This is an R package for interfacing with the BIOM format. This package includes basic tools for reading biom-format files, accessing and subsetting data tables from a biom object (which is more complex than a single table), as well as limited support for writing a biom-object back to a biom-format file. The design of this API is intended to match the Python API and other tools included with the biom-format project, but with a decidedly "R flavor" that should be familiar to R users. This includes S4 classes and methods, as well as extensions of common core functions/methods.

This package is built to perform GWAS analysis using Bayesian techniques. Currently, GWAS.BAYES has functionality for the implementation of BICOSS (Williams, J., Ferreira, M. A., and Ji, T. (2022). BICOSS: Bayesian iterative conditional stochastic search for GWAS. BMC Bioinformatics), BGWAS (Williams, J., Xu, S., Ferreira, M. A.. (2023) "BGWAS: Bayesian variable selection in linear mixed models with nonlocal priors for genome-wide association studies." BMC Bioinformatics), and GINA. All methods currently are for the analysis of Gaussian phenotypes The research related to this package was supported in part by National Science Foundation awards DMS 1853549, DMS 1853556, and DMS 2054173.

This package provides functionality for users who are learning R or the techniques of data analysis. Written as a collection of wrapper functions, the DTwrapper package facilitates many core operations of data processing. This is achieved with relatively few requirements about the order of the processing steps or knowledge of specialized syntax. DTwrappers creates coding results along with translations to data.table's code. This enables users to benefit from the speed and efficiency of data.table's calculations. Furthermore, the package also provides the translated code for educational purposes so that users can review working examples of coding syntax and calculations.

Fits logistic regression models in which the binary response is represented by a triangular fuzzy number rather than an exact crisp label, allowing uncertainty in class membership to be encoded directly in the outcome. Model parameters are estimated using the Fuzzy Least Squares approach of Diamond (1988) <doi:10.1016/0020-0255(88)90047-3>, following the integrated fuzzy logistic regression method of Yapici Pehlivan and Sahin (2018) <https://dergipark.org.tr/en/pub/jssa/issue/37877/437725>. Provides fitting, prediction, classification, cross-validation, and diagnostic plotting methods, along with tools for comparing model behaviour across different assumed levels of label uncertainty.

An implementation of the methodology described in Petersen and Mueller (2016) <doi:10.1214/15-AOS1363> for the functional data analysis of samples of density functions. Densities are first transformed to their corresponding log quantile densities, followed by ordinary Functional Principal Components Analysis (FPCA). Transformation modes of variation yield improved interpretation of the variability in the data as compared to FPCA on the densities themselves. The standard fraction of variance explained (FVE) criterion commonly used for functional data is adapted to the transformation setting, also allowing for an alternative quantification of variability for density data through the Wasserstein metric of optimal transport.

Generates/modifies RNA-seq data for use in simulations. We provide a suite of functions that will add a known amount of signal to a real RNA-seq dataset. The advantage of using this approach over simulating under a theoretical distribution is that common/annoying aspects of the data are more preserved, giving a more realistic evaluation of your method. The main functions are select_counts(), thin_diff(), thin_lib(), thin_gene(), thin_2group(), thin_all(), and effective_cor(). See Gerard (2020) <doi:10.1186/s12859-020-3450-9> for details on the implemented methods.

Likelihood evaluations for stationary Gaussian time series are typically obtained via the Durbin-Levinson algorithm, which scales as O(n^2) in the number of time series observations. This package provides a "superfast" O(n log^2 n) algorithm written in C++, crossing over with Durbin-Levinson around n = 300. Efficient implementations of the score and Hessian functions are also provided, leading to superfast versions of inference algorithms such as Newton-Raphson and Hamiltonian Monte Carlo. The C++ code provides a Toeplitz matrix class packaged as a header-only library, to simplify low-level usage in other packages and outside of R.

An implementation of the representation-dependent gene level operations of grammar-based genetic programming with genes which are derivation trees of a context-free grammar: Initialization of a gene with a complete random derivation tree, decoding of a derivation tree. Crossover is implemented by exchanging subtrees. Depth-bounds for the minimal and the maximal depth of the roots of the subtrees exchanged by crossover can be set. Mutation is implemented by replacing a subtree by a random subtree. The depth of the random subtree and the insertion node are configurable. For details, see Geyer-Schulz (1997, ISBN:978-3-7908-0830-X).

This package implements the Cross-Sectionally Augmented Panel Quantile Autoregressive Distributed Lag (CS-PQARDL) model and the Quantile Common Correlated Effects Mean Group (QCCEMG) estimator for panel data with cross-sectional dependence. The package handles unobserved common factors through cross-sectional averages following Pesaran (2006) <doi:10.1111/j.1468-0262.2006.00692.x> and Chudik and Pesaran (2015) <doi:10.1016/j.jeconom.2015.03.007>. Quantile regression for dynamic panels follows Harding, Lamarche, and Pesaran (2020) <doi:10.1002/jae.2753>. The ARDL approach to cointegration testing is based on Pesaran, Shin, and Smith (2001) <doi:10.1002/jae.616>.

