This package implements adaptive tau leaping to approximate the trajectory of a continuous-time stochastic process as described by Cao et al. (2007) The Journal of Chemical Physics <doi:10.1063/1.2745299> (aka. the Gillespie stochastic simulation algorithm). This package is based upon work supported by NSF DBI-0906041 and NIH K99-GM104158 to Philip Johnson and NIH R01-AI049334 to Rustom Antia.

Builds the coincident profile proposed by Martinez, W and Nieto, Fabio H and Poncela, P (2016) <doi:10.1016/j.spl.2015.11.008>. This methodology studies the relationship between a couple of time series based on the the set of turning points of each time series. The coincident profile establishes if two time series are coincident, or one of them leads the second.

Randomization-Based Inference for customized experiments. Computes Fisher-Exact P-Values alongside null randomization distributions. Retrieves counternull sets and generates counternull distributions. Computes Fisher Intervals and Fisher-Adjusted P-Values. Package includes visualization of randomization distributions and Fisher Intervals. Users can input custom test statistics and their own methods for randomization. Rosenthal and Rubin (1994) <doi:10.1111/j.1467-9280.1994.tb00281.x>.

Create and integrate maps in your R workflow. This package helps to design cartographic representations such as proportional symbols, choropleth, typology, flows or discontinuities maps. It also offers several features that improve the graphic presentation of maps, for instance, map palettes, layout elements (scale, north arrow, title...), labels or legends. See Giraud and Lambert (2017) <doi:10.1007/978-3-319-57336-6_13>.

This package implements event extraction and early classification of events in data streams in R. It has the functionality to generate 2-dimensional data streams with events belonging to 2 classes. These events can be extracted and features computed. The event features extracted from incomplete-events can be classified using a partial-observations-classifier (Kandanaarachchi et al. 2018) <doi:10.1371/journal.pone.0236331>.

Several functions to compute indicators for organization and efficiency in visual foraging, multi-target visual search, and cancellation tasks. The current version of this package includes the following indicators: best-r, mean Inter-target Distance, Percentage Above Optimal (PAO) scan path, and intersections in the scan path. For more detailed descriptions, see Mark et al. (2004) <doi:10.1212/01.WNL.0000131947.08670.D4>.

Using the DNA sequence and gene annotation files provided in ENSEMBL <https://www.ensembl.org/index.html>, the functions implemented in the package try to find the DNA sequences and protein sequences of any given genomic loci, and to find the genomic coordinates and protein sequences of any given protein locations, which are the frequent tasks in the analysis of genomic and proteomic data.

An elegant tool for processing and visualizing lipidomics data generated by mass spectrometry. LipidomicsR simplifies channel and replicate handling while providing thorough lipid species annotation. Its visualization capabilities encompass principal components analysis plots, heatmaps, volcano plots, and radar plots, enabling concise data summarization and quality assessment. Additionally, it can generate bar plots and line plots to visualize the abundance of each lipid species.

This package provides a lightweight framework for model selection and hyperparameter tuning in R. The package offers intuitive tools for grid search, cross-validation, and combined grid search with cross-validation that work seamlessly with virtually any modeling package. Designed for flexibility and ease of use, it standardizes tuning workflows while remaining fully compatible with a wide range of model interfaces and estimation functions.

Datasets for nlmixr2 and rxode2'. nlmixr2 is used for fitting and comparing nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Create regular pivot tables with just a few lines of R. More complex pivot tables can also be created, e.g. pivot tables with irregular layouts, multiple calculations and/or derived calculations based on multiple data frames. Pivot tables are constructed using R only and can be written to a range of output formats (plain text, HTML', Latex and Excel'), including with styling/formatting.

Considering the singly imputed synthetic data generated via plug-in sampling under the multivariate normal model, draws inference procedures including the generalized variance, the sphericity test, the test for independence between two subsets of variables, and the test for the regression of one set of variables on the other. For more details see Klein et al. (2021) <doi:10.1007/s13571-019-00215-9>.

This package provides ggplot2 extensions to construct glyph-maps for visualizing seasonality in spatiotemporal data. See the Journal of Statistical Software reference: Zhang, H. S., Cook, D., Laa, U., Langrené, N., & Menéndez, P. (2024) <doi:10.18637/jss.v110.i07>. The manuscript for this package is currently under preparation and can be found on GitHub at <https://github.com/maliny12/paper-sugarglider>.

