estimating equations and generalized linear mixed models for binary outcomes. Period inclusion for aggregation is determined automatically: only periods with both treated and control clusters are included in the construction of the marginal means and treatment effect contrasts. See Fang et al. (2025) <doi:10.48550/arXiv.2507.17190>.

The monotone package contains a fast up-and-down-blocks implementation for the pool-adjacent-violators algorithm for simple linear ordered monotone regression, including two spin-off functions for unimodal and bivariate monotone regression (see <doi:10.18637/jss.v102.c01>).

Various utilities to manipulate multivariate polynomials. The package is almost completely superceded by the spray and mvp packages, which are much more efficient.

Quick and simple Tcl/Tk Graphical User Interface to call functions. Also comprises a very simple experimental GUI framework.

Transforms, calculates, and presents results from the Mental Health Quality of Life Questionnaire (MHQoL), a measure of health-related quality of life for individuals with mental health conditions. Provides scoring functions, summary statistics, and visualization tools to facilitate interpretation. For more details see van Krugten et al.(2022) <doi:10.1007/s11136-021-02935-w>.

Pearson and Spearman correlation coefficients are commonly used to quantify the strength of bivariate associations of genomic variables. For example, correlations of gene-level DNA copy number and gene expression measurements may be used to assess the impact of DNA copy number changes on gene expression in tumor tissue. MVisAGe enables users to quickly compute and visualize the correlations in order to assess the effect of regional genomic events such as changes in DNA copy number or DNA methylation level. Please see Walter V, Du Y, Danilova L, Hayward MC, Hayes DN, 2018. Cancer Research <doi:10.1158/0008-5472.CAN-17-3464>.

This package provides functions for model-based response dimension reduction. Usual dimension reduction methods in multivariate regression focus on the reduction of predictors, not responses. The response dimension reduction is theoretically founded in Yoo and Cook (2008) <doi:10.1016/j.csda.2008.07.029>. Later, three model-based response dimension reduction approaches are proposed in Yoo (2016) <doi:10.1080/02331888.2017.1410152> and Yoo (2019) <doi:10.1016/j.jkss.2019.02.001>. The method by Yoo and Cook (2008) is based on non-parametric ordinary least squares, but the model-based approaches are done through maximum likelihood estimation. For two model-based response dimension reduction methods called principal fitted response reduction and unstructured principal fitted response reduction, chi-squared tests are provided for determining the dimension of the response subspace.

Matrix is an universal and sometimes primary object/unit in applied mathematics and statistics. We provide a number of algorithms for selected problems in optimization and statistical inference. For general exposition to the topic with focus on statistical context, see the book by Banerjee and Roy (2014, ISBN:9781420095388).

This package provides a simulation modeling framework which significantly extends capabilities from the MGDrivE simulation package via a new mathematical and computational framework based on stochastic Petri nets. For more information about MGDrivE', see our publication: Sánchez et al. (2019) <doi:10.1111/2041-210X.13318> Some of the notable capabilities of MGDrivE2 include: incorporation of human populations, epidemiological dynamics, time-varying parameters, and a continuous-time simulation framework with various sampling algorithms for both deterministic and stochastic interpretations. MGDrivE2 relies on the genetic inheritance structures provided in package MGDrivE', so we suggest installing that package initially.

Function multiroc() can be used for computing and visualizing Receiver Operating Characteristics (ROC) and Area Under the Curve (AUC) for multi-class classification problems. It supports both One-vs-One approach by M.Bishop, C. (2006, ISBN:978-0-387-31073-2) and One-vs-All approach by Murphy P., K. (2012, ISBN:9780262018029).

Based on the input data an n-dimensional cube with sub cells of user specified side length is created. The number of sample points which fall in each sub cube is counted, and with the cell volume and overall sample size an empirical probability can be computed. A number of cubes of higher resolution can be superimposed. The basic method stems from J.L. Bentley in "Multidimensional Divide and Conquer". J. L. Bentley (1980) <doi:10.1145/358841.358850>. Furthermore a simple kernel density estimation method is made available, as well as an expansion of Bentleys method, which offers a kernel approach for the grid method.

Makes Mapbox GL JS <https://docs.mapbox.com/mapbox-gl-js/api/>, an open source JavaScript library that uses WebGL to render interactive maps, available within R via the htmlwidgets package. Visualizations can be used from the R console, in R Markdown documents and in Shiny apps.

This package implements Meta Fuzzy Functions (MFFs) for regression Tak and Ucan (2026) <doi:10.1016/j.asoc.2026.114592> by aggregating predictions from multiple base learners using membership weights learned in the prediction space of validation set. The package supports fuzzy and crisp meta-ensemble structures via Fuzzy C-Means (FCM) Tak (2018) <doi:10.1016/j.asoc.2018.08.009>, Possibilistic FCM (PFCM) Tak (2021) <doi:10.1016/j.ins.2021.01.024>, and k-means, and provides a workflow to (i) generate validation/test prediction matrices from common regression learners (linear and penalized regression via glmnet', random forests, gradient boosting with xgboost and lightgbm'), (ii) fit cluster-wise meta fuzzy functions and compute membership-based weights, (iii) tune clustering-related hyperparameters (number of clusters/functions, fuzziness exponent, possibilistic regularization) via grid search on validation loss, and (iv) predict on new/test prediction matrices and evaluate performance using standard regression metrics (MAE, RMSE, MAPE, SMAPE, MSE, MedAE). This enables flexible, interpretable ensemble regression where different base models contribute to different meta components according to learned memberships.

This package provides a compilation of functions to create visually appealing and information-rich plots of meta-analytic data using ggplot2'. Currently allows to create forest plots, funnel plots, and many of their variants, such as rainforest plots, thick forest plots, additional evidence contour funnel plots, and sunset funnel plots. In addition, functionalities for visual inference with the funnel plot in the context of meta-analysis are provided.

An easy-to-use IMAP client that provides tools for message searching, selective fetching of message attributes, mailbox management, attachment extraction, and several other IMAP features, paving the way for e-mail data analysis in R.

This package provides a guidance system for analysis with missing data. It incorporates expert, up-to-date methodology to help researchers choose the most appropriate analysis approach when some data are missing. You provide the available data and the assumed causal structure, including the likely causes of missing data. midoc will advise which analysis approaches can be used, and how best to perform them. midoc follows the framework for the treatment and reporting of missing data in observational studies (TARMOS). Lee et al (2021). <doi:10.1016/j.jclinepi.2021.01.008>.