High-throughput experimental data are accumulating exponentially in public databases. However, mining valid scientific discoveries from these abundant resources is hampered by technical artifacts and inherent biological heterogeneity. The former are usually termed "batch effects," and the latter is often modelled by "subtypes." The R package BUScorrect fits a Bayesian hierarchical model, the Batch-effects-correction-with-Unknown-Subtypes model (BUS), to correct batch effects in the presence of unknown subtypes. BUS is capable of (a) correcting batch effects explicitly, (b) grouping samples that share similar characteristics into subtypes, (c) identifying features that distinguish subtypes, and (d) enjoying a linear-order computation complexity.

Facilitates many of the analyses performed in studies of behavioral economic demand. The package supports commonly-used options for modeling operant demand including (1) data screening proposed by Stein, Koffarnus, Snider, Quisenberry, & Bickel (2015; <doi:10.1037/pha0000020>), (2) fitting models of demand such as linear (Hursh, Raslear, Bauman, & Black, 1989, <doi:10.1007/978-94-009-2470-3_22>), exponential (Hursh & Silberberg, 2008, <doi:10.1037/0033-295X.115.1.186>) and modified exponential (Koffarnus, Franck, Stein, & Bickel, 2015, <doi:10.1037/pha0000045>), and (3) calculating numerous measures relevant to applied behavioral economists (Intensity, Pmax, Omax). Also supports plotting and comparing data.

Belief propagation methods in Bayesian Networks to propagate evidence through the network. The implementation of these methods are based on the article: Cowell, RG (2005). Local Propagation in Conditional Gaussian Bayesian Networks <https://www.jmlr.org/papers/v6/cowell05a.html>. For details please see Yu et. al. (2020) BayesNetBP: An R Package for Probabilistic Reasoning in Bayesian Networks <doi:10.18637/jss.v094.i03>. The optional cyjShiny package for running the Shiny app is available at <https://github.com/cytoscape/cyjShiny>. Please see the example in the documentation of runBayesNetApp function for installing cyjShiny package from GitHub.

Process raw force-plate data (txt-files) by segmenting them into trials and, if needed, calculating (user-defined) descriptive statistics of variables for user-defined time bins (relative to trigger onsets) for each trial. When segmenting the data a baseline correction, a filter, and a data imputation can be applied if needed. Experimental data can also be processed and combined with the segmented force-plate data. This procedure is suggested by Johannsen et al. (2023) <doi:10.6084/m9.figshare.22190155> and some of the options (e.g., choice of low-pass filter) are also suggested by Winter (2009) <doi:10.1002/9780470549148>.

This package provides plotting functions for visualizing pedigrees and family trees. The package complements a behavior genetics package BGmisc [Garrison et al. (2024) <doi:10.21105/joss.06203>] by rendering pedigrees using the ggplot2 framework. Features include support for duplicated individuals, complex mating structures, integration with simulated pedigrees, and layout customization. Due to the impending deprecation of kinship2, version 1.0 incorporates the layout helper functions from kinship2. The pedigree alignment algorithms are adapted from kinship2 [Sinnwell et al. (2014) <doi:10.1159/000363105>]. We gratefully acknowledge the original authors: Jason Sinnwell, Terry Therneau, Daniel Schaid, and Elizabeth Atkinson for their foundational work.

Quantification is a prominent machine learning task that has received an increasing amount of attention in the last years. The objective is to predict the class distribution of a data sample. This package is a collection of machine learning algorithms for class distribution estimation. This package include algorithms from different paradigms of quantification. These methods are described in the paper: A. Maletzke, W. Hassan, D. dos Reis, and G. Batista. The importance of the test set size in quantification assessment. In Proceedings of the Twenty-Ninth International Joint Conference on Artificial Intelligence, IJCAI20, pages 2640â 2646, 2020. <doi:10.24963/ijcai.2020/366>.

Implement multiverse style analyses (Steegen S., Tuerlinckx F, Gelman A., Vanpaemal, W., 2016) <doi:10.1177/1745691616658637> to show the robustness of statistical inference. Multiverse analysis is a philosophy of statistical reporting where paper authors report the outcomes of many different statistical analyses in order to show how fragile or robust their findings are. The multiverse package (Sarma A., Kale A., Moon M., Taback N., Chevalier F., Hullman J., Kay M., 2021) <doi:10.31219/osf.io/yfbwm> allows users to concisely and flexibly implement multiverse-style analysis, which involve declaring alternate ways of performing an analysis step, in R and R Notebooks.

This package implements propensity score weighting methods for estimating counterfactual survival functions, marginal hazard ratios, and weighted Kaplan-Meier and cumulative risk curves in observational studies with time-to-event outcomes. Supports binary and multiple treatment groups with inverse probability of treatment weighting (IPW), overlap weighting (OW), and average treatment effect on the treated (ATT). Includes symmetric trimming (Crump extension) for extreme propensity scores. Variance estimation via analytical M-estimation or bootstrap. Methods based on Li et al. (2018) <doi:10.1080/01621459.2016.1260466>, Li & Li (2019) <doi:10.1214/19-AOAS1282>, and Cheng et al. (2022) <doi:10.1093/aje/kwac043>.