This package performs estimation and testing of the treatment effect in a 2-group randomized clinical trial with a quantitative, dichotomous, or right-censored time-to-event endpoint. The method improves efficiency by leveraging baseline predictors of the endpoint. The inverse probability weighting technique of Robins, Rotnitzky, and Zhao (JASA, 1994) is used to provide unbiased estimation when the endpoint is missing at random.

Calculates evaluation metrics for implicit-feedback recommender systems that are based on low-rank matrix factorization models, given the fitted model matrices and data, thus allowing to compare models from a variety of libraries. Metrics include P@K (precision-at-k, for top-K recommendations), R@K (recall at k), AP@K (average precision at k), NDCG@K (normalized discounted cumulative gain at k), Hit@K (from which the Hit Rate is calculated), RR@K (reciprocal rank at k, from which the MRR or mean reciprocal rank is calculated), ROC-AUC (area under the receiver-operating characteristic curve), and PR-AUC (area under the precision-recall curve). These are calculated on a per-user basis according to the ranking of items induced by the model, using efficient multi-threaded routines. Also provides functions for creating train-test splits for model fitting and evaluation.

MsgPack header files are provided for use by R packages, along with the ability to access, create and alter MsgPack objects directly from R. MsgPack is an efficient binary serialization format. It lets you exchange data among multiple languages like JSON but it is faster and smaller. Small integers are encoded into a single byte, and typical short strings require only one extra byte in addition to the strings themselves. This package provides headers from the msgpack-c implementation for C and C++(11) for use by R, particularly Rcpp'. The included msgpack-c headers are licensed under the Boost Software License (Version 1.0); the code added by this package as well the R integration are licensed under the GPL (>= 2). See the files COPYRIGHTS and AUTHORS for a full list of copyright holders and contributors to msgpack-c'.

This package adds distinctive yet unobtrusive geometric patterns where solid color fills are normally used. Patterned figures look just as professional when viewed by colorblind readers or when printed in black and white. The dozen included patterns can be customized in terms of scale, rotation, color, fill, line type, and line width. It is compatible with the ggplot2 package as well as grid graphics.

This package helps you create plots of p-values using single SNP and/or haplotype data. Main features of the package include options to display a linkage disequilibrium (LD) plot and the ability to plot multiple datasets simultaneously. Plots can be created using global and/or individual haplotype p-values along with single SNP p-values. Images are created as either PDF/EPS files.

This package provides an XML-RPC client for Emacs capable of both synchronous and asynchronous method calls using the url package's async retrieval functionality. xml-rpc.el represents XML-RPC datatypes as Lisp values, automatically converting to and from the XML datastructures as needed, both for method parameters and return values, making using XML-RPC methods fairly transparent to the Lisp code.

Blacksheep is a tool designed for outlier analysis in the context of pairwise comparisons in an effort to find distinguishing characteristics from two groups. This tool was designed to be applied for biological applications such as phosphoproteomics or transcriptomics, but it can be used for any data that can be represented by a 2D table, and has two sub populations within the table to compare.

The classification protocol starts with a feature selection step and continues with nearest-centroid classification. The accurarcy of the predictor can be evaluated using training and test set validation, leave-one-out cross-validation or in a multiple random validation protocol. Methods for calculation and visualization of continuous prediction scores allow to balance sensitivity and specificity and define a cutoff value according to clinical requirements.

The crisprVerse is a modular ecosystem of R packages developed for the design and manipulation of CRISPR guide RNAs (gRNAs). All packages share a common language and design principles. This package is designed to make it easy to install and load the crisprVerse packages in a single step. To learn more about the crisprVerse, visit <https://www.github.com/crisprVerse>.

Empirical Bayes methods for learning prior distributions from data. An unknown prior distribution (g) has yielded (unobservable) parameters, each of which produces a data point from a parametric exponential family (f). The goal is to estimate the unknown prior ("g-modeling") by deconvolution and Empirical Bayes methods. Details and examples are in the paper by Narasimhan and Efron (2020, <doi:10.18637/jss.v094.i11>).

This package provides methods to estimate dynamic treatment regimes using Interactive Q-Learning, Q-Learning, weighted learning, and value-search methods based on Augmented Inverse Probability Weighted Estimators and Inverse Probability Weighted Estimators. Dynamic Treatment Regimes: Statistical Methods for Precision Medicine, Tsiatis, A. A., Davidian, M. D., Holloway, S. T., and Laber, E. B., Chapman & Hall/CRC Press, 2020, ISBN:978-1-4987-6977-8.