Offers a core selection of interactivity-first shiny modules for many plot types meant to serve as flexible building blocks for applications and as the base for more complex modules. These modules allow for the rapid and convenient construction of shiny apps with very few lines of code and decouple plotting from the underlying data. These modules allow for full plot aesthetic customization by the end user through UI inputs. Utility functions for simple UI organization, automated UI tooltips, and additional plot enhancements are also provided. Includes a multi-panel figure builder app for arranging multiple modules together in a free-form layout.

This package provides tools for fitting, diagnosing, and analyzing tie-oriented and actor-oriented relational event models, under both frequentist and Bayesian approaches. The package supports tie-oriented modeling (Butts, 2008, <doi:10.1111/j.1467-9531.2008.00203.x>) and an actor-oriented modeling framework (Stadtfeld et al., 2017, <doi:10.15195/v4.a14>), with additional model diagnostics and goodness-of-fit tools. Interfaces to estimation backends provide a range of extensions: random-effects (frailty) relational event models capturing sender, receiver, and dyadic heterogeneity (Juozaitiene & Wit 2024, <doi:10.1007/s11336-024-09952-x>; Mulder & Hoff, 2024, <doi:10.1214/24-AOAS1885>), finite mixture and dyadic latent class models for unobserved dyadic heterogeneity (Lakdawala et al., 2026, <doi:10.1016/j.socnet.2026.06.006>), penalized estimation via the lasso, ridge, and elastic net (Tibshirani, R., 1996, <doi:10.1111/j.2517-6161.1996.tb02080.x>; Karimova et al., 2023, <doi:10.1016/j.socnet.2023.02.006>), and approximate Bayesian regularization (Karimova et al., 2025, <doi:10.1016/j.jmp.2025.102925>). Modeling of events with a duration is also supported (Lakdawala et al., 2026, <doi:10.48550/arXiv.2602.21000>) and moving window relational event models (Mulder & Leenders, 2019, <doi:10.1016/j.chaos.2018.11.027>; Meijerink et al., 2023, <doi:10.1371/journal.pone.0272309>).

Representing nucleotide modifications in a nucleotide sequence is usually done via special characters from a number of sources. This represents a challenge to work with in R and the Biostrings package. The Modstrings package implements this functionality for RNA and DNA sequences containing modified nucleotides by translating the character internally in order to work with the infrastructure of the Biostrings package. For this the ModRNAString and ModDNAString classes and derivates and functions to construct and modify these objects despite the encoding issues are implemenented. In addition the conversion from sequences to list like location information (and the reverse operation) is implemented as well.

This package provides methods for mediation analysis with missing data and non-normal data are implemented. For missing data, four methods are available: Listwise deletion, Pairwise deletion, Multiple imputation, and Two Stage Maximum Likelihood algorithm. For MI and TS-ML, auxiliary variables can be included to handle missing data. For handling non-normal data, bootstrap and two-stage robust methods can be used. Technical details of the methods can be found in Zhang and Wang (2013, <doi:10.1007/s11336-012-9301-5>), Zhang (2014, <doi:10.3758/s13428-013-0424-0>), and Yuan and Zhang (2012, <doi:10.1007/s11336-012-9282-4>).

Implementation of different statistical tools for the description and analysis of gene expression data based on the concept of data depth, namely, the scale curves for visualizing the dispersion of one or various groups of samples (e.g. types of tumors), a rank test to decide whether two groups of samples come from a single distribution and two methods of supervised classification techniques, the DS and TAD methods. All these techniques are based on the Modified Band Depth, which is a recent notion of depth with a low computational cost, what renders it very appropriate for high dimensional data such as gene expression data.

Three functional modules, including genetic features, differential expression analysis and non-additive expression analysis were integrated into the package. And the package is suitable for RNA-seq and small RNA sequencing data. Besides, two methods of non-additive expression analysis were provided. One is the calculation of the additive (a) and dominant (d), the other is the evaluation of expression level dominance by comparing the total expression of the gene in hybrid offspring with the expression level in parents. For non-additive expression analysis of RNA-seq data, it is only applicable to hybrid offspring (including two sub-genomes) species for the time being.

This package provides tools for econometric analysis and economic modelling with the traditional two-input Constant Elasticity of Substitution (CES) function and with nested CES functions with three and four inputs. The econometric estimation can be done by the Kmenta approximation, or non-linear least-squares using various gradient-based or global optimisation algorithms. Some of these algorithms can constrain the parameters to certain ranges, e.g. economically meaningful values. Furthermore, the non-linear least-squares estimation can be combined with a grid-search for the rho-parameter(s). The estimation methods are described in Henningsen et al. (2021) <doi:10.4337/9781788976480.00030